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Helen Ayles @helenzambart.bsky.social · 17/04/2025

This is heartbreaking- not only for the cuts but also that the systems are clearly not working to get people on treatment in the govt clinics which are still working. Zambia does have ART still available in stock and so people can continue their ART…. But as always the health system is kafkaesque….

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Helen Ayles @helenzambart.bsky.social · 13/04/2025

Fascinating session with great talks from Vietnam, Nigeria and Thaïland. POC CRP could easily be deployed but why isn’t it?

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Reposted by Helen Ayles

TB Centre LSHTM @tb-lshtm.bsky.social · 23/03/2025

#WorldTBDay tomorrow, don't miss our joint WTBD Symposium with @ucltb.bsky.social You may still be able to join us in person www.eventbrite.co.uk/e/world-tb-d... or if not, online. It's going to be an amazing event! #WTBD2025 #Commit #Invest #Deliver

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Reposted by Helen Ayles

Madhu Pai, MD, PhD @madhupai.bsky.social · 17/02/2025

Trump and Co are giving the term "structural violence" a whole new meaning

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Reposted by Helen Ayles

Prof Sheena Cruickshank @sheencr.bsky.social · 18/02/2025

This by Michael Rosen is terrifying and apt for the times we live in now.

Fascism: I sometimes fear...
I sometimes fear that
people think that fascism arrives in fancy dress
worn by grotesques and monsters
as played out in endless re-runs of the Nazis.

Fascism arrives as your friend.
It will restore your honour,
make you feel proud,
protect your house,
give you a job,
clean up the neighbourhood,
remind you of how great you once were,
clear out the venal and the corrupt,
remove anything you feel is unlike you...

It doesn't walk in saying,
"Our programme means militias, mass imprisonments, transportations, war and persecution."

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Reposted by Helen Ayles

Samuel G. Schumacher @sgschumacher.bsky.social · 29/11/2024

READ THIS: Clinical trials versus the real world in tuberculosis control Editorial from @thelancet.bsky.social Infectious Diseases. Could not agree more with many of the challenges outlined here in relation to clinical trials. buff.ly/4i8LJ0d

thelancet.com

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Helen Ayles @helenzambart.bsky.social · 15/11/2024

#UnionConf2024 Disappointing results from EXULTANT trial which found no increase in TB diagnosed with universal sputum, urine (Xpert &LAM) and stool Xpert compared to standard algorithm in hospitalized patients with HIV. Most were symptomatic so absolute benefit only 4% extra (powered for 7%)

% of participants diagnosed with TB within 72 hours was 15.3% in control arm compared to 16% in intervention arm

Figure shows intervention involving testing sputum, urine and stool. Control arm is WHO standard

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Helen Ayles @helenzambart.bsky.social · 15/11/2024

#UnionConf2024 intriguing talk on serum LAM with some promising results. Very small numbers and no details on what the test complexity will be but watch this space…..

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Helen Ayles @helenzambart.bsky.social · 15/11/2024

#UnionConf2024 Fascinating talk by Arjan Van Laarhoven showing possible different endotypes in TB meningitis which could suggest individualised treatment needed to reduce mortality

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Helen Ayles @helenzambart.bsky.social · 15/11/2024

Can an electronic stethoscope with AI predict disease severity? Seems that there is an interesting initial signal that needs further testing out…. #UnionConf2024

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Helen Ayles @helenzambart.bsky.social · 15/11/2024

#UnionConf2024 great sessions in TBScience🧪this morning on heterogeneity in TB. Why are men more susceptible? Does ancestry play a role? And who resists infection?

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Helen Ayles @helenzambart.bsky.social · 13/11/2024

#UnionConf2024 Why are 1.3m people still dying of TB? Despite increasing access to TB drugs we need to do more. Lots of wins getting drug prices down but battles take time and effort- people die waiting! Great talk by Christopher Perrin #IDsky #GHsky #TBsky 🧪🛟😷🩺

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Helen Ayles @helenzambart.bsky.social · 12/11/2024

Lots of discussion on phase 3 TB vaccine trials at #UnionConf2024. We desperately need more trial sites but hearing stories of sites/countries feeling abused by sponsors as delays in site initiation/IP and competitive recruitment mean “less favored” sites likely to end up out of pocket.

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Helen Ayles @helenzambart.bsky.social · 12/11/2024

At #UnionConf2024 at StopTB (are they on Balt?) New tools meeting. Great to hear Indonesia planning for TB vaccines- roll out and manufacturing plans….💪🧪🛟🩺😷

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Helen Ayles @helenzambart.bsky.social · 12/11/2024

So am at #Unionconf2024 in Bali Indonesia. Will try to post highlights. Anyone else on blusky here? Union and TB world seem to be behind and still on X……🙄

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Helen Ayles @helenzambart.bsky.social · 12/09/2024

So in the early days of COVID, pre vaccines, Zambart took part in COPCOV- a trial of chloroquine/ hydroxychloroquine as prevention. I know you all think you know the answers but here is the paper journals.plos.org/plosmedicine.... Read it before you comment….. 🧪 #ID

journals.plos.org

Evaluation of hydroxychloroquine or chloroquine for the prevention of COVID-19 (COPCOV): A double-blind, randomised, placebo-controlled trial

In a randomised controlled trial, William Schilling and co-workers investigate potential prevention of COVID-19 by chloroquine or hydroxychloroquine.

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