iiinova — where your digital self keeps evolving

Reposted by Giovanni Rabuffo

Demetrio Ferro @d-ferro.bsky.social · 28/07/2026

Excited to share our latest publication, out now in @natcomms.nature.com !🧠🔍 Accumulating virtual rewards enhances both decision-making accuracy and neural value encoding in dorsal anterior cingulate cortex by dynamically shifting a goal-dependent internal reference point. doi.org/10.1038/s414...

13013

Giovanni Rabuffo @grabuffo.bsky.social · 17/07/2026

Work done with Irene Acero-Pousa, Tomas Berjaga-Buisan, and Gustavo Deco at the Center for Brain and Cognition (CBC), @UPFBarcelona, as part of my Marie Skłodowska-Curie project CAERUS (grant agreement No. 101199894).

000

Giovanni Rabuffo @grabuffo.bsky.social · 17/07/2026

@bsky.app New preprint: "A personalized map of where, when, and how to stimulate the brain to elicit controlled responses." biorxiv.org/content/10.6... We use personalized AI surrogate brains to predict where, when & how to stimulate for reliable effects. Thread 👇 www.linkedin.com/posts/grabuf...

biorxiv.org

A personalized map of where, when, and how to stimulate the brain to elicit controlled responses

Brain stimulation has transformed the treatment of several neurological and psychiatric disorders and is now widely used to read out causal interactions in the human brain. However, its effects vary f...

152

Giovanni Rabuffo @grabuffo.bsky.social · 18/12/2025

A really nice work, worth reading from top to bottom 👍

030

Giovanni Rabuffo @grabuffo.bsky.social · 17/12/2025

Big thanks to the solid team @ldallap.bsky.social, @pierpasorre.bsky.social, @mnpompili.bsky.social, Pietro Bozzo, Bach Nguyen, Tomoki Fukai, Damien Depannemaecker, Leonardo Gollo

021

Giovanni Rabuffo @grabuffo.bsky.social · 17/12/2025

Takeaway: criticality in the brain is not simply scale-invariant, but emerges from interactions between local circuits and large-scale network structure. 6/n

110

Giovanni Rabuffo @grabuffo.bsky.social · 17/12/2025

We find that long-range connectivity tunes regions toward or away from criticality, and that the best match to empirical static and dynamic functional connectivity occurs when local and global criticality coemerge. 5/n

110

Giovanni Rabuffo @grabuffo.bsky.social · 17/12/2025

Directly testing this across scales experimentally is extremely challenging. We address this using a whole-brain connectome-based model that links local neuronal dynamics to global brain organization and is constrained by mouse fMRI data. 4/n

100

Giovanni Rabuffo @grabuffo.bsky.social · 17/12/2025

In physics, scale-free behavior often implies scale invariance. In the brain, however, different scales rely on distinct biological structures (cortical columns, connectome,..), so criticality at one level does not automatically imply criticality at another. 3/n

110

Giovanni Rabuffo @grabuffo.bsky.social · 17/12/2025

Evidence for scale-free dynamics has been reported at many levels — from spiking neurons to EEG and fMRI. But most experiments probe only one scale at a time, constrained by the recording modality. 2/n

100

Giovanni Rabuffo @grabuffo.bsky.social · 17/12/2025

The brain criticality hypothesis proposes that neural activity operates near a tipping point between order and disorder, a regime thought to optimize information processing. 1/n

100

Giovanni Rabuffo @grabuffo.bsky.social · 17/12/2025

New preprint out! How does criticality propagate from local neuronal circuits to whole-brain dynamics? We tackle this with a multiscale, connectome-based mouse model @ldallap.bsky.social . 🧵/n 👉 biorxiv.org/content/10.6...

1144

Giovanni Rabuffo @grabuffo.bsky.social · 22/09/2025

With deep gratitude to my extraordinary co-authors @MariannaAngiolelli, @FukaiTomoki, @GustavoDeco, @pierpasorre.bsky.social, and @davemomi.bsky.social —this work would not have been possible without them. Supported by the MSCA grant @ec.europa.eu and @upf.edu—more to come!

021

Giovanni Rabuffo @grabuffo.bsky.social · 22/09/2025

Not all networks behave the same. Sensorimotor regions showed stronger state-dependence than higher-order association areas, revealing a hierarchy—especially in SEEG analyses. 6/n

100

Giovanni Rabuffo @grabuffo.bsky.social · 22/09/2025

Conditioning stimulation on favorable pre-stimulus states reduced response variability by over 20%. This shows that brain-state monitoring can make interventions more reproducible, offering a concrete step toward refined closed-loop and precision neuromodulation. 5/n

100

Giovanni Rabuffo @grabuffo.bsky.social · 22/09/2025

Whole-brain context matters. When predictions are based only on activity close to the stimulation site, accuracy is limited. Expanding to include wider pre-stimulus dynamics across the whole brain consistently improves predictability of outcomes. 4/n

100

Giovanni Rabuffo @grabuffo.bsky.social · 22/09/2025

Across 125 candidate metrics, measures of synchronization, connectivity, and spatiotemporal signal diversity consistently predicted responses—sometimes explaining up to 80% of the variability within a session. 3/n

100

Giovanni Rabuffo @grabuffo.bsky.social · 22/09/2025

We analyzed a rare dataset: 36 patients, ~320 sessions, and more than >10,000 stimulations, combining intracranial and high-density EEG recordings. We asked: which pre-stimulus features are most reliable in predicting stimulation outcomes? 2/n

100

Giovanni Rabuffo @grabuffo.bsky.social · 22/09/2025

🧠⚡️Brain stimulation is powerful, yet its effects are notoriously variable: identical parameters can produce very different outcomes. In our new preprint, we show how the brain’s state before stimulation helps explain and reduce this variability. 🧵1/n doi.org/10.1101/2025...

doi.org

Pre-stimulus Brain States Predict and Control Variability in Stimulation Responses

Does the ongoing brain state determine how it responds to localized electrical stimulation? This fundamental question has major implications for neuroscience and medicine, as stimulation outcomes rema...

152

Reposted by Giovanni Rabuffo

Simone Poetto @poetz.bsky.social · 30/06/2025

Thrilled to finally share a huge piece of my PhD project! Our paper “The Topological Architecture of Brain Identity” is now out on bioRxiv: biorxiv.org/content/10.1... 🧵 1/n

1157

Reposted by Giovanni Rabuffo

Dr. Robin Carhart-Harris @robincarhartharris.bsky.social · 14/05/2025

Rise in higher frequency oscillations in brain of a person in a disorder of consciousness given magic mushrooms 🍄✨ Find the full research “Psilocybin for disorders of consciousness: A case-report study” with the link in my bio ☝️ #psychedelics #neuroscience #researchpaper

171

Giovanni Rabuffo @grabuffo.bsky.social · 19/04/2025

🙏 Armelle Lokossou, Zengmin Li, Abolfazl Ziaee-Mehr, Meysam Hashemi, Pascale Quilichini, A. Ghestem, O. Arab, M. Esclapez, Parul Verma, Ashish Raj, @gozziale.bsky.social , @pierpasorre.bsky.social , Kai-Hsiang Chuang, Adriana Perles-Barbacaru, Angèle Viola, Viktor Jirsa, Christophe Bernard 🔥

030

Reposted by Giovanni Rabuffo

Jonathan A. Michaels @jonathanamichaels.bsky.social · 13/03/2025

I'll never stop being in awe of the brain. Raster of a single neuron in medial geniculate body responding to auditory tones.

6939