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JAMA Internal Medicine @jamainternalmed.com · 29/09/2026

Among patients hospitalized with #OpioidUseDisorder in Philadelphia, dexmedetomidine use rose after medetomidine emerged in the illicit fentanyl supply, and nearly all such admissions involved the intensive care unit. ja.ma/4y1jQy4

Stacked bar chart of OUD-related hospitalizations by quarter (2020-2025). Orange bars show 'Without dexmedetomidine,' gray show 'With dexmedetomidine.' Total hospitalizations rise from ~400 in 2020 to over 800 by 2025 Q3, with dexmedetomidine use increasing sharply in 2024-2025.

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JAMA Internal Medicine @jamainternalmed.com · 29/09/2026

For most routine laboratory tests, fasting duration was not associated with clinically meaningful differences. #Glucose, triglycerides, γ-glutamyl transferase, and lipase were the main exceptions. ja.ma/47qrdny

A JAMA Internal Medicine article page titled 'Fasting Duration and Differences Across Routine Laboratory Tests' by Sunghwan Shin, Sollip Kim, Shinae Yu, et al. Published online September 28, 2026. A lock icon indicates restricted access.

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JAMA Internal Medicine @jamainternalmed.com · 25/09/2026

This JAMA Internal Medicine Patient Page describes use of continuous #glucose monitors, as well as their benefits and drawbacks. ja.ma/4xA7FYA

Table comparing Continuous Glucose Monitors (CGMs) for people with type 2 diabetes and those without. For type 2, CGMs show a modest A1c reduction, help detect low glucose, and may aid treatment changes. For non-diabetics, blood glucose fluctuations are uncertain, potentially leading to misguided diet choices.

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JAMA Internal Medicine @jamainternalmed.com · 24/09/2026

In the US Veterans Affairs system, female emergency physicians modestly increased testing and hospital admissions compared with male colleagues, with no difference in 30-day mortality or short admission rates. ja.ma/3Tkcfw6

JAMA Internal Medicine Research Letter: 'Practice Pattern and Outcome Differences in the Emergency Department by Physician Sex.' Authors: Dan P. Ly, Stephen Coussens, Laura G. Burke. Published Online: July 20, 2026.

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JAMA Internal Medicine @jamainternalmed.com · 23/09/2026

This review examines the evidence for continuous #glucose monitoring use beyond type 1 #diabetes or #pregnancy, explores its usefulness as a behavior change aid, and critically assesses its expanding role in the care of people with dysglycemia. ja.ma/4yE2B6s

Diagram of a Continuous Glucose Monitoring (CGM) sensor on an arm, showing its filament embedded in skin layers. Text describes CGM modalities, benefits (e.g., less fingersticks, shown by crossed-out device), drawbacks (e.g., anxiety, shown by anxious person with phone), and appropriate use cases.

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JAMA Internal Medicine @jamainternalmed.com · 22/09/2026

Among patients hospitalized for #HeartFailure, only 54% of new guideline-directed medications were filled in 7 days and just half of patients remained persistent at 6 months after discharge. ja.ma/3UW1MYd

Figure 2: Four Sankey plots showing initiation of guideline-directed medical therapy classes (β-Blocker, RASi, MRA, SGLT2i) after heart failure hospitalization. They illustrate patient transitions between Nonuser, Primary nonadherence, New initiator, and Newly prescribed statuses over 90 days post-discharge.

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JAMA Internal Medicine @jamainternalmed.com · 21/09/2026

Patients with end-stage kidney disease and #DevelopmentalDisabilities had lower rates of #KidneyTransplant evaluation and receipt than matched controls, and state antidiscrimination laws were not associated with more equitable access. ja.ma/47gbwiF

JAMA Internal Medicine article: Research Letter on 'Antidiscrimination Laws and Kidney Transplant for Patients With Developmental Disabilities.' Authors: Brittany N. Hand, J. Madison Hyer, Melica Nikahd et al. Published online September 21, 2026. DOI: 10.1001/jamainternmed.2026.4392.

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JAMA Internal Medicine @jamainternalmed.com · 21/09/2026

In more than 850 000 adults with #SteatoticLiverDisease, the steatosis-associated fibrosis estimator (SAFE) score provided the greatest net benefit for identifying 10-year cirrhosis risk and may help guide repeat surveillance. ja.ma/4xGTuBh

Line graph shows net benefit of 9 clinical risk scores for cirrhosis intervention vs. 10-yr risk threshold. FIB-4 & SAFE show high initial net benefit. "Treat all" drops sharply at low thresholds. All curves converge to near zero net benefit at higher risk thresholds.

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JAMA Internal Medicine @jamainternalmed.com · 21/09/2026

Medicare patients of general internists with higher Longitudinal Knowledge Assessment scores were significantly less likely to receive low-value services, underscoring the role of physician knowledge in reducing unnecessary care. ja.ma/4AecLMF

Bar-and-Whisker Plot: Patients receiving low-value services if internists matched top-quartile physicians. X-axis: Beneficiaries (No.), Y-axis: Medical Services. Shows potential reduction in beneficiaries for most low-value services, with largest for Total/free T3 testing and Prostate-specific antigen testing, decreasing by tens of thousands.

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JAMA Internal Medicine @jamainternalmed.com · 20/09/2026

Among Medicare beneficiaries with newly diagnosed cancer, #MedicareAdvantage was associated with similarly timely and optimal treatment as traditional Medicare, but with lower cancer drug costs. ja.ma/473ktMd

Line graph: time to treatment initiation & death by insurance type. TM (traditional Medicare) & MA (Medicare Advantage) treatment lines show similar rapid cumulative incidence increase to ~0.9. TM & MA death lines show similar slow increase to ~0.08. Outcomes are very similar for both.

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JAMA Internal Medicine @jamainternalmed.com · 18/09/2026

Cluster RCT: On-site #POC-RMPCR in nursing homes did not reduce outbreak size or frequency, but reduced ED transfers and enabled faster antiviral therapy compared to standard off-site testing. ja.ma/4j9zlzR

JAMA Internal Medicine study on respiratory outbreak mitigation. 20 nursing homes compared point-of-care vs. standard testing. Findings show no significant difference in outbreak number or size between groups (Rate ratio 1.12; P=.55). Box plots confirm similar distributions.

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JAMA Internal Medicine @jamainternalmed.com · 15/09/2026

A randomized trial in rural #NavajoNation found that a culturally tailored meal program for adults with #HeartFailure reduced hospitalizations or emergency visits and improved food insecurity, quality of life, and blood pressure. ja.ma/4xp5IhE

Infographic: RCT on Indigenous Food as Medicine. 206 patients (mean age 65.8) with heart failure. Tailored Navajo meal program (40.6%) showed lower hospitalizations/ED visits vs. usual care (57.0%) over 90 days. Relative risk 0.72.

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JAMA Internal Medicine @jamainternalmed.com · 07/09/2026

Among nursing home residents aged ≥65 years in Medicare, #RespiratorySyncytialVirus vaccination was associated with lower risk of #RSV-associated hospitalization, death, severe outcomes, and thromboembolic events during the 2023-2024 season. ja.ma/465EzFn

JAMA Internal Medicine article titled 'Respiratory Syncytial Virus Vaccine Effectiveness in Medicare Beneficiaries Residing in Nursing Homes.' Authored by Ryan E. Wiegand, Heng-Ming Sung, Yue Zhang et al., published online August 31, 2026.

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JAMA Internal Medicine @jamainternalmed.com · 06/09/2026

Routine referral of patients with #ProstateCancer to a #Cardiovascular specialist improved cholesterol control and overall risk factor management, but did not reduce major cardiovascular events vs usual care. ja.ma/4czduOu

JAMA Internal Medicine graphic: RCT on specialist referral for cardiovascular risk in prostate cancer. 2487 male adults (avg. 68y) from 55 clinics in 8 countries. 2501 randomized: 1243 to intervention (referral, counseling, statins) or 1250 to usual care. Intervention favored (win ratio 1.60, P<.001). Intervention group pairs: 48%; Control: 30%.

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JAMA Internal Medicine @jamainternalmed.com · 06/09/2026

The 2025 #NIH Public Access Policy may still leave NIH-funded investigators facing new article processing charges for immediate public access, with an estimated upper-bound annual cost of more than $100 million. ja.ma/3UHGVrq

Table: Open-Access Manuscript Types, Descriptions, and APC Payments. It details 6 types (Green, Closed, Fully Open Access with/without APC, Hybrid, Bronze), showing their public availability, and APC payment status for updated NIH policy. Abbreviations: APC, NIH.

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JAMA Internal Medicine @jamainternalmed.com · 30/08/2026

Presented at #ESCCongress: Routine referral of patients with #ProstateCancer to a #Cardiovascular specialist improved cholesterol control and overall risk factor management, but did not reduce major cardiovascular events vs usual care. ja.ma/4zDpSGW

JAMA Internal Medicine: Specialist Referral for Cardiovascular Risk in Patients With Prostate Cancer. Figure 2 line graph shows cumulative incidence (%) over 9 years for Control and Intervention groups. The Control line is slightly above Intervention. sHR 1.08 (95% CI, 0.79-1.49).

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JAMA Internal Medicine @jamainternalmed.com · 19/08/2026

US pilots and flight attendants had the highest and second-highest percentages of deaths from radiation-related #Cancer across 503 occupations, while deaths from other cancers were not similarly elevated. ja.ma/4fZrl2K

Scatterplots of deaths from radiation-related (A) and other cancers (B) by occupation rank. Both show increasing risk with rank. Flight attendants, Pilots, and Nuclear technologists have higher risk-adjusted % of deaths in both categories.

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JAMA Internal Medicine @jamainternalmed.com · 18/08/2026

This case report describes the electrocardiogram findings of a patient in their 40s with dizziness and presyncope after hematemesis and multiple black stools. ja.ma/4fY4Zyv

Figure. 12-Lead Electrocardiogram Obtained on Presentation. A cardiac rhythm is displayed on a grid across leads I, II, III, aVR, aVL, aVF, and V1-V6. Prominent, rapid, wide QRS complexes are clearly visible in leads V4, V5, and V6, specifically marked by red arrows.

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JAMA Internal Medicine @jamainternalmed.com · 17/08/2026

📑 JAMA Internal Medicine Review: This review provides an evidence-based update on the diagnosis and management of #ShoulderPain to support clinical decision-making and improve patient outcomes. ja.ma/4q7sBE9

Figure 1: Musculoskeletal anatomy of the right shoulder. Section A shows anterior and posterior views of bony & periarticular structures (clavicle, humerus, scapula) with rotator cuff insertions. Section B illustrates muscular anatomy, including the subscapularis, supraspinatus, infraspinatus, and teres minor.

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JAMA Internal Medicine @jamainternalmed.com · 17/08/2026

In US adults, serologic immunity to #HepatitisA and #HepatitisB remained low, with substantial susceptibility persisting across high-risk clinical subgroups. ja.ma/4gmDqPv

Bar graphs display Hepatitis A (HAV) and B (HBV) serologic immunity prevalence across sex, age, race/ethnicity, and birthplace from NHANES 2017-2023 data. HAV immunity rises with age & is higher in some minority groups/non-US born. HBV shows similar variations.

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JAMA Internal Medicine @jamainternalmed.com · 11/08/2026

Among older adults with #Type2Diabetes and hemoglobin A1c below goal, medication deintensification increased from 2019 to 2023 but remained uncommon, with only 16.9% deintensified in 2023. ja.ma/4q8bJgs

Prevalence of medication changes (intensification, deintensification, no change) in older Type 2 diabetes patients, 2019-2023. Graphs show these trends stratified by HbA1c level (above, at, below goal) and health status (good, intermediate, poor).

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JAMA Internal Medicine @jamainternalmed.com · 11/08/2026

A community health worker-led, telehealth #diabetes intervention improved HbA1c, cholesterol, and ADA guideline adherence vs usual care in low-income Hispanic adults, addressing 87% of participant concerns via a structured feedback loop. ja.ma/4hX22zu

RCT on telehealth CHW feedback for diabetes. 257 uninsured, low-income Hispanic adults with type 2 diabetes. Intervention group showed significantly greater HbA1c reduction over 12 months (-1.0 percentage points) vs. control, depicted by a graph showing intervention's decline.

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JAMA Internal Medicine @jamainternalmed.com · 10/08/2026

Among patients due for annual #LungCancer screening, stepped reminders to primary care physicians to order and patients to schedule low-dose computed tomography increased guideline-concordant screening adherence vs usual care. ja.ma/4zoMaMG

JAMA Internal Medicine RCT on lung cancer screening for 1837 adults (mean age 66.3). A bar chart shows Stepped Reminders (SR, 78.1%) & Both HC & SR (72.8%) significantly increased annual screening adherence vs. Usual Care (48.7%) & Health Communication (46.1%).

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JAMA Internal Medicine @jamainternalmed.com · 10/08/2026

Among adults with #Type2Diabetes, #MedicareAdvantage was not associated with better hemoglobin A1c, blood pressure, or low-density lipoprotein cholesterol vs original Medicare after accounting for pre-Medicare differences. ja.ma/4g0v9PR

Four line graphs showing adjusted trends in clinical outcomes over 24 months for Medicare Advantage and Original Medicare. Hemoglobin A1c, LDL cholesterol, systolic, and diastolic blood pressure all show slight decreases, with very similar trends for both groups.

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JAMA Internal Medicine @jamainternalmed.com · 08/08/2026

Among acutely ill adults receiving supplemental oxygen, #AutonomousOxygenTitration increased time in normoxemia and decreased time in hypoxemia vs usual care. ja.ma/4z6os7x

JAMA Internal Medicine presents an RCT on Autonomous Oxygen Titration for Normoxemia in Acutely Ill Adults. A bar chart shows autonomous titration achieved 85% time in normoxemia vs. 63% for usual care (P<.001), with less hypoxemia/hyperoxemia.

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JAMA Internal Medicine @jamainternalmed.com · 08/08/2026

Among US adults, 2024–2025 COVID-19 vaccination was associated with a 26% lower risk of COVID-19 ED/UC visits, 35% lower risk of hospitalization, and 41% lower risk of critical illness, with effectiveness declining >6 months post vaccination. ja.ma/4xq8uDJ

JAMA Internal Medicine article titled "Estimated Effectiveness of 2024-2025 COVID-19 Vaccines in Adults." Authored by Ryan E. Wiegand, Amanda B. Payne, Josephine Mak, et al. Published Online: June 15, 2026.

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JAMA Internal Medicine @jamainternalmed.com · 03/08/2026

💬 Invited Commentary: Autonomous #Oxygen titration in hospitalized patients with acute hypoxemic respiratory failure increased time in normoxemia to 85% vs 63% with usual care and reduced time in hypoxemia to 2.0% vs 3.6%. #MHSRS2026 ja.ma/4bq4hYf

JAMA Internal Medicine: Invited Commentary, "Potential Transformative Impact of Autonomous Oxygen Delivery in Hospitalized Patients" by Melanie F. Weingart, MD & Michael A. Matthay, MD. Published Online: August 3, 2026. DOI: 10.1001/jamainternmed.2026.4038.

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JAMA Internal Medicine @jamainternalmed.com · 03/08/2026

Presented today at #MHSRS2026: Among acutely ill adults receiving supplemental oxygen, #AutonomousOxygenTitration increased time in normoxemia and decreased time in hypoxemia vs usual care. ja.ma/3TTVGa9

JAMA Internal Medicine RCT: Autonomous oxygen titration (152 patients) vs. usual care (148) for acutely ill adults (median age 66). Autonomous group spent 85% of time in normoxemia vs. 63% for usual care, also significantly reducing hyperoxemia shown in a bar chart.

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JAMA Internal Medicine @jamainternalmed.com · 03/08/2026

Food-specific IgE panel testing should not be ordered without a clinical history suggestive of IgE-mediated #FoodAllergy. Sensitization alone does not establish diagnosis and may contribute to unnecessary dietary restriction, patient harm and avoidable costs. Learn more: ja.ma/4wxEFAW

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JAMA Internal Medicine @jamainternalmed.com · 01/08/2026

RCT on 'An Indigenous Food is Medicine Intervention' for 206 adults with heart failure in Navajo Nation. Tailored meal program group (40.6%) had lower 90-day hospitalizations/ED visits than usual care group (57.0%). Relative risk 0.72.

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JAMA Internal Medicine @jamainternalmed.com · 01/08/2026

A large cluster randomized trial found no reduction in winter respiratory infection rates among care home residents with the use of portable high-efficiency particulate air filters, compared with standard infection prevention measures. ja.ma/4w4m0Mf

JAMA Internal Medicine RCT: High-efficiency air filters in 47 care homes (vs. 44 usual care homes) showed no significant difference in winter respiratory infection rates (0.99 vs 1.04 infections/resident/winter). Study involved 1158 residents (median age 88) across 91 English homes. Graph depicts no significant effect.

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JAMA Internal Medicine @jamainternalmed.com · 11/07/2026

💬 Viewpoint: Most lethal #zoonotic #viruses, including Andes virus, lack sufficient transmissibility for global spread. Balanced public health communication is essential to prevent undue alarm. ja.ma/3SZ7fwk

JAMA Internal Medicine article: 'Viewpoint: Hantavirus on a Nature Cruise and the Risk of a Pandemic'. Authored by Daniel J. Morgan et al. Published Online: July 9, 2026. Features options for author affiliations & article information.

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JAMA Internal Medicine @jamainternalmed.com · 10/07/2026

Cluster RCT: On-site #POC-RMPCR in nursing homes did not reduce outbreak size or frequency, but reduced ED transfers and enabled faster #antiviral therapy compared to standard off-site testing. ja.ma/3QJe3O4

JAMA Internal Medicine RCT: Respiratory Outbreak Mitigation with Point-of-Care Testing in Long-Term Care. A study in 20 Canadian nursing homes (3963 beds) comparing point-of-care vs standard testing found no significant difference in outbreak number/size between groups (rate ratio 1.12, P=.55).

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JAMA Internal Medicine @jamainternalmed.com · 02/07/2026

A large sibling-matched cohort study in Hong Kong found no evidence of an association between prenatal paracetamol (acetaminophen) exposure and risk of #Autism or #ADHD in offspring when accounting for unmeasured familial confounding. ja.ma/4eZLjbL

JAMA Internal Medicine, Original Investigation on Women's Health: 'Prenatal Acetaminophen (Paracetamol) Use & Risk of Autism/ADHD Among Sibling-Matched Cohorts' by Luo et al. Published online June 29, 2026. DOI: 10.1001/jamainternmed.2026.2215

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JAMA Internal Medicine @jamainternalmed.com · 01/07/2026

An 8-week telehealth mindfulness group medical visit program for adults with #LowBackPain produced modest but sustained improvements in pain intensity and interference at 6 and 12 months vs usual care. ja.ma/3SumjSz

RCT summary: Mindfulness-Based Group Medical Visits for Chronic Low Back Pain. 451 adults (133M, 318F, avg 52.1y) at 3 US sites. 224 received MBSR, 227 usual care. MBSR showed significantly greater pain improvement (PEG score change -1.21 vs -0.59; P<.002), with more participants reporting improvement.

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JAMA Internal Medicine @jamainternalmed.com · 01/07/2026

Asynchronous electronic screening prior to #telemedicine visits improved completion and detection rates for unhealthy alcohol use among #veterans in primary care compared with usual staff-administered screening. ja.ma/4vGDRt6

Table 2: Adjusted Primary & Secondary Outcomes. Compares Usual care vs. E-screening results. For ITT, E-screening shows higher % completed (74.4 vs 43.9) & positive results (10.6 vs 2.7). Similar trend for PP: completed (88.3 vs 46.4) & positive (13.2 vs 2.9).

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JAMA Internal Medicine @jamainternalmed.com · 28/06/2026

In a national cohort, Black living kidney donors with #APOL1 high-risk genotypes had more than twice the risk of reduced kidney function nearly 20 years after donation, supporting genotyping for better risk stratification. ja.ma/4g2acpz

A JAMA Internal Medicine article: 'Apolipoprotein L1 Gene Genotype and Kidney Outcomes After Living Kidney Donation.' Authors include Chi-yuan Hsu, Ying Gao, Barry I. Freedman, et al. Published online June 22, 2026. DOI: 10.1001/jamainternmed.2026.0996.

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JAMA Internal Medicine @jamainternalmed.com · 26/06/2026

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JAMA Internal Medicine @jamainternalmed.com · 24/06/2026

In a randomized trial, higher financial incentives eliminated racial enrollment disparities in a smoking cessation trial, but did not affect gaps by sex, age, or education. ja.ma/4eszegc

JAMA Internal Medicine Research Letter: 'Financial Incentives to Address Representativeness in Randomized Clinical Trials: A Secondary Analysis of RETAIN.' By J.S. Benson, B.P. Patel, B. Bayes, et al. Health Equity topic. Published June 22, 2026.

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JAMA Internal Medicine @jamainternalmed.com · 24/06/2026

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JAMA Internal Medicine @jamainternalmed.com · 22/06/2026

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JAMA Internal Medicine @jamainternalmed.com · 16/06/2026

Page from JAMA Internal Medicine showing an Original Investigation: "Estimated Effectiveness of 2024-2025 COVID-19 Vaccines in Adults." Authors include Ryan E. Wiegand, Amanda B. Payne, Josephine Mak, et al. Published online June 15, 2026.

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JAMA Internal Medicine @jamainternalmed.com · 16/06/2026

Among older adults after #surgery, postoperative #delirium was independently associated with long-term #cognitive decline; rehospitalization did not mediate this association. ja.ma/4vnBefJ

Figure 2 displays two line graphs (A, B) tracking General Cognitive Performance (GCP) over 60 months, based on delirium and rehospitalization. Graph A shows absolute scores; B is offset. Both indicate declining GCP, with lower scores linked to delirium and rehospitalizations. Participant numbers are tabled below.

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JAMA Internal Medicine @jamainternalmed.com · 15/06/2026

Among US veterans, the 2024-2025 COVID-19 vaccine was associated with a 37.7% lower risk of COVID-19–associated #MACE, with the largest benefit in adults >75 years and those with comorbidities. ja.ma/4aAEWKt

Line graph of cumulative COVID-19-associated MACEs risk for 2024-2025. Unvaccinated people show a higher, increasing risk (over 5 per 10,000 by 8 months) compared to vaccinated individuals, whose risk remains lower (below 3.5 per 10,000).

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JAMA Internal Medicine @jamainternalmed.com · 14/06/2026

In adults at risk for chronic low back pain, clinician-supported biopsychosocial self-management was more effective than #medical care at reducing LBP impact and chronicity, while #spinal manipulation showed no added benefit. ja.ma/4eg0PQs

JAMA Internal Medicine RCT summary: Spinal Manipulation (SMT) and Clinician-Supported Self-Management (SSM) for chronic low back pain. 1000 patients randomized across 4 groups. SSM showed significantly lower LBP impact scores vs Medical Care (MC). SMT and MC did not differ.

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JAMA Internal Medicine @jamainternalmed.com · 14/06/2026

#Arthritis is a leading cause of pain and disability that affects nearly one-third of older US adults, many have inflammatory arthritis. 💡 This Clinical Insights discusses inflammatory arthritis in older adults and offers practical guidance. ja.ma/4a6Cf3p

Flowchart "Approach to Joint Pain in Older Adults" starts with Joint Pain, branching into Chronic, Acute, and Noninflammatory pain types. Each branch details symptoms, diagnostic criteria, and leads to conditions like Rheumatoid arthritis, Septic arthritis, or Osteoarthritis. Body diagrams highlight affected joints.

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JAMA Internal Medicine @jamainternalmed.com · 10/06/2026

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JAMA Internal Medicine @jamainternalmed.com · 09/06/2026

Line graph: HbA1c changes over 12 months in 257 low-income, uninsured Hispanic adults with Type 2 Diabetes. Intervention group dropped from 9.2% to 8.2%, while control stayed stable at ~8.8%.

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JAMA Internal Medicine @jamainternalmed.com · 08/06/2026

Among older adults after surgery, postoperative delirium was independently associated with long-term cognitive decline; rehospitalization did not mediate this association. ja.ma/4umBqui

Two graphs display General Cognitive Performance (GCP) trajectory for N=560 over 60 months post-surgery. X-axis: Time since surgery, Y-axis: GCP score. Graph A is 'Offset by mean difference in GCP score'; Graph B is 'Not offset'. Both compare GCP trajectories for groups with/without delirium and rehospitalizations, showing declines. Tables below list participant numbers for each group.

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JAMA Internal Medicine @jamainternalmed.com · 07/06/2026

Older adults living alone with cognitive impairment are at elevated risk for medication-related harm due to barriers at multiple levels, including lack of reminders, regimen complexity, and unwitnessed adverse effects. ja.ma/4xuvzGn

Conceptual diagram of study findings on barriers to medication management. Concentric circles show individual, interpersonal, and system/policy barriers faced by older adults, along with potential solutions. "Figure. Conceptual Diagram of Study Findings"

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