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Jack Tierney @jackatierney.bsky.social · 05/09/2025

And with Lepidoptober coming fast...

Jack Tierney @jackatierney.bsky.social · 02/09/2025

In 1891, Stoney coined electron as the unit of electric charge borrowing the neuter Greek suffix -on. Others followed with proton, neutron cementing “-on” as the mark of a fundamental unit. In the 50s we got cistron, codon as the units of gene expression were defined and then exon, intron, translon

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Jack Tierney @jackatierney.bsky.social · 02/09/2025

Believe it or not, the term Translon as the translational unit predates Walter Gilberts 'Exon' (1978). In 1973 Suresh Goel had a letter published in Nature arguing for the establishment of units of Transcription (Transcon) and Translation (Translon). www.nature.com/articles/245...

nature.com

Transcription Unit - Nature

Nature - Transcription Unit

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Reposted by Jack Tierney

Mariotti Genomics Lab @mariottilab.bsky.social · 02/09/2025

Here's an interesting paper @natmethods.nature.com introducing the term "Translon", filling a terminology gap in the field of gene expression. Kudos to Pasha Baranov for leading this initiative and gathering many contributors (including myself) for an healthy discussion on fundamental principles 👏

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Jack Tierney @jackatierney.bsky.social · 01/09/2025

Writing this short correspondence sparked great semantic discussions with leaders of a diverse set of fields and particularly among the primary instigators of this initiative (myself, Michał Świrski, Eivind Valen and Pasha Baranov) Full Text: rdcu.be/eDnOj

rdcu.be

Translon: a single term for translated regions

Nature Methods - Translon: a single term for translated regions

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Jack Tierney @jackatierney.bsky.social · 01/09/2025

Just as Walter Gilbert's exon/intron terminology ('Why genes in pieces?', Nature 1978) gave us language to discuss and understand gene structure, 'Translon' aims to provide vocabulary to better conceptualise the pervasive, largely still enigmatic, translation revealed by Ribo-Seq

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Jack Tierney @jackatierney.bsky.social · 01/09/2025

Many transcriptome regions are translated but not known to encode proteins. They remain poorly annotated and thus under studied, partly due to the lack of terminology for these features. In @natmethods.nature.com we propose using "Translon" for any region decoded by the ribosome

Snapshot of the Correspondence titled 'Translon: a single term for translated regions'

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