iiinova — where your digital self keeps evolving

Jack Tierney

@jackatierney.bsky.social

Bioinformatician @ EMBL-EBI - Ensembl Genebuild Formerly: Post Doctoral Researcher @ UCC, Ireland RNA Biology, Translation, Ribo-Seq Bioinformatic Method Development & Research Infrastructure

Posts Replies Media

Jack Tierney @jackatierney.bsky.social · 02/09/2025

Believe it or not, the term Translon as the translational unit predates Walter Gilberts 'Exon' (1978). In 1973 Suresh Goel had a letter published in Nature arguing for the establishment of units of Transcription (Transcon) and Translation (Translon). www.nature.com/articles/245...

nature.com

Transcription Unit - Nature

Nature - Transcription Unit

140

Reposted by Jack Tierney

Mariotti Genomics Lab @mariottilab.bsky.social · 02/09/2025

Here's an interesting paper @natmethods.nature.com introducing the term "Translon", filling a terminology gap in the field of gene expression. Kudos to Pasha Baranov for leading this initiative and gathering many contributors (including myself) for an healthy discussion on fundamental principles 👏

031

Jack Tierney @jackatierney.bsky.social · 01/09/2025

Many transcriptome regions are translated but not known to encode proteins. They remain poorly annotated and thus under studied, partly due to the lack of terminology for these features. In @natmethods.nature.com we propose using "Translon" for any region decoded by the ribosome

Snapshot of the Correspondence titled 'Translon: a single term for translated regions'

11011