iiinova — where your digital self keeps evolving

Reposted by James Zwierzynski

Emma R Andersson @anderssonlab.bsky.social · 23/09/2026

🧬 Preprint! 🧵 Our goal is to genetically manipulate every embryonic germ layer to enable high throughput in vivo studies. We previously showed mouse ectoderm can be targeted by amniotic injection, enabling cell-specific manipulation, lineage tracing, and knockouts. But how to reach mesoderm?

Schematic of method developed and application. At embryonic day 7.5, a lentiviral library carrying unique 30-nucleotide barcodes and a fluorescent reporter is injected into the mouse exocoelomic cavity. An E8 embryo cross-section shows that this cavity is continuous with the intraembryonic coelomic cavity, allowing the virus to reach and barcode mesodermal progenitors, including lateral plate and paraxial mesoderm.

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James Zwierzynski @jamesbzsci.bsky.social · 08/09/2026

A wonderful past two weeks, presenting my work at the 10th Anniversary @HHMIJanelia / @embl Imaging Mouse Development Conference, submitting the DP5, and doing plenty of hiking after turning the big 3-0 and celebrating with a visit from my mom! Onto the best decade yet!

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James Zwierzynski @jamesbzsci.bsky.social · 28/08/2026

#FluorescenceFriday! Light sheet of the whole guinea pig uterus at E9.5 -epithelium (CK7, teal), smooth muscle (SMA, yellow). The middle pit is a uterine crypt where the embryo implanted and is undergoing gastrulation. These beautiful gland projections seen are key regulators of these processes too!

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Reposted by James Zwierzynski

@NicoliLab @nicolilab.bsky.social · 17/08/2026

🎉 It’s official! Vascular Cell Biology GRC 2027 is live!🎉 Join us January 10–15, 2027, in Ventura, California🌞 “Vascular Resilience: Mechanisms, Function, and Disease” Incredible group of scientists, many new ideas all focused on understanding how to build resilient blood vessels! 📢 PLEASE REPOST!📣

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James Zwierzynski @jamesbzsci.bsky.social · 28/05/2026

Looking to join a collaborative team studying coronary artery development? Love taking pretty microscope images? The Red-Horse lab(@hhmi-science.bsky.social/Stanford) is hiring for a senior scientist to research coronary & collateral artery development apply below!: tinyurl.com/5d85xjze

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Reposted by James Zwierzynski

Dr Kathleen Millen @neurodevkathy.bsky.social · 20/05/2026

🚨🧪🧵URGENT INPUT NEEDED: NIH asks input for next strategic plan-including emphasis on non-animal models (NAMs) to replace animals. Per NIH insider, anti-animal responses now outnumber scientists 200-700x. Please please provide input. Deadline: May 26, 11:59 PM ET. grants.nih.gov/news-events/...

grants.nih.gov

NIH Seeks Input on Framework for Next NIH-Wide Strategic Plan | Grants & Funding

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Reposted by James Zwierzynski

Molly Schumer @mollyschumer.bsky.social · 12/05/2026

Do you know any students who are planning to apply to graduate school this cycle? Encourage them to apply to the Biology Preview Program! We provide intensive workshops to help students w/ their applications + 1:1 mentorship.

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James Zwierzynski @jamesbzsci.bsky.social · 04/05/2026

Why do guinea pigs naturally develop collateral arteries while other species don't? Check out this wonderful preprint from our lab using in vivo Peturb-seq to discover differences in tip cell programming contribute to artery formation in guinea pig development!

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James Zwierzynski @jamesbzsci.bsky.social · 13/04/2026

If this work is interesting to you, we're hiring for a Senior Scientist with post-doctoral experience and a background in RNA molecular biology or whole-organ imaging and analysis to join our small, collaborative team! Come take more pretty pictures with us! Interested applicants should apply below:

careersearch.stanford.edu

Basic Life Research Scientist in School of Humanities and Sciences, Stanford, California, United States

Basic Life Research ScientistThis position has been deemed critical by the School of Humanities and Sciences Dean’s Office and is exempt from the...

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James Zwierzynski @jamesbzsci.bsky.social · 12/04/2026

I'm now on Bluesky!🤗 Excited to share our preprint, reviving Kristy Red-Horse's interest in the placenta from her PhD ~20 years ago! We find using 3D imaging that the mouse placenta is far more invasive than previously thought. Furthermore, we find a surprise from our favorite chemokine CXCL12...🧵:

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