iiinova — where your digital self keeps evolving

Reposted by Jake Chernicky

Caterina Gratton @caterinagratton.bsky.social · 22/01/2026

🚨 I'm searching for a full-time research coordinator to join my group & work on precision brain 🧠 network and cognitive control projects at both 3T and 7T. Please rt 🙌 Applications due: Feb. 26 Start date: flexible, as early as June More 👇 #neuroskyence #PsychSciSky

13640

Reposted by Jake Chernicky

Caterina Gratton @caterinagratton.bsky.social · 08/01/2026

Now officially out in NIMG: Clinical! See it here: doi.org/10.1016/j.ni...

071

Reposted by Jake Chernicky

Thomas Yeo @bttyeo.bsky.social · 17/07/2025

1/11 Excited to share our @Naturestudy led by @leonooi.bsky.social @csabaorban.bsky.social @shaoshiz.bsky.social AI performance is known to scale with logarithm of sample size (Kaplan 2020), but in many domains, sample size can be # participants or # measurements... doi.org/10.1038/s415...

317182

Reposted by Jake Chernicky

Alex Fornito @alexfornito.bsky.social · 11/07/2025

1000s of studies have been published mapping neuroanatomical changes in psychiatric disorders. Can we ever converge on robust disease phenotypes? Our latest PP led by Trang Cao in a huge collab effort investigates this question... @nsb-lab.bsky.social

25526

Jake Chernicky @jakechernicky.bsky.social · 09/07/2025

12/12 I’d like to thank my amazing mentors, @caterinagratton.bsky.social & @campbell-thelab.bsky.social, my coauthors at WashU: @allydworetsky.bsky.social, Sarah Grossen, Emma Carr, @ameid.bsky.social and the participants who made this work possible. Please let us know if you have any feedback! 🎆

020

Jake Chernicky @jakechernicky.bsky.social · 09/07/2025

11/12 🧠 Bottom line: Precision RSFC is feasible, reliable, and clinically promising in Parkinson’s disease. This approach could explain the huge variation we see across individuals—and help us treat each person more effectively.

120

Jake Chernicky @jakechernicky.bsky.social · 09/07/2025

10/12 These differences aren’t noise—they’re real, reliable, and potentially clinically meaningful. 🚀 Implications? ✔️ Understand heterogeneity in progression/symptoms ✔️ Map functional changes before symptoms appear ✔️ Improve DBS targeting ✔️ Develop personalized interventions

110

Jake Chernicky @jakechernicky.bsky.social · 09/07/2025

9/12 🗺️ Finding 4: Individual Network Maps Using seed-based + data-driven techniques (Infomap), we mapped networks in two individuals with PD. Despite the same diagnosis, locations in primary motor cortex can have very different connectivity → One showed SCAN; one showed somatomotor-face network.

110

Jake Chernicky @jakechernicky.bsky.social · 09/07/2025

8/12 🧮 Finding 3: Stability & Distinction We tested whether RSFC patterns hold up across days. With 25 mins/session: 🧠 Within-subject similarity: r = 0.70 🧠 Across-subject similarity: r = 0.32 PD participants showed stable, person-specific network profiles.

110

Jake Chernicky @jakechernicky.bsky.social · 09/07/2025

7/12 📈 Finding 2: Reliability With conventional 5 mins of data, reliability was modest (r = 0.49 in subcortex). With 40 mins? 🧠 Cortical: r ≈ 0.90 🧠 Subcortical: r ≈ 0.81 🧠 Cerebellar: r ≈ 0.87 That's a massive boost—critical for clinical applications!

110

Jake Chernicky @jakechernicky.bsky.social · 09/07/2025

6/12 📊 Finding 1: Feasibility Even with stringent motion thresholds (fFD < 0.1 mm), PD participants provided comparable data to controls. ✅ 91.5% of data retained ✅ Motion manageable despite PD symptoms

110

Jake Chernicky @jakechernicky.bsky.social · 09/07/2025

5/12 We tested this! 🧪 20 people with PD (OFF medications!), 6 healthy controls 🕒 >100 mins of RSFC per person 📍 Multiple (4-5) sessions All with the goal: can we reliably map functional brain networks in PD?

110

Jake Chernicky @jakechernicky.bsky.social · 09/07/2025

4/12 That’s where precision RSFC comes in: ✅ 100+ mins of data ✅ Advanced motion correction ✅ Individualized network mapping It’s been used in healthy people— but can it work in individuals with PD with tremor, fatigue, or increased head motion? 🤔

110

Jake Chernicky @jakechernicky.bsky.social · 09/07/2025

3/12 RSFC has identified brain-behavior relationships in healthy adults (see work by @bttyeo.bsky.social) and those with PD (see @andreashorn.org‬), but most studies fail to reliably detect individual differences— offering little insight into clinical heterogeneity.

110

Jake Chernicky @jakechernicky.bsky.social · 09/07/2025

2/12 Parkinson’s disease (PD) isn’t just a movement disorder. It’s a complex condition affecting mood, cognition & more. Complicating matters further, there is a huge variability in what, when, and how severe symptoms present. Why symptoms vary so much across individuals with PD is unclear. 🧩

110

Jake Chernicky @jakechernicky.bsky.social · 09/07/2025

Excited to share my first preprint investigating the feasibility and reliability of using precision RSFC in people with Parkinson’s disease! 🧠👇 📄: go.illinois.edu/PDfeasibility 🧵 Thread ⬇️ 1/12

1157