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Jacky Goetz

@goetzjacky.bsky.social
1.8K followers 781 following 318 posts

Cancer and Cell biologist🦀, CLEMist🔬, fan of #mechanobiology, #metastasis, #extracellularvesicles, #imaging. Lab website : www.goetzlab.fr Also, Amateur & addict triathlete 🚴‍♂️🏊👟.

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Jacky Goetz @goetzjacky.bsky.social · 10/07/2026
I hope this perspective will stimulate new discussions and collaborations at the interface of #mechanobiology, #immunology and #metastasis @inserm.fr @unistra.fr
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Jacky Goetz @goetzjacky.bsky.social · 10/07/2026
🤝 Huge kudos to Valentin Gensbittel who shaped that with high maturity 💪 , and to our co-authors Eduardo Garvín Jiménez and María Casanova Acebes 🇪🇸 @cniostopcancer.bsky.social for this inspiring collaboration.
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Jacky Goetz @goetzjacky.bsky.social · 10/07/2026
💡 This perspective reflects a growing conviction : mechanics is not simply a consequence of #cancer, it is a fundamental regulator of tumour–host interactions. Integrating #biomechanics with #immunology, happening live, may help uncover new ways to understand and ultimately target metastasis.
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Jacky Goetz @goetzjacky.bsky.social · 10/07/2026
We also explore how tumour cells exploit mechanical adaptations to evade immune destruction and how these vulnerabilities could inspire new therapeutic strategies.
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Jacky Goetz @goetzjacky.bsky.social · 10/07/2026
⚙️ How do physical forces shape anti-tumour #immunity during #metastatic progression? We discuss the emerging concept of mechano-immunology, highlighting how mechanical cues influence immune surveillance across the metastatic cascade—from the primary tumour to CTCs and metastatic niches.
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Jacky Goetz @goetzjacky.bsky.social · 10/07/2026
🚀 Excited to share our latest publication in #NatureMaterials Nature Portfolio ! 💥 Let's say it loud : #Mechanics is emerging as a new dimension of anti-tumour #immunity 📺 Link : www.nature.com/articles/s41... Tiny thread 👉🧵
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Jacky Goetz @goetzjacky.bsky.social · 01/07/2026
Encore Bravo Nicolas 💪
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Jacky Goetz @goetzjacky.bsky.social · 01/07/2026
Next challenge : Strasbourg’s cathedral 😜😎
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Jacky Goetz @goetzjacky.bsky.social · 01/07/2026
Check out our latest work, spearheaded by @hyennev.bsky.social in the lab. Thank you @cnrsbiologie.bsky.social for promoting it. @inserm.fr @unistra.fr
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Jacky Goetz @goetzjacky.bsky.social · 27/06/2026
The Heart beats Cancer ! Very happy to share some thoughts about the fascinating study published in by the group of Serena Zacchigna Another amazing demonstration of the major impact of #mechanics on #cancer Thank you @cp-trendscancer.bsky.social www.sciencedirect.com/science/arti...
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Jacky Goetz @goetzjacky.bsky.social · 26/04/2026
Another proof that #mechanics count in #cancer ! Check out this fascinating study 🤩 providing insight as to why the #heart is rarely colonized by #tumor cells : 🖥️ lnkd.in/e-WNR6KN You can also read this french article by O/HERTEL in @lepoint.fr with some of my comments : 🖥️ lnkd.in/eudUx2Fd
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Jacky Goetz @goetzjacky.bsky.social · 25/04/2026
We will be there and KJ will show you his EM wizardry (among other - he made this video) and provide new insights on MVB biogenesis and subsequent pro-metastatic EV secretion.
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Jacky Goetz @goetzjacky.bsky.social · 25/04/2026
Are you at #ISEV2026 and wonder which MVB you should have as a cookie 😎 ? @isev.org Come & listen to our post-doc Kuang-Jing Huang at talk OR15.2 in an exciting session on intercellular communcation and #EV uptake which I will co-chair with Samuel Žvanut tomorrow.
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Jacky Goetz @goetzjacky.bsky.social · 24/04/2026
Are you at #ISEV2026 and wonder what this is ? Come & listen to our Ph.D student Louis Bochler at talk OR11.1 in a session on #metastasis chaired by David Lyden (on friday). We will be there and explain what makes these #neutrophils imaged in a living mouse lung so crazy.
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Jacky Goetz @goetzjacky.bsky.social · 07/04/2026
We are all 🤩 with our work and image being selected for the cover of @natmater.nature.com Thank you again @brunommcastro.bsky.social ! ALT : This is a PAA bead stuck in a #zebrafisg ISV vessel
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Jacky Goetz @goetzjacky.bsky.social · 04/04/2026
Thx Tom 🙏
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Jacky Goetz @goetzjacky.bsky.social · 04/04/2026
Thanks Man 🙏
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Jacky Goetz @goetzjacky.bsky.social · 04/04/2026
Thx Guy 🙏
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Jacky Goetz @goetzjacky.bsky.social · 04/04/2026
This cover is a beautiful ending of one of life's adventures from which you and your colleagues grow so much, at all levels ! Conclusion : time and failures are perfect food for success
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Jacky Goetz @goetzjacky.bsky.social · 04/04/2026
We then faced the 🎢 of scientific publishing but were again galvanized by failures. We fought and benefited from the understanding of editors and reviewers in a constructive and productive discussion.
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Jacky Goetz @goetzjacky.bsky.social · 04/04/2026
The project was then beautifully taken over by Valentin Gensbittel and @naelosmani.bsky.social in the lab, based on the previous work of many in the lab and the help of many many many people.
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Jacky Goetz @goetzjacky.bsky.social · 04/04/2026
Intense brainstorming with the brilliant mind of Jochen Guck (I miss him so much). Luckily, Ligue contre le cancer and many others took over and allowed use to pursue some preliminary data obtained in the lab.
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Jacky Goetz @goetzjacky.bsky.social · 04/04/2026
Some context 💡 : It all started with a simple concept & question and during a sabbatical at @garvaninstitute.bsky.social (awesome opportunity for scientists to actually do science) where I drafted a later-failed European Research Council (ERC) proposal.
lnkd.in
LinkedIn
This link will take you to a page that’s not on LinkedIn
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Jacky Goetz @goetzjacky.bsky.social · 04/04/2026
💥 We made the COVER 🤩 of @natmater.nature.com ! CELL VISCOSITY 🎈 IN METASTATIC EXTRAVASATION Check the entire issue here : lnkd.in/e9USS44n @inserm.fr @unistra.fr #zebrafish #mouse #metastasis #mechanobiology #imaging #materials Note : Image's credit is V.Gensbittel (PAA bead in a ZF ISV)
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Jacky Goetz @goetzjacky.bsky.social · 31/03/2026
Very nice 👍
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Jacky Goetz @goetzjacky.bsky.social · 25/03/2026
Really sorry to hear about your daughter, breaking my heart.
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Jacky Goetz @goetzjacky.bsky.social · 24/03/2026
I would 🤗, but quoting K.Konstantopoulos 😜
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Jacky Goetz @goetzjacky.bsky.social · 20/03/2026
Check out the french 🇫🇷 digest we just published in MédecineSciences Awesome work (this one and the original) by @katkajerabkova.bsky.social & @hyennev.bsky.social in the lab Digest : www.medecinesciences.org/fr/articles/...
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Jacky Goetz @goetzjacky.bsky.social · 20/03/2026
Not just soft 🎈 Many thanks to the team of K.Konstantopoulous #JohnsHopkins for throughly discussing our recently-published story in @aacrjournals.bsky.social #CancerResearch Highly appreciated 🙏 Link : aacrjournals.org/cancerres/ar... Our original paper : www.nature.com/articles/s41...
aacrjournals.org
Not Just Soft: Cell Viscosity Emerges as a Driver of Tumor Cell Dissemination
Abstract. The mechanical properties of cells and tissues have emerged as important biophysical markers for distinguishing between healthy and diseased states. In cancer, mechanical heterogeneity spans...
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Jacky Goetz @goetzjacky.bsky.social · 27/02/2026
Check out the awesome highlight (+ video) of our recent work on the #biophysics of #metastasis published by Le Point, by O.HERTEL 🔗 lnkd.in/eywzr8kn 🖥️ dai.ly/xa0dwds Such a blast to see our #zebrafish 🐠 experiments making the (web) front page (but there are also 🐁 ones in the original paper 😜)
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Jacky Goetz @goetzjacky.bsky.social · 26/02/2026
Awesome 👏 work !
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Jacky Goetz @goetzjacky.bsky.social · 06/02/2026
💡 Interested in mechano-immunology (or biology of adult B-ALL) ? 💥 We have an #MSCA postdoctoral fellowship offer for you @ec.europa.eu 🖥️ : euraxess.ec.europa.eu/jobs/hosting... 🏙️ Where ? In beautiful #Strasbourg #CRBS @inserm.fr @unistra.fr 🥼 Interested ? 📧 jacky.goetz@inserm.fr
lnkd.in
LinkedIn
This link will take you to a page that’s not on LinkedIn
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Jacky Goetz @goetzjacky.bsky.social · 06/02/2026
💡 Interested in mechano-immunology (or biology of adult B-ALL) ? 💥 We have an #MSCA postdoctoral fellowship offer for you @ec.europa.eu 🖥️ : euraxess.ec.europa.eu/jobs/hosting... 🏙️ Where ? In beautiful #Strasbourg #CRBS @inserm.fr @unistra.fr 🥼 Interested ? 📧 jacky.goetz@inserm.fr
lnkd.in
LinkedIn
This link will take you to a page that’s not on LinkedIn
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Jacky Goetz @goetzjacky.bsky.social · 06/02/2026
France should also not forget to preserve their best minds !
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Max Planck Institute for the Science of Light (MPL) @mpi-scienceoflight.bsky.social · 26/01/2026
A #research team investigated how the mechanical properties of tumor cells influence their metastatic pathway. 🔑 🔍: Viscosity – rather than elasticity – determines how tumor cells invade surrounding tissue. 👉 mpzpm.mpg.de/news/news-de... 📸 V. Gensbittel, J. Goetz #science #biophysics #metastasis
Tumor cell in the maze of the lung vasculature in a mouse.
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Jacky Goetz @goetzjacky.bsky.social · 26/01/2026
Thank you 🙏 @inserm.fr @unistra.fr
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Jacky Goetz @goetzjacky.bsky.social · 26/01/2026
Thank you 🙏 healthmedicinet.com/mechanical-v...
healthmedicinet.com
HMN 2026: How Tumor cell viscosity found to guide key steps in cancer spread
Mechanical view metastasis tumor cell: Tumor cell in the maze of the lung vasculature of a mouse. Credit: © V. Gensbittel, J.Goetz Millions of people...
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Jacky Goetz @goetzjacky.bsky.social · 25/01/2026
@inserm.fr @unistra.fr
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MED @medtriage.bsky.social · 24/01/2026
🧬 New study in Nature finds cancer spread depends on how “thick” tumour cells are. Higher cell viscosity helps them survive blood flow and escape into new tissues - a key step in metastasis. 🔬 www.nature.com/artic... #CancerResearch #Science #Health
New study finds cancer spread driven by how “thick” tumour cells are
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Reposted by Jacky Goetz
Nature Materials @natmater.nature.com · 23/01/2026
Cell viscosity influences haematogenous dissemination and metastatic extravasation of tumour cells go.nature.com/4jZ8OUu
go.nature.com
Cell viscosity influences haematogenous dissemination and metastatic extravasation of tumour cells - Nature Materials
The viscosity of tumour cells is shown to govern their ability to disseminate through the bloodstream and extravasate, establishing a key biomechanical factor of metastasis.
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Jacky Goetz @goetzjacky.bsky.social · 22/01/2026
🙏
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Robert Arkowitz @robertarkowitz.bsky.social · 21/01/2026
www.nature.com/articles/s41...
nature.com
Cell viscosity influences haematogenous dissemination and metastatic extravasation of tumour cells - Nature Materials
The viscosity of tumour cells is shown to govern their ability to disseminate through the bloodstream and extravasate, establishing a key biomechanical factor of metastasis.
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Jacky Goetz @goetzjacky.bsky.social · 20/01/2026
💡 Have you ever wondered how #circulating #tumor cells squeeze through narrow #capillaries during hashtag#metastasis ? 💥 We did, check out our latest publication just out #NatureMaterials: rdcu.be/eZHxJ
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Jacky Goetz @goetzjacky.bsky.social · 21/01/2026
Un plaisir aussi de voir Elodie Marchal et Laurie Nemoz-Billet jouer avec notre cytométre de déformabilité développé par Jochen Guck et son équipe Martin Kräter #Rivercyte, et Laetitia PAULEN à la paillasse
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Jacky Goetz @goetzjacky.bsky.social · 21/01/2026
Un plaisir d'être mis en lumière, ainsi que notre #CRBS @inserm.fr @unistra.fr et sa plateforme #PICSTRA orchestrée par #PascalKessler que nous avons pu labelliser #FBI et #GIS IBiSA (ici Louis Bochler et Zeynep YESILATA devant un de ses microscopes)
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Jacky Goetz @goetzjacky.bsky.social · 21/01/2026
Merci #France3Alsace @francetv.bsky.social et en particulier #MarieCoulon pour ce nouveau reportage sur nos tout derniers travaux dans la Région Grand Est 📺 (start at 00:12:45) www.france.tv/france-3/gra...
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Jacky Goetz @goetzjacky.bsky.social · 21/01/2026
Merci 🙏 @unistra 😊
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Université de Strasbourg @unistra.fr · 21/01/2026
Pour former des métastases, les cellules cancéreuses doivent franchir une course d’obstacles qui exige des propriétés physiques spécifiques. Une étude montre que leur viscosité joue un rôle crucial, mais pas à toutes les étapes de la progression métastatique. @goetzjacky.bsky.social @inserm.fr
radiofrance.fr
La viscosité, une propriété clé des cellules cancéreuses
Pour former des métastases, les cellules cancéreuses doivent franchir une course d’obstacles qui exige des propriétés physiques spécifiques. Une nouvelle étude montre que leur viscosité joue un rôle c...
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Jacky Goetz @goetzjacky.bsky.social · 20/01/2026
Un grand merci @alexandramaz.bsky.social pour ce highlight, un vrai plaisir de travailler et d'échanger avec vous ! @inserm.fr @unistra.fr
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Alexandra Delbot @alexandradelbot.bsky.social · 20/01/2026
Pour former des métastases, les cellules cancéreuses doivent franchir une course d’obstacles qui exige des propriétés physiques spécifiques. Une nouvelle étude montre que leur viscosité joue un rôle crucial, mais paradoxalement, pas à toutes les étapes de la progression métastatique.
radiofrance.fr
La viscosité, une capacité clé des cellules cancéreuses
Pour se disséminer en métastases, les cellules cancéreuses doivent présenter certaines compétences physiques. Une nouvelle étude montre que leur viscosité joue crucial, mais paradoxalement, pas à tout...
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