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UCSC Genome Browser @genomebrowser.bsky.social · 21/09/2026

New public hub: Sci-ModoM RNA modification sites. 7.9M m6A, pseudouridine, m5C and 2'-O-methylation sites on hg38 and mm39, each with its coverage and percent modified. Explore hub: genome.ucsc.edu/s/Lo... More public hubs: genome.ucsc.edu/cgi-...

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UCSC Genome Browser @genomebrowser.bsky.social · 10/09/2026

New on hg38: Google DeepMind's AlphaGenome Variant Impact (AVI) scores, all 8.8 billion possible single-base changes. It scores non-coding DNA too, flagging things like the TERT promoter mutations common in cancer. See our news for more: bit.ly/GenomeBrowser...

AVI scores at the TERT locus on hg38, one subtrack per alternate allele. Scores stay high across the highlighted promoter, shown in red as EH38E3622530, and fall to background either side. The two promoter mutations most often seen in cancer sit inside it, beyond the end of every TERT transcript.

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UCSC Genome Browser @genomebrowser.bsky.social · 04/09/2026

See how any mouse gene's expression shifts through development! New ENCODE Expression default tracks on mm10/mm39 show bulk RNA-seq across 17 tissues and 8 stages, from embryonic day 10.5 to birth. See our news for more info: bit.ly/UCSCencodeExp...

Expression of Gap43 across the developmental time course on mm10. Each bar is one sample, colored by tissue and darkening with developmental age. Expression rises through development and is highest in the four neural tissues on the right of the chart.

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UCSC Genome Browser @genomebrowser.bsky.social · 01/09/2026

We have a new facet interface for composite tracks! A faceted composite is an alternative display with facets along the left side that filter the collection, while a paginated table on the right lists matching subtracks. Read more: bit.ly/4xx88LQ

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UCSC Genome Browser @genomebrowser.bsky.social · 27/08/2026

We are excited to announce the gnomAD v4.1.1 and MPC tracks on the UCSC Genome Browser. This release updates gnomAD's variant and constraint tracks and adds new MPC tracks predicting missense deleteriousness. Learn more at: genome.ucsc.edu/gold...

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UCSC Genome Browser @genomebrowser.bsky.social · 17/08/2026

ENCODE GRAMMAR is now on the UCSC Genome Browser! 🧬 Base-resolution deep learning predictions, sequence contribution scores & motif instances (BPNet, ChromBPNet, ProCapNet, ReporterNet) across thousands of ENCODE experiments. Explore on hg38: genome.ucsc.edu/s/Lo...

UCSC Genome Browser view on human genome hg38 at chr8:127,898,412-127,899,647, showing the ENCODE GRAMMAR track hub. Ten stacked blue signal tracks display ChromBPNet observed and predicted DNase-seq and ATAC-seq signal for the K562 cell line, plus bias-corrected predicted profiles that rise to a sharp central peak, and base-resolution sequence contribution scores. At the bottom, a row of colored blocks marks predicted transcription factor motif instances (including GATA, KLF-SP, ELF-GABP, and FOS-JUN) directly beneath the peak.

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UCSC Genome Browser @genomebrowser.bsky.social · 12/08/2026

ClinPred pathogenicity score track for hg19 and hg38 is now available! ClinPred is a machine-learning predictor of pathogenicity for nonsynonymous SNVs, combining existing pathogenicity scores with population allele frequency from gnomAD. Learn more at: bit.ly/3SsKDV2

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UCSC Genome Browser @genomebrowser.bsky.social · 23/07/2026

Together, these tracks represent the final ENCODE Phase 4 data release integrated into the browser and cover chromatin accessibility, histone modification and CTCF ChIP-seq, transcription factor binding, and transcription across thousands of individual biosamples.

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UCSC Genome Browser @genomebrowser.bsky.social · 23/07/2026

We are excited to announce the ENCODE4 data collection on the UCSC Genome Browser for hg38 and mm10. This release consists of two major components: the ENCODE Registry of cCREs and the new ENCODE4 Regulation container. Learn more at: bit.ly/Encode4Release

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UCSC Genome Browser @genomebrowser.bsky.social · 17/07/2026

🧬 New: Long-read Structural Variants tracks for human (hg38 & T2T-CHM13/hs1). SV callsets from 14 long-read studies merged into ~2.3M sites, so you can compare structural variation across populations. See our news to learn more: bit.ly/UCSClong-readSVs

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UCSC Genome Browser @genomebrowser.bsky.social · 07/07/2026

26 years ago today, the first public assembly of the human genome went online at UC Santa Cruz. Today, we release version 500 of the UCSC Genome Browser. From Jim Kent's first assembly to thousands of genomes, the data is still free and open. genome.ucsc.edu/gold...

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UCSC Genome Browser @genomebrowser.bsky.social · 01/07/2026

Which variants are common in your ancestry but rare globally? New on hg38: SNV Frequencies. Over 1.2 billion variants pooled from ~1.5M people across 30+ cohorts, including population references, biobanks, and disease case/control studies. Learn more: bit.ly/GBsnvFrequencies

rs4986893, a CYP2C19 stop-gained variant common in East Asian populations. The mouseover ranks ToMMo Japan, KOVA Korea, and WBBC China at the top, well above the 1.6% pooled background AF.

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UCSC Genome Browser @genomebrowser.bsky.social · 26/06/2026

We are happy to announce Release 3 of the Varaico Variants and Varaico Variants (suppl) tracks for hg38/hg19. This release contains a precision improvement and an update of the underlying literature. Learn more at: genome.ucsc.edu/gold...

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UCSC Genome Browser @genomebrowser.bsky.social · 25/06/2026

We are pleased to announce our new public hub, EVA score for synthetic gRNA efficiency for hg38, hg19 & mm39. Named after MPI-EVA, it predicts on-target SpCas9 cutting activity using chemically synthesized gRNAs: bit.ly/MPI-EVA. Thanks to Tomislav Maricic at MPI-EVA.

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UCSC Genome Browser @genomebrowser.bsky.social · 23/06/2026

New on the UCSC Genome Browser: a Non-canonical ORFs track collection for hg38! Explore 1M+ ORFs outside annotated coding genes — uORFs, sORFs & more — from UTRannotator, GENCODE, 5ULTRA, nuORFdb, MetamORF & OpenProt, all colored by Kozak strength. genome.ucsc.edu/gold...

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UCSC Genome Browser @genomebrowser.bsky.social · 02/06/2026

New on the UCSC Genome Browser (hg38): MPRA tracks. MPRA Base catalogs 40,938 experimentally tested enhancer elements across 6 cell lines; MPRAVarDB scores 239,028 allelic variant effects from 18 studies. Great for GWAS fine-mapping. Learn more: bit.ly/4a8KDPD

MPRA Base elements and MPRAVarDB variants at the TERT promoter (chr5, GRCh38/hg38). MPRA Base (top) shows reporter activity for melanoma risk variants tested in HEK293FT and UACC903 cells (Choi et al., 2020). MPRAVarDB (bottom) highlights high-confidence allelic effects from saturation mutagenesis of the TERT promoter (Kircher et al., 2019).

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UCSC Genome Browser @genomebrowser.bsky.social · 01/05/2026

Two new variant-impact tracks from Illumina on the UCSC Genome Browser: PrimateAI-3D scores every coding missense variant (hg38/hg19); PromoterAI scores every non-coding substitution near transcription start sites (hg38). See our news for more: bit.ly/illuminaTracks

PrimateAI-3D and PromoterAI at the start of HBB on hg38 (chr11:5,226,883-5,227,212). PrimateAI-3D scores every coding missense variant as red (pathogenic) or blue (benign), while the four PromoterAI per-allele bigWig subtracks score every possible non-coding substitution in the 5′ UTR and proximal promoter just upstream of the HBB start codon.

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UCSC Genome Browser @genomebrowser.bsky.social · 22/04/2026

Check out our new NMD Escape tracks on hg38! They predict where premature stop codons escape nonsense-mediated decay. Useful for interpreting truncating variants under ACMG PVS1. Includes GENCODE+RefSeq rulesets + predictive scores. See our news for more: bit.ly/browserNMD

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UCSC Genome Browser @genomebrowser.bsky.social · 11/04/2026

New "Tandem Repeat Variation" tracks on hg38. Browse STR/VNTR data from WebSTR, STRchive, TRExplorer, ToMMo, and 1000 Genomes ONT, plus gnomAD STR genotypes at 87 disease loci. Explore allele frequencies across diverse populations. Read more at: genome.ucsc.edu/gold...

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UCSC Genome Browser @genomebrowser.bsky.social · 03/04/2026

New heatmap display mode for bigBed tracks in the UCSC Genome Browser! Visualize multi-sample quantitative data as color-coded grids directly in genomic context, great for variant effects, expression & methylation. See our docs & try it out: bit.ly/ucscGBheatmap

Heatmap display in the UCSC Genome Browser

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UCSC Genome Browser @genomebrowser.bsky.social · 17/03/2026

The supertrack configuration page has new controls for track visibility. "Apply visibility" buttons set visibility across visible or all tracks, Hide/Dense/Squish/Pack/Full buttons replace dropdowns, folder icons indicate container tracks. More info: genome.ucsc.edu/gold...

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UCSC Genome Browser @genomebrowser.bsky.social · 17/03/2026

We are excited to announce the release of the Human Methylation Atlas Summary and Signals tracks for hg38 and hg19. The tracks display genome-wide DNA methylation profiles across 39 primary human cell types from 205 healthy tissue samples. Learn more at bit.ly/humanMethylat...

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UCSC Genome Browser @genomebrowser.bsky.social · 13/03/2026

We've added two gnomAD coverage tracks on human hg38: gnomAD v4 Exome Coverage — mean/median depth & sample % at 1X–100X thresholds across exome samples. gnomAD v3 Genome Coverage — same metrics for 71,702 whole-genome samples. Learn more at: genome.ucsc.edu/gold...

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UCSC Genome Browser @genomebrowser.bsky.social · 25/02/2026

New Recent Genomes & Connected Hub Assemblies lists on the Gateway page, plus genome search across more tools. Recent Genomes also appears in the blue bar under Genomes. Species Tree now hidden by default (click “Show species tree” to view). More info at genome.ucsc.edu/gold...

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UCSC Genome Browser @genomebrowser.bsky.social · 19/02/2026

We are happy to announce our new public hub, VRMOD CRM for hg38/mm10. It shows experimentally defined, predicted, and epigenomically supported cis-regulatory elements across tissues & cell types: bit.ly/VRMOD_CRMs Thanks to Zhao Lab at WashU Medicine for creating this hub.

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UCSC Genome Browser @genomebrowser.bsky.social · 18/02/2026

We are happy to announce the JASPAR 2026 tracks for hg38, mm39, danRer11, galGal6, dm6, ce11, ci3, and sacCer3, which represent genome-wide predicted binding sites for transcription factors with binding profiles in the JASPAR CORE collection. More info: bit.ly/JASPAR...

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UCSC Genome Browser @genomebrowser.bsky.social · 10/02/2026

A new Phased Variants container track for hg38 and hg19, and brings phased individual-level genotype data from: Human Diversity Genome Project, Simons Genome Diversity Project, gnomad's HGDP+1000 Genomes callset, and the Mexico Biobank. Learn more at: bit.ly/4rxS60Q

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UCSC Genome Browser @genomebrowser.bsky.social · 05/02/2026

We are happy to announce the recount3 tracks for hg38 and mm10: uniformly processed RNA-seq data from multiple studies, featuring intron data, split read counts, and splice junction motifs for cross-study comparisons and meta-analyses. Learn more at: bit.ly/recount3_track

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UCSC Genome Browser @genomebrowser.bsky.social · 04/02/2026

We are excited to introduce Hub Space, a new hosting service that enables users to upload and visualize track hub files directly on the UCSC Genome Browser without relying on third-party hosting services such as Dropbox, Google Drive, or AWS. Learn more: bit.ly/3NTZBkq

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UCSC Genome Browser @genomebrowser.bsky.social · 04/02/2026

We are excited to announce that the Genome Browser now includes a dynamic track group that automatically displays all currently visible tracks in one convenient location. The group has more than 32 tracks available for a genome assembly. Read more here: bit.ly/4qj1jt7

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UCSC Genome Browser @genomebrowser.bsky.social · 15/01/2026

These data display regions identified by biochemical signatures predicted to regulate gene expression as promoters, enhancers, or other regulatory elements. We would like to thank Zhiping Weng, and Jill Moore for their work in producing and displaying these data.

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UCSC Genome Browser @genomebrowser.bsky.social · 15/01/2026

We are proud to announce a new ENCODE Registry of cCREs (candidate Cis-Regulatory Elements) track for hg38 as described in Moore et al., Nature 2026. See our news for more: bit.ly/ucscENCODE4cCREs

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UCSC Genome Browser @genomebrowser.bsky.social · 07/01/2026

We recently added Neanderthal and Denisova variant tracks for GRCh38/hg38. Thanks to the Archaic Sequence Hub (www.arcseqhub...) for compiling the data and making it available. View the data on the Genome Browser: bit.ly/ancientHominids.

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UCSC Genome Browser @genomebrowser.bsky.social · 23/12/2025

We are pleased to announce the release of the EVA SNP Release 8 tracks, now available for 41 assemblies and covering 945 million variants. Learn more at genome.ucsc.e...

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UCSC Genome Browser @genomebrowser.bsky.social · 19/12/2025

The new public hub from @GHFC_lab displays genes connected with autism and neurodevelopmental disorders. It additionally displays variants from diagnosed autistic individuals and their undiagnosed families. View it on the Genome Browser here: bit.ly/4pUpC1e.

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UCSC Genome Browser @genomebrowser.bsky.social · 19/12/2025

We recently added a public track hub of "cancer effect size" across 20 TCGA cancer cohorts. Thank you to @jeffreytownsend.bsky.social and his lab at Yale University for providing the data. View it on the Genome Browser here: bit.ly/496Cx92.

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UCSC Genome Browser @genomebrowser.bsky.social · 16/12/2025

We would love to hear your feedback on QuickLift and welcome any suggestions you may have for improving the QuickLift guide. Your input will help us refine QuickLift and shape the official help page. Please feel free to write to us at genome-www@soe.ucsc.edu.

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Reposted by UCSC Genome Browser

UC Santa Cruz Genomics Institute @ucscgenomics.bsky.social · 04/12/2025

📢 We're hiring a Genomics Senior Systems Architect! The incumbent will be responsible for the Genomics Institute's complex computing infrastructure, including central and departmental systems, high-throughput storage, web systems, & cloud environments. Apply at jobs.ucsc.edu using job code 82880.

Image of an animated banana slug with glasses sitting at the ucsc genome browser. Text reads: we're hiring.

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UCSC Genome Browser @genomebrowser.bsky.social · 03/12/2025

New gnomAD Missense Deleteriousness Prediction by Constraint (MPC) track for hg19. It shows a score that identifies missense-depleted regions using rare missense variation in 125,748 gnomAD v2.1.1 exomes. OE values: yellow=low, blue-purple=high. More at genome.ucsc.edu/gold...

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UCSC Genome Browser @genomebrowser.bsky.social · 17/11/2025

We are pleased to announce Release 2 of the Varaico Variants track and a new Varaico Variants (suppl) track for hg38/hg19. The update brings the track to over 5.5M variants, and the new suppl track shows variants from supplementary files. Learn more at: genome.ucsc.edu/gold...

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UCSC Genome Browser @genomebrowser.bsky.social · 12/11/2025

A new hub is available for the new T2T Rhesus and Crab-eating macaque genomes. The hub includes tracks for copy number variation, assembly validation, alignments, and more. Thanks to @ShilongZha297 for creating this hub. View it here: genome.ucsc.edu/cgi-...

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UCSC Genome Browser @genomebrowser.bsky.social · 31/10/2025

We are happy to announce the release of the GENCODE "knownGene" V49 (hg38/hg19) and VM38 (mm39) gene tracks. Learn more about the release from the following news post: genome.ucsc.edu/gold...

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UCSC Genome Browser @genomebrowser.bsky.social · 17/10/2025

These tracks are useful in combination with the variants track for evaluating new transcript models. They can be used to assess potential exon boundaries or possible splice acceptor sites.

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UCSC Genome Browser @genomebrowser.bsky.social · 17/10/2025

We are pleased to announce the hg38 SpliceAI Wildtype tracks. These tracks show the scores for the genome sequence itself, without variants, from predicted splice donor and splice acceptor sites. More at bit.ly/spliceAIWt

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UCSC Genome Browser @genomebrowser.bsky.social · 25/09/2025

We are happy to announce the hg38 Panmask Easy 151b Regions track. It contains a set of sample-agnostic easy regions where short-read variant calling reaches high accuracy and can be used to filter variant calls for clinical or research samples. More at bit.ly/Panmask

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UCSC Genome Browser @genomebrowser.bsky.social · 25/09/2025

We are excited to announce the release of the CoLoRSdb small and structural variant tracks for the human assemblies GRCh38/hg38 and CHM13/hs1. Learn more about this release at: genome.ucsc.edu/gold...

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UCSC Genome Browser @genomebrowser.bsky.social · 19/09/2025

We are pleased to announce the release of the Developmental Disorders Genotype-to-Phenotype (DDG2P) track for hg19 and hg38. The DDG2P track displays genes associated with severe developmental disorders. Learn more at: genome.ucsc.edu/gold...

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