iiinova — where your digital self keeps evolving

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🧬Jacob L Steenwyk @jlsteenwyk.bsky.social · 15/11/2025

The number of free subscriptions to @genomelybio.bsky.social substack has been steadily growing. Super thankful folks find my BioAI and biotech development weeklys helpful. Looking forward to writing more deep dives in the future. Appreciate you :) open.substack.com/pub/genomely...

open.substack.com

Genomely | 🧬Jacob L Steenwyk | Substack

Where Genomics and Evolution Converge. Click to read Genomely, by 🧬Jacob L Steenwyk, a Substack publication with hundreds of subscribers.

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🧬Jacob L Steenwyk @jlsteenwyk.bsky.social · 15/11/2025

I decided to join in on the fun and write a popular science-y article about the recent manuscript. It is available on the @genomelybio.bsky.social Substack Subscribe for free :D genomely.substack.com/p/what-was-t... bsky.app/profile/jlst...

genomely.substack.com

What was the first animal like?

Settling Earth’s First Animal Debate

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🧬Jacob L Steenwyk @jlsteenwyk.bsky.social · 06/11/2025

The @genomelybio.bsky.social SubStack is expanding and will now feature a weekly update on the top 10 biotech business developments based on deal size, event type, company star power, innovation factor, source credibility, and recency. Here is the first post! genomely.substack.com/p/top-10-bio...

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Top 10 Biotech Business Developments: Oct 30 - Nov 6

Acquisitions, Funding, Clinical Advances & More 📊 Analyzed 119 biotech business articles from 10 sources ⭐ Curated down to the Top 10 Most Exciting Stories

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🧬Jacob L Steenwyk @jlsteenwyk.bsky.social · 13/10/2025

BioAI Weekly: October 06 - 13 This week, 47 BioAI articles and posts (35 from research outlets and 12 community updates) were reviewed. Discussion centered on AI / machine learning applications in cell biology and human diseases. #machinelearning #cell #disease

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🧬Jacob L Steenwyk @jlsteenwyk.bsky.social · 23/09/2025

The Genomely substack is growing 😄🥳😄🥳!! Subscribe for free :) genomely.substack.com @genomelybio.bsky.social

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🧬Jacob L Steenwyk @jlsteenwyk.bsky.social · 22/09/2025

BioAI Weekly: Sept 15 - 22 📊 This week: 203 articles analyzed, 36 community posts tracked, 10 trending topics identified Full article here: genomely.substack.com/p/bioai-week... An overview 🧵 below 👇 #AI #machinelearning #llms

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🧬Jacob L Steenwyk @jlsteenwyk.bsky.social · 09/09/2025

There's a lot happening in AI, and we made a way to keep up. @genomelybio.bsky.social will now post weekly reports about AI (& beyond). Eg, we examined & summarized 166 articles, 56 community posts (eg, from Reddit), and 10 trending topics (eg, from Bluesky) genomely.substack.com/p/ai-weekly-...

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🧬Jacob L Steenwyk @jlsteenwyk.bsky.social · 07/02/2025

Elated to share the PhyKIT protocols manuscript appeared on the cover of Current Protocols🥳🥳🥳 bsky.app/profile/jlst...

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🧬Jacob L Steenwyk @jlsteenwyk.bsky.social · 30/01/2025

NEW Publication🥳 Solu enables easy genome-scale pathogen surveillance! Solu is a cloud-based real-time #pathogen surveillance platform integrating privacy, speed & usability. It automatically assembles, characterizes & compares WGS data—no bioinformatics expertise required. 🔗: tinyurl.com/y8p24uya

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🧬Jacob L Steenwyk @jlsteenwyk.bsky.social · 23/12/2024

This blog post is part of a general series I write about genomics, bioinformatics, academia, and beyond. You can subscribe for free if you'd like 😄 You can even tell your friends, your parents, your dog walking partner, and your loose acquaintances to subscribe 😆 genomely.substack.com

genomely.substack.com

Genomely | 🧬Jacob L Steenwyk | Substack

Where Genomics and Evolution Converge. Click to read Genomely, by 🧬Jacob L Steenwyk, a Substack publication with hundreds of subscribers.

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🧬Jacob L Steenwyk @jlsteenwyk.bsky.social · 23/12/2024

I wrote a blog post about OrthoHMM, which goes into slightly more depth than this thread. If you have any questions or want clarifications, I would be happy to provide them :) genomely.substack.com/p/improving-... bsky.app/profile/jlst...

genomely.substack.com

Improving a Fundamental Method for Comparative Genomics: Introducing OrthoHMM

Enhanced Ortholog Inference Using Hidden Markov Models for Improved Genomic Comparisons

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🧬Jacob L Steenwyk @jlsteenwyk.bsky.social · 25/12/2024

OrthoHMM v0.1.0 now handles the all-by-all search step differently by enabling better multiprocessing. Now, multiple search commands can be executed in one step :) github.com/JLSteenwyk/o... bsky.app/profile/jlst...

github.com

GitHub - JLSteenwyk/orthohmm: Improved Inference of Ortholog Groups using Hidden Markov Models

Improved Inference of Ortholog Groups using Hidden Markov Models - JLSteenwyk/orthohmm

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🧬Jacob L Steenwyk @jlsteenwyk.bsky.social · 25/12/2024

Happy holidays, everyone!! 🫶

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🧬Jacob L Steenwyk @jlsteenwyk.bsky.social · 17/12/2024

NEW preprint!🥳 Orthogroups are a prerequisite for comparative genomics and Tree of Life inquiries Introducing #OrthoHMM, software that improves the inference of orthogroups (blue in fig) OrthoHMM may refine our understanding of genome evolution and the Tree of Life 🔗 tinyurl.com/4s9mwxz6 🧵 1/8

Benchmarking analysis of OrthoHMM and previously published algorithms. OrthoHMM has better precision, recall, and FMI scores. Benchmarking was conducted against the Orthobench dataset of expertly curated orthogroups

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🧬Jacob L Steenwyk @jlsteenwyk.bsky.social · 14/12/2024

Thank you again for your inquiry. Given that many people need to create graphical abstracts, I decided it might be most productive to write a blog post on the topic. After organizing my thoughts, I'm happy to share them here on the @genomelybio.bsky.social blog. open.substack.com/pub/genomely...

open.substack.com

Notes on Creating a Graphical Abstract

Recommendations for effective graphical abstracts

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