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Molecular Instruments, Inc. @hcrimaging.bsky.social · 01/10/2026

Upcoming Webinar: Prof. Houston will share a Xenopus case study exploring how HCR™ Pro RNA-CISH and HCR™ Gold RNA-FISH can be used together to balance extreme-sensitivity RNA detection with multiplexed fluorescent analysis. 🗓️ Thursday, October 29 🕗 8:00 AM PT Register here: tinyurl.com/yp575ehh

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Molecular Instruments, Inc. @hcrimaging.bsky.social · 29/09/2026

HCR™ Gold Amplifiers are now available with 488, 546, 594, and 647 labels across every X system, giving you more flexibility when designing panels around your targets and imaging channels. Ready to explore the new options? Shop the expanded amplifier selection today. 🛒 tinyurl.com/34ydc357

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Molecular Instruments, Inc. @hcrimaging.bsky.social · 24/09/2026

Yesterday, we hosted another installment of HCR™ webinars! Thank you to our speakers, Xiqian Jiang and Lun Wang from Stanford, for sharing how TRU-FACT integrates #HCRtechnology with functional imaging and connectivity data to link cellular activity, molecular identity, and projection targets.

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Molecular Instruments, Inc. @hcrimaging.bsky.social · 23/09/2026

We’re heading to NSH this weekend! Stop by Booth #620 to connect with our team and join us for our workshop, “Translating Spatial RNA Biomarkers into Point-of-Care Lateral Flow Assays,” where we’ll highlight how #HCRtechnology can be adapted for lateral flow detection. 🗓️ Sept. 29 🕤 9:15–10:15 AM

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Molecular Instruments, Inc. @hcrimaging.bsky.social · 22/09/2026

We're excited to introduce Slide Wash Chambers for manual slide-based workflows! Orders that include HCR™ Wash Buffers for tissue sections or cells on a slide will now receive two complimentary Slide Wash Chambers. Add HCR™ Wash Buffers to your next order to receive yours: tinyurl.com/mp6svpy6

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Molecular Instruments, Inc. @hcrimaging.bsky.social · 18/09/2026

What a fantastic time at the German Fish Meeting! It’s always exciting to see #HCRtechnology used in such a wide range of model systems. This week, it was especially fun to hear about so many fish models, including zebrafish, cavefish, and more. Next up for the MI team: NSH Convention!

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Molecular Instruments, Inc. @hcrimaging.bsky.social · 17/09/2026

Lun Wang and Xiqian Jiang from Stanford are sharing an in-depth look at how TRU-FACT can match thousands of neurons across in vivo imaging and molecular profiling datasets, including those generated with #HCRtechnology. 🗓️ Wednesday, September 23 🕤 10:00 AM PT Register here: tinyurl.com/45r6eza6

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Molecular Instruments, Inc. @hcrimaging.bsky.social · 16/09/2026

The MI team will be at NSH! Stop by Booth #620 to talk about how our team can support your research goals. Don’t miss our workshop, “Translating Spatial RNA Biomarkers into Point-of-Care Lateral Flow Assays,” for a look at adapting #HCRimaging for lateral flow detection. 🗓️ Sept. 29 🕤 9:15–10:15 AM

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Molecular Instruments, Inc. @hcrimaging.bsky.social · 15/09/2026

HCR™ Gold Amplifiers with 488, 546, 594, and 647 labels are now available for every X system, giving you more flexibility to configure assays around your specific target panel and imaging setup. All new catalog amplifiers are available to order on our webstore. Order here: tinyurl.com/34ydc357

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Molecular Instruments, Inc. @hcrimaging.bsky.social · 10/09/2026

Webinar Alert! Join Lun Wang and Xiqian Jiang from Stanford University on Sept 23 at 10:00 am PT for a closer look at TRU-FACT, an experimental and computational pipeline for registering individual cells across in vivo imaging and molecular profiling datasets. Register here: tinyurl.com/45r6eza6

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Molecular Instruments, Inc. @hcrimaging.bsky.social · 08/09/2026

We’re thrilled to share that HCR™ Gold IF is now available on the Biocare Medical ONCORE Pro X staining platform. HCR™ Gold IF helps researchers build multiplex IF assays with off-the-shelf primary antibodies without custom conjugation or fixed antibody panels. Read more: tinyurl.com/2jcrr6s8

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Molecular Instruments, Inc. @hcrimaging.bsky.social · 03/09/2026

Don’t miss our upcoming webinar ft. Lun Wang and Xiqian Jiang from Stanford University! Discover how TRU-FACT registers individual cells across in vivo imaging and molecular profiling datasets. 🗓️ Sept. 23 🕤 10:00 AM PT Register here: tinyurl.com/45r6eza6

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Molecular Instruments, Inc. @hcrimaging.bsky.social · 01/09/2026

Next stop: the 1st German Fish Meeting! Join us on Wednesday (Sept. 16) for our workshop featuring an overview of the platform, deeper dives into HCR™ Gold RNA-FISH and HCR™ Gold IF, and office hours for live experiment planning. Session 1: 9:00 AM Session 2: 10:45 AM 📍University of Heidelberg

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Molecular Instruments, Inc. @hcrimaging.bsky.social · 27/08/2026

Spotlighted by the International Zebrafish Society: Dr. Elliot Perens (UCSD, Rady Children’s Hospital San Diego) used HCR™ imaging to capture the posterior lateral mesoderm in zebrafish. 🟠 gata1a 🟢 etv2 🔵 hand2 🟣 hnf1ba Check out the IZFS feature here: www.izfs.org/news/new-izf...

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Molecular Instruments, Inc. @hcrimaging.bsky.social · 25/08/2026

Build HCR™ Gold IF Around More Primary Antibodies With Rabbit IgG and Mouse IgG1 Encoders across X1-X10 + new Mouse IgG2a and Human IgG options, you now have more flexibility to design sensitive, multiplexed protein imaging experiments! Configure your manual HCR™ Gold IF assay: lnkd.in/gyxQvTPA

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Molecular Instruments, Inc. @hcrimaging.bsky.social · 19/08/2026

Up next: Santa Cruz Dev Bio Meeting We're excited to connect with researchers working across developmental systems, stages, and sample types. If HCR™ workflows are already part of your research or if you’re thinking about RNA and protein imaging for a new project, come say hello! 📅 August 24–28

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Molecular Instruments, Inc. @hcrimaging.bsky.social · 13/08/2026

Meet the team heading to the 2026 Summer Conference on Neural Circuits in Health and Disease! We’re looking forward to connecting with researchers exploring the complexities of neural circuits and sharing how HCR™ technology enables multiplexed RNA and protein imaging across diverse applications.

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Molecular Instruments, Inc. @hcrimaging.bsky.social · 12/08/2026

Image RNA, protein, or both with HCR™ Gold. With HCR™ Gold, researchers can: • Image RNA targets with HCR™ Gold RNA-FISH • Image protein targets with HCR™ Gold IF • Image up to 10 RNA and/or protein targets simultaneously HCR™ Gold RNA-FISH: tinyurl.com/4keekbn4 HCR™ Gold IF: tinyurl.com/4bw5kc69

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Molecular Instruments, Inc. @hcrimaging.bsky.social · 04/08/2026

Deciding between HCR™ Gold or HCR™ Pro? HCR™ Gold delivers quantitative, multiplexed fluorescent imaging of up to 10 RNA and/or protein targets. HCR™ Pro supports ultra-sensitive, protease-free detection with fluorescent or chromogenic readouts. Explore here: www.molecularinstruments.com/shop

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Molecular Instruments, Inc. @hcrimaging.bsky.social · 30/07/2026

HCR™ Gold IF supports multiplexed protein detection across manual and automated workflows, so researchers can choose the setup that best fits their needs. Configure your manual HCR™ Gold IF kit: tinyurl.com/5n7dbher Interested in automated workflows? Contact us at info@molecularinstruments.com.

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Molecular Instruments, Inc. @hcrimaging.bsky.social · 28/07/2026

Thank you to everyone who spent time with us at SDB! It was a pleasure hearing about the developmental systems you’re working with and how #HCRtechnology supports your research. If we missed you at SDB, reach out to us at info@molecularinstruments.com. We’d be happy to connect!

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Molecular Instruments, Inc. @hcrimaging.bsky.social · 23/07/2026

Headed to SDB? This year, we’ll be joined by Leica Biosystems to talk about bringing HCR™ assays onto the automated BOND RX research stainer for less hands-on staining and a faster path from signal to interpretation. Stop by Booth #5 to connect with the MI and LBS teams! 📅 July 23–26

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Molecular Instruments, Inc. @hcrimaging.bsky.social · 22/07/2026

On World Brain Day, we recognize the scientists, clinicians, and research teams working to better understand the brain. Their discoveries continue to shape what we know about neural development, function, and disease. We’re proud to support the people and research moving neuroscience forward.

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Molecular Instruments, Inc. @hcrimaging.bsky.social · 16/07/2026

There’s still time to enter the Best-in-Suit: HCR™ Image Contest! This submission from Maria Jesús Vásquez Ramírez (Universidad Mayor) shows HCR™ Gold RNA-FISH in whole-mount zebrafish, capturing a key stage of ocular neurodevelopment with clear anatomical context. Submit here: lnkd.in/gyBws_yY

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Molecular Instruments, Inc. @hcrimaging.bsky.social · 14/07/2026

What can HCR™ imaging reveal about embryonic kidney development? In this webinar clip, the Miller Lab shares how they use Xenopus laevis to map gene expression to nephron segments and study kidney development. Watch: tinyurl.com/2ps48ats

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Molecular Instruments, Inc. @hcrimaging.bsky.social · 09/07/2026

SDB is one of our favorite places to catch up with the dev bio community, and it’s always fun to see how #HCRtechnology is being used across both model and non-model organisms. We’d love to hear what you’re working on and chat about how the HCR™ platform might fit! 📅 July 23–26 📍 Booth #5

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Molecular Instruments, Inc. @hcrimaging.bsky.social · 07/07/2026

HCR™ Gold IF is on the Leica Bio BOND RX research staining instrument! This workflow supports: • Compatibility with existing primaries • Parallel amplification of same-species primaries • Efficient, reproducible multiplex workflows To get started, reach out to info@molecularinstruments.com.

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Molecular Instruments, Inc. @hcrimaging.bsky.social · 02/07/2026

HCR™ HiFi Probes support high-fidelity detection of short targets, including miRNAs and siRNAs, in both manual and automated workflows. Shown here is let-7a-5p, a conserved tumor-suppressive miRNA that regulates cell differentiation and oncogenic pathways. Order today: tinyurl.com/4thytcry

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Molecular Instruments, Inc. @hcrimaging.bsky.social · 30/06/2026

Some images are hard to forget. This is your chance to share them! We’re looking for standout submissions that capture the detail, color, and character of HCR™ technology in action. If you’ve generated an image you keep coming back to, we'd love to see it. 📥Submit your image here: lnkd.in/gyBws_yY

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Molecular Instruments, Inc. @hcrimaging.bsky.social · 25/06/2026

HCR™ Gold IF is now available on the BOND RX research staining platform! Together, we’re making multiplex IF more accessible through automated workflows designed for efficiency, flexibility, and high-quality results. 🔗 Press release: tinyurl.com/uxjebewp 🔗 Brochure: tinyurl.com/4r8u5xm2

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Molecular Instruments, Inc. @hcrimaging.bsky.social · 23/06/2026

HCR™ HiFi Probes now support short target detection in manual workflows. Built with next-generation probe design, they deliver stronger on-target signal and background-suppressed performance for targets like microRNAs and siRNAs. Learn more: info@molecularinstruments.com

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Molecular Instruments, Inc. @hcrimaging.bsky.social · 18/06/2026

A preprint from Martik Lab revealed a layer of Twist1 regulation during cranial neural crest development. @laracbusby.bsky.social shared, "The sensitivity of HCR™ staining allowed us to observe transcripts that would have been missed with traditional ISH staining." Read more: tinyurl.com/32r6exrn

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Molecular Instruments, Inc. @hcrimaging.bsky.social · 16/06/2026

One of the most rewarding parts of being on the road is hearing how our users are putting #HCRtechnology to work in their own labs. From the Euro Evo Devo meeting to our HCR™ Office Hours, we loved connecting with researchers exploring a wide range of questions, organisms, and applications.

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Molecular Instruments, Inc. @hcrimaging.bsky.social · 11/06/2026

Got an HCR™ image you’re proud of? 🃏The HCR™ Image Contest: Best-in-Suit is open, and we’re looking for images that capture the detail, color, and character of your work. If you have a favorite result, send it our way! 📥 Submit your entry here: lnkd.in/gyBws_yY

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Molecular Instruments, Inc. @hcrimaging.bsky.social · 09/06/2026

Multiplex IF doesn’t have to be complicated. In Ep. 3 of our HCR™ HiFi Encoder series, we walk through the protocol and show just how easy it is to encode your primary antibodies for HCR™ Gold IF. View the full walkthrough here: tinyurl.com/4mw9baen

youtube.com

Episode 3: How to Encode

YouTube video by Molecular Instruments

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Molecular Instruments, Inc. @hcrimaging.bsky.social · 04/06/2026

We’re looking forward to attending Euro Evo Devo! If you’ll be there, stop by and meet Joyce Yoo and Michelle Saylor from the MI team. We’d love to hear more about your research and talk about how #HCRtechnology could support your next set of experiments. Schedule a meeting: tinyurl.com/3a9fpzdv

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Molecular Instruments, Inc. @hcrimaging.bsky.social · 02/06/2026

Curious about the HCR™ HiFi Encoder workflow or want a quick visual guide to the simple 10-minute encoding process? Our HCR™ HiFi Encoder YouTube playlist brings everything together in one place to help you get started with confidence. Check out the playlist here: tinyurl.com/yzy9prh7

tinyurl.com

HCR™ HiFi Encoder - YouTube

Explore the breakthrough technology redefining multiplex IF. This series dives into the HCR™ HiFi Encoder, a powerful, fast, and flexible tool for encoding u...

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Molecular Instruments, Inc. @hcrimaging.bsky.social · 28/05/2026

We’re heading to the European Society for Evolutionary Developmental Biology Meeting! If you’ll be there, stop by and say hello. We’d love to hear what you’re working on and share how the HCR™ platform can support your research. 📅 June 10–12 Register here: tinyurl.com/3ekpsxyt

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Molecular Instruments, Inc. @hcrimaging.bsky.social · 26/05/2026

A study from the Cepko Lab at Harvard used #HCRimaging to map gene expression in the developing chicken retina. “HCR™ [imaging] allowed us to scale spatial validation across many genes and developmental stages with high sensitivity and consistency.” — Heer Joisher Read more: tinyurl.com/mw9vrtew

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Molecular Instruments, Inc. @hcrimaging.bsky.social · 21/05/2026

It was great to see such a strong turnout at the In Situ Hybridization and Spatial Omics Symposium at the CRUK! If you’d like to follow up on any of the topics from the session, feel free to reach out to us at info@molecularinstruments.com. We’d be happy to continue the conversation!

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Molecular Instruments, Inc. @hcrimaging.bsky.social · 19/05/2026

We’re excited to be a part of the In Situ Hybridization and Spatial Omics Symposium at the Cancer Research UK Cambridge Institute! 🗓️ Wednesday (May 20) at 11:10 AM 📍 Lecture Theatre, CRUK Register here: tinyurl.com/5yc39x5f

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Molecular Instruments, Inc. @hcrimaging.bsky.social · 14/05/2026

We’ve got another exciting webinar for you! Our webinar with the Miller Lab is now on demand. Join Rachel Miller and Adrian Romero Mora as they explore how genetic variants can disrupt kidney development and contribute to congenital kidney diseases. Watch the recording here: youtu.be/czqh3VsYopI

youtu.be

Spatial Mapping of Kidney Development and Disease Mechanisms in Xenopus laevis | Webinar

YouTube video by Molecular Instruments

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Molecular Instruments, Inc. @hcrimaging.bsky.social · 13/05/2026

Don’t miss your chance to stand out in the HCR™ Image Contest: Best-In-Suit! We’re looking for images that showcase the precision, originality, and real-world impact of your work. 📥 Submit your entry here: lnkd.in/gyBws_yY

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Molecular Instruments, Inc. @hcrimaging.bsky.social · 12/05/2026

Our webinar on Enabling Precision Medicine in Dermatology: A Clinically Validated LDT Powered by HCR™ Pro with Dr. William Damsky from Yale New Haven Hospital is now available to watch on demand. Watch the full recording here: youtu.be/gPyPR0p917s

youtu.be

Enabling Precision Medicine in Dermatology: A Clinically Validated LDT Powered by HCR™ Pro | Webinar

YouTube video by Molecular Instruments

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Molecular Instruments, Inc. @hcrimaging.bsky.social · 08/05/2026

It was a pleasure meeting everyone who joined us for yesterday’s Lunch and Learn at Northwestern University! We always appreciate the opportunity to connect with the academic community. Interested in hosting a Lunch and Learn with MI? Feel free to reach out to us at info@molecularinstruments.com.

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Molecular Instruments, Inc. @hcrimaging.bsky.social · 06/05/2026

We’re excited to share that MI will be attending the Indica Labs HALO® User Group Meeting! If you’re in the Boston area, we would love to connect. Our team will be on-site to answer any questions you may have about adding #HCRtechnology to your workflows. 🗓️ May 12th 📍Le Méridien Boston Cambridge

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Molecular Instruments, Inc. @hcrimaging.bsky.social · 05/05/2026

We're excited to be working with Empire Genomics, a Biocare Medical company, to bring HCR™ Pro RNA-ISH kits to the NeoPATH Pro automated staining platform. Together, this creates a faster, more scalable path for labs looking to expand RNA-ISH workflows in tissue-based research.

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Molecular Instruments, Inc. @hcrimaging.bsky.social · 30/04/2026

Our final #MIatAACR recap features a poster created with Hamamatsu on 9-plex spatial co-detection of clinically relevant protein and RNA targets in FFPE tumors. Thank you to everyone who stopped by our poster sessions at #AACR2026! View all of our posters here: tinyurl.com/5w9yc6wc

hcrimaging.com

Molecular Instruments

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Molecular Instruments, Inc. @hcrimaging.bsky.social · 29/04/2026

For the next installment in our #MIatAACR recap series, we’re spotlighting a poster presented alongside Abcam, Leica Biosystems, and Indica Labs on automated multiplex IF for tumor microenvironment profiling. Take a closer look at the poster here: tinyurl.com/ypw5fmss

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Molecular Instruments, Inc. @hcrimaging.bsky.social · 28/04/2026

We’re kicking off our #MIatAACR poster recap series with a poster developed with Abcam: Same-species multiplex IF with HCR™ Gold IF: Cross-clone benchmarking using Abcam’s oncology-validated primaries. Explore the poster in more detail: cdn.prod.website-files.com/633286c697eb...

cdn.prod.website-files.com

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