iiinova — where your digital self keeps evolving

UCSC Genome Browser @genomebrowser.bsky.social · 21/09/2026

New public hub: Sci-ModoM RNA modification sites. 7.9M m6A, pseudouridine, m5C and 2'-O-methylation sites on hg38 and mm39, each with its coverage and percent modified. Explore hub: genome.ucsc.edu/s/Lo... More public hubs: genome.ucsc.edu/cgi-...

067 7

UCSC Genome Browser @genomebrowser.bsky.social · 10/09/2026

New on hg38: Google DeepMind's AlphaGenome Variant Impact (AVI) scores, all 8.8 billion possible single-base changes. It scores non-coding DNA too, flagging things like the TERT promoter mutations common in cancer. See our news for more: bit.ly/GenomeBrowser...

AVI scores at the TERT locus on hg38, one subtrack per alternate allele. Scores stay high across the highlighted promoter, shown in red as EH38E3622530, and fall to background either side. The two promoter mutations most often seen in cancer sit inside it, beyond the end of every TERT transcript.

083 8

UCSC Genome Browser @genomebrowser.bsky.social · 04/09/2026

See how any mouse gene's expression shifts through development! New ENCODE Expression default tracks on mm10/mm39 show bulk RNA-seq across 17 tissues and 8 stages, from embryonic day 10.5 to birth. See our news for more info: bit.ly/UCSCencodeExp...

Expression of Gap43 across the developmental time course on mm10. Each bar is one sample, colored by tissue and darkening with developmental age. Expression rises through development and is highest in the four neural tissues on the right of the chart.

021 2

UCSC Genome Browser @genomebrowser.bsky.social · 27/08/2026

We are excited to announce the gnomAD v4.1.1 and MPC tracks on the UCSC Genome Browser. This release updates gnomAD's variant and constraint tracks and adds new MPC tracks predicting missense deleteriousness. Learn more at: genome.ucsc.edu/gold...

010 1

UCSC Genome Browser @genomebrowser.bsky.social · 17/08/2026

ENCODE GRAMMAR is now on the UCSC Genome Browser! 🧬 Base-resolution deep learning predictions, sequence contribution scores & motif instances (BPNet, ChromBPNet, ProCapNet, ReporterNet) across thousands of ENCODE experiments. Explore on hg38: genome.ucsc.edu/s/Lo...

UCSC Genome Browser view on human genome hg38 at chr8:127,898,412-127,899,647, showing the ENCODE GRAMMAR track hub. Ten stacked blue signal tracks display ChromBPNet observed and predicted DNase-seq and ATAC-seq signal for the K562 cell line, plus bias-corrected predicted profiles that rise to a sharp central peak, and base-resolution sequence contribution scores. At the bottom, a row of colored blocks marks predicted transcription factor motif instances (including GATA, KLF-SP, ELF-GABP, and FOS-JUN) directly beneath the peak.

0114 11

UCSC Genome Browser @genomebrowser.bsky.social · 23/07/2026

We are excited to announce the ENCODE4 data collection on the UCSC Genome Browser for hg38 and mm10. This release consists of two major components: the ENCODE Registry of cCREs and the new ENCODE4 Regulation container. Learn more at: bit.ly/Encode4Release

121 2

UCSC Genome Browser @genomebrowser.bsky.social · 17/07/2026

🧬 New: Long-read Structural Variants tracks for human (hg38 & T2T-CHM13/hs1). SV callsets from 14 long-read studies merged into ~2.3M sites, so you can compare structural variation across populations. See our news to learn more: bit.ly/UCSClong-readSVs

010 1

UCSC Genome Browser @genomebrowser.bsky.social · 01/07/2026

Which variants are common in your ancestry but rare globally? New on hg38: SNV Frequencies. Over 1.2 billion variants pooled from ~1.5M people across 30+ cohorts, including population references, biobanks, and disease case/control studies. Learn more: bit.ly/GBsnvFrequencies

rs4986893, a CYP2C19 stop-gained variant common in East Asian populations. The mouseover ranks ToMMo Japan, KOVA Korea, and WBBC China at the top, well above the 1.6% pooled background AF.

001 1

UCSC Genome Browser @genomebrowser.bsky.social · 02/06/2026

New on the UCSC Genome Browser (hg38): MPRA tracks. MPRA Base catalogs 40,938 experimentally tested enhancer elements across 6 cell lines; MPRAVarDB scores 239,028 allelic variant effects from 18 studies. Great for GWAS fine-mapping. Learn more: bit.ly/4a8KDPD

MPRA Base elements and MPRAVarDB variants at the TERT promoter (chr5, GRCh38/hg38). MPRA Base (top) shows reporter activity for melanoma risk variants tested in HEK293FT and UACC903 cells (Choi et al., 2020). MPRAVarDB (bottom) highlights high-confidence allelic effects from saturation mutagenesis of the TERT promoter (Kircher et al., 2019).

000 0

UCSC Genome Browser @genomebrowser.bsky.social · 01/05/2026

Two new variant-impact tracks from Illumina on the UCSC Genome Browser: PrimateAI-3D scores every coding missense variant (hg38/hg19); PromoterAI scores every non-coding substitution near transcription start sites (hg38). See our news for more: bit.ly/illuminaTracks

PrimateAI-3D and PromoterAI at the start of HBB on hg38 (chr11:5,226,883-5,227,212). PrimateAI-3D scores every coding missense variant as red (pathogenic) or blue (benign), while the four PromoterAI per-allele bigWig subtracks score every possible non-coding substitution in the 5′ UTR and proximal promoter just upstream of the HBB start codon.

010 1

UCSC Genome Browser @genomebrowser.bsky.social · 03/04/2026

New heatmap display mode for bigBed tracks in the UCSC Genome Browser! Visualize multi-sample quantitative data as color-coded grids directly in genomic context, great for variant effects, expression & methylation. See our docs & try it out: bit.ly/ucscGBheatmap

Heatmap display in the UCSC Genome Browser

031 3

UCSC Genome Browser @genomebrowser.bsky.social · 17/03/2026

The supertrack configuration page has new controls for track visibility. "Apply visibility" buttons set visibility across visible or all tracks, Hide/Dense/Squish/Pack/Full buttons replace dropdowns, folder icons indicate container tracks. More info: genome.ucsc.edu/gold...

010 1

UCSC Genome Browser @genomebrowser.bsky.social · 17/03/2026

We are excited to announce the release of the Human Methylation Atlas Summary and Signals tracks for hg38 and hg19. The tracks display genome-wide DNA methylation profiles across 39 primary human cell types from 205 healthy tissue samples. Learn more at bit.ly/humanMethylat...

032 3

UCSC Genome Browser @genomebrowser.bsky.social · 25/02/2026

New Recent Genomes & Connected Hub Assemblies lists on the Gateway page, plus genome search across more tools. Recent Genomes also appears in the blue bar under Genomes. Species Tree now hidden by default (click “Show species tree” to view). More info at genome.ucsc.edu/gold...

010 1

UCSC Genome Browser @genomebrowser.bsky.social · 05/02/2026

We are happy to announce the recount3 tracks for hg38 and mm10: uniformly processed RNA-seq data from multiple studies, featuring intron data, split read counts, and splice junction motifs for cross-study comparisons and meta-analyses. Learn more at: bit.ly/recount3_track

021 2

UCSC Genome Browser @genomebrowser.bsky.social · 15/01/2026

We are proud to announce a new ENCODE Registry of cCREs (candidate Cis-Regulatory Elements) track for hg38 as described in Moore et al., Nature 2026. See our news for more: bit.ly/ucscENCODE4cCREs

184 8

UCSC Genome Browser @genomebrowser.bsky.social · 23/12/2025

We are pleased to announce the release of the EVA SNP Release 8 tracks, now available for 41 assemblies and covering 945 million variants. Learn more at genome.ucsc.e...

031 3

UCSC Genome Browser @genomebrowser.bsky.social · 03/12/2025

New gnomAD Missense Deleteriousness Prediction by Constraint (MPC) track for hg19. It shows a score that identifies missense-depleted regions using rare missense variation in 125,748 gnomAD v2.1.1 exomes. OE values: yellow=low, blue-purple=high. More at genome.ucsc.edu/gold...

000 0

UCSC Genome Browser @genomebrowser.bsky.social · 17/11/2025

We are pleased to announce Release 2 of the Varaico Variants track and a new Varaico Variants (suppl) track for hg38/hg19. The update brings the track to over 5.5M variants, and the new suppl track shows variants from supplementary files. Learn more at: genome.ucsc.edu/gold...

120 2

UCSC Genome Browser @genomebrowser.bsky.social · 17/10/2025

We are pleased to announce the hg38 SpliceAI Wildtype tracks. These tracks show the scores for the genome sequence itself, without variants, from predicted splice donor and splice acceptor sites. More at bit.ly/spliceAIWt

132 3

UCSC Genome Browser @genomebrowser.bsky.social · 25/09/2025

We are happy to announce the hg38 Panmask Easy 151b Regions track. It contains a set of sample-agnostic easy regions where short-read variant calling reaches high accuracy and can be used to filter variant calls for clinical or research samples. More at bit.ly/Panmask

010 1

UCSC Genome Browser @genomebrowser.bsky.social · 25/09/2025

We are excited to announce the release of the CoLoRSdb small and structural variant tracks for the human assemblies GRCh38/hg38 and CHM13/hs1. Learn more about this release at: genome.ucsc.edu/gold...

010 1

UCSC Genome Browser @genomebrowser.bsky.social · 19/09/2025

We are pleased to announce the release of the Developmental Disorders Genotype-to-Phenotype (DDG2P) track for hg19 and hg38. The DDG2P track displays genes associated with severe developmental disorders. Learn more at: genome.ucsc.edu/gold...

084 8

UCSC Genome Browser @genomebrowser.bsky.social · 21/08/2025

We are excited to announce the release of the MaveDB Experiment Heatmaps and Alignment track for hg38. Each heatmap shows the results of many small substitutions that were tested within a gene to examine their functional consequences. Learn more at: bit.ly/4lCIlLq

064 6

UCSC Genome Browser @genomebrowser.bsky.social · 13/08/2025

New Capture long-seq (CLS) long-read lncRNAs tracks are available for hg38 and mm10. These tracks represent the results of targeted long-read RNA sequencing aimed at identifying lowly expressed lncRNAs. See our news for more: bit.ly/CLSlongRead

010 1

UCSC Genome Browser @genomebrowser.bsky.social · 09/08/2025

We are pleased to announce new PanelApp Australia tracks for hg38/hg19 in the PanelApp composite track. These display expert, crowdsourced diagnostic disease panels for genes, CNVs, and STRs, with data distinct from the Genomics England PanelApp. More at bit.ly/PanelAppAustr...

010 1

UCSC Genome Browser @genomebrowser.bsky.social · 31/07/2025

We’re excited to announce support for bedMethyl and bigMethyl, new track formats for visualizing base-resolution DNA methylation from bisulfite sequencing or similar methods at single-base resolution across the genome in the UCSC Genome Browser. More info: genome.ucsc.edu/gold...

052 5

UCSC Genome Browser @genomebrowser.bsky.social · 29/07/2025

We’re adding two new UI features to the Genome Browser: a gear icon in the grey bar and an "X" to quickly remove tracks. We’d love your feedback—thanks for helping us improve! 🔗 forms.gle/s2QnMrbEYu...

063 6

UCSC Genome Browser @genomebrowser.bsky.social · 16/07/2025

New ENCODE4 long-read RNA-seq transcripts track for hg38 and mm10. Triplets (e.g. [1,1,3]) indicate start site, exon combination, and stop site for each transcript. Enrichment scores show how these change across tissue and cell line samples. Read more: genome.ucsc.edu/gold...

0267 26

UCSC Genome Browser @genomebrowser.bsky.social · 15/07/2025

We have two new pathogenicity prediction score tracks available in our Deleteriousness Predictions super track: MCAP and MutScore! Both are aimed at interpreting the pathogenicity of variants in a clinical setting. See our news for more: bit.ly/UCSCmutScoreMCAP

110 1

UCSC Genome Browser @genomebrowser.bsky.social · 07/07/2025

We turn 25 today! July 7th marks the 25th anniversary of the human genome going online and the start of the UCSC Genome Browser. Then vs. now, we have 165k monthly visitors, and our codebase is over three million lines of code. See our news for more: bit.ly/genomeBrowser...

03714 37

UCSC Genome Browser @genomebrowser.bsky.social · 26/06/2025

We have a new training page with updated tutorials covering our most popular tools. Each includes an annotated screenshot, guided walkthroughs, and an interactive click-through tutorial. See our news for more: bit.ly/genomeBrowser...

035 5

UCSC Genome Browser @genomebrowser.bsky.social · 12/06/2025

We are happy to announce the release of the EVA SNP Release 7 tracks, now available for 40 assemblies and covering nearly 910 million variants. Learn more at genome.ucsc.e....

020 2

UCSC Genome Browser @genomebrowser.bsky.social · 25/05/2025

Are you at #eshg2025 ? Visit us at booth 226! We will also be co-presenting a workshop on Monday, 5/26, with @ensembl at 14:15.

030 3

UCSC Genome Browser @genomebrowser.bsky.social · 22/05/2025

We are excited to announce the release of the Varaico tracks for human assemblies hg38 and hg19. Varaico stands for "Variation Research Advancing Insight in Complex Organisms". Varaico was created using literature mining, similar to AVADA. Learn more at: genome.ucsc.edu/gold...

020 2

UCSC Genome Browser @genomebrowser.bsky.social · 16/05/2025

The pext track is also present in our new Exon Relevance RTS, which can assist in variant interpretation by evaluating if the variant is present in an exon required for the gene product's function. See our news for more: bit.ly/ExonRelevance...

010 1

UCSC Genome Browser @genomebrowser.bsky.social · 16/05/2025

We have a new Recommended Track Set (RTS), Exon Relevance, and a new track, gnomAD Proportion Expression Across Transcript Scores (pext) for hg38. The pext track shows @gnomad-project.bsky.social data in combination with GTExV10 to compute a metric quantifying isoform expression for variants.

100 1

UCSC Genome Browser @genomebrowser.bsky.social · 01/04/2025

Announcing the new Pseudogenes track for hg38! The composite track contains pseudogene predictions and their corresponding parent genes, as identified by PseudoPipe. This release includes the Pseudogene Parents and Pseudogenes tracks. Learn more at genome.ucsc.edu/gold....

000 0

UCSC Genome Browser @genomebrowser.bsky.social · 12/03/2025

We are excited to share new AlphaMissense tracks for the hg38/hg19 human assemblies. AlphaMissense scores predict the pathogenicity of missense variants for all possible single amino acid substitutions in the human proteome. See our news for more: genome.ucsc.edu/gold...

000 0

UCSC Genome Browser @genomebrowser.bsky.social · 06/03/2025

We are pleased to announce the release of the MITOMAP track for hg38/hg19. MITOMAP is a human mitochondrial genome database. This release includes the MITOMAP Control and Coding Variants track & the MITOMAP Disease Mutations track. Learn more at genome.ucsc.edu/gold....

021 2

UCSC Genome Browser @genomebrowser.bsky.social · 05/03/2025

We are excited to announce the new Splicing Impact super track for hg38 and hg19. This super track includes AbSplice Scores, SpliceAI, and, for hg38, the new SpliceVarDB track. Learn more at genome.ucsc.e....

140 4

UCSC Genome Browser @genomebrowser.bsky.social · 03/03/2025

We are happy to announce the release of new highlight features for track hubs. Items can now be striped with a colored background to appear "highlighted" compared to the other items in the display. Learn more about this release at: genome.ucsc.edu/gold...

Items in the NCBI RefSeq Historical track for hg38 has all items that begin with "NM" are highlighted red.

001 1

UCSC Genome Browser @genomebrowser.bsky.social · 24/02/2025

We are excited to announce the release of the enGenome VarChat track for hg38 and hg19. This track uses AI to search papers for variants, providing information such as its gene, HGVS nomenclature, and dbSNP rsID. Learn more at genome.ucsc.edu/gold....

010 1

UCSC Genome Browser @genomebrowser.bsky.social · 20/02/2025

The Clinical Interpretation of Variants in Cancer (CIViC) track for hg19/GRCh37 and hg38/GRCh38 is now available. The details page for a feature will list diseases and therapies that have been associated with a genomic variant. Learn more at: genome.ucsc.edu/gold...

020 2