Various forms of solid tumors harbor intracellular bacteria, but the physiological consequences of these microorganisms are poorly understood. We show…

SARS-CoV-2 infection can lead to long-lasting neurological sequelae, but underlying mechanisms are unclear. Rong et al. report that SARS-CoV-2 spike protein persists in the skull-meninges-brain axis, inducing inflammation, neurodegeneration-related changes, and increasing the brain’s vulnerability to further injury.

Approaches for profiling the spatial proteome in tissues are the basis of atlas-scale projects that are delivering on their promise for understanding biological complexity in health and disease.

In this Review, Segata, Waldron and colleagues discuss important key concepts of machine learning that are relevant to microbiologists and provide them with a set of tools essential to apply machine l...

Vaccination plays a crucial role in mediating protection against infectious diseases, but immune responses to vaccination are highly variable and frequently sub-optimal in vulnerable populations. Her...

Clostridioides difficile infection (CDI) is an urgent public health threat with limited preventative options. In this work, we developed a messenger RNA (mRNA)–lipid nanoparticle (LNP) vaccine targeti...

Background The accuracy of internal-transcribed-spacer (ITS) and shotgun metagenomics has not been robustly evaluated, and the effect of diet on the composition and function of the bacterial and funga...

Diverse communities of commensal gut bacteria collectively limit pathogen colonization by blocking nutrient access.

Spatial host–microbiome sequencing simultaneously profiles microbes and host transcriptomes from mouse colons.

In this Review, Segata, Waldron and colleagues discuss important key concepts of machine learning that are relevant to microbiologists and provide them with a set of tools essential to apply machine l...

An analysis of over 2,000 genomes from Human Microbiome Project metagenomic data led to the identification of several extended- and narrow-spectrum antibiotics against clinical multidrug-resistant pat...

Examining the interplay of environmental exposure with the airway microbiome provides insights for possible intervention in lung health.

Background Bacterial strains under the same species can exhibit different biological properties, making strain-level composition analysis an important step in understanding the dynamics of microbial c...

Engineered probiotics produce synthetic targets to facilitate immunotherapy of solid tumors by CAR T cells.

Gut microbiome configurations and activity exhibit similarities across distinct types of inflammatory arthritis.

In this Review, Fishbein, Mahmud and Dantas discuss factors that influence restructuring of the gut microbiome on antibiotic exposure, and they explore promising therapeutic avenues aimed at minimizin...