iiinova — where your digital self keeps evolving

Jack - amatica health @jackamatica.bsky.social · 22/07/2026

At Amatica Health, we're working to build one of the largest linked biological and patient datasets in this space, to support research into the biology of conditions like ME/CFS and Long COVID. Our mission and methods: www.amaticahealth.com

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Jack - amatica health @jackamatica.bsky.social · 22/07/2026

A new study found overlapping resistance patterns across Paxlovid-like SARS-CoV-2 antivirals. This matters for future Long COVID viral-persistence trials, where resistance could block clearance, similar to why HIV treatment uses combinations. Let's break it down.

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Jack - amatica health @jackamatica.bsky.social · 21/07/2026

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Jack - amatica health @jackamatica.bsky.social · 21/07/2026

An interesting new MRI study found a lower brain waste-clearance signal in ME/CFS, linked with worse sleep disturbance and impaired concentration. Let's put that in simple language.

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Jack - amatica health @jackamatica.bsky.social · 21/07/2026

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Jack - amatica health @jackamatica.bsky.social · 21/07/2026

Two interesting new saliva studies found HHV-6 viral DNA linked with Long COVID severity, and microRNAs, small gene-control molecules, linked with inflammation and viral-persistence pathways. Let's get into it simply.

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Jack - amatica health @jackamatica.bsky.social · 17/07/2026

Order here: www.amaticahealth.com/products/ama...

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Jack - amatica health @jackamatica.bsky.social · 17/07/2026

RNA sequencing is one of the best ways to study active changes across many biological systems at once. This thread covers major RNA findings in Long COVID, ME/CFS, and other diseases, and the value RNA may have for future research.

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Jack - amatica health @jackamatica.bsky.social · 17/07/2026

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Jack - amatica health @jackamatica.bsky.social · 17/07/2026

An interesting new paediatric Long COVID study found more microclots, more neutrophil trap formation and more vessel-lining injury. In lab work, COVID spike bound to antibodies helped trigger that injury. Let's break it down.

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Jack - amatica health @jackamatica.bsky.social · 16/07/2026

A new ME/CFS study points to mast cells being primed to react to EBV-related stimulation. EBV protein triggered strong MMP-9 release from mast cells in the lab, and patient blood showed higher IL-11 and MMP-9. Let's break it down.

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Jack - amatica health @jackamatica.bsky.social · 15/07/2026

CSF studies in Long COVID and ME/CFS have found altered immune-cell states, stress signals, cytokine differences and CSF-blood mismatch. Given the neurological nature of these diseases, CSF could answer questions that are less accessible from blood. Let's break it down.

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Jack - amatica health @jackamatica.bsky.social · 13/07/2026

Muscle biopsy studies in ME/CFS and Long COVID have found oxidative muscle stress, altered glucose use, mitochondrial changes, capillary injury, nerve-muscle damage and worse muscle pathology after PEM. Let's break down what the findings mean.

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Jack - amatica health @jackamatica.bsky.social · 11/07/2026

COVID is often described as a respiratory infection, but acute and fatal COVID brain autopsy studies show it can affect the brain. Findings include viral RNA in some brain tissue, brainstem inflammation, microglial activation and vascular injury. Let's break it down.

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Jack - amatica health @jackamatica.bsky.social · 10/07/2026

Among more than one million US veterans, the 2024 to 2025 COVID vaccine was linked with a 37.7% lower relative risk of a combined outcome: COVID-associated cardiovascular death, heart attack, stroke or heart-failure admission.

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Jack - amatica health @jackamatica.bsky.social · 09/07/2026

Researchers found that SARS-CoV-2 can remain infectious inside sealed fragments released by dying cells. Macrophages swallowed these fragments, bringing virus inside and activating strong inflammatory signals.

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Jack - amatica health @jackamatica.bsky.social · 09/07/2026

Company biobanks have helped move diseases forward: cancer tests reaching ~90% accuracy, Alzheimer’s and diabetes genetics, and liver disease clues. This is why we at Amatica Health are building one for Long COVID and ME/CFS and how individuals can help the mission. 🧵

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Jack - amatica health @jackamatica.bsky.social · 08/07/2026

USA ordering for the Amatica Health RNA test is designed to be simple. You order online, we ship your kit, the kit includes everything required, you book a blood draw locally, and we arrange and manage return shipping and customs.

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Jack - amatica health @jackamatica.bsky.social · 08/07/2026

In a selected group with POTS or other upright symptoms plus signs of pelvic vein disease, 83% had pelvic vein compression or congestion. In a larger, partly overlapping group of 271 women, symptoms and quality of life improved after stenting.

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Jack - amatica health @jackamatica.bsky.social · 07/07/2026

Bezuclastinib cut total symptom burden by about 54% after 48 weeks in nonadvanced systemic mastocytosis. Nearly every tested patient also had at least a 50% fall in blood tryptase, a marker linked with mast- cell burden.

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Jack - amatica health @jackamatica.bsky.social · 07/07/2026

Reminder to join the Amatica RNA batch heading to the lab this month. Order within the next week or so to make the cutoff. Each person receives 20,000+ blood RNA results from a single draw.

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Jack - amatica health @jackamatica.bsky.social · 07/07/2026

Mitochondrial findings in ME/CFS and Long COVID include altered fuel use, lower energy efficiency, immune-cell energy stress, muscle-cell abnormalities and worse muscle findings after PEM. This thread breaks down what that means in simple language.

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Jack - amatica health @jackamatica.bsky.social · 06/07/2026

Children with Long COVID may show different biology depending on illness stage. At the start, SARS-CoV-2 immune signals were elevated, then faded. Later patterns pointed to innate, Th2-like allergy-associated immune activity, plus energy and clotting-marker differences.

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Jack - amatica health @jackamatica.bsky.social · 06/07/2026

In 2,141 people with hEDS or HSD, about one in four had a high mast-cell-related score based on 11 self-reported conditions. Higher scores were linked with more symptoms and reported conditions.

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Jack - amatica health @jackamatica.bsky.social · 06/07/2026

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Jack - amatica health @jackamatica.bsky.social · 05/07/2026

My overview listed 2 broad areas higher, 13 lower, 8 mixed, and 6 typical against the reference range. Some key systems were cell cycle, metabolism, immune system, programmed cell death, signal passing, neuronal system, hemostasis, and more.

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Jack - amatica health @jackamatica.bsky.social · 04/07/2026

Sharing some of my own exploratory pathway results from my RNA data. This is n=1, my own sample, early exploratory, and information only. I find the biology genuinely interesting, so I wanted to discuss what enrichment means and what these systems do.

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Jack - amatica health @jackamatica.bsky.social · 04/07/2026

Women with fibromyalgia had higher anti-GFAP assay signals. GFAP is a structural protein found in nerve-support cells that can influence how pain signals are handled.

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Jack - amatica health @jackamatica.bsky.social · 03/07/2026

Gene-expression methods have become clinically relevant elsewhere, but only after validation for specific uses. Examples include Oncotype DX and MammaPrint in breast cancer, and PrismRA in rheumatoid arthritis.

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Jack - amatica health @jackamatica.bsky.social · 03/07/2026

RNA data is more valuable for research when paired with real-world context. - Symptoms - severity - diagnoses - treatment history add context to gene activity patterns and support deeper analysis across groups.

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Jack - amatica health @jackamatica.bsky.social · 03/07/2026

The research goal is to identify - candidate diagnostic signals - biological subgroups - RNA-based biomarkers - treatment-response patterns that may be taken forward for future validation

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Jack - amatica health @jackamatica.bsky.social · 03/07/2026

Ordering is designed to work worldwide. We send a kit with custom-packed PAXgene RNA tubes, which preserve blood RNA and allow room-temperature shipping. After collection, return shipping is arranged using our medical courier.

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Jack - amatica health @jackamatica.bsky.social · 03/07/2026

Individuals receive around 20,000 to 25,000 RNA results, plus raw FASTQ files and platform access. FASTQ files contain the raw RNA reads and quality information. Platform has many features discussed below & continues to update at no additional cost.

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Jack - amatica health @jackamatica.bsky.social · 03/07/2026

Serum from people with fibromyalgia activated support cells around mouse nerves involved in pain, facial sensation, internal organs and automatic body functions. This points to one or more circulating factors that can activate these support cells.

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Jack - amatica health @jackamatica.bsky.social · 02/07/2026

Post-exertional malaise is a delayed or prolonged worsening of symptoms after physical, cognitive or emotional exertion. Understanding its biology is critical to understanding ME/CFS. What changes when blood is tested before and during PEM? 🧵

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Jack - amatica health @jackamatica.bsky.social · 02/07/2026

In fibromyalgia, severe irritable bowel symptoms were linked with fewer tiny nerve fibers in skin biopsies. The study connects gut symptoms with a measured change in nerves that also help control pain and automatic body functions.

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Jack - amatica health @jackamatica.bsky.social · 01/07/2026

Viral persistence and viral reactivation are often discussed together in Long COVID and ME/CFS, but they are not the same process. One concerns the original virus. The other concerns older latent viruses becoming active again. Let's break it down 🧵

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Jack - amatica health @jackamatica.bsky.social · 01/07/2026

After 40 hyperbaric oxygen sessions, unusually strong thalamus connections shifted toward patterns seen in healthy controls. Larger shifts appeared in people whose physical function improved most.

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Jack - amatica health @jackamatica.bsky.social · 30/06/2026

In ME/CFS, heavier gut symptoms were linked with worse fatigue, pain, sleep, thinking, flu-like and sensory problems, plus higher CRP, a blood sign of inflammation. The study identified a gut-linked pattern across core symptoms.

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Jack - amatica health @jackamatica.bsky.social · 29/06/2026

A light-based blood analysis separated ME/CFS from inactive healthy controls with 79% accuracy at rest and 84% after a standard stress task. The distinguishing patterns involved signals consistent with proteins, fats and small metabolic chemicals.

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Jack - amatica health @jackamatica.bsky.social · 28/06/2026

Low blood volume has been reported in a subset of people with ME/CFS, especially those who feel worse when standing. With less blood circulating, it may be harder to keep enough returning to the heart and reaching the brain. Let's break it down 🧵

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Jack - amatica health @jackamatica.bsky.social · 28/06/2026

Red blood cells may be disrupted during acute COVID, with further abnormalities reported in Long COVID and ME/CFS. They carry oxygen and must squeeze through tiny vessels. If they change shape, stiffen or break apart, blood flow may be affected. 🧵

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Jack - amatica health @jackamatica.bsky.social · 27/06/2026

Two of the main biological theories being studied in Long COVID are autoimmunity and viral persistence. Both can produce ongoing inflammation and immune activation, so separating them may be difficult. Let's break it down🧵

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Jack - amatica health @jackamatica.bsky.social · 27/06/2026

Children with post-COVID illness had wider tiny arteries and veins at the back of the eye. After adjustment, the arteries were about 28 micrometers wider and the veins about 22 micrometers wider than in matched healthy children.

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Jack - amatica health @jackamatica.bsky.social · 26/06/2026

A two-year study found that SARS-CoV-2 proteins in blood were not specific to Long COVID. At 6 to 12 months, they appeared in 31% of people with Long COVID and 20% of people who had fully recovered without ongoing symptoms.

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Jack - amatica health @jackamatica.bsky.social · 26/06/2026

Being able to tell a bacterial infection from a viral one matters because they may require very different care. Researchers have shown that RNA from the body's own immune response can sometimes separate them. Let's break down 🧵

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Jack - amatica health @jackamatica.bsky.social · 25/06/2026

Antibodies from people with neurological Long COVID produced fatigue-like behavior, balance problems, pain sensitivity and small-nerve damage when transferred into mice. This provides direct evidence that harmful antibodies may contribute in a subgroup.

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Jack - amatica health @jackamatica.bsky.social · 25/06/2026

Mast cells are best known for allergy and MCAS, but research has found they may also be implicated in Alzheimer's, ALS, multiple sclerosis, rheumatoid arthritis, infection and heart disease. They sit at tissue barriers beside nerves and blood vessels. Let's break it down 🧵

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Jack - amatica health @jackamatica.bsky.social · 24/06/2026

A brain scan study found higher AMPA receptor signals across much of the brain in people with Long COVID brain fog. AMPA receptors carry much of the brain's fast glutamate-based excitation, which makes nerve cells more likely to fire.

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