iiinova — where your digital self keeps evolving

Hocek lab @hoceklab.bsky.social · 24/08/2026

Our newest paper on biotin- and chloroalkane-modified nucleotides for dual display of proteins on DNA ruler through streptavidin and halotag binding just published in Angew. Chem. doi.org/10.1002/anie.... @iocbprague.bsky.social @sciencecharles.bsky.social @akademievedcr.bsky.social

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Hocek lab @hoceklab.bsky.social · 22/07/2026

Our newest paper on fast single-round selection of hyper-modified aptamers from over-represented dually nucleobase-modified DNA libraries has been published in @natcomms.nature.com. @iocbprague.bsky.social doi.org/10.1038/s414...

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Hocek lab @hoceklab.bsky.social · 26/03/2026

Ivana Jestřábová has successfully defended at the Faculty of Science (Charles University) her PhD thesis entitled: Chemical synthesis of hypermodified oligonucleotides and DNA. PhD No. 50 from the Hocek group. Congratulations !

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Hocek lab @hoceklab.bsky.social · 23/03/2026

Tania Sanchez-Quirante has successfully defended at the Charles University her PhD thesis entitled Enzymatic synthesis of RNA containing selected base modifications and their influence on stability, translation and CRISPR-Cas9 cleavage. PhD No. 49 from the Hocek group. Congrats!

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Hocek lab @hoceklab.bsky.social · 23/12/2025

Picomolar inhibitors of CD73 developed in great collaboration with Jan Konvalinka group. Check out our latest paper in ACS Pharmacol. Transl. Res.: doi.org/10.1021/acsp... @iocbprague.bsky.social

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Hocek lab @hoceklab.bsky.social · 08/12/2025

Hydrophobic nucleoside phosphoramidites for solid-phase synthesis of hypermodified oligonucleotides. Our new paper published in RSC Advances doi.org/10.1039/D5RA... @iocbprague.bsky.social @akademievedcr.bsky.social @sciencecharles.bsky.social

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Hocek lab @hoceklab.bsky.social · 12/11/2025

Our new paper on Enzymatic synthesis of base-modified RNA and influence of the modifications on stability, translation, and CRISPR-Cas9 cleavage - published in ACS Chem. Biol.: doi.org/10.1021/acsc.... @iocbprague.bsky.social @sciencecharles.bsky.social @akademievedcr.bsky.social

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Hocek lab @hoceklab.bsky.social · 30/09/2025

Our newest paper Versatile Enzymatic Approach for Truncation, Labeling, and Mutation of Nucleobase-Modified Aptamers Demonstrated on Indole-Modified β-Conglutin Aptamer published in ChemBioChem: doi.org/10.1002/cbic... ; @iocbprague.bsky.social

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Hocek lab @hoceklab.bsky.social · 09/09/2025

New paper in great collaboration with @cardosolab.bsky.social on Super-Resolution Compatible DNA Labeling Technique Reveals Chromatin Mobility and Organization Changes During Differentiation published in Advanced Science: doi.org/10.1002/advs... @iocbprague.bsky.social

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Hocek lab @hoceklab.bsky.social · 07/08/2025

Polymerase synthesis of base-modified DNA scaled-up to milligram quantities suitable for NMR structure studies. Check our newest work published in ChemistryEurope doi.org/10.1002/ceur... @iocbprague.bsky.social

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Hocek lab @hoceklab.bsky.social · 02/06/2025

Natalia Kuprikova has successfully defended (at the Charles University) her PhD thesis entitled Enzymatic synthesis of hypermodified DNA bearing anionic or cationic functional groups. PhD No. 48 from the Hocek group. Congratulations!

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Hocek lab @hoceklab.bsky.social · 22/05/2025

Our newest paper on enzymatic incorporation of 2-substituted adenine nucleotides into RNA and their use for RNA labeling has been published in ChemBioChem: doi.org/10.1002/cbic... @iocbprague.bsky.social

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Hocek lab @hoceklab.bsky.social · 21/03/2025

Ugnė Šinkevičiūtė has successfully defended the Charles University her PhD thesis entitled: New deazapurine nucleobases, nucleosides and nucleotides as potential cytostatics or CD73 inhibitors. PhD No. 47 from the Hocek group. Congratulations !

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Hocek lab @hoceklab.bsky.social · 10/03/2025

Our newest paper on enzymatic synthesis of hypermodified zwitterionic DNA bearing 4 different cationic groups has just been published in NAR. doi.org/10.1093/nar/...

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Hocek lab @hoceklab.bsky.social · 28/02/2025

Filip Gracias has successfully defended at UCT Prague his PhD thesis entitled: Synthesis of epigenetic pyrimidine nucleotides and their non-natural analogues for regulation of transcription. PhD No. 46 from the Hocek group. Congratulations Dr. Gracias! @iocbprague.bsky.social

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Hocek lab @hoceklab.bsky.social · 15/01/2025

Our new paper (collaboration with P. Rezacova group) on the use of environment-sensitive fluorophore-linked nucleotide in DNA probes for identification of effectors of TFs and studying conformational changes of protein-DNA complexes has been published in RSC Chem. Biol.: doi.org/10.1039/D4CB...

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