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JAMA Ophthalmology @jamaophthalmology.bsky.social · 01/10/2026

Among high-attention #Ophthalmology publications, article-level Altmetric Attention Score rankings were not associated with citation rankings, suggesting that online attention and scholarly uptake reflect different dimensions of dissemination. ja.ma/4jrxeaU

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JAMA Ophthalmology @jamaophthalmology.bsky.social · 26/09/2026

Among patients with #Ophthalmic conditions, nearly 1 in 5 reported exposure to a treatment they perceived to be bogus, and about one-fourth of those exposed reported treatment uptake. ja.ma/4xD7vjn

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JAMA Ophthalmology @jamaophthalmology.bsky.social · 25/09/2026

📄 This case report of a 31-year-old woman who underwent Nd:YAG laser vitreolysis for floaters describes the postoperative development of a macular hole and its treatment. ja.ma/4rsT1kl

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JAMA Ophthalmology @jamaophthalmology.bsky.social · 25/09/2026

A 53-year-old woman with long-standing autoimmune disease and chronic hydroxychloroquine/intravenous immunoglobulin therapy presented with new bilateral yellow conjunctival cysts. What would you do next? ja.ma/4d03XQL

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JAMA Ophthalmology @jamaophthalmology.bsky.social · 25/09/2026

Global #CornealTransplant volume increased from 2012 to 2022, but the supply-demand gap remained severe and access stayed highly unequal across country income groups. ja.ma/4yV4VGl

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JAMA Ophthalmology @jamaophthalmology.bsky.social · 25/09/2026

A smartphone-based 3-dimensional facial reconstruction system showed high agreement with specialist measurements for #Blepharoptosis and accurately supported diagnosis and surgical classification. ja.ma/3TRnool

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JAMA Ophthalmology @jamaophthalmology.bsky.social · 17/09/2026

After complete regression in #PolypoidalChoroidalVasculopathy, as-needed aflibercept left about half of eyes fluid free for up to 2 years, while the remainder recurred and required resumed treatment. ja.ma/4yESHl6

Kaplan-Meier curve: Probability of fluid-free retina over 84 weeks. Starts at 1.0, drops steeply to 57% by 24 weeks, then plateaus. At week 84, probability is 53%. X-axis: Time from polypoidal regression (wk). No. at risk: 32 down to 6.

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JAMA Ophthalmology @jamaophthalmology.bsky.social · 06/09/2026

Among US children with #Myopia, highly aspherical lenslet spectacle lenses reduced myopia progression and axial elongation over 24 months vs single-vision spectacle lenses. ja.ma/46aVfew

RCT on myopia control: 159 children (6-12 yrs) received either highly aspherical lenslet (HAL) or single-vision (SVL) spectacles. Over 24 months, HAL group showed significantly less myopia progression & axial elongation. Graph illustrates HAL's flatter curve. CSER: 0.64 D, AL: -0.24 mm.

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JAMA Ophthalmology @jamaophthalmology.bsky.social · 09/08/2026

An international Delphi panel established standardized definitions for #RetinalVasculitis and related terms, with distinctions that may improve diagnostic clarity and interpretation of retinal imaging. ja.ma/4hhDpNN

Four medical images of a left eye. A: Color ultra-widefield fundus photo shows optic disc, vessels, and an inset of retinal detail. B: Grayscale red-free imaging. C: Early-phase fluorescein angiography reveals bright retinal vasculature. D: Late-phase fluorescein angiography highlights vascular patterns.

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JAMA Ophthalmology @jamaophthalmology.bsky.social · 08/08/2026

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JAMA Ophthalmology @jamaophthalmology.bsky.social · 03/08/2026

In a patient with dome-shaped macula, acute hypotony after lens implantation led to complete resolution of chronic subretinal fluid sustained for >7 months, suggesting intraocular pressure modulation may influence fluid dynamics. ja.ma/3TANrjd

Figure. Spectral-Domain Optical Coherence Tomography Imaging in Dome-Shaped Macula. A Before surgery. Two grayscale medical images: a fundus photo with green scan lines & a cross-sectional OCT showing a dome-shaped macula. Both have 200 µm scale bars.

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JAMA Ophthalmology @jamaophthalmology.bsky.social · 12/07/2026

Iqbal Ike K. Ahmed, MD, Jawad Muayad, MD, and Neil Bressler, MD, discuss a US cohort study indicating that patients who had documented nicotinamide use showed lower rates of glaucoma diagnosis, topical therapy, and laser intervention. 🎧 Listen now: ja.ma/4f4EBkQ

Podcast graphic with 'Author Interviews', 'JN', and 'openr' branding. Episode title: 'Nicotinamide and Primary Open-Angle Glaucoma in Ocular...' from 'JAMA Ophthalmology Author Int...'. Dated July 9, 21 min long, with a 'Play' button.

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JAMA Ophthalmology @jamaophthalmology.bsky.social · 11/07/2026

After refractive surgery, 18% of patients experienced prolonged ocular pain at 3 or 6 months, with higher risk seen after photorefractive keratectomy and in patients with preoperative chronic pain or greater ocular symptom burden. ja.ma/4yhUInT

$Webpage showing a JAMA Ophthalmology article titled 'Ocular Symptoms After Refractive Surgery' by Sujin Kang, Jason D. Betz, Elyana V. T. Locatelli, et al. Published Online: July 9, 2026. doi: 10.1001/jamaophthalmol.2026.2500$

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JAMA Ophthalmology @jamaophthalmology.bsky.social · 10/07/2026

Systemic #Nicotinamide supplementation in patients with #OcularHypertension was associated with a lower risk of developing primary open-angle #Glaucoma and delayed need for medical or surgical intervention. ja.ma/4fqmbwa

Forest plot showing cumulative incidence of POAG diagnosis over 5 years. Nicotinamide group (dark teal) shows significantly lower incidence than Control (orange). At 5 years, Control is ~14%, Nicotinamide ~6%. HR: 0.34 (95% CI: 0.25-0.47), Log-rank P<.001.

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JAMA Ophthalmology @jamaophthalmology.bsky.social · 26/06/2026

#Amblyopia is the leading cause of monocular vision loss in children, and early detection & treatment are crucial for the best outcomes. This Special Communication introduces an evidence-derived, web-based amblyopia decision support tool. ja.ma/4b8OJaU

JAMA Ophthalmology article: "Web-Based Amblyopia Decision Support Tool" (Special Communication). Authors: Allison I. Summers, Stanley W. Hatch, Sarah R. Hatt, et al. Published online May 7, 2026. DOI: 10.1001/jamaophthalmol.2026.1095.

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JAMA Ophthalmology @jamaophthalmology.bsky.social · 25/06/2026

In a patient with classic #Aniridia and negative conventional genetic testing, OGM and lrWGS revealed a small intrachromosomal translocation separating #PAX6 from its regulatory region, resulting in gene haploinsufficiency. ja.ma/4f1fOPJ

A: Ocular image, right eye, shows cloudy lens. B: Ocular image, left eye, reveals significant corneal opacity. C: OCT, right eye, depicts tissue layers with white arrowheads. D: OCT B-scan, left eye, shows retinal vasculature with a scan line and 200μm scale.

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JAMA Ophthalmology @jamaophthalmology.bsky.social · 23/06/2026

For #GeographicAtrophy clinical trials incorporating run-in phases in randomized clinical trials or single-arm designs can improve trial efficiency and decrease sample sizes, exploiting the inherent stability of atrophy enlargement rates. ja.ma/4waCKC5

Figure 2. Line graph showing total sample size required for different active treatment proportions for (A) any geographic atrophy and (B) nonsubfoveal geographic atrophy. As treatment proportion increases, sample size decreases across three trial types: 2-year with 9-month run-in, 2-year with 6-month run-in, and 1-year with 6-month run-in.

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JAMA Ophthalmology @jamaophthalmology.bsky.social · 21/06/2026

In a large UK Biobank study, genetic risk scores for #IntraocularPressure were more accurate in older individuals, but accounting for genotype × age interactions did not improve predictive accuracy. ja.ma/4w3UXkH

Four QQ plots compare observed vs. expected -log10 P values. A: Nonadditive allelic effects. B: Pairwise SNP x GRS interaction. C: SNP x GRS interaction. D: Interaction by age, age², and sex (SNP x age, SNP x age², SNP x sex distinguished by color). Most points follow the diagonal line, with some clear deviations at higher P-values.

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JAMA Ophthalmology @jamaophthalmology.bsky.social · 20/06/2026

Following copayment assistance defunding, nAMD patients who switched to bevacizumab had similar 6-month vision & retinal thickness outcomes as those continuing prior therapy, but required shorter injection intervals and faced increased out-of-pocket costs. ja.ma/4uMdQHG

JAMA Ophthalmology Research Letter: 'Outcomes in Neovascular Age-Related Macular Degeneration After Copayment Assistance Defunding' by W. Carrera, A. Zeng, K.X. Cheong, et al. Published online June 18, 2026.

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JAMA Ophthalmology @jamaophthalmology.bsky.social · 20/06/2026

In proliferative #diabetic #retinopathy, brolucizumab was more effective than panretinal laser photocoagulation for preserving visual acuity at 54 weeks and associated with fewer ocular adverse events but increased intraocular inflammation. ja.ma/3SfRDUY

JAMA Ophthalmology: RCT on Brolucizumab for Proliferative Diabetic Retinopathy. Study of 689 eyes (413M, 276W, avg 53.9y) shows Brolucizumab noninferior & superior to Panretinal laser photocoagulation (PRP) for BCVA. Graph reveals Brolucizumab improved/stable BCVA vs. PRP decline over 54 weeks (LS mean diff: 4.4 letters, P<.001).

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JAMA Ophthalmology @jamaophthalmology.bsky.social · 19/06/2026

Among #astronauts and bed rest participants, repeat #spaceflight or head-down tilt bed rest did not increase the magnitude of optic disc edema or brain ventricular expansion, with similar structural changes observed after first and second exposures. ja.ma/4xIpeHm

Figure 2. Line Graph Showing the Change in Peripapillary Total Retinal Thickness (ΔTRT) for Participants in Head-Down Tilt Bed Rest (HDTBR) by Campaign and Countermeasure. The y-axis shows ΔTRT in µm (0-80), x-axis shows countermeasure condition. Multiple lines indicate individual patient responses.

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Reposted by JAMA Ophthalmology

Duke Health @dukehealth.bsky.social · 10/06/2026

A routine eye scan used in the NICU may help predict developmental delays in very preterm infants, according to new Duke Health research in @jamaophthalmology.bsky.social. The retina may offer a non-invasive “window into the brain”, helping identify risk earlier. More: duke.is/c/rw6a

A Duke healthcare worker wearing purple gloves is using a medical scanner to provide care to a sleeping newborn wrapped in a blanket. The newborn is on a bed with a cute cloud-patterned cover and has medical tape on their face with a tube.

Duke physician Cynthia Toth is in scrubs smiling in front of multiple computer monitors displaying detailed eye scans.

A Duke healthcare professional in a blue uniform attending to a newborn in an incubator surrounded by medical equipment in a hospital room.

A Duke Health clinician points at a medical imaging screen showing detailed scans of an eye. The display includes multiple views and data related to the eye examination.

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JAMA Ophthalmology @jamaophthalmology.bsky.social · 16/06/2026

Among three leading ophthalmology journals between mid-2024 and late 2025, STROBE guideline adherence was high for core reporting items but suboptimal for missing data, participant flow, and generalizability in ophthalmology observational studies. ja.ma/43C1hDK

JAMA Ophthalmology Research Letter: 'STROBE Guideline Adherence Among Ophthalmology Journals' by C. Winkler, M. Ludke, T. Janetos. Published Online: June 11, 2026. DOI: 10.1001/jamaophthalmol.2026.1930.

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JAMA Ophthalmology @jamaophthalmology.bsky.social · 13/06/2026

JAMA Ophthalmology journal page displaying a "Research Letter" titled "STROBE Guideline Adherence Among Ophthalmology Journals." Authors are Calvin J. Winkler, BS¹, Meghan J. Ludke, BS¹, and Timothy M. Janetos, MD, MBA². Published Online: June 11, 2026. doi: 10.1001/jamaophthalmol.2026.1930

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JAMA Ophthalmology @jamaophthalmology.bsky.social · 12/06/2026

📄 This case report discusses a diagnosis of central retinal artery occlusion with gradual reperfusion and improvement in the visual acuity after alprostadil treatment in a female patient aged 67 years. ja.ma/4eCllMs

Ophthalmic images titled 'Gradual Reperfusion After Central Retinal Artery Occlusion' by Song, Chu, Chen. Left: Initial visit fundus photo reveals retinal edema & cherry-red spot. Right: Post-treatment images show initial decreased vascular signal & hyperreflectivity, improving with recovered signal & diminished hyperreflectivity 6 days later.

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JAMA Ophthalmology @jamaophthalmology.bsky.social · 11/06/2026

Swept-source #OCTA biomarkers, including choriocapillaris flow deficit and vessel skeleton density, distinguished normal cognition, MCI, and #AlzheimerDisease dementia, suggesting potential for noninvasive cognitive screening. ja.ma/43sRa48

Four bar charts with error bars comparing Control, MCI, and Dementia groups. A: VAD (q=.33) shows Control>MCI>Dementia. B: VSD (q=.20) shows Control>MCI>Dementia. C: Flux (q=.14) shows Control>MCI>Dementia. D: FAZ, mm² (q=.10) shows Control>MCI>Dementia. All groups display overlapping error bars.

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JAMA Ophthalmology @jamaophthalmology.bsky.social · 08/06/2026

Spectral-Domain OCT imaging of a dome-shaped macula (A) before surgery. Left: Fundus image of retina with green scan lines. Right: Corresponding cross-sectional OCT showing a dome-shaped macula and foveal detachment. Both images have 200 µm scale bars.

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JAMA Ophthalmology @jamaophthalmology.bsky.social · 07/06/2026

Among patients with #diabetes in both SEED and UK Biobank cohorts, metformin use was not associated with reduced risk of age-related macular degeneration compared to other antidiabetic medication or no antidiabetic medication. ja.ma/4fum6rQ

Bar chart & table show Age-Related Macular Degeneration (AMD) prevalence & incidence in SEED and UK Biobank by antidiabetic medication use. "Other antidiabetic medication" often shows higher AMD rates, while "No antidiabetic medication" can be lowest, particularly in UK Biobank incidence (2.7%).

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JAMA Ophthalmology @jamaophthalmology.bsky.social · 06/06/2026

📄 This case report discusses the finding of granular fluorescein flow on fluorescein angiography in a young boy with stage E retinoblastoma. ja.ma/4dUqE9W

Color fundus photo (A) shows total retinal detachment, sausage-string vessels (black arrow), and darker retinal vessels (white arrow). Inset: eye with leukocoria. Fluorescein angiography (B) displays granular flow (blue arrow) and ghost vessels (pink arrow), all related to retinoblastoma.

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JAMA Ophthalmology @jamaophthalmology.bsky.social · 05/06/2026

Bedside optical coherence tomography imaging at 36 weeks' postmenstrual age in very preterm infants indicated RNFL thickness predicts motor and cognitive outcomes and lowers autism risk at age 2 years. ja.ma/4ocz6Vx

A healthcare worker performs a noncontact retinal OCT scan on an infant in an incubator (A). Accompanying images show: B) Macula-centered OCT, C) RNFL thickness map (0-140 µm scale), D) Foveal B-scan, E) Foveal B-scan with retinal layer segmentation, F) B-scan with inner retinal segmentation.

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JAMA Ophthalmology @jamaophthalmology.bsky.social · 04/06/2026

A smartphone-based #AI application enabled population-level self-screening for ocular surface malignancies, achieving specialist-level diagnostic accuracy and identifying rare tumors without enucleation. ja.ma/4x9lEpm

Four plots. A: Prediction distributions for benign/malignant lesions, depicted with example images and dot plots for conditions like SCC, MM. B: Confusion matrix for multiclass classification, showing 213 true benign, 29 true malignant, 26 false benign, 6 false malignant. C: ROC curve for binary classification. D: ROC curves for 5-class classification, with AUCs (e.g., Microaverage AUC=0.874) listed.

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JAMA Ophthalmology @jamaophthalmology.bsky.social · 01/06/2026

In preterm infants undergoing retinopathy of prematurity screening, noncontact handheld optical coherence tomography caused less behavioral and physiological stress and fewer adverse events than contact fundus photography. ja.ma/4uLdKkv

Figure: Stress changes during/after imaging with OCT or Fundus Photography. Four bar charts show cry score, facial expression, heart rate, and O2 saturation. Fundus camera consistently indicates higher stress (cry score, worsening facial expression, heart rate increases, O2 sat decreases) compared to OCT.

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JAMA Ophthalmology @jamaophthalmology.bsky.social · 25/05/2026

Six cases of postoperative fungal #Endophthalmitis after #CataractSurgery were linked to Sarocladium kiliense contamination in off-label trypan blue solution, emphasizing the need for sterilization and infection control. ja.ma/4aa31rl

Figure 1. Preoperative and Postoperative Images of Case 2. A) Fibrin formation. B) Fundus details not visible. C) Vitreous opacities. TG: text@66.0 dB+0.0 dB. DR: text@59.0 dB+0.0 dB. NG: text@27 Steps. FG: text@24 Steps. D) No vitreous opacities.

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JAMA Ophthalmology @jamaophthalmology.bsky.social · 25/05/2026

No strong or consistent association was identified between reticular pseudodrusen and #CardiovascularDisease events or mortality in separate analyses from the #AREDS and #AREDS2 clinical trials. ja.ma/4uG4xtq

JAMA Ophthalmology article: "Reticular Pseudodrusen and Cardiovascular Disease or Related Mortality in AREDS and AREDS2" by Ayman G. Elnahry@1, Elvira Agrón@1, Catherine Cukras@1, et al. Published online May 21, 2026.

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JAMA Ophthalmology @jamaophthalmology.bsky.social · 24/05/2026

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JAMA Ophthalmology @jamaophthalmology.bsky.social · 24/05/2026

Figure 1. Ocular Images and Optical Coherence Tomography (OCT) Showing Typical Aniridia. The image shows the ocular image of the right eye, the ocular image of the left eye, OCT of the right eye, and OCT B-scan of the left eye.

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JAMA Ophthalmology @jamaophthalmology.bsky.social · 17/05/2026

A qualitative study found that a voice-based #AI assistant for #Ophthalmology was perceived as empathetic, understandable, and helpful for patient education, but clinicians and patients agreed it could complement human interaction. ja.ma/4nEqQgK

Survey responses before and after AI interaction, split by Patients (A) and Healthcare professionals (B). Each group shows agreement levels on AI in healthcare, with a scale from 'Strongly disagree' to 'Strongly agree'.

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JAMA Ophthalmology @jamaophthalmology.bsky.social · 17/05/2026

📄 This case report discusses intralenticular stratification in the #cataract of a boy aged 13 years with a history of familial exudative vitreoretinopathy and total retinal detachment. ja.ma/43cOHdL

A side-view eye exam shows opacity in the crystalline lens. A smaller inset image shows an eye exam of the anterior segment. An AS-OCT image shows hyperreflective bands extending throughout the lens.

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JAMA Ophthalmology @jamaophthalmology.bsky.social · 16/05/2026

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JAMA Ophthalmology @jamaophthalmology.bsky.social · 16/05/2026

Line graphs show the effects on total sample size requirements of active treatment proportion. Graph A shows "Any geographic atrophy". Graph B shows "Nonsubfoveal geographic atrophy". Includes legends for 2-y and 1-y trials with different run-in periods.

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JAMA Ophthalmology @jamaophthalmology.bsky.social · 12/05/2026

📄 This case report discusses a patient with vitiligolike hypopigmentation and eczematous dermatitis associated with topical treatment with atropine and dorzolamide. ja.ma/3RA6ysv

JAMA Ophthalmology presents "Vitiligolike Leukoderma Associated With Chronic Unilateral Topical Ophthalmic Atropine and Dorzolamide" by Francesco Bruni, Zaid Alsafi, and Ali Abbas. Published May 7, 2026; doi: 10.1001/jamaophthalmol.2026.1241.

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JAMA Ophthalmology @jamaophthalmology.bsky.social · 11/05/2026

Allison I. Summers, OD, MCR, discusses the Amblyopia Navigator Decision-Support Instrument, a user-friendly decision support tools for diagnosing and managing the most common forms of amblyopia in children, with Neil Bressler, MD. 🎧 Listen now: ja.ma/4n3O2oj

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JAMA Ophthalmology @jamaophthalmology.bsky.social · 10/05/2026

Screenshot of JAMA Ophthalmology's "Web-Based Amblyopia Decision Support Tool" article. It lists authors Allison I. Summers, text@1, Stanley W. Hatch, text@2, Sarah R. Hatt, text@3, and publication details for May 7, 2026, with its DOI.

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JAMA Ophthalmology @jamaophthalmology.bsky.social · 10/05/2026

📄 This case report discusses a patient with vitiligolike hypopigmentation and eczematous dermatitis associated with topical treatment with atropine and dorzolamide. ja.ma/4cW1uHu

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JAMA Ophthalmology @jamaophthalmology.bsky.social · 09/05/2026

📄 This case report describes the ocular injury incurred after blunt ocular trauma secondary to a fishhook in the left eye of a male child, aged 6 years. jamanetwork.com/journals/jam...

Ophthalmic images show 'Blunt Ocular Trauma in a 6-Year-Old Child' by Wu Xiang, Zhihao Jiang, and Yantao Wei. Image A shows 'Blunt ocular trauma' and image B shows 'Five mo postinjury'. Figure displays fundus photographs.

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JAMA Ophthalmology @jamaophthalmology.bsky.social · 09/05/2026

FOXC1 duplications were among the most common monogenic causes of juvenile open-angle glaucoma (JOAG) in two large registries, with high penetrance and variable ocular features. ja.ma/4uGsFMs

Images of patient irises, labeled A, B, and C. A shows "C/II/1", B shows "D/II/1", and C shows "J/II/1". Each section contains an eye diagram labeled OD and OS. Figure 1. Subset of Images of Patient Irises, Displaying Varying Phenotypes.

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JAMA Ophthalmology @jamaophthalmology.bsky.social · 09/05/2026

FOXC1 duplications were among the most common monogenic causes of juvenile open-angle glaucoma (JOAG) in two large registries, with high penetrance and variable ocular features. ja.ma/4u2aHnJ

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