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Holmqvist Lab

@holmqvist-lab.bsky.social
135 followers 246 following 3 posts
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Holmqvist Lab @holmqvist-lab.bsky.social · 19/03/2026
New paper from the lab! Spearheaded by soon-to-be doctor Athina Eleftheraki. Fantastic collaboration with Anaïs Le Rhun lab at Uni Bordeaux! academic.oup.com/nar/article/...
academic.oup.com
An RNA structural switch controlling bacterial toxin translation
Abstract. Type I toxin–antitoxin systems (T1TAs) rely on tight posttranscriptional control to prevent inadvertent toxin synthesis, yet the molecular mechan
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Reposted by Holmqvist Lab
Lars Barquist @lbarquist.bsky.social · 12/06/2025
Very excited about our latest combining advanced cell culture, transposon-insertion sequencing, and statistical modeling to map Shigella virulence determinants in organoid models. Great collaboration w/ @mldm.bsky.social @sellinlab.bsky.social in @natgenet.nature.com www.nature.com/articles/s41...
nature.com
A scalable gut epithelial organoid model reveals the genome-wide colonization landscape of a human-adapted pathogen - Nature Genetics
A genome-wide screen using human gut epithelial organoids combined with transposon-directed insertion sequencing identifies over 100 Shigella flexneri genes required for epithelial colonization.
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Holmqvist Lab @holmqvist-lab.bsky.social · 27/02/2025
New paper from the lab out now. ProQ prevents polyadenylation to stabilise mRNA in Salmonella. Fantastic work by Sofia Bergman and Christopher Birk.
track.smtpsendmail.com
ProQ prevents mRNA degradation through inhibition of poly(A) polymerase
Abstract. The RNA-binding protein ProQ interacts with many transcripts in the bacterial cell. ProQ binding is associated with increased messenger RNA (mRNA
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Holmqvist Lab @holmqvist-lab.bsky.social · 03/02/2025
As our very first Bluesky post we congratulate Sofia Bergman who according to the Swedish tradition has nailed her thesis! The celebration included a homemade Salmonella cake 😀 In perfect time for the dissertation (14/2) she just had a paper accepted as a Breakthrough Article in NAR. Stay tuned.
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