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IJOS_Editorial Office @ijosjournal.bsky.social · 17/09/2026

Can #dental stem cells help rebuild #bone around teeth? Researchers made these cells produce more #IGFBP5 protein, reducing signs of ageing in lab tests. A #gel carrying the modified cells improved bone repair in rats with #gum disease.👍 @ijosjournal.bsky.social www.nature.com/articles/s41...

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IJOS_Editorial Office @ijosjournal.bsky.social · 15/09/2026

#Ultrasound may help #bone heal by easing a molecular brake. In cells and mice, low-intensity pulsed ultrasound lowered Id3, which normally suppresses #BMP4 bone-building signals. Blocking #Id3 with a peptide further strengthened these signals and improved skull-defect repair in mice.👍

https://www.nature.com/articles/s41368-026-00456-1

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IJOS_Editorial Office @ijosjournal.bsky.social · 11/09/2026

In mice, removing both #Piezo1 and #Piezo2 slowed the maturation of dentin-forming odontoblasts and reduced Wnt/β-catenin signaling. Adding #Wnt10a restored odontoblast development in cultured tooth germs, connecting mechanical sensing with #tooth development.👇 www.nature.com/articles/s41...

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IJOS_Editorial Office @ijosjournal.bsky.social · 10/09/2026

#Teeth and #jaws are shaped by more than genes. This review shows how forces from growth, chewing and #orthodontic treatment can guide cells, helping shape teeth, roots and jaws as they develop and continue to adapt over time.🦷 @brjournal.bsky.social www.nature.com/articles/s41...

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IJOS_Editorial Office @ijosjournal.bsky.social · 03/09/2026

What if reshaping #mitochondria could help #bone heal? In stem cells, lowering #PFKM created donut-shaped mitochondria, improved cellular energy management and boosted bone formation. In rats, #gene delivery that suppressed PFKM accelerated repair of skull and thigh-bone defects.🤓

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IJOS_Editorial Office @ijosjournal.bsky.social · 01/09/2026

Every bite, word and facial movement places force on the #mouth and #jaw. This review shows how oral tissues sense and remember those forces, and how the same signals could guide healing through smarter, increasingly adaptive #biomaterials.🤓 @ijosjournal.bsky.social www.nature.com/articles/s41...

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IJOS_Editorial Office @ijosjournal.bsky.social · 28/08/2026

Inflammatory #DNA webs can damage #bone around #teeth. Nanodecoys engineered with Toll-like receptor 9 released #DNase I under near-infrared light to clear them. In a mouse model of #periodontitis, treatment reduced bone-resorbing activity, supported bone formation, and limited bone loss.😀

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IJOS_Editorial Office @ijosjournal.bsky.social · 25/08/2026

Normal #enamel thickness does not guarantee normal enamel quality. In mice, disrupting a cell-binding motif in ameloblastin impaired ameloblast polarity and prism organization. Homozygous mutants also had hypomineralized enamel—revealing how cell–matrix contact shapes enamel architecture.👇

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IJOS_Editorial Office @ijosjournal.bsky.social · 21/08/2026

Two #collagen receptors work together during skull repair. In mice, disabling either integrin β1 or #DDR2 in #skeletal progenitor cells impaired healing; disabling both reduced #bone regeneration by 73%, revealing a cooperative pathway that may guide future bone-repair strategies.👍

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IJOS_Editorial Office @ijosjournal.bsky.social · 18/08/2026

Why do #coronal sutures sometimes fuse too early? In mice, excessive FGFR2–P38 signaling increased #retinoic acid and premature bone formation. Restoring retinoic acid signaling kept the suture open and improved #neurocognitive outcomes.👇 @ijosjournal.bsky.social www.nature.com/articles/s41...

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IJOS_Editorial Office @ijosjournal.bsky.social · 03/08/2026

#Gum #disease creates rogue immune hubs that activate bone-destroying cells. Scientists found #oral bugs trigger fibroblasts to build these hubs via IFN-I signaling. Blocking this pathway stops bone loss, pointing to a new treatment.🤓 @ijosjournal.bsky.social www.nature.com/articles/s41...

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IJOS_Editorial Office @ijosjournal.bsky.social · 30/07/2026

University of Washington’s Hannele Ruohola-Baker research team’s cover article in IJOS Vol 18 Issue 3 reveals a designer drug that turns stem cells into #enamel producers on their own, without partner cells. These cells formed enamel-like tissue in mice, pointing toward regenerative #dental care.😀

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IJOS_Editorial Office @ijosjournal.bsky.social · 29/07/2026

Aging #dental stem cells lose their vessel-building capacity, hampering #tooth repair. Reprogramming restored youthful metabolic activity and vascular potential—paving the way for living tissue regeneration over extraction.🦷 @ijosjournal.bsky.social www.nature.com/articles/s41...

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IJOS_Editorial Office @ijosjournal.bsky.social · 15/07/2026

A #cholesterol drug and other existing medicines can block #gum disease bacteria from hiding inside cells, making standard antibiotics work better at lower doses. In rat tests, this combo slashed inflammation and bone loss, pointing to a faster, cheaper path to treating stubborn #periodontitis.🦷

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IJOS_Editorial Office @ijosjournal.bsky.social · 10/07/2026

#Gum disease rewires #bone marrow immune cells to fuel body-wide inflammation by hijacking their antioxidant balance. Targeting the CHAC2 enzyme could tame this inflammatory storm and improve blood sugar control, pointing to a new way to treat #diabetes complications linked to #oral health.👇

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IJOS_Editorial Office @ijosjournal.bsky.social · 07/07/2026

#Dental implant infections trap #immune cells in a stubborn inflammation loop that erodes bone. Blocking this cell chat with targeted drugs curbs #bone loss in #models, pointing to therapies that could save failing implants without repeated #surgery.👍 www.nature.com/articles/s41...

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IJOS_Editorial Office @ijosjournal.bsky.social · 03/07/2026

An autonomous #robot mills tooth sockets with precision matching donor root shape, cutting deep positioning errors especially for double-rooted #teeth. This could make tooth autotransplantation safer and more reliable, preserving more bone and improving success rates.👇 www.nature.com/articles/s41...

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IJOS_Editorial Office @ijosjournal.bsky.social · 17/06/2026

#YTHDC1 protein keeps stem cells young. In #jaw joint #arthritis, it drops under inflammation, causing cells to age too fast. Boosting it in stem cells repaired joint damage. This offers a new path to treat joint degeneration and could help many patients avoid joint replacement #surgery.😀

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IJOS_Editorial Office @ijosjournal.bsky.social · 11/06/2026

#Jaw joint overgrowth skews faces and bites. A new #expert #consensus maps tailored surgery combos, from joint reshaping to bite correction, guiding clinicians to restore function and harmony for each patient type.👍 @ijosjournal.bsky.social www.nature.com/articles/s41...

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IJOS_Editorial Office @ijosjournal.bsky.social · 09/06/2026

#Stem #cells age and lose healing power. A master regulator called #OCT4 revives worn-out #dental stem cells by reactivating their internal rhythm gene, restoring their ability to grow and repair #tooth pulp. This points to broader anti-aging cell therapies.😀 www.nature.com/articles/s41...

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IJOS_Editorial Office @ijosjournal.bsky.social · 02/06/2026

A broken cell #glue #gene causes inherited brittle #teeth. Drug treatment fixes the overactive growth signal and rescues enamel, shifting care from lifelong #dental repairs to targeting the root cause with medication.👍 @ijosjournal.bsky.social www.nature.com/articles/s41...

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IJOS_Editorial Office @ijosjournal.bsky.social · 29/05/2026

Scientists found #CAR3 protein packs minerals into collagen for strong #bones. Without it #skeletons weaken, yet CAR3-coated implants attract repair cells and speed healing, pointing to faster fracture recovery.🥳 @ijosjournal.bsky.social www.nature.com/articles/s41...

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IJOS_Editorial Office @ijosjournal.bsky.social · 27/05/2026

#AI screens #DNA-like molecules to design #antibacterial gels for #gum disease. Two candidates validated in periodontitis models, and this data-driven approach could speed up targeted #oral therapies.😀 @ijosjournal.bsky.social www.nature.com/articles/s41...

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IJOS_Editorial Office @ijosjournal.bsky.social · 22/05/2026

Adult bodies struggle to regrow complex tissues like #gums. Tiny repair #bubbles from young immune cells recharge adult cell batteries, restoring energy levels and sparking true gum regeneration. This unlocks a fresh path to heal adult organs long thought irreparable.🥳 www.nature.com/articles/s41...

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IJOS_Editorial Office @ijosjournal.bsky.social · 20/05/2026

A #DNA-based nanoplatform targets gums with curcumin and defensin to combat infection, inflammation, and #bone resorption. This clean system boosts therapeutic efficacy against periodontal and related bone-wasting disorders.👍 @ijosjournal.bsky.social www.nature.com/articles/s41...

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IJOS_Editorial Office @ijosjournal.bsky.social · 14/05/2026

#Oral #cancer is rising in non-smokers. Body aging and germs, not tobacco, drive two hidden #tumor subtypes. First #molecular profiling redefines early detection and prevention for low-risk patients.🥳 @ijosjournal.bsky.social www.nature.com/articles/s41...

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IJOS_Editorial Office @ijosjournal.bsky.social · 12/05/2026

A gut bacteria compound (tributyrin) relieves jaw joint pain by restoring brainstem gene activity damaged by chronic pain. This gut-brain link could replace addictive painkillers with safer, non-habit-forming therapies for jaw joint disorders. @ijosjournal.bsky.social www.nature.com/articles/s41...

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IJOS_Editorial Office @ijosjournal.bsky.social · 09/05/2026

Wisdom #teeth often damage neighboring molars and cause painful infections. New expert #guidelines standardize when removal is truly needed, helping #dentists avoid unnecessary surgery while protecting #oral health.🦷 @ijosjournal.bsky.social www.nature.com/articles/s41...

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IJOS_Editorial Office @ijosjournal.bsky.social · 07/05/2026

#SLIT3 promotes #dental stem cell proliferation and mineralization via a key pathway, enabling targeted molecular regulation for clinical root/dentin regeneration and advancing next-generation #biological tooth repair.😀 @ijosjournal.bsky.social www.nature.com/articles/s41...

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IJOS_Editorial Office @ijosjournal.bsky.social · 30/04/2026

Taste sensors in the mouth also exist in lungs and gut, controlling immune responses and metabolism. Understanding these dual roles could offers new therapeutic avenues for diabetes, asthma, and immune disorders beyond dietary interventions.😀 @ijosjournal.bsky.social www.nature.com/articles/s41...

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IJOS_Editorial Office @ijosjournal.bsky.social · 28/04/2026

Severe gum disease is three times more common in people with early kidney disease. Treating gum inflammation could help protect kidney health, offering a simple way to catch and slow kidney decline early.👍 #gum #oral #kidney @ijosjournal.bsky.social www.nature.com/articles/s41...

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IJOS_Editorial Office @ijosjournal.bsky.social · 24/04/2026

A sugar coating on proteins controls how facial bones fuse during pregnancy. When disrupted, it causes cleft palate. Understanding this process could lead to early screening and prevention for this common birth defect.😀 #oral #proteins @ijosjournal.bsky.social www.nature.com/articles/s41...

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IJOS_Editorial Office @ijosjournal.bsky.social · 21/04/2026

The mouth contains diverse stem cells that build teeth, roots, and gums. Mapping these cell types advances regenerative dentistry, potentially enabling living tooth repair and gum regeneration without implants.👍 #mouth #oral #teeth @ijosjournal.bsky.social www.nature.com/articles/s41...

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IJOS_Editorial Office @ijosjournal.bsky.social · 17/04/2026

Expert consensus establishes guidelines for bone grafting during adult orthodontic treatment. This framework helps clinicians safely rebuild jawbone, expand tooth movement options, and reduce periodontal risks where bone defects previously limited treatment.👍 www.nature.com/articles/s41...

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IJOS_Editorial Office @ijosjournal.bsky.social · 14/04/2026

Jaw joint arthritis causes hidden damage like fat buildup and scarring in the disc. Understanding these early cellular changes could enable targeted therapies to prevent severe joint deterioration, advancing treatment beyond pain management.👇 @ijosjournal.bsky.social www.nature.com/articles/s41...

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IJOS_Editorial Office @ijosjournal.bsky.social · 10/04/2026

Two proteins (Gli2 and Gli3) team up to build tooth roots by guiding stem cell growth. Mapping this process reveals how facial structures form and could enable regenerative therapies for dental defects and craniofacial disorders.😀 @ijosjournal.bsky.social www.nature.com/articles/s41...

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IJOS_Editorial Office @ijosjournal.bsky.social · 08/04/2026

A cellular signaling pathway (JAK-STAT) controls how jaw and face bones grow. When it malfunctions, severe facial deformities result. Existing drugs like baricitinib could treat these conditions, offering new precision therapy options and avoiding complex surgeries.👍 www.nature.com/articles/s41...

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IJOS_Editorial Office @ijosjournal.bsky.social · 03/04/2026

A novel engineered peptide (TKH) seals exposed tooth tubules and rebuilds dentin through self-assembly, offering a biocompatible long-term fix for sensitive teeth without harsh chemicals.👍 #tooth #oral #dental #biocompatible @ijosjournal.bsky.social www.nature.com/articles/s41...

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IJOS_Editorial Office @ijosjournal.bsky.social · 31/03/2026

KDM6B is a molecule drives tooth root repair by boosting lactate production. This metabolic mechanism suggests simple lactate supplements could reverse damage from severe gum disease.👍 #KDM6B #tooth #oral #lactate @ijosjournal.bsky.social www.nature.com/articles/s41...

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IJOS_Editorial Office @ijosjournal.bsky.social · 27/03/2026

Researchers used a drug to transform stem cells into enamel-producing cells, creating tooth enamel without natural cell contact. This could enable living tooth repair for adults who cannot naturally regenerate damaged enamel.👍 #tooth #enamel @ijosjournal.bsky.social www.nature.com/articles/s41...

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IJOS_Editorial Office @ijosjournal.bsky.social · 26/03/2026

ANKRD1 is a chromatin regulator that preserves bone marrow stem cells' ability to become neurons. Its decline with age drives cognitive decline. Restoring it benefits memory and could transform approaches to cognitive aging.😀 #ANKRD1 #oral @ijosjournal.bsky.social www.nature.com/articles/s41...

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IJOS_Editorial Office @ijosjournal.bsky.social · 20/03/2026

Scientists mapped how immune cells attack jaw cartilage in arthritis via specific damage signals. Blocking these pathways shows therapeutic potential, offering precise drug targets for treating this painful jaw condition.🤓 #jaw #oral @ijosjournal.bsky.social www.nature.com/articles/s41...

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IJOS_Editorial Office @ijosjournal.bsky.social · 18/03/2026

Scientists identified a rare stem cell type (GLDN+) in dental pulp that builds teeth and blood vessels. These cells could enable living tooth repair, offering an alternative to artificial fillings and implants.👍 #dental #oral #teeth @ijosjournal.bsky.social www.nature.com/articles/s41...

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IJOS_Editorial Office @ijosjournal.bsky.social · 13/03/2026

Two active bacteria found deep in children's cavities may drive severe tooth decay. Targeting these microbes could lead to better treatments for early childhood caries.😀 #tooth #microbes #oral @ijosjournal.bsky.social www.nature.com/articles/s41...

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IJOS_Editorial Office @ijosjournal.bsky.social · 11/03/2026

Dental implants prevent jawbone loss by triggering a protein called sorting nexin 5 (Snx5). This discovery could improve implant success and lead to new bone healing treatments.😀 #Snx5 #jawbone #dental @ijosjournal.bsky.social www.nature.com/articles/s41...

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IJOS_Editorial Office @ijosjournal.bsky.social · 05/03/2026

Dentists face 3.6 times higher vision risks due to chronic exposure to bright dental lights, with blue and white LEDs damaging blood-retinal barriers. Switching to low-intensity halogen lighting could protect dentist eye health.👀 #oral @ijosjournal.bsky.social www.nature.com/articles/s41...

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IJOS_Editorial Office @ijosjournal.bsky.social · 03/03/2026

Excess copper triggers "cuproptosis"—a unique cell death that destroys bone by blocking sugar storage. This copper-sugar link explains bone loss in gum disease and suggests new treatments for copper-related bone conditions.😀 #copper #oral @ijosjournal.bsky.social www.nature.com/articles/s41...

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IJOS_Editorial Office @ijosjournal.bsky.social · 27/02/2026

Enamel's toughness comes from its unique crisscross pattern, now explained by cell sliding during formation. This insight could lead to stronger dental materials.👍 #enamel #dental #oral @ijosjournal.bsky.social www.nature.com/articles/s41...

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IJOS_Editorial Office @ijosjournal.bsky.social · 11/02/2026

Oral cancer cells in a hybrid state drive spread and resist treatment. Targeting this partial-Epithelial-Mesenchymal Transition (EMT) state could improve therapies, potentially boosting patient survival and quality of life.👇 #cancer #oral @ijosjournal.bsky.social www.nature.com/articles/s41...

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IJOS_Editorial Office @ijosjournal.bsky.social · 06/02/2026

Gum disease bacteria worsen osteoporosis through the gut, but a natural compound called ILA can stop bone loss by blocking bone-breakdown cells, offering new therapy for people with both conditions.👇 #gum #bacteria #ILA @ijosjournal.bsky.social www.nature.com/articles/s41...

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