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jakbosch.bsky.social

@jakbosch.bsky.social
30 followers 13 following 17 posts
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jakbosch.bsky.social @jakbosch.bsky.social · 04/09/2026
Check out this blog on a fun protein 3D-printing project in my lab. All done by terrific summer high-school student Rayne Weinstein! library.med.utah.edu/blog/eccles/...
library.med.utah.edu
Meet the Makers: Rayne Weinstein | Spencer S. Eccles Health Sciences Library - EHSL Vitals
Located in the Spencer F. and Cleone P. Eccles Health Sciences Education Building (EHSEB) 3100, the computer and 3D printer lab, operated by the Eccles Health Sciences Library (EHSL). 3D printing serv...
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jakbosch.bsky.social @jakbosch.bsky.social · 28/08/2026
Join my department! The Department of Human Genetics at the University of Utah has an open search for faculty positions at Assistant Professor level. utah.peopleadmin.com/postings/208...
utah.peopleadmin.com
Assistant Professor in the Tenure Track
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jakbosch.bsky.social @jakbosch.bsky.social · 19/06/2026
My lab is hiring! Computational postdoc + post-bac to support our AlphaFold screens - hiring ASAP. utah.peopleadmin.com/postings/203... utah.peopleadmin.com/postings/203... Post-doc (wet-lab) - start date flexible. Post-bac (wet-lab) - start date late spring '27 See www.boschlab.com for details
utah.peopleadmin.com
Research Technicians
The Bosch Lab at the University of Utah (https://www.boschlab.com/) invites applications for a computational research technician position to support projects related to biomolecular interaction predic...
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jakbosch.bsky.social @jakbosch.bsky.social · 19/06/2026
Excited that our tissue-secretome work is now PUBLISHED in @natcomms.nature.com! Original preprint tutorial below 👇 Final paper expands bioinformatic analyses and details improved HDR donor plasmids for Gal4/GFP knock-ins (@addgene.bsky.social, @dgrc.bsky.social). www.nature.com/articles/s41...
nature.com
Multi-omic mapping of Drosophila protein secretomes reveals tissue-specific origins and inter-organ trafficking - Nature Communications
A Drosophila secretome atlas identifies the tissue origins of circulating proteins, revealing unusual sources, uncharacterized proteins, ectodomain shedding, and candidate mediators of inter-organ com...
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jakbosch.bsky.social @jakbosch.bsky.social · 07/03/2026
Hello from fly meeting #DROS26! Check out two posters from the Bosch lab Saturday. Saya (863S) and Giulia (701S).
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jakbosch.bsky.social @jakbosch.bsky.social · 11/07/2025
Bluesky handles: @biorxivpreprint.bsky.social‬ ‪@perrimonlab.bsky.social‬ @addgene.bsky.social‬ ‪@dgrc.bsky.social‬ @bdsc.bsky.social‬ @damonrunyon.org‬ Collaborators: ‪@aliceyting.bsky.social‬, Steve Carr, John Asara.
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jakbosch.bsky.social @jakbosch.bsky.social · 11/07/2025
My lab is recruiting post-docs! We study inter-organ communication using cutting-edge tools like proximity labeling (TurboID), in silico modeling (AlphaFold), and genome engineering (CRISPR). Come join us @UofUGenetics, Utah is beautiful! (View from our fly room 👇)
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jakbosch.bsky.social @jakbosch.bsky.social · 11/07/2025
Huge thanks to my amazing co-authors, mentors, and lab mates! Also grateful to the @DRSC_TRiP and fly community for resources and support 🪰, @DamonRunyon and @NIH for funding. 8/8
media.tenor.com
a blood drop with a face and arms and legs
ALT: a blood drop with a face and arms and legs
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jakbosch.bsky.social @jakbosch.bsky.social · 11/07/2025
Plasmids 🧬, cell lines 🧫, and fly lines 🪰are available NOW from @Addgene, @DrosDGRC, and Bloomington Drosophila Stock Center (BDSC)! A web-based portal to visualize our snRNA-seq data is at www.flyrnai.org/scRNA/body_l... 7/8
flyrnai.org
Single-Cell RNA-seq Drosophila 3rd instar larvae, full body at single-nucleus transcriptome resolution
single-cell RNA-seq data portal
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jakbosch.bsky.social @jakbosch.bsky.social · 11/07/2025
Why does this matter?💡 Mapping the sources of circulating proteins unlocks new ways to study biology and disease. This atlas can help others explore tissues (e.g. brain), proteins (e.g. Lectins), and processes (e.g. inter-organ communication) - or even discover biomarkers. 6/8
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jakbosch.bsky.social @jakbosch.bsky.social · 11/07/2025
Amazingly, we also found tissue-specific secreted proteins that accumulate in entirely different tissues! These may be remote-control factors that allow two organs to communicate (aka inter-organ communication). 5/8
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jakbosch.bsky.social @jakbosch.bsky.social · 11/07/2025
We discovered a gold mine of 535 circulating proteins! Highlights: -Tissue-specific secreted proteins -Unexpected sources like glia 🧠 -Shed ectodomains of transmembrane proteins -Uncharacterized proteins -Human-conserved proteins 🧬 4/8
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jakbosch.bsky.social @jakbosch.bsky.social · 11/07/2025
We built an atlas of secreted proteins in Drosophila blood from 10 different tissues using complementary ‘omics tools 🧬- transgenic TurboID proximity labeling, mass spectrometry, single nucleus RNA-seq, and CRISPR knock-in flies. 3/8
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jakbosch.bsky.social @jakbosch.bsky.social · 11/07/2025
Extracellular proteins are critical for basic biology (development, physiology, immunity, etc), and thousands circulate in our blood plasma🩸. We know they’re secreted from cells in different tissues… so… *which* tissues secrete *which* proteins?🤔 🤷 2/8
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jakbosch.bsky.social @jakbosch.bsky.social · 11/07/2025
I’m thrilled to share a @biorxivpreprint for my postdoc work in the @PerrimonLab🎉. Together with our collaborators, we built a tissue-specific atlas of circulating secreted proteins in Drosophila 🧬🪰🧪🗺️. Thread below🧵 1/8 www.biorxiv.org/content/10.1...
biorxiv.org
Multi-omic mapping of Drosophila protein secretomes reveals tissue-specific origins and inter-organ trafficking
Secreted proteins regulate many aspects of animal biology and are attractive targets for biomarkers and therapeutics. However, comprehensively identifying the "secretome", along with their tissues of ...
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jakbosch.bsky.social @jakbosch.bsky.social · 02/04/2025
Post-docs - apply to speak at the Rising Stars in Genetics and Genomics Symposium at the University of Utah! Research areas include 1) evolutionary genetics and genomics, 2) functional and disease genetics, or 3) computational genomics docs.google.com/forms/d/e/1F...
docs.google.com
Google Forms: Sign-in
Access Google Forms with a personal Google account or Google Workspace account (for business use).
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jakbosch.bsky.social @jakbosch.bsky.social · 20/03/2025
Excited to be at fly meeting! #Dros25 🪰 Come by my poster #909F and see my talk #176. My lab is hiring! Including post-docs and lab techs. utah.peopleadmin.com/postings/179...
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