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Hannelore Longin

@hannelorelongin.bsky.social
163 followers 161 following 3 posts

PhD student @ Computational Systems Biology & Lab of Gene Technology. Investigating PTMs in viruses and bacteria with bioinformatics 💻🦠

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Reposted by Hannelore Longin
Susie Grigson @susiegriggo.bsky.social · 26/05/2026
New preprint! 🚨 Phage proteins don't act alone. Phages rely on homooligomerisation to assemble identical protein subunits into functional forms. But figuring out those exact configurations experimentally is tough. Learn about our approach in our new preprint! 👇 (1/n) www.biorxiv.org/content/10.6...
biorxiv.org
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Reposted by Hannelore Longin
Stefaan Verwimp @sverwimp.bsky.social · 24/11/2025
Protein domains have no single definition, so why stick to one segmentation? 🧩 Instead of forcing structures into rigid classifications, we built AFragmenter. It uses AlphaFold PAE networks for a tuneable approach to domain parsing. You control the granularity. 👇 🔗 doi.org/10.1093/bioi...
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Reposted by Hannelore Longin
George Bouras @gbouras13.bsky.social · 08/08/2025
Stoked to finally have a preprint out for Phold, our tool that uses protein structural information to enhance phage genome annotation #phagesky 1/n www.biorxiv.org/content/10.1...
biorxiv.org
Protein Structure Informed Bacteriophage Genome Annotation with Phold
Bacteriophage (phage) genome annotation is essential for understanding their functional potential and suitability for use as therapeutic agents. Here we introduce Phold, an annotation framework utilis...
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Reposted by Hannelore Longin
Susie Grigson @susiegriggo.bsky.social · 30/07/2025
🚨 New preprint 🚨 My phage annotation tool, Phynteny, finally has a preprint and a brand new version powered by a cool AI transformer architecture and protein language models! #phagesky www.biorxiv.org/content/10.1...
biorxiv.org
Synteny-aware functional annotation of bacteriophage genomes with Phynteny
Accurate genome annotation is fundamental to decoding viral diversity and understanding bacteriophage biology; yet, the majority of bacteriophage genes remain functionally uncharacterised. Bacteriopha...
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Hannelore Longin @hannelorelongin.bsky.social · 21/07/2025
📣 New preprint alert! Happy to share the first results from our effort to reannotate Pseudomonas #phage proteins of unknown function, using structural bioinformatics. 📄 doi.org/10.1101/2025...
doi.org
Fold first, ask later: structure-informed function annotation of Pseudomonas phage proteins
Phages, the viruses of bacteria, harbor an incredibly diverse repertoire of proteins capable of manipulating their bacterial hosts, inspiring many medical and biotechnological applications. However, t...
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Reposted by Hannelore Longin
Susie Grigson @susiegriggo.bsky.social · 07/07/2025
We've folded a lot of proteins! You can see some of them here @linsalrob.bsky.social @gbouras13.bsky.social
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Hannelore Longin @hannelorelongin.bsky.social · 28/01/2025
Hip hip hooray: our #PTM conservation tool FLAMS turns 1 🎂 To celebrate, we have added handy new features to FLAMS web, incl. 3D visualization of hit proteins & PTM sites with known active/binding sites. Come check it out @ tinyurl.com/flamsweb & let us know what you think!
biw.kuleuven.be
FLAMS – Find Lysine Acylations & other Modification Sites
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Reposted by Hannelore Longin
Tara Bartolec @tarabartolec.bsky.social · 23/12/2024
1/11 - With Karin Mitosch and Clément Potel + colleagues in Savitski lab and @typaslab.bsky.social @embl.org, I’m very happy to share our discovery of a hyper-promiscuous phage protein kinase (T7K) which broadly deactivates bacterial defenses! 🦠 www.biorxiv.org/content/10.1...
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