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ISSLS

@issls.bsky.social
30 followers 17 following 46 posts

The International Society for the Study of Lumbar Spine (ISSLS) brings together individuals from across the globe for the purpose of research and clinical study into the lumbar spine.

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Reposted by ISSLS
Guy Cameron @guycameron.me · 30/06/2025
Does every patient with lumbar spinal stenosis and high-signal facet joints need spinal fusion? 🧵 Our new study says no, not always! A simpler approach might be the way forward for some patients in the Hunter New England Local Health District. www.doi.org/10.1007/s005...
doi.org
Comparable long-term pain and disability outcomes following decompression alone versus decompression with fusion in lumbar spinal stenosis patients with high-signal facet joints - European Spine Journ...
Purpose This study aimed to evaluate the long-term outcomes of decompressive surgery with or without fusion in patients with lumbar spinal stenosis (LSS) exhibiting high-signal facet joints, a radiolo...
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ISSLS @issls.bsky.social · 18/01/2026
The International Society for the Study of the Lumbar Spine #ISSLS is pleased to announce that the European Spine Journal #ESJ is now the official journal of ISSLS!
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ISSLS @issls.bsky.social · 07/11/2025
📣 One week left to submit your abstract ‼️ The abstract deadline for the combined #ISSLS & #SASS 2026 Annual Meeting in Cape Town, South Africa (May 11–15, 2026) has been extended until November 15, 2025 ‼️ issls2026.org/abstracts/ #ISSLS2026 #CapeTown #SpineResearch
issls2026.org
Abstracts - ISSLS/SASS Annual Meeting 2026
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ISSLS @issls.bsky.social · 09/09/2025
Why join ISSLS? ✔️ Discounted registration ✔️ Access to a truly interdisciplinary, international network ✔️ Eligibility for fellowships, awards, and committee roles ✔️ Voting rights to help shape the future of ISSLS ✔️ Opportunities to contribute to global initiatives, taskforces, and consensus papers
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ISSLS @issls.bsky.social · 09/09/2025
ISSLS membership applications are now open until the 19th of September! Join our global community of world-class spine researchers, clinicians, surgeons, and more before the deadline closes 📅 Deadline to apply: September 19th 🔗 Learn more and apply: www.issls.org/membership Why join ISSLS? 👇🏼
issls.org
MEMBERSHIP APPLICATION — The International Society for the Study of the Lumbar Spine
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ISSLS @issls.bsky.social · 21/07/2025
Let’s give a warm welcome to Dr. Mengis! 🫴 💬 Say hi in the comments & connect on LinkedIn: 🔗 www.linkedin.com/in/tamara-me... Are you also pushing the boundaries of #LumbarSpine research? Join ISSLS and be part of a global community shaping the future of spine science: 🔗 www.issls.org/membership
linkedin.com
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ISSLS @issls.bsky.social · 21/07/2025
One of Dr. Mengis's recent impactful studies, published in JCI Insight, investigates immune responses linked to vertebral bone marrow changes, offering promising new perspectives for understanding and treating chronic low back pain. 📖 Read it here: pubmed.ncbi.nlm.nih.gov/38585427/
pubmed.ncbi.nlm.nih.gov
Intervertebral disc microbiome in Modic changes: Lack of result replication underscores the need for a consensus in low-biomass microbiome analysis - PubMed
There is dysbiosis in MC discs. Bioinformatic parameters impact results yet cannot explain the different findings from this and a previous study. Therefore, discrepancies are likely caused by differen...
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ISSLS @issls.bsky.social · 21/07/2025
Dr. Mengis is a Postdoctoral Researcher at the Center of Experimental Rheumatology, University of Zurich, where she explores the intricate biology of spinal conditions with a focus on Modic changes. Her research highlights the key role of the intervertebral disc in the development of Modic changes.
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ISSLS @issls.bsky.social · 21/07/2025
🌟 Welcome Dr. Tamara Mengis – Our Newest ISSLS Member! 🌟 We’re excited to welcome Dr. Tamara Mengis, PhD to the #ISSLS community of spine researchers and clinicians!
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ISSLS @issls.bsky.social · 21/07/2025
The study showed: ➡️ Significant reduction in LBP (VAS scores) in the BM-MSC group ➡️ Improved quality of life and work ability ➡️ Strong safety profile, with no serious adverse events
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ISSLS @issls.bsky.social · 21/07/2025
In this randomized controlled trial, the team investigated the use of autologous bone marrow-derived mesenchymal stromal cells BM- #MSCs to treat patients with chronic low back pain #LBP linked to multilevel intervertebral disc degeneration (IDD). issls-2025.p.asnevents.com.au/days/2025-05...
issls-2025.p.asnevents.com.au
Oral Presentation — ASN Events
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ISSLS @issls.bsky.social · 21/07/2025
🎉 Congratulations to the 2025 ISSLS Best Paper Award Winner! 🎉 We are thrilled to spotlight some of the most compelling research in #LumbarSpine science and clinical innovation. This year’s Best Paper Award was to Prof. Gianluca Vadalà et al of the Università Campus Bio-Medico di Roma
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ISSLS @issls.bsky.social · 09/07/2025
In Memoriam of Dr. Margareta Nordin (1945–2025) Please read the beautiful obituary by Dino Samartzis and Björn Rydevik in the #EuropeanSpineJournal here: 🔗 link.springer.com/article/10.1...
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ISSLS @issls.bsky.social · 15/05/2025
We’re already halfway through ISSLS 2025! 😲 From cutting-edge research to truly inspiring discussions, the energy here is amazing. #ISSLS2025
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ISSLS @issls.bsky.social · 14/05/2025
Great special poster session this morning #ISSLS2025 on #IVD degeneration chaired by Stefan Dudli and Kotaro Nishida
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ISSLS @issls.bsky.social · 13/05/2025
Presenters are getting robust and constructive questioning here very much in the spirit of #ISSLS2025! Halfway through a great session here including studies on #Modicchanges and deep learning spine variables extracted from UK biobank
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ISSLS @issls.bsky.social · 13/05/2025
#ISSLS2025 has officially kicked off here in Atlanta with the basic science session!
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ISSLS @issls.bsky.social · 10/04/2025
Preoperative #SleepDisturbances and #Depression independently and jointly predict higher disability and pain 12 months after lumbar #SpineSurgery.​ The latest publication in Spine by #ISSLS member Kristin R. Archer and team: journals.lww.com/spinejournal...
journals.lww.com
The Combined Influence of Sleep Disturbance and Depression... : Spine
havioral factors are considered major risk factors for poor outcomes after LSS. However, there is a need to explore the combined effects of preoperative factors such as sleep disturbance and depressio...
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ISSLS @issls.bsky.social · 10/04/2025
The latest publication in The Spine Journal by Todd Alamin investigates patient acceptance of reoperation risk following lumbar decompression and fusion surgeries, revealing some important findings that could impact the future of #LumbarSpine research. www.thespinejournalonline.com/article/S152...
thespinejournalonline.com
Patient acceptance of reoperation risk for lumbar decompression versus fusion
Lumbar decompression and lumbar fusion are effective methods of treating spinal compressive pathologies refractory to conservative management. These surgeries are typically used to treat different spi...
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ISSLS @issls.bsky.social · 10/04/2025
This research provides valuable insights into the role of mitochondrial oxidative stress in disc degeneration and highlights potential therapeutic strategies for low back pain interventions. Read the full study here: www.sciencedirect.com/science/arti...
sciencedirect.com
SOD2 orchestrates redox homeostasis in intervertebral discs: A novel insight into oxidative stress-mediated degeneration and therapeutic potential
Low back pain (LBP) is a pervasive global health concern, primarily associated with intervertebral disc (IVD) degeneration. Although oxidative stress …
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ISSLS @issls.bsky.social · 10/04/2025
Check out his latest study in #RedoxBiology! His work sheds light on how #OxidativeStress contributes to intervertebral disc degeneration and explores the therapeutic potential of targeting superoxide dismutase 2 to restore redox homeostasis in the disc.
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ISSLS @issls.bsky.social · 10/04/2025
🌟 Introducing Dr. Shota Tamagawa – Our Newest ISSLS Member! 🌟 ISSLS is thrilled to welcome Shota Tamagawa, MD, PhD, Assistant Professor at Juntendo University Faculty of Medicine, Tokyo, Japan, to our #ISSLS community of spine researchers and clinicians!
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ISSLS @issls.bsky.social · 10/04/2025
One of his recent studies uses deep learning to analyze MRI data, revealing how lumbar muscle cross-sectional area and fat infiltration vary by sex, age, and clinical condition. Read their complete work here: link.springer.com/article/10.1...
link.springer.com
Cross-sectional area and fat infiltration of the lumbar spine muscles in patients with back disorders: a deep learning-based big data analysis - European Spine Journal
Purpose Validated deep learning models represent a valuable option to perform large-scale research studies aiming to evaluate muscle quality and quantity of paravertebral lumbar muscles at the populat...
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ISSLS @issls.bsky.social · 10/04/2025
Dr Jacopo Vitale's work bridges clinical practice and sports science, with a focus on enhancing spine health in individuals with back disorders. Dr Vitale investigates how spinal muscle morphology & function relate to patient-reported outcomes, aiming to optimize recovery & long-term spinal health.
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ISSLS @issls.bsky.social · 10/04/2025
🌟 Welcome Dr. Jacopo Vitale – Our Newest ISSLS Member! 🌟 Dr. Vitale is a Research Associate at the Spine Centre at Schulthess Klinik in Zürich (Switzerland) and Associate Professor at the Institute of Sports Sciences at University of Physical Culture in Cracow (Poland).
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ISSLS @issls.bsky.social · 10/04/2025
In this study oral administration of senolytic drugs in a mouse model significantly reduced LBP, eliminated SnCs in intervertebral discs and the spinal cord, decreased inflammatory senescence-associated secretory phenotype factors, improved disc & bone health, & lowered pain marker expression
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ISSLS @issls.bsky.social · 10/04/2025
Publication in #ScienceAdvances by #ISSLS member Prof. Lisbet Haglund: www.science.org/doi/full/10.... This study investigates the potential of two senolytic drugs in treating #LowBackPain by targeting senescent cells, which accumulate with aging and contribute to #inflammation and degeneration
science.org
Senolytic treatment for low back pain
Senolytics drugs can reduce back pain by removing senescent cells from the intervertebral discs and spinal cord.
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ISSLS @issls.bsky.social · 19/03/2025
Single Cell RNA Sequencing Reveals Emergent Notochord-Derived Cell Subpopulations in the Postnatal Nucleus Pulposus: 🔗 pmc.ncbi.nlm.nih.gov/articles/PMC...
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ISSLS @issls.bsky.social · 19/03/2025
📢 Publication in FASEB J by #ISSLS member Dr. Lachlan Smith et al highlights key findings using single cell RNA seq., revealing the diversity & crucial roles of notochord-derived NP cells in the postnatal mouse disc #SpineResearch #LumbarSpine #LowBackPain #RegenerativeMedicine #Biotechnology Link 👇🏼
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ISSLS @issls.bsky.social · 11/03/2025
The #ISSLS Phenotype/Precision Spine Focus Group is driving advancements in low back pain management through predictive biomarkers. Their 2024 recommendations, now published in the European Spine Journal, emphasize unified terminology, robust research designs, and overcoming development barriers 👇🏼
link.springer.com
Development and application of predictive clinical biomarkers for low back pain care: recommendations from the ISSLS phenotype/precision spine focus group - European Spine Journal
Predictive biomarkers (or moderators of treatment) are features, or more likely feature clusters, that discriminate individuals who are more likely to experience a favourable or unfavourable effect fr...
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ISSLS @issls.bsky.social · 11/03/2025
Meet Clara Ruiz Fernández who joined ISSLS because of the great collaborative environment between basic researchers and clinicians. As as a postdoctoral researcher at the the Tokai University School of Medicine, Clara is a key member of the #ISSLS Social Media Committee!
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ISSLS @issls.bsky.social · 11/03/2025
Next to be introduced is Chantal Voskamp PhD, a postdoctoral researcher at the Utrecht University (Netherlands) whose research focuses on intervertebral disc regeneration using biomolecules derived from notochordal cells. Most importantly Chantal is a member of the #ISSLS Social Media Committee!
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ISSLS @issls.bsky.social · 11/03/2025
Terence McSweeney, MSc is a doctoral researcher at the University of Oulu and #ISSLS SoMe member. His advice for (fellow) young researchers: take a few risks and go out of your comfort zone whether that's by promoting your work, networking, learning a new skill, or tackling a new topic.
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ISSLS @issls.bsky.social · 11/03/2025
📢 New study by #ISSLS member Dr. Kakutani reveals TRPV4 knockdown impairs ECM synthesis via autophagy suppression, leading to disc degeneration in rats. Underscores autophagy's role in disc health, suggesting TRPV4 as a target for new therapies #SpineResearch onlinelibrary.wiley.com/doi/10.1002/...
onlinelibrary.wiley.com
Transient Receptor Potential Vanilloid 4 Knockdown Decreases Extracellular Matrix Synthesis via Autophagy Suppression in the Rat Intervertebral Disc
We conducted in vitro and in vivo TRPV4 RNA interference study in the rat intervertebral disc cells and tissues. In vitro, TRPV4 knockdown decreased extracellular matrix synthesis, cell viability, an...
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ISSLS @issls.bsky.social · 11/03/2025
🚨 Perioperative spinal cord injury in high-risk adult deformity surgery is rare but devastating. The latest study in Spinal Cord Series & Cases by #ISSLS members Fan Jiang & colleagues examines its incidence, causes, outcomes, and management strategies. 🧠🔍 Full paper: www.nature.com/articles/s41...
nature.com
Spinal cord injury in high-risk complex adult spinal deformity surgery: review of incidence and outcomes from the Scoli-RISK-1 study - Spinal Cord Series and Cases
Spinal Cord Series and Cases - Spinal cord injury in high-risk complex adult spinal deformity surgery: review of incidence and outcomes from the Scoli-RISK-1 study
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ISSLS @issls.bsky.social · 06/03/2025
Key findings: 1️⃣ PHLPP1 increased in IVD degeneration; its deficiency decelerates degeneration. 2️⃣ NSC117079 reduces PHLPP1 expression, boosts NP cell proliferation, ECM & reduces apoptosis. 3️⃣ Activates AKT & inhibits NF-κB, suggesting that it promotes NP cell health.
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ISSLS @issls.bsky.social · 06/03/2025
📢 Check out the work of #ISSLS member Svenja Illien-Junger et al. in #JORSpine on PHLPP1’s role in IVD degeneration & small molecule inhibitors. Full study 👉 onlinelibrary.wiley.com/doi/10.1002/... #SpineResearch
onlinelibrary.wiley.com
Differential efficacy of two small molecule PHLPP inhibitors to promote nucleus Pulposus cell health
Pharmacological inhibition of PHLPP via NSC45586 promotes nucleus pulposus cell health. NSC45586 is a potential drug candidate in treating IVD degeneration.
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ISSLS @issls.bsky.social · 05/03/2025
📢 Get ready for #ISSLS2025, abstract decisions have been out for a few weeks now! We can't wait for an exciting meeting in Atlanta this May, where groundbreaking #SpineResearch takes centre stage. Check out the programme and speakers: www.isslsmeetings.org/2025-program
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Reposted by ISSLS
Orthopaedic Research Society @orssociety.bsky.social · 19/02/2025
Your curriculum vitae (CV) is essential for showcasing your accomplishments as a scientist, leader, and colleague. Join this #WebinarWednesday on March 12 to learn key tips for crafting an effective CV for academia and industry. Register now: bit.ly/4b5XIYl
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ISSLS @issls.bsky.social · 14/02/2025
Next let's introduce Luca Ambrosio, MD As an Orthopaedic Surgeon and PhD student at Università Campus Bio-Medico di Roma, Luca is a valued member of the #ISSLS Social Media Committee. We had the chance to learn more about his journey in #SpineResearch and #ISSLS. Here's a quick Q&A!
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ISSLS @issls.bsky.social · 14/02/2025
Today is the last change to apply for a travel grant to ISSLS Eligibility 🎯: 🔹 First-time ISSLS in-person attendee 🔹 First/presenting author on an accepted abstract 🔹 Graduate student or within 4 years post-qualification (or under 40 as an independent researcher) www.isslsmeetings.org/travel-grant
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ISSLS @issls.bsky.social · 14/02/2025
Next up introducing our #ISSLS SoMe committee member Elisabetta de Rinaldis! As an undergraduate medical student at Campus Bio-Medico University of Rome, Elisabetta is a valued member of the ISSLS Social Media Committee, we had the chance to learn more about her journey in spine research and ISSLS
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ISSLS @issls.bsky.social · 28/01/2025
This research highlights that epimuscular fat may be a relevant factor in the presentation of low back pain. #ISSLS congratulate member Jacopo A Vitale and colleagues for their work in advancing #LumbarSpine research. #Muscle #LowBackPain #LBP #LumbarSpine #ISSLS
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ISSLS @issls.bsky.social · 28/01/2025
Jacopo A Vitale et al. in the journal Brain and Spine have shown a significant correlation between epimuscular fat and #LowBackPain intensity. 🔗 doi: doi.org/10.1016/j.ba...
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ISSLS @issls.bsky.social · 28/01/2025
Meet Jordy Schol @jordyschol.bsky.social a research fellow at the Tokai University School of Medicine. Jordy is a valued member of the #ISSLS Social Media Committee - check out his Q & A below! #SpineResearch #RegenerativeMedicine #BioTech
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ISSLS @issls.bsky.social · 28/01/2025
First up is Jeannie Bailey @spinesinspace.bsky.social who founded and leads the committee. Associate Professor in Orthopaedic Surgery at University of California, San Francisco and Director of the Physical Function and Biomechanics Research Core within REACH. Q & A with Jeannie 👇🏼
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ISSLS @issls.bsky.social · 28/01/2025
Kicking things off here with a thread highlighting the #ISSLS social media committee members who curate the research highlights, event updates, and society news here, on LinkedIn and Instagram. More info about the society committees can be found on the website: www.issls.org/officers-and...
issls.org
OFFICERS AND COMMITTEES — The International Society for the Study of the Lumbar Spine
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ISSLS @issls.bsky.social · 28/01/2025
👋 Welcome to the official Bluesky account of the International Society for the Study of the Lumbar Spine (ISSLS)! 🌍✨ Whether clinician, researcher, or just passionate about #lumbarspine research, we’d love to connect with you. Follow us for event updates and regular highlights of member's research
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