heenaa02.bsky.social @heenaa02.bsky.social · 22/07/20256/ 🙏 Huge thanks to the amazing collaborators and co-authors who made this work possible! 🧑🔬 Basile Leduque, Leandro Quadrana, Keith Slotkin, Alexandros Bousios (@abousios.bsky.social) & Hans-wilhelm Nuetzmann 011
heenaa02.bsky.social @heenaa02.bsky.social · 22/07/20255/ 💻 Surprise package! We developed a custom pipeline, deNOVOEnrich, to profile somatic TE insertions from TEd-seq short-read data. Using split-read mapping, we pinpoint new somatic insertions at base-pair resolution 🧬🔍 Check it out: github.com/hAmbreen02/d...github.comGitHub - hAmbreen02/deNOVOEnrich: Identification of de novo transposon insertion sites from targeted sequencing dataIdentification of de novo transposon insertion sites from targeted sequencing data - hAmbreen02/deNOVOEnrich 011
heenaa02.bsky.social @heenaa02.bsky.social · 22/07/20254/ 🔥 Somatic insertion hotspots of the EVADE transposon are enriched at environmentally responsive genes 🌄 - including Resistance gene and biosynthetic gene clusters. Is stress guiding TE activity, or are TEs tuning stress responses? Somatic genome plasticity 🧬 011
heenaa02.bsky.social @heenaa02.bsky.social · 22/07/20253/ 🧬 Our work shows somatic TE activity in Arabidopsis is non‑random and family‑specific. Different TE families prefer distinct genomic niches - is it driven by underlying epigenetic code, or are they avoiding conflict in a shared genome ecosystem? 🤔 011
heenaa02.bsky.social @heenaa02.bsky.social · 22/07/20252/ Combining distinct experimental conditions, we traced a roadmap of expected TE movement in somatic cells 🌿, capturing ~200K new TE insertions across multiple families in the process. 011
heenaa02.bsky.social @heenaa02.bsky.social · 22/07/20251/📢News from TE diary - Somatic transposition in Arabidopsis is more explosive than we imagined! Thrilled to share our latest findings - TEs make new somatic insertions en masse, reshaping the somatic genome🧬with surprising frequency🍃 @abousios Hans-Wilhelm Nuetzmann www.biorxiv.org/content/10.1...biorxiv.orgSomatic mobility of transposons is explosive and shaped by distinct integration biases in Arabidopsis thalianaBackground The movement of transposable elements (TEs) in somatic cells generates genetic and phenotypic diversity across the soma of individual organisms. This process is especially important in plan... 531
