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Emma Ridley, PhD @icunutrition.bsky.social · 10/12/2025

Ascorbate is its ionised (deprotonated) form, which predominates in the body at physiological pH. Ascorbate is the focus of new Vitamin C research #ccrdownunder

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Emma Ridley, PhD @icunutrition.bsky.social · 10/12/2025

The preparation is important- Mark Plummer nicely outlining the importance of understanding what is studied in Vit C trials Ascorbic acid is the acidic, protonated form of Vit C (used in many trials and may explain the harm 1/2 #ccrdownunder #VITACCtrial

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Emma Ridley, PhD @icunutrition.bsky.social · 10/12/2025

Next up VITaCC results session (Early high-dose vitamin C in post-cardiac arrest syndrome) up next at #CCRdownunder #VITACCtrial

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Emma Ridley, PhD @icunutrition.bsky.social · 10/12/2025

Next up RSI results session (Etomidate vs Ketamine for intubation) up next at #CCRdownunder #RSItrial

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Emma Ridley, PhD @icunutrition.bsky.social · 09/12/2025

#ARISEAFRICAtrial is a stepped wedge cluster- this design is useful for interventions delivered at the ICU/hospital level and individual randomisation is difficult. Clusters transition from control to intervention at different times www.bmj.com/content/350/... #ccrdownunder @criticalcarereviews.com

bmj.com

The stepped wedge cluster randomised trial: rationale, design, analysis, and reporting

#### Summary points

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Reposted by Emma Ridley, PhD

JAMA @jama.com · 09/12/2025

Research Summary: Early use of automated closed-loop ventilation did not increase ventilator-free days at day 28 compared with protocolized conventional ventilation. #CCRdownunder ja.ma/48AgJCj

JAMA Research Summary: Effect of Automated Closed-Loop Ventilation vs Protocolized Conventional Ventilation on Ventilator-Free Days in Critically Ill Adults. Closed-loop ventilation: 16.7 days. Conventional ventilation: 16.3 days.

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Reposted by Emma Ridley, PhD

JAMA @jama.com · 09/12/2025

Among adults undergoing cardiac surgery at high risk of bleeding and platelet transfusion, cryopreserved platelets did not meet noninferiority for controlling postoperative bleeding and were less effective than liquid-stored platelets. #CCRdownunder ja.ma/4rEC06z

JAMA article titled 'Cryopreserved vs Liquid-Stored Platelets for the Treatment of Surgical Bleeding'. Key points: cryopreserved platelets may be less effective/safe than liquid-stored for cardiac surgery bleeding; didn't meet noninferiority criterion.

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Emma Ridley, PhD @icunutrition.bsky.social · 08/12/2025

ImmunoSep uses a double-dummy design. What is this? It is a design to maintain blinding when 2 treatments can't be made identical- all participants receive 2 treatments- one which is active and the other which is placebo #ccrdownunder

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Reposted by Emma Ridley, PhD

JAMA @jama.com · 08/12/2025

RCT: Among patients with #sepsis, a precision immunotherapy strategy targeting macrophage activation-like syndrome and sepsis-induced immunoparalysis improved organ dysfunction by day 9 compared to placebo.#CCRdownunder ja.ma/3MkSb95

JAMA graph titled 'Figure 2. Primary End Point'. 'Change from the baseline SOFA score' is plotted for precision immunotherapy (orange) and placebo (blue). SOFA scores range from 0 to 20; x-axis is 1 to 145.

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Emma Ridley, PhD @icunutrition.bsky.social · 08/12/2025

Looking forward to #ccrdownunder- if you are following along please include this hashtag in any posts and I can moderate your questions online- enjoy the live!!!

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Emma Ridley, PhD @icunutrition.bsky.social · 11/06/2025

Very proud to be here as part of the TARGET PROTEIN study team and support Lee-anne Chapple, Matt Summers and Adam Deane (with Sandy Peake) #CCR25 jamanetwork.com/journals/jam...

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Reposted by Emma Ridley, PhD

Beatriz Goulão @beatrizgoulao.bsky.social · 11/06/2025

Always a good conference to follow for innovative trial designs in the context of critical care 👇🏻 #CCR25

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Emma Ridley, PhD @icunutrition.bsky.social · 11/06/2025

Congratulations to all the sites of TARGET PROTEIN, the ANZICS CTG and all members of the management committee #CCR25

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Emma Ridley, PhD @icunutrition.bsky.social · 26/04/2025

🍎 Our international practice varies so much- this is why initiatives such as #FRANC24 are so important. More to come- we are not finished yet!!!

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Emma Ridley, PhD @icunutrition.bsky.social · 26/04/2025

🍎 Prof Mette Berger, international expert in ICU metabolism and nutrition, reminds us to GO BACK TO PHYSIOLOGY- don't discount early physiology studies. 🍎Have you read the 1981 WHO report on energy and protein requirements that summarises metabolism? iris.who.int/bitstream/ha...

iris.who.int

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Emma Ridley, PhD @icunutrition.bsky.social · 26/04/2025

Thank you to Fresenius Kabi for a fabulous #FRANCASIA25 in beautiful Taiwan. It was my privilege to be part of the speaking team and share knowledge. The combined program of ICU, oncology and surgery provides the opportunity to learn from each field Some key takeaways 1/

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Emma Ridley, PhD @icunutrition.bsky.social · 19/02/2025

Hi all!! I have recently come across from X (@ICUnutrition)- I am an A/Prof and Critical Care Dietitian- you can see more about my work here: www.monash.edu/medicine/sph... Follow along if you want to receive my updates!

monash.edu

ANZIC-RC Nutrition Program

Our research includes observational studies, feasibility projects and randomised controlled trials.

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