That’s What Biological (Epigenetic) Aging Clocks Are Measuring

A Gaping Lack of Evidence for Health Benefits

A Gaping Lack of Evidence for Health Benefits

On May 29, 2026, the Office of Management and Budget issued a Notice of Proposed Rulemaking (NPRM), OMB-2026-0034, Regulation for Federal Financial Assistance. The scope of this proposed regulation is...

The opinions expressed in this editorial are the personal views of the authors (S.E. Kahn, C.A.M. Anderson, J.B. Buse, and E. Selvin) and do not represent

The opinions expressed in this editorial are the personal views of the authors (S.E. Kahn, C.A.M. Anderson, J.B. Buse, and E. Selvin) and do not represent

Most dietary guidance relies on lousy evidence. How are we supposed to know what to eat?

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Middle-of-the-night insomnia is common. These techniques might help.

Forty-three current and former C.D.C. employees on the changes they say are replacing science with ideology — and making Americans more vulnerable.

Objective To assess the effect of intermittent fasting diets, with continuous energy restriction or unrestricted (ad-libitum) diets on intermediate cardiometabolic outcomes from randomised clinical ...

Intermittent fasting has gained a following, in part because of tantalizing hints that it can boost cognition, fend off cancer and even slow ageing.

Lower risk of all-cause and cardiovascular mortality observed only among morning drinkers

Their letter calls the choice of Robert F. Kennedy Jr., who is known for promoting false medical claims, “a slap in the face” to health care professionals.

Hofer et al. show that fasting promotes the synthesis of spermidine, which stimulates eIF5A hypusination to induce autophagy and increase lifespan in various species in a conserved manner.

Aaron Siri, who specializes in vaccine lawsuits, has been at Robert F. Kennedy Jr.’s side reviewing candidates for top jobs at the Department of Health and Human Services.

St. Ange et al. provide a single-nucleus RNA sequencing atlas of adult wild-type and IIS mutant Caenorhabditis elegans neurons, identifying genes that turn on from L4 to adulthood, including GPCRs. Functional behavior experiments revealed the roles of genes expressed in single neurons, including previously unidentified IIS targets.

Abstract. Organismal aging is marked by decline in cellular function and anatomy, ultimately resulting in death. To inform our understanding of the mechani

Yeh et al. explore the effects of restricting dietary protein, or isoleucine specifically, in aged mice. They uncover benefits to metabolic health and certain indicators of aging and a sexually dimorp...

Critics say extraordinary life spans reflect faulty record keeping, not healthy lifestyles