Glucose performs key functions as a signaling molecule in the yeast Saccharomyces cerevisiae. Glucose depletion is known to regulate gene expression via pathways that lead to derepression of genes at ...

Although in the wild bacteria likely spend most of their time deprived of nutrients and slowly starving to death, very little is known about how bacteria adapt their phenotype to starvation. Here we combine microfluidics with quantitative fluorescence microscopy of transcriptional reporters to comprehensively quantify growth and gene expression at the single-cell level in E. coli during carbon starvation. We find that all cells immediately stop growing upon loss of carbon source and that almost all remain alive for over 30 hours. Furthermore, entry into starvation triggers a dynamic expression program that is remarkably homogeneous across single cells, but highly variable across genes, causing dramatic remodeling of the proteome early in starvation. We further show that, as protein production and the rate of protein degradation both decay approximately exponentially, protein concentrations become essentially ‘frozen’ after the first 5 to 10 hours, setting phenotypes for several days of starvation. Finally, using experiments in which gene expression is inhibited for different periods, we show that protein production in the first 5 hours is crucial for protecting cells from stresses late in starvation.

Trending News: A Japanese diver’s long-running interaction with a wild fish has drawn global attention, offering a rare, well-documented example of repeated recognit.

You are logged into jeevacation@gmail.com, Jeffrey Epstein's email. Sourced from the November 2025 House Oversight Committee data release.

The World Nature Photography awards have announced the winners for 2026 and Australian Jono Allen has taken out the top prize

JeffTube lets you use a clone of YouTube to view videos released by the DOJ that relate to the investigation of Jeffrey Epstein.