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Irene Sanchez Lopez

@isanchezlo.bsky.social
122 followers 235 following 0 posts

Postdoctoral researcher in DNA damage response | Early-career scientist focused on advancing knowledge in genome stability

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Reposted by Irene Sanchez Lopez
Javier Martin @fjvrmrtn.bsky.social · 06/05/2026
Paper alert 📣 Our group has just published a new review in Biochemical Society Transactions on emerging functions of STIM1, expanding its role beyond its classical function as an ER Ca2+ sensor. We discuss new insights into its involvement in key cellular processes portlandpress.com/biochemsoctr...
portlandpress.com
Unraveling new functions of the Ca2+ sensor STIM1 in cell signaling
Abstract. Calcium (Ca2+) signaling is a fundamental regulator of virtually all aspects of eukaryotic cell physiology, including gene expression, secretion, metabolism, motility, and cell fate decision...
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Reposted by Irene Sanchez Lopez
The EMBO Journal @embojournal.org · 11/02/2026
Calcium sensor STIM1 affects mitochondrial calcium content not only indirectly via store-operated calcium entry into the cytoplasm, but also by promoting direct ER-to-mitochondria ion flow at contact sites @fjvrmrtn.bsky.social , @jorgms.bsky.social and coworkers link.springer.com/article/10.1...
link.springer.com
STIM1-containing contact sites promote direct calcium flux from the endoplasmic reticulum to mitochondria - The EMBO Journal
STIM1 is a transmembrane protein localized in the endoplasmic reticulum (ER), where it acts as a calcium ion sensor, activating store-operated Ca2+ entry upon ER Ca2+ depletion. Via cellular calcium i...
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