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Reposted by Innate2Adaptive research group @ UCL

Gabriele Pollara @gpollara.bsky.social · 05/12/2024

Really pleased to share collaborative project led by @emilybethwong.bsky.social & 1st author @maphemthembu.bsky.social A careful dissection of dysfunctional immune responses in ART-naive HIV infection. TL:DR bronchoalveolar ≠ blood responses #HIVSky #IDSky #ImmunoSky www.cell.com/iscience/ful...

cell.com

Dysfunctional bronchoalveolar effector memory CD8+ T cells in tuberculosis-exposed people living with antiretroviral-naïve HIV infection

Immunology; Virology

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Reposted by Innate2Adaptive research group @ UCL

Gabriele Pollara @gpollara.bsky.social · 21/11/2024

🚨 Delighted to share our paper defining a new role for IL-6 in TB. 🚨 We used genetic variation to show *reduced* IL-6 signalling is causally associated with *lower* risk of TB. Lead author @gushamilton.bsky.social #TBSky #IDSky #ImmunoSky www.thelancet.com/journals/lan... Thread 👇 (1/8)

thelancet.com

Altered IL-6 signalling and risk of tuberculosis: a multi-ancestry mendelian randomisation study

Our findings propose a causal relationship between reduced IL-6 signalling and lower risk of tuberculosis, akin to the effect seen in other IL-6 mediated diseases. This study suggests that IL-6 antago...

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Reposted by Innate2Adaptive research group @ UCL

Gabriele Pollara @gpollara.bsky.social · 26/11/2024

Presented interesting paper in @innate2adaptive.bsky.social journal club today. Monocyte-T cell doublets in blood of TB & dengue pts - single cell transcriptional profiling: - activated cells - T cell-like monocytes & monocyte-like T cells Unclear functional role & if 100% not artefact #Immunosky

biorxiv.org

A novel method for characterizing cell-cell interactions at single-cell resolution reveals unique signatures in blood T cell-monocyte complexes during infection

Communication between immune cells through direct contact is a critical feature of immune responses. Here, we developed a novel high-throughput method to study the transcriptome and adaptive immune re...

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Reposted by Innate2Adaptive research group @ UCL

Q-Immuno lab at UCL @qimmuno.bsky.social · 25/11/2024

📣 We are hiring! Postdoc opportunity in Quantitative Immunology at University College London. . 🔬 Develop computational approaches to discover clonal and functional T cell determinants of protection against Tuberculosis. Fully funded 2-year position. 🗓️ Apply by Dec 10 www.ucl.ac.uk/work-at-ucl/...

ucl.ac.uk

UCL – University College London

UCL is consistently ranked as one of the top ten universities in the world (QS World University Rankings 2010-2022) and is No.2 in the UK for research power (Research Excellence Framework 2021).

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Reposted by Innate2Adaptive research group @ UCL

Gabriele Pollara @gpollara.bsky.social · 15/11/2024

More evidence of immune cell (macrophage) -> stromal cell (fibroblast) inflammatory communication to alter organ function (deleteriously, in this case) #ImmunoSky www.nature.com/artic...

nature.com

Targeting immune–fibroblast cell communication in heart failure

Nature - A fibroblast lineage marked by FAP gives rise to POSTN-expressing fibroblasts resembling matrifibrocytes and IL-1β regulates FAP/POSTN fibroblast specification by directly signalling...

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