Jake Jordan @jakejsays.bsky.social · 25/07/2026www.nature.com/articles/d41...nature.comAI identifies interactions in CRISPR complexes to improve specificity of DNA editingAlphaFold3 predictions of the molecular contacts made by a genome-editing enzyme have been used to improve the enzyme’s selectivity for target DNA sequences. 010
Jake Jordan @jakejsays.bsky.social · 25/07/2026The same AI that predicts protein structures is now making gene editing safer. A new AlphaFold3-guided method in @nature.com cut off-target base editing by up to 99% with little loss in on-target activity. Safer tools enable more widespread use. (Link to news & views in the reply)nature.comPrecise DNA base editing using AlphaFold3-based contact modelling - NatureContactSeek is an AlphaFold3-driven model that can improve the precision of genome-editing tools. 100
Jake Jordan @jakejsays.bsky.social · 22/07/2026Lots of recent work uses wastewater for disease surveillance. Turns out the same approach says a lot about a community's diet too. Duke and UNC pulled plant and animal DNA from sewage in NC communities: hops in wealthier areas, seafood along the coast. Underused, data-rich pipes.pnas.orgDietary DNA in municipal wastewater reveals signatures of wealth, immigration, and coastal proximity | PNASPublic health nutrition lacks scalable, objective tools for real-time dietary surveillance. We developed FoodSeq-FLOW (Food Landscape Observation i... 000
Jake Jordan @jakejsays.bsky.social · 20/07/2026Original Science article: www.science.org/doi/10.1126/... Nature News article: www.nature.com/articles/d41...science.orgStructure and evolution-guided design of minimal RNA-guided nucleasesThe design of RNA-guided nucleases with properties not limited by evolution can expand programmable genome-editing capabilities. However, generating diverse multidomain proteins with robust enzymatic ... 020
Jake Jordan @jakejsays.bsky.social · 20/07/2026Jennifer Doudna and team used AI to design gene-editing enzymes that match or beat their natural CRISPR versions. 🤯 Purpose-built biological AI models make the former researcher in me so jealous. The same design power that speeds cures can strengthen our defenses too. Links in reply. 110
Jake Jordan @jakejsays.bsky.social · 16/07/2026I'm late to highlight, worth noting: OpenAI turned its Bio Bug Bounty into a standing program: up to $50K to red-teamers who can jailbreak its biosecurity guardrails. Paying outside experts to keep breaking your own safeguards is accountability worth copying. Who's next? openai.com/index/bio-bu...openai.comOpenAI Bio Bug BountyDetails about the OpenAI Bio Bounty program 000
Jake Jordan @jakejsays.bsky.social · 20/04/2026AIxBio Hackathon Site: apartresearch.com/sprints/aixb... 000
Jake Jordan @jakejsays.bsky.social · 20/04/2026An AIxBio Hackathon to solve real problems: DNA screening, pandemic early warning, benchtop synthesizer security. No biosecurity background required. Good to see NTI's work on managed access and benchtop synthesizers on the reading list. These problems need more builders. Link in the comments. 110
Jake Jordan @jakejsays.bsky.social · 04/04/2026Dr. William Goedel @brownpublichealth.bsky.social created an interactive map of everyone World Cup training site, team hotel, and stadium across all 16 cities. Useful for fans. Essential for public health professionals. Smart infrastructure, built before it's needed. www.arcgis.com/apps/dashboa... 010
Jake Jordan @jakejsays.bsky.social · 01/04/2026False biological claims move at the speed of social media. Credible correction moves at the speed of institutions. That gap is exploitable—and the decisions that prevent a biological event from becoming a catastrophe happen early. Figure out who you'd trust before you need to. 010
Jake Jordan @jakejsays.bsky.social · 01/04/2026April Fools' Day comes with a warning label. Biological threats won't. When a scary claim goes viral, most people—including some decision-makers—don't know who to trust or how fast they can get a real answer. That's a societal problem, not a personal failing. 🧵 #nojoke 110
Jake Jordan @jakejsays.bsky.social · 14/03/2026Happy Pi Day! 🥧 Pi’s refusal to follow a pattern mirrors biotechnology: capabilities and risks today will look nothing like those of tomorrow. Governance is already struggling to keep pace. NTI | bio is working to change that. #PiDay #Biosecurity #AIxBio www.nti.org/analysis/art...nti.orgAIxBio Horizon Scan Winter 2025-2026The AIxBio field stands at a critical juncture where rapid capability advances are outpacing governance frameworks and safety measures. The next 18 months will likely prove pivotal in determining whet... 050