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jakecrouse.bsky.social

@jakecrouse.bsky.social
120 followers 587 following 6 posts
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jakecrouse.bsky.social @jakecrouse.bsky.social · 13/07/2026
What do clinicians need to know about chronobiology & chronotherapeutics to support their care of people with bipolar disorders? Our international expert consensus study has distilled ~50 years of research into the “must know” information for clinicians. onlinelibrary.wiley.com/doi/10.1111/...
onlinelibrary.wiley.com
Essential Information About Chronobiology and Chronotherapy for the Optimal Care of People With Bipolar Disorders: An Expert Consensus
Introduction Circadian dysfunction is involved in the pathophysiology of bipolar disorders (BD), and circadian-based interventions are gaining recognition in their management. Moreover, basic and ep...
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Reposted by @jakecrouse.bsky.social
Department of Psychiatry, University of Oxford @oxfordpsychiatry.bsky.social · 29/01/2026
📢 NEW RESEARCH: Why do some people respond to one antidepressant medication and not another? A new paper used prescription data & genetic information from 12,000+ participants to test whether genetic differences distinguish patterns of antidepressant prescribing 👇 jamanetwork.com/journals/jam...
jamanetwork.com
Genetic and Phenotypic Associations With Sustained Antidepressant Use in Major Depressive Disorder
This cohort study evaluates phenotypic and genetic heterogeneity in major depressive disorder.
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Reposted by @jakecrouse.bsky.social
JAMA Psychiatry @jamapsychiatry.com · 28/01/2026
Among adults with #Depression, complex antidepressant treatment patterns were associated with higher polygenic risk for psychiatric traits but not with sustained use of a single antidepressant. ja.ma/4k3LpkN
Figure 1 shows Antidepressant use in the Australian Genetics of Depression Study. Graph A depicts the number of participants using each antidepressant; Graph B shows the distribution of cumulative prescription duration for antidepressants.
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jakecrouse.bsky.social @jakecrouse.bsky.social · 29/01/2026
New in @jamapsychiatry.com - in the Australian Genetics of Depression Study we show using 4.5 yrs of prescription data that genetic risk for ADHD, depression, neuroticism and bipolar disorder influence the complexity of an individual's depression treatment journey jamanetwork.com/journals/jam...
jamanetwork.com
Genetic and Phenotypic Associations With Sustained Antidepressant Use in Major Depressive Disorder
This cohort study evaluates phenotypic and genetic heterogeneity in major depressive disorder.
010
Reposted by @jakecrouse.bsky.social
jakecrouse.bsky.social @jakecrouse.bsky.social · 19/01/2026
Our new paper in Biological Psychiatry #SOBP in 3,000 Australians with #atypical #depression (N=15K) links atypicality with poorer response to SSRIs and SNRIs + genetic risk for #metabolic, #inflammatory, and #circadian traits. www.biologicalpsychiatryjournal.com/article/S000...
biologicalpsychiatryjournal.com
Atypical depression is associated with a distinct clinical, neurobiological, treatment response and polygenic risk profile
Atypical depression is considered a distinct clinical subtype of major depression, yet its predictive validity and clinical utility remain contested. We investigated association between atypical depre...
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jakecrouse.bsky.social @jakecrouse.bsky.social · 19/01/2026
Our new paper in Biological Psychiatry #SOBP in 3,000 Australians with #atypical #depression (N=15K) links atypicality with poorer response to SSRIs and SNRIs + genetic risk for #metabolic, #inflammatory, and #circadian traits. www.biologicalpsychiatryjournal.com/article/S000...
biologicalpsychiatryjournal.com
Atypical depression is associated with a distinct clinical, neurobiological, treatment response and polygenic risk profile
Atypical depression is considered a distinct clinical subtype of major depression, yet its predictive validity and clinical utility remain contested. We investigated association between atypical depre...
033
Reposted by @jakecrouse.bsky.social
jakecrouse.bsky.social @jakecrouse.bsky.social · 23/06/2025
More evidence linking #depression & #daylight 🌞 In 13,000 Australians with depression, more time in daylight was associated with better sleep and mental health (adjusting for genetic risk, season, etc) #sleep #circadian #mentalhealth bit.ly/4ei9th5
bit.ly
Mental health and sleep correlates of self-reported outdoor daylight exposure in over 13,000 adults with depression | European Psychiatry | Cambridge Core
Mental health and sleep correlates of self-reported outdoor daylight exposure in over 13,000 adults with depression - Volume 68 Issue 1
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jakecrouse.bsky.social @jakecrouse.bsky.social · 23/06/2025
More evidence linking #depression & #daylight 🌞 In 13,000 Australians with depression, more time in daylight was associated with better sleep and mental health (adjusting for genetic risk, season, etc) #sleep #circadian #mentalhealth bit.ly/4ei9th5
bit.ly
Mental health and sleep correlates of self-reported outdoor daylight exposure in over 13,000 adults with depression | European Psychiatry | Cambridge Core
Mental health and sleep correlates of self-reported outdoor daylight exposure in over 13,000 adults with depression - Volume 68 Issue 1
042
Reposted by @jakecrouse.bsky.social
jakecrouse.bsky.social @jakecrouse.bsky.social · 18/05/2025
Grateful to have played a small part in this letter published in World Psychiatry We identify 9 challenges to advancing early intervention in #bipolardisorders and hope to galvanise action on these issues onlinelibrary.wiley.com/doi/10.1002/...
onlinelibrary.wiley.com
Views of international experts on challenges to early intervention for bipolar disorder
Click on the article title to read more.
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jakecrouse.bsky.social @jakecrouse.bsky.social · 18/05/2025
Grateful to have played a small part in this letter published in World Psychiatry We identify 9 challenges to advancing early intervention in #bipolardisorders and hope to galvanise action on these issues onlinelibrary.wiley.com/doi/10.1002/...
onlinelibrary.wiley.com
Views of international experts on challenges to early intervention for bipolar disorder
Click on the article title to read more.
031
Reposted by @jakecrouse.bsky.social
jakecrouse.bsky.social @jakecrouse.bsky.social · 05/05/2025
Wearables can detect skin temperature dysrhythmias in young people with mood disorders 🌡️ @brainandmindcentre.bsky.social @ucsandiego.bsky.social @isbd4.bsky.social @smhr.org.au @circadianmhnetw.bsky.social journals.sagepub.com/doi/10.1177/... #circadian #bipolardisorder #depression
journals.sagepub.com
Twenty-four-hour Skin Temperature Rhythms in Young People With Emerging Mood Disorders: Relationships With Illness Subtypes and Clinical Stage - Mirim Shin, Joanne S. Carpenter, Shin H. Park, Connie J...
While circadian disruptions are common in some sub-groups of youth with mood disorders, skin temperature rhythms in these cohorts are understudied. We examined ...
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jakecrouse.bsky.social @jakecrouse.bsky.social · 05/05/2025
Wearables can detect skin temperature dysrhythmias in young people with mood disorders 🌡️ @brainandmindcentre.bsky.social @ucsandiego.bsky.social @isbd4.bsky.social @smhr.org.au @circadianmhnetw.bsky.social journals.sagepub.com/doi/10.1177/... #circadian #bipolardisorder #depression
journals.sagepub.com
Twenty-four-hour Skin Temperature Rhythms in Young People With Emerging Mood Disorders: Relationships With Illness Subtypes and Clinical Stage - Mirim Shin, Joanne S. Carpenter, Shin H. Park, Connie J...
While circadian disruptions are common in some sub-groups of youth with mood disorders, skin temperature rhythms in these cohorts are understudied. We examined ...
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