Reposted by Gokilavani(Goks) ThangavelJana Helsen @helsenjana.bsky.social · 26/11/2025How do new centromeres evolve while staying compatible with the division machinery? Discover it in our new Nature paper! We show centromeres transition gradually via a mix of drift, selection, and sex, reaching new states that still work with the kinetochore. 👉 doi.org/10.1038/s41586-025-09779-1 818584
Reposted by Gokilavani(Goks) ThangavelBinyam Mogessie ቢንያም ሞገሴ @binyammogessie.bsky.social · 04/11/2025We built a targeted protein degradation–based system to mimic reproductive age-related aneuploidy in young eggs - revealing how chromosome errors associated with female infertility arise with age. 🧬✨ With @jiyeonleem.bsky.social and our team at Yale MCDB. Read: www.nature.com/articles/s43...nature.comA versatile cohesion manipulation system probes female reproductive age-related egg aneuploidy - Nature AgingTo study pathways that lead to aneuploidy during aging, the authors provide a system that enables cohesion protein depletion in mouse oocytes, mimicking effects that occur during aging. They uncover a... 12618
Reposted by Gokilavani(Goks) ThangavelHarmit Singh Malik @harmitmalik.bsky.social · 03/08/2025I spoke to Renaud Pourpe (of @lonelypipette.bsky.social fame with @epigenetique.bsky.social) about the unique challenges faced by postdocs and early-career PIs worldwide on the transition from postdoc to PI. Lots of useful advice shared (by others): www.alba.network/diversity-po... Check it out.alba.networkALBA-IBRO Diversity Podcast - Season 2Episode 4 is out. In season 2, we focus on the transition from postdoc to PI, highlighting the unique challenges faced by postdocs and early-career PIs worldwide. Hosted by the Lonely Pipette. 03413
Reposted by Gokilavani(Goks) ThangavelAndré Marques @amarques.bsky.social · 13/11/2024🧵𝐀 𝐭𝐡𝐫𝐞𝐚𝐝 𝐰𝐢𝐭𝐡 𝐟𝐞𝐚𝐭𝐮𝐫𝐞𝐝 𝐥𝐚𝐛 𝐩𝐮𝐛𝐥𝐢𝐜𝐚𝐭𝐢𝐨𝐧𝐬: 🧵 #1️⃣ Hofstatter, Thangavel, Lux et al. 2022 𝘊𝘦𝘭𝘭: 𝗥𝗲𝗽𝗲𝗮𝘁-𝗯𝗮𝘀𝗲𝗱 𝗵𝗼𝗹𝗼𝗰𝗲𝗻𝘁𝗿𝗼𝗺𝗲𝗿𝗲𝘀 𝗶𝗻𝗳𝗹𝘂𝗲𝗻𝗰𝗲 𝗴𝗲𝗻𝗼𝗺𝗲 𝗮𝗿𝗰𝗵𝗶𝘁𝗲𝗰𝘁𝘂𝗿𝗲 𝗮𝗻𝗱 𝗸𝗮𝗿𝘆𝗼𝘁𝘆𝗽𝗲 𝗲𝘃𝗼𝗹𝘂𝘁𝗶𝗼𝗻 www.cell.com/cell/fulltex... @gokilavani.bsky.social #PlantSciences #Chromosome #Genomics #Meiosis4eva #Centromere 🌱🧬🔬cell.comRepeat-based holocentromeres influence genome architecture and karyotype evolutionWhile most eukaryotes contain single regional centromeres, several plant and animal lineages assemble holocentromeres along the entire chromosome length. The assembly of chromosome-scale holocentric g... 13111
Reposted by Gokilavani(Goks) ThangavelAndré Marques @amarques.bsky.social · 12/11/2024I put together a list of profiles in somehow related subjects of chromosome biology go.bsky.app/KqsM3kd 33322
Reposted by Gokilavani(Goks) ThangavelKaren Miga @khmiga.bsky.social · 28/03/2024Want to learn more about the tricks and tips for generating ONT Ultra-long DNA? The T2T Consortium and UCSC SeqTech Center are hosting a Technology-focused Webinar next Thursday with a group of experts. Register today: bit.ly/3PFTa2f @aphillippy.bsky.social 055