iiinova — where your digital self keeps evolving

JAMA Network Open @jamanetworkopen.com · 14/09/2026

📈 Integrating #SmokingCessation treatment into #LungCancerScreening was cost-saving vs screening alone, with higher-intensity pharmacotherapy and counseling associated with the greatest long-term health gains. ja.ma/4j91hUu

A scatter plot shows QALYs (thousands) on Y-axis vs. total lifetime costs (million $) on X-axis. 'HighMED + HighCSL' shows highest QALYs (2269k) at $1545M cost. 'Screening alone' is lowest at 2240k QALYs for $1630M. Other strategies vary between.

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JAMA Network Open @jamanetworkopen.com · 14/09/2026

📈 Among infants who were tested for respiratory syncytial virus (#RSV) in 2 Canadian provinces, receipt of #Nirsevimab was associated with lower risk of RSV-related emergency department visits, hospitalization, and intensive care unit admission. ja.ma/4gTRRLd

Bar and line graph showing the number of infants with positive RSV test results (bars) and infants with nirsevimab immunization (line) from Oct 27, 2024 to Feb 23, 2025. RSV peaks around 75 in early Dec, while immunization peaks around 60 in early Nov, then both decline.

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JAMA Network Open @jamanetworkopen.com · 14/09/2026

📊 Among patients at #HRSA health centers, #FoodInsecurity was associated with more referrals to food assistance, but more than one-third of food-insecure patients reported receiving neither SNAP or WIC nor a referral. ja.ma/4yBbfCH

Bar chart shows patient percentages by food security (insecure/secure) and DRHC referral status (No DRHC/DRHC). Bars represent SNAP/WIC enrollment and referral source: from health center (dark gray/orange) or no referral from health center (light blue/light orange).

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JAMA Network Open @jamanetworkopen.com · 14/09/2026

📊 Among older inpatients with #Malnutrition at admission, implementation of a nutrition clinical framework was associated with lower in-hospital mortality and shorter length of stay. ja.ma/4xoHNPm

Five line graphs compare "Wards without framework" (dark circles) to "Wards with framework" (orange squares, dashed line) from January 2022 to January 2026. Metrics are in-hospital, 6-month, 1-year, and overall mortality, and length of stay. "Wards with framework" generally show lower values across all metrics. A shaded area and dotted line mark a period in late 2023-early 2024.

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JAMA Network Open @jamanetworkopen.com · 14/09/2026

🧠 In #MajorDepressiveDisorder, gray matter volume trajectories over 10 years were associated with cumulative illness burden rather than diagnosis alone or acute symptom fluctuations. ja.ma/46jQsrk

Brain scans highlight dLPFC & Hippocampus. Two graphs show estimated age-adjusted GMV over 10 years by CIS quartile. For both regions, the highest CIS quartile (Q4) exhibits a marked decline in GMV, while lower quartiles remain stable.

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JAMA Network Open @jamanetworkopen.com · 14/09/2026

📊 Among survivors of #BreastCancer in a longitudinal cohort, nonresponsiveness increased over time and was associated with social vulnerability, unhealthy behaviors, symptom burden, and enrollment at smaller centers. ja.ma/4AvsDL9

Stacked bar chart showing patient status from Baseline to Year 6 follow-up. The Y-axis is Patients, %. 'Responsive' patients decline from nearly 100% to ~75%. 'No response from enrolled patients,' 'Lost to follow-up,' and 'Withdrew consent' categories collectively increase, reaching ~25% by Year 6.

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JAMA Network Open @jamanetworkopen.com · 14/09/2026

📊 Perceived good death priorities differed across settings, while patient-caregiver differences were generally small, supporting culturally sensitive #PalliativeCare that reflects both shared and setting-specific end-of-life values. ja.ma/4xY4iMe

JAMA Network Open article: "Perceived Importance of Good Death Components Among Patients With Advanced Cancer and Family Caregivers" by Hammoda Abu-Odah et al. An Original Investigation in Oncology, published online September 14, 2026.

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JAMA Network Open @jamanetworkopen.com · 14/09/2026

Among Denmark children, a history of #FebrileSeizures was reassuringly associated with school test performances largely similar to that of unaffected peers. Children with many recurrences or later epilepsy may benefit from additional educational support. ja.ma/4xtiWdc

Table & forest plot showing test score differences by febrile seizure history, age, hospital contacts, and duration. No febrile seizures is reference (55.8). Test scores generally decrease with more hospital contacts or longer contact duration. Largest difference: -5.7 for >=7 hospital contacts. Basic & fully adjusted shown.

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JAMA Network Open @jamanetworkopen.com · 14/09/2026

📈 In Tanzania, simulation-based #NeonatalVentilation training with a low-cost, high-fidelity simulator was associated with improved knowledge and practical performance among students and health professionals. ja.ma/4cFGzrE

Four line graphs display pressure and BPM metrics over 6 trials for Medium-fidelity passive, High-fidelity passive, and High-fidelity active groups vs. a criterion standard. A: Mean pressure, High-fidelity passive is highest, medium-fidelity passive lowest. B: CV pressure, High-fidelity active peaks at trial 4. C: BPM, High-fidelity passive highest. D: CV BPM shows downward trends.

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JAMA Network Open @jamanetworkopen.com · 08/09/2026

Can a social media break help mental health? A new JAMA Network Open study suggests a one-week detox may reduce symptoms of #anxiety, #depression and #insomnia. #mentalhealth 📖Read to learn more: ja.ma/4yG1QKn

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JAMA Network Open @jamanetworkopen.com · 07/09/2026

📚 Among US preschool-aged children, parent-child shared #BookReading declined after the onset of the #COVID19 pandemic and remained below pre-pandemic levels through 2024. ja.ma/4gMUI7u

JAMA Network Open Research Letter in Pediatrics: 'Parent-Child Shared Book Reading With Preschoolers During and After the COVID-19 Pandemic.' Authors: Kwanghee Jung, PhD; W. Steven Barnett, PhD. Published online August 31, 2026.

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JAMA Network Open @jamanetworkopen.com · 07/09/2026

🩺📊 In this survey of US adults, trust in government health agencies as a source of #cancer information was lower during and after the #COVID-19 pandemic than in the years preceding it, while trust in doctors remained consistently high. ja.ma/3UDKiQe

JAMA Network Open article (open access) titled 'Trust in Cancer Information Sources During and After the COVID-19 Pandemic' by Todd Burus et al., published August 31, 2026. A Public Health Research Letter.

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JAMA Network Open @jamanetworkopen.com · 07/09/2026

📊 Among US #Hispanic and #Latino adults without hypertension at baseline, approximately half developed #Hypertension over 12 years, with higher incidence among adults of Central American, Cuban, and Dominican heritage. ja.ma/4gX338M

Nine bar charts display the prevalence of normal blood pressure (orange) and hypertension (grey) across three visits (V1, V2, V3) for various groups. Generally, the prevalence of normal BP decreases while hypertension prevalence increases from V1 to V3 across all cohorts.

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JAMA Network Open @jamanetworkopen.com · 07/09/2026

🏥 Hospital-operated #MedicareAdvantage plans were associated with different post-acute care use after hospitalization, including less skilled nursing facility use and more healthy days at home, without worse clinical outcomes. ja.ma/4x4AXOJ

Four forest plots show adjusted percentage point differences vs. other MA plans for medical and surgical conditions. Subsequent inpatient care and Inpatient rehabilitation show mainly positive differences (up to 3.7%). Observational stay and Skilled nursing show mainly negative differences (down to -4.0%).

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JAMA Network Open @jamanetworkopen.com · 07/09/2026

📈 In preterm infants, routine implementation of a multistrain #Probiotic was associated with lower risk of #NecrotizingEnterocolitis in neonatal intensive care settings, with rare cases of probiotic-associated sepsis. ja.ma/3UWahCs

Line graph: NEC incidence (%) from Jan 2018 to Jul 2024. Before implementation (orange line, 2018-Oct 2020), incidence widely fluctuated, generally high (6-19%). After implementation (grey line, from Oct 2020), incidence is lower (0-13%) with a decreasing overall trend.

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JAMA Network Open @jamanetworkopen.com · 07/09/2026

📈 In Richmond, California, the Peacemaker Fellowship was associated with sustained reductions in fatal and nonfatal firearm assaults over 14 years, supporting its potential as a public health approach to #GunViolence prevention. ja.ma/4r1G4Or

Line graph of Estimated ATT vs. Study year (1994-2026). Multiple light blue 'Control units' and one dark blue 'Richmond' line fluctuate around a horizontal dashed line. After a vertical dashed line at 2010, 'Richmond' generally declines, while 'Control units' become highly divergent, with peaks over 400 and lows below -170.

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JAMA Network Open @jamanetworkopen.com · 07/09/2026

💡📊 Edible #THC was associated with poorer simulated driving performance and lower self-reported willingness to drive, indicating dose-dependent impairment relevant to #DrivingSafety and roadside enforcement policy. ja.ma/4iboWmY

Four line graphs display THC dose-response data over 5 hours. Graphs A&B show blood THC & THC-COOH levels (ng/mL), while C&D show VAS ratings for effect & feeling high. Higher doses (10mg, 20mg) consistently lead to increased substance levels and stronger subjective effects, peaking around 1.5-2h.

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JAMA Network Open @jamanetworkopen.com · 07/09/2026

📊 In the Medicare Physician Fee Schedule valuation process, most specialty society proposals were unchanged by the Relative Value Scale Update Committee, and most RUC adjustments were devaluations. ja.ma/4xaG2Fm

Table 1: Proportion of services with negative adjustments during the RUC valuation process, by specialty. Data includes No. of codes and percentages for Specialty society-RUC, RUC-CMS, & Specialty society-CMS devaluations. Anesthesiology shows highest total devaluation (83.3%).

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JAMA Network Open @jamanetworkopen.com · 07/09/2026

📊 Among Australian children, preterm birth was associated with lower #Numeracy and #Reading scores, with the largest differences observed among those born at less than 28 weeks' gestation. ja.ma/3ThvFBF

Two line graphs compare AMD in z scores for Numeracy & Reading by gestational age (wk). Both show Full & Sibling-comparison cohorts' scores increasing from low values at 23-27wks to near zero by 39-42wks. Full cohort often starts lower.

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JAMA Network Open @jamanetworkopen.com · 07/09/2026

📊 In the University of Kansas Cancer Center catchment area, historical redlining was associated with lower #BreastCancer screening prevalence after accounting for social vulnerability, neighborhood conditions, and geographic access. ja.ma/4qVNh2m

Two maps of the Kansas City area. Map A, "Posterior ICAR spatial random effects," uses a purple to yellow gradient to show OR values (0.8 to 1.2). Map B, "Model-adjusted lower- and higher-than-expected screening areas," uses red for lower, yellow for not significant, and green for higher screening. Both maps mark mammogram centers.

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JAMA Network Open @jamanetworkopen.com · 07/09/2026

📊 A care navigation intervention for adults with #MethamphetamineUseDisorder increased engagement with the navigator but did not increase likelihood of linkage to treatment, highlighting persistent barriers to care. ja.ma/466vP1N

RCT: Care Navigation for Methamphetamine Use Disorder. 192 patients (156M, 29F, 7 transgender/nonbinary, med age 39) in Colorado. 96 received care navigation, 96 usual care. No significant differences in treatment linkage at 30 or 90 days, with linkage rates visually similar in bar graph (around 25-32%).

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JAMA Network Open @jamanetworkopen.com · 06/09/2026

💻 Case managers estimated hospital discharge dates more accurately than #ArtificialIntelligence near discharge, although performance was similar at admission and varied by length of stay and unit type. ja.ma/4zXmNll

Three graphs compare AI vs. case manager. (A) Mean absolute error (d) shows case manager more accurate nearer discharge. (B) Within-1-day accuracy (%) shows case manager consistently higher. (C) Bland-Altman plot for 24h estimates shows AI bias of 1.21 d vs. case manager.

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JAMA Network Open @jamanetworkopen.com · 06/09/2026

📝 In immunotherapy clinical trials, #LargeLanguageModels identified adverse events from clinical notes with performance comparable to human reviewers. ja.ma/4iULvfQ

A 3-circle Venn diagram shows overlaps in Adverse Events (AEs). Left: 91 Trial-reported AEs (41 unique). Top: 186 LLM-extracted AEs (46 unique). Bottom: 200 RC-identified AEs (50 unique). 34 AEs are common to all three methods.

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JAMA Network Open @jamanetworkopen.com · 06/09/2026

📊 #BladderCancer trial access in the US was concentrated in less socially vulnerable counties and was less available in counties with higher mortality, indicating a mismatch between trial location and disease burden. ja.ma/4dp0FGG

Map of the US and territories by county, showing the number of bladder cancer trials. A color gradient from light brown (0 trials) to dark red (≥50 trials) highlights concentrations in major urban centers and coastal regions, especially CA, Northeast, and FL.

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JAMA Network Open @jamanetworkopen.com · 06/09/2026

📈 Patients with a larger initial #ZDrug supply were more likely to continue filling these medications over time, indicating that initial prescribing decisions may have lasting implications for long-term use. ja.ma/4xeLO8W

Three line graphs show Z-drug usage trends over 7 years. A: Annual share with a Z-drug fill. B: Annual share with ≥180-d supply. C: Annual mean supply. All graphs show decreasing values over time, with groups having higher initial supply consistently starting and remaining higher.

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JAMA Network Open @jamanetworkopen.com · 06/09/2026

📊 In children born in Norway, maternal #COVID19 during pregnancy was not linked to autism, epilepsy, sensory impairments, or other broad neurodevelopmental outcomes. A possible association with speech or language disorders requires further examination. ja.ma/4gOYOMm

Four graphs show cumulative risk (0-0.10) vs. child age (0-6y) for unexposed (dark) and exposed (orange) groups. A) Neurodevelopmental: Exposed slightly higher from age 4. B) Autism: Exposed significantly higher from age 4. C) Neurological: Lines closely track. D) Sensory: Lines closely track, very low risk. No. at risk tables below.

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JAMA Network Open @jamanetworkopen.com · 06/09/2026

📊 Prenatal exposure to regulated public drinking water #Fluoride was not associated with children's emotional or behavioral behavioral problems in a pooled US cohort. ja.ma/4ibbUWF

Map of the US displaying 2017-2019 fluoride concentration by census tract (red shades, up to 3100 µg/L) and participants by state (tan shades, up to ≥500). CA, WA, NY, CO show high participant counts and varying fluoride levels. Some states have no data.

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JAMA Network Open @jamanetworkopen.com · 06/09/2026

📈 Among women with newly diagnosed #BreastCancer in a publicly funded setting, more than 90% underwent genetic testing when it was offered. Uptake was associated with younger age and family history of cancer. ja.ma/4dmE5hQ

JAMA Network Open article: 'Genetic Testing Uptake Among Patients With Newly Diagnosed Breast Cancer' by Stephanie P. Totten et al. This Research Letter in Genetics and Genomics was published online September 4, 2026.

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JAMA Network Open @jamanetworkopen.com · 06/09/2026

📈 In 24 US states, adults with diagnosed #HIV are projected to age from a median age of 51 years in 2025 to 61 years in 2040, indicating health programs may need to adapt to rising age-related comorbidity and care needs. ja.ma/4yoMaLb

Four scatter plots analyze change in median age of people with HIV (2025-2040) for various states. Each plot shows this change against a different 2025 HIV metric: A) New diagnoses to prevalence ratio, B) Median age among adults with diagnosed HIV, C) Median age for newly diagnosed HIV, D) HIV prevalence. Bubble color indicates Urbanicity score (yellow 0.6 to red 0.9), and R-values show correlation.

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JAMA Network Open @jamanetworkopen.com · 06/09/2026

📝 In leading medical journals, #OpenScience policies were only partly aligned with current transparency standards, and article-level practices were reported more often in randomized clinical trials than in other study designs. ja.ma/46tC7c1

Dot plot showing "Articles with practice, %" vs. "Practice" categories. Global analysis (orange) shows high percentages for COI, Funding, Author contribution, Open access (80-100%), dropping to 20-50% for Data sharing, Reporting, Protocol, Registration, ORCID, Code, SAP. Preprint is near 0%. Weighted frequencies also shown.

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JAMA Network Open @jamanetworkopen.com · 06/09/2026

🩸 In US trauma centers, balanced component and #WholeBlood transfusion increased from 2018 to 2024, largely associated with greater #WholeBlood adoption, while substantial between-hospital variation persisted. ja.ma/3TfWuWU

Two graphs show trends in balanced blood component and WB use from 2018-2024. Graph A: Total balanced transfusion (blue line) rose from 12% to 38%; WB use (orange bars) increased significantly from 2020. Graph B: "More permissive (≥0.8)" (orange line) rose from 14% to 48%, outpacing "Optimal (≥1.0)" (grey line) which rose from 12% to 38%.

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JAMA Network Open @jamanetworkopen.com · 06/09/2026

📊 In patients with #MechanicalHeartValves, omitting postoperative bridging was associated with a higher estimated risk of arterial thromboembolism in exploratory analyses, indicating the need to balance thromboembolism and bleeding risk perioperatively. ja.ma/4ibaPOB

Kaplan-Meier plot showing cumulative incidence over 30 days. Red (TB/HR) shows highest incidence (~0.09), followed by orange (NTB/HR, ~0.05), blue (TB/LMR, ~0.02), and grey (NTB/LMR, ~0.01). A table shows number at risk, and statistical results for TB (sHR 1.75, P=.16) and HR (sHR 4.61, P=.003) are included.

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JAMA Network Open @jamanetworkopen.com · 06/09/2026

Among patients with #AtrialFibrillation and advanced #ChronicKidneyDisease not receiving dialysis, apixaban was associated with lower ischemic stroke risk and higher bleeding risk vs no anticoagulation, but lower bleeding and stroke risk vs warfarin. ja.ma/4ibaM5n

Three forest plots with tables comparing drug outcomes. A: Apixaban vs no use shows increased GI bleeding but reduced death. B: Warfarin vs no use shows increased GI and intracranial bleeding but reduced death. C: Apixaban vs Warfarin shows Apixaban reduces all three outcomes.

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JAMA Network Open @jamanetworkopen.com · 29/08/2026

🩺 In Japan, elective #AtrialFibrillation ablation was associated with low in-hospital mortality during a decade of rapid expansion, with no evidence that broader adoption reduced procedural safety. #ESCCongress ja.ma/4xYo9KO

Temporal Trends in In-Hospital Mortality After Elective Atrial Fibrillation Ablation, 2012-2022. Y-axis: Mortality during hospitalization (%). X-axis: Year. Shows annual mortality (orange, fluctuating) and 3-y moving average mortality (blue, generally decreasing trend, P=.04).

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JAMA Network Open @jamanetworkopen.com · 25/08/2026

Among women with their first delivery, obstetric anal sphincter injury was associated with several nonmodifiable risk factors, highlighting that #Cesarean delivery on maternal request is the only known, universally effective preventive strategy. ja.ma/4gjZb2C

Forest plot shows adjusted relative risk (aRR) and 95% CI for maternal and neonatal factors associated with second-degree (grey) and third-/fourth-degree (orange) perineal lacerations. Factors include age, race, BMI, delivery payment, birth attendant, delivery type, hypertension, diabetes, & gestational age.

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JAMA Network Open @jamanetworkopen.com · 25/08/2026

Among commercially insured patients in Rhode Island, vertical integration and professional fees for hospital-affiliated clinicians increased more slowly than in neighboring states, suggesting Rhode Island’s Affordability Standards limit price increases. ja.ma/4wSO6KB

Line graph showing the percentage of vertically integrated clinicians from 2013 to 2019. The dark gray line for "Other New England states" rises from 0.46 to 0.63. The orange line for "Rhode Island" shows a steady increase from 0.32 to 0.44. Both trends are upward.

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JAMA Network Open @jamanetworkopen.com · 25/08/2026

Among 2600 older women, earlier menopause was associated with faster white matter lesion accumulation decades after the menopause transition, suggesting menopausing timing is a midlife marker for late-life #dementia risk. ja.ma/4gr9DE8

Two graphs show cognitive decline over 30 years based on age at menopause. Graph A: Global cognition. Graph B: Episodic memory. Both show a decline in z-score, with earlier menopause (dark blue lines, ≤43 years) associated with a steeper decline than later menopause (light blue lines, >51 years).

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JAMA Network Open @jamanetworkopen.com · 25/08/2026

Among men with #STEMI receiving #PCI, taking 5-alpha reductase inhibitors (finasteride or dutasteride) was associated with lower rates of severe complication from their STEMI, suggesting future research to investigate a protective effect. ja.ma/4qpa8TU

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JAMA Network Open @jamanetworkopen.com · 25/08/2026

Following the loss of universal free school meals as pandemic-era federal waivers ended in June 2022, students in states that did not maintain access to universal free school meals had less favorable BMI trajectories than states that maintained access. ja.ma/4cOBNb5

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JAMA Network Open @jamanetworkopen.com · 25/08/2026

📊 Across US #Urology clinics, most provided a self-pay price for a new appointment, but #HospitalBased and #Academic clinics were less likely than private practices to disclose upfront prices, indicating major gaps in price transparency remain. ja.ma/4xkxZXh

Dot plot showing median and interquartile range (IQR) of adjusted self-pay prices for US states, listed on the Y-axis. West Virginia has the highest median at $472, Virginia the lowest at $148. The X-axis shows 'Adjusted self-pay price, $'.

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JAMA Network Open @jamanetworkopen.com · 25/08/2026

📈 Among individuals with a past-year #OpioidOverdose, starting #Methadone was associated with significantly lower 1-year mortality vs starting #BuprenorphineNaloxone. ja.ma/3Sf70xe

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JAMA Network Open @jamanetworkopen.com · 25/08/2026

🩺 Among pregnant or postpartum individuals with #Depression or #Anxiety, facilitated transition to #PrimaryCare after obstetric care was associated with more postpartum mental health screening, counseling, prescriptions, and referrals vs standard care. ja.ma/4xJRZ5o

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JAMA Network Open @jamanetworkopen.com · 25/08/2026

🔬 In a clinical trial of adults with #Dengue, a single dose of #DengueMonoclonalAntibody was safe and rapidly reduced viremia and fever vs placebo, indicating potential for a specific therapeutic option in dengue. ja.ma/4xGToK8

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JAMA Network Open @jamanetworkopen.com · 24/08/2026

📊 In #PeripheralArteryDisease care, physician implicit racial bias was not associated with guideline-concordant #VascularCare, suggesting that clear and monitored guidelines may reduce disparities. ja.ma/3UiDlUr

Forest plots show physician bias effect on patient incidence. A) Guideline practices: little difference across white/black patients, no/pro-Black, pro-White biases. B) Nonguideline procedures: Pro-White bias leads to lower incidence for white patients (AOR 0.84) but significantly higher incidence for black patients (AOR 1.67).

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JAMA Network Open @jamanetworkopen.com · 24/08/2026

In pregnant women with #Asthma, continuation of #InhaledCorticosteroids during the first trimester was not associated with higher risk of adverse maternal or neonatal outcomes and supports treatment when clinically indicated. ja.ma/4zF6vgU

Forest plot displays PS-weighted RR (95% CI) for maternal outcomes like Preeclampsia, Antepartum hemorrhage, and infant outcomes like Preterm birth, Congenital malformation. Data is stratified by age (>=35, <35) and asthma exacerbation (Yes, No). Notably, Antepartum hemorrhage RR is 2.17 with asthma exacerbation.

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JAMA Network Open @jamanetworkopen.com · 24/08/2026

Among patient portal messages in primary care, message content was associated with care team response, but writing style explained much of the lower response from target clinicians for historically marginalized patient groups. ja.ma/4x9tZci

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JAMA Network Open @jamanetworkopen.com · 21/08/2026

🫀 In postdischarge #HeartFailure care, #MobileIntegratedHealth was associated with high patient satisfaction, but it did not improve 30-day all-cause readmissions vs a transitions-of-care coordinator intervention. ja.ma/4x9u1AW

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JAMA Network Open @jamanetworkopen.com · 21/08/2026

📈 Reducing antiretroviral therapy access was associated with thousands of additional #HIV acquisitions in projected analyses, substantially reversing gains associated with #TreatmentAsPrevention. ja.ma/4x9u1Rs

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JAMA Network Open @jamanetworkopen.com · 21/08/2026

📊 Among patients undergoing #PeritonealDialysis before #KidneyTransplant, a history of peritonitis was associated with higher risks of graft failure and adverse post-transplant outcomes. ja.ma/4x4MLRP

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JAMA Network Open @jamanetworkopen.com · 21/08/2026

🔬 Among full-term infants with #HypoxicIschemicEncephalopathy, whole-blood gene expression at birth distinguished mild disease from moderate or severe disease and from healthy controls. ja.ma/4xGRyJ9

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