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Ivan Mindlin

@ivanmindlin.bsky.social

Finishing PhD candidate at Paris Brain Institute. Enjoying the ride from computer science to complex systems and biology :)

Posts Replies Media

Ivan Mindlin @ivanmindlin.bsky.social · 14/01/2026

🔗 fastDMF-powered implementation: github.com/Picardian14/... pure Python version by Carlos :) github.com/carlosmig/Ho... Thanks to all co-authors for the collaboration, and my colleague and friend @rherzoga.bsky.social for leading this work. Feedback, reuse, and extensions are very welcome. 5/5

github.com

GitHub - Picardian14/fastHDMF-code

Contribute to Picardian14/fastHDMF-code development by creating an account on GitHub.

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Ivan Mindlin @ivanmindlin.bsky.social · 14/01/2026

Because inhibitory control is local and homeostatic, adaptiveness can be heterogeneous across regions while remaining stable. This enables coexisting SW and asynchronous regimes—chimeric-like—suggesting a potential mechanism to cognitive states such as local-sleep–related attentional lapses. 4/5

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Ivan Mindlin @ivanmindlin.bsky.social · 14/01/2026

In a high-coupling regime, the adaptive inhibitory feedback gives rise to bistable UP–DOWN dynamics (delta-range slow waves (SW) ), while faster adaptation supports asynchronous activity. 3/5

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Ivan Mindlin @ivanmindlin.bsky.social · 14/01/2026

In the DMF, resting-state activity emerges from noisy firing rates stabilized by feedback inhibitory control (FIC). Previous implementations (e.g. fastDMF) use static inhibition. Here, we introduce a local plastic inhibitory rule that can dynamically self adjust toward homeostasis. 2/5

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Ivan Mindlin @ivanmindlin.bsky.social · 14/01/2026

📄Very happy to share our new pre-print!! 🧠 We introduce a homeostatic inhibitory plasticity rule into the Dynamic Mean Field (DMF) model which stabilizes firing rates and expands the model’s dynamical repertoire—for example, enabling slow-wave activity. www.biorxiv.org/content/10.6... ⬇️⬇️⬇️ 1/5

biorxiv.org

The impact of homeostatic inhibitory plasticity in a generative biophysical model

A main characteristic of biological systems is their capacity to dynamically adapt to environmental changes. In the brain, synaptic plasticity enables the strengthening or weakening of connections bet...

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