Crystal @gemzme.bsky.social · 19/09/2026David J Black's articles in Scottish Legal News give some background. Also, Wessely's wife had significant influence within RCGP and is now in the House of Lords. Other BPS were in core positions globally. 220
Crystal @gemzme.bsky.social · 19/09/2026MECFS has been reduced to idiopathic symptoms disconnected from the pathogens found in the original disease and syndrome, the pathology from the compensatory mechanisms, and the other conditions associated with the same pathogens and core disease components. www.encephalitis.info/effects-of-e...encephalitis.infoPhysical difficulties after encephalitis | Encephalitis International 011
Crystal @gemzme.bsky.social · 16/09/2026Worse, echoviruses are part of the EV-B species i.e. the hub of the original ME archetype. Thanks to the CFS debacle, people (including researchers) were redirected to HHVs and 'anything but EV-Bs' (if that sounds familiar, 'anything but COVID' excuses often come from the same people/organisations). 000
Crystal @gemzme.bsky.social · 15/09/2026And the difference between permanent/long-term disability support being downgraded to short-term support. Some policies don't allow long-term support for DSM conditions. 010
Crystal @gemzme.bsky.social · 15/09/2026Much will depend on what individual cases have. We need a range of treatments and we need to be particularly careful when choosing them. Treatment for one may kill another. 110
Crystal @gemzme.bsky.social · 15/09/2026ME was EV-B. www.sciencedirect.com/science/arti... pubmed.ncbi.nlm.nih.gov/33149253/ pmc.ncbi.nlm.nih.gov/articles/PMC... "levels of viral RNA were also increased under rapamycin treatment in a dose-dependent manner ( Figure 6D ). [suggesting] induction of autophagy promoted echovirus replication.pmc.ncbi.nlm.nih.govEchovirus induces autophagy to promote viral replication via regulating mTOR/ULK1 signaling pathwayAmong enteroviruses, echovirus can cause severe illnesses in neonates or infants, with high morbidity and mortality. Autophagy, a central component of host defense mechanisms, can function against div... 110
Crystal @gemzme.bsky.social · 15/09/2026They also are responsible for private health insurance disability payments. That's where the catch is. Reinsurance companies like Swiss: www.swissre.com/institute/co... www.theguardian.com/commentisfre... virology.ws/2017/08/07/t...swissre.comExpert forum Covid-19 interview: Michael Sharpe | Swiss ReExpert forum Covid-19 interview Heather Haq 120
Crystal @gemzme.bsky.social · 13/09/2026Yes, they didn't have any other EVs to test for. In 1934, they had only recently discovered the 2nd and 3rd polioviruses. The others were more than a decade away. Some had a characteristic muscle, CNS (& multi-system) pattern of distributed focal point necrosis. www.annualreviews.org/content/jour...annualreviews.orgMY ROLE IN THE DISCOVERY AND CLASSIFICATION OF THE ENTEROVIRUSESThe enteroviruses constitute one of the genera of the picornavirus family. The genus includes the polioviruses, the coxsackieviruses, and the echoviruses of humans, plus a number of enteroviruses of l... 000
Crystal @gemzme.bsky.social · 13/09/2026It can be the difference between lifelong financial support, time-limited support (e.g. 2 years), or no support. 110
Crystal @gemzme.bsky.social · 13/09/2026It does depend on more, of course. This aspect, though, is routinely missed and contributed to the pandemic mistake of using a Flu plan instead of a Nidovirales/Picornavirales/Pisoniviricetes plan. The class has existed since 2019 and is still mostly unknown. pmc.ncbi.nlm.nih.gov/articles/PMC...pmc.ncbi.nlm.nih.govCOVID-19 Shuts Doors to Flu but Keeps Them Open to RhinovirusesTen years have passed since the beginning of the H1N1pdm09 flu pandemic. No sooner had humanity recovered from its consequences than a new attack came—the COVID-19 pandemic. What happens to other resp... 000
Crystal @gemzme.bsky.social · 13/09/2026The wastewater results show multiple Pisoniviricetes members present concurrently. It's important to know their interactions, since some combinations can produce milder acute presentations and some exacerbate the damage. pubmed.ncbi.nlm.nih.gov/39907434/ pubmed.ncbi.nlm.nih.gov/14850636/pubmed.ncbi.nlm.nih.govSerology supportive of recent coxsackievirus B infection is correlated with multisystem inflammatory syndrome in children (MIS-C) - PubMedRarely, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) will lead to myocarditis associated with multisystem inflammatory syndrome in children (MIS-C). It remains unclear why MIS-C only targets specific children. To explore an association between coxsackievirus infections with MIS-C, we … 000
Crystal @gemzme.bsky.social · 13/09/2026Pisoniviricetes-induced diseases include all diseases induced by members of the class, a useful category for comparing class features, for example, how the 3C(L)pro contributes to each virus's pathologies, especially during coinfection. dholab.github.io/public_viz/0...dholab.github.ioLungfish Wastewater Monitoring Network 200
Crystal @gemzme.bsky.social · 13/09/2026I didn't say they did exactly the same things. I said that they were the categories that can be directly compared, rather than comparing different subsets within each. Just as a truck, a car and a motorcycle can be compared as complete vehicles, not truck axle vs car engine vs bike wheel. 000
Crystal @gemzme.bsky.social · 13/09/2026The common denominator of LC and the original ME archetype (CVB/EV-Bs) is Pisoniviricetes-induced disease, the ICTV 2025 virus class that both belong to. This disease category includes COVID, EVID, NOVID (NoV: norovirus), etc. EV-ME is part of EVID, as are the EV-induced cases of other diseases. 200
Crystal @gemzme.bsky.social · 12/09/2026By 1994, they were already ignoring the acute "myalgic" + "lymphoreticular" + "encephalomyelitis" phase of the disease, which subsides from the outbreak form over weeks or months to a more heterogeneous mix of sequelae that may include POTS, MCAS, fibromyalgia, Sjögrens and other overlapping terms. 022
Crystal @gemzme.bsky.social · 11/09/2026ME & ME/CFS have become idiopathic terms, having lost their associations with their specific pathogens over the last 4 decades. Without knowing what's there, it's impossible to know whether or how an intervention will affect a specific case. Suppress one, aggravate another, remove a support, etc. 010
Crystal @gemzme.bsky.social · 11/09/2026PEM was a poorly defined term, often described as feeling a bit off (possibly apt for the mild cases). The term has evolved beyond the original scope to describe what's seen in or experienced by cohorts and cases. 010
Crystal @gemzme.bsky.social · 11/09/2026Few, if any, organisations have institutional memory of ME. Mostly, they were influenced by CFS, subsequent and hybrid iterations. Modern usage of the ME splits between the "sounds more scientific" adoption to describe the diagnostically drifted and hybrid ME/CFS versions and diluted original ME. 000
Crystal @gemzme.bsky.social · 11/09/2026If you remove the EV-Bs, myalgic, lymphoreticular and encephalomyelitis/encephalomyelopathies from ME, you get idiopathic MCAS, dysautonomias, SFNs,…reactivated HHVs, and many other signs, symptoms, conditions typically induced by EV-B infection that can be reframed as fatigue, & CFS after 6 months. 010
Crystal @gemzme.bsky.social · 11/09/2026ME was inconvenient. Non-polio enterovirus-induced diseases were inconvenient when the world was eradicating poliovirus-induced paralysis & being forced to recognise the rise of HIV/AIDS. Far better to wait until the acute stages had subsided and the remainder could be framed as fatigue or hysteria. 110
Crystal @gemzme.bsky.social · 11/09/2026CFS was deliberately created to be different from ME: different causes, different timings, different criteria. Later conflation led to ME/CFS and CFS/ME. It's possible to have CFS (sequelae from the ME infection or comorbid from other causes) after ME, and CFS without ever having had ME. 030
Crystal @gemzme.bsky.social · 11/09/2026He's an author of the 1991 Oxford CFS criteria, 1994 Fukuda criteria & the 2010 FND admission that FND was coined to make conversion disorder a more palatable diagnosis. His 2018 tweet is consistent with the 1980s diagnostic shift from "outbreak" ME after (mostly) EV-Bs to idiopathic post-acute CFS. 160
Crystal @gemzme.bsky.social · 09/09/2026The effect on poliovirus: pubmed.ncbi.nlm.nih.gov/14850636/ pmc.ncbi.nlm.nih.gov/articles/PMC... link.springer.com/article/10.1... Has anyone looked at the correlation between the outbreaks of ME and contemporaneous EV outbreaks elsewhere in the literature ?pmc.ncbi.nlm.nih.govCHRONOLOGIC ASSOCIATION OF POLIOMYELITIS AND COXSACKIE VIRUS INFECTIONS 110
Crystal @gemzme.bsky.social · 05/05/2026The 1988 paper: www.acpjournals.org/doi/10.7326/...acpjournals.orgACP Journals 120
Crystal @gemzme.bsky.social · 02/05/2026And me-pedia.org/wiki/Autopsy...me-pedia.orgAutopsy in Myalgic Encephalomyelitis 020
Crystal @gemzme.bsky.social · 25/03/2026We also need pathologies included. The Wüst Lab biopsy findings are plausible contributors and similar to CVB pathology. 020
Crystal @gemzme.bsky.social · 15/09/2025It's not as different as it's portrayed and can be grouped as Pisoniviricetes-induced disease, Pisoniviricetes being the viral class that includes the orders Picornavirales and Nidovirales responsible for ME, COVID and many more diseases. What's missing is any serious attempt to deal with the class. 011
Crystal @gemzme.bsky.social · 15/09/2025Here Briggs and Levine describe subgroups seen in outbreaks. Other descriptions of the acute disease are described in ME outbreak literature and other research on the specific viruses involved. MECFS is a broader, more complicated mix of long-term outcomes. www.researchgate.net/publication/...researchgate.net(PDF) A Comparative Review of Systemic and Neurological Symptomatology in 12 Outbreaks Collectively Described as Chronic Fatigue Syndrome, Epidemic Neuromyasthenia, and Myalgic EncephalomyelitisPDF | Outbreaks of illnesses of unknown etiology typified by a chronic relapsing course of constitutional symptoms and nervous system involvement have... | Find, read and cite all the research you nee... 100
Crystal @gemzme.bsky.social · 15/09/2025The viruses mentioned in Ramsay's 1976 article are the founders of the phylum to which SARS2 belongs, Pisuviricota (picornavirus supergroup), and have similar infectious outcomes. This is why some of LC looks like ME. They can also occur together. Kordi 2025 pubmed.ncbi.nlm.nih.gov/39907434/pubmed.ncbi.nlm.nih.govSerology supportive of recent coxsackievirus B infection is correlated with multisystem inflammatory syndrome in children (MIS-C) - PubMedRarely, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) will lead to myocarditis associated with multisystem inflammatory syndrome in children (MIS-C). It remains unclear why MIS-C only t... 110
Crystal @gemzme.bsky.social · 15/09/2025The viruses mentioned in that article are a clue. Acheson (1959) wrote that ameningitic myalgic lympho-reticular encephalomyelopathy was a more accurate albeit less practicable name (ME being the practicable, abridged name). pubmed.ncbi.nlm.nih.gov/13637100/ www.meresearch.org.uk/research/oth...pubmed.ncbi.nlm.nih.govThe clinical syndrome variously called benign myalgic encephalomyelitis, Iceland disease and epidemic neuromyasthenia - PubMedThe clinical syndrome variously called benign myalgic encephalomyelitis, Iceland disease and epidemic neuromyasthenia 100
Crystal @gemzme.bsky.social · 08/09/2025Having a TYMES Trust involvement might make the works of Colby, Dowsett and related authorships relevant. pmc.ncbi.nlm.nih.gov/articles/PMC... www.tandfonline.com/doi/abs/10.1...pmc.ncbi.nlm.nih.govSpecial problems of children with myalgic encephalomyelitis/chronic fatigue syndrome and the enteroviral linkSince 1997, it has been known that myalgic encephalomyelitis/chronic fatigue syndrome constitutes the biggest cause of long‐term sickness leading to absence from school, in both staff and pupils. The ... 010
Crystal @gemzme.bsky.social · 29/08/2025This one had some help to get the "don't look for the virus" kind of complicated. Once you reassemble the pieces, it's even more complicated, but much easier to see how the pieces fit together. 000
Crystal @gemzme.bsky.social · 29/08/2025Outside of ME, there is also some some possibility that other pathogens may matter selectively according to location. pubmed.ncbi.nlm.nih.gov/38339075/pubmed.ncbi.nlm.nih.govT-Cell Receptor Sequences Identify Combined Coxsackievirus- Streptococci Infections as Triggers for Autoimmune Myocarditis and Coxsackievirus- Clostridia Infections for Type 1 Diabetes - PubMedRecent research suggests that T-cell receptor (TCR) sequences expanded during human immunodeficiency virus and SARS-CoV-2 infections unexpectedly mimic these viruses. The hypothesis tested here is tha... 000
Crystal @gemzme.bsky.social · 29/08/2025They are, but these affect people differently according to viral strain and the host's age & sex. Teen girls are in the first peak of ME. In utero affects development and survival even more than the neonatal myocarditis/sepsis, while men are at higher risk of dropping dead during strenuous exercise. 100
Crystal @gemzme.bsky.social · 29/08/2025The original holds true for many. Others come in at various points along the way. EV-Bs are the older, smaller cousins of SARS2 and just as nasty. 100
Crystal @gemzme.bsky.social · 29/08/2025The original ME was deemed most likely to be [Enterovirus betacoxsackie (EV-B), the current name for Coxsackie Bs, Echoviruses, and some others]. The modern variations of ME/CFS include EVs, HHVs, and other infections as well as non-infectious onsets. In both cases, it can involve metabolic effects. 110
Crystal @gemzme.bsky.social · 27/08/2025And as the polio receded, the ME became more visible until someone decided it shouldn't be. 010
Crystal @gemzme.bsky.social · 13/08/2025Yet, the definition is built into the name: long-term coronavirus-induced disease, a category, just as heart disease is. 010
Crystal @gemzme.bsky.social · 10/08/2025One interesting finding from elsewhere: journals.plos.org/plosbiology/... "we find that a single nucleotide polymorphism (SNP) in humans reduces CARD8’s ability to sense coronavirus 3CLpros and, instead, enables sensing of 3C proteases (3Cpro) from select picornaviruses."journals.plos.orgHost-specific sensing of coronaviruses and picornaviruses by the CARD8 inflammasomeThis study describes an innate immune mechanism for sensing coronavirus and picornavirus infection by detecting the activity of virus-encoded proteases. Genetic variants among mammalian hosts affect w... 000
Crystal @gemzme.bsky.social · 06/08/2025The latter are generally the people who created or were influenced by the Waddell-Aylward-Wessely-et al BPS models and see LC as PVFS/PIFS/CFS 2.0, just as they did the other Pisoniviricetes that induce ME, cardiovascular diseases, diabetes and many other conditions. 141
Crystal @gemzme.bsky.social · 06/08/2025Prior to the SARS-CoV-2 pandemic, the acronym COVID stood for coronavirus-induced disease (a category that included any and all coronavirus-induced diseases). Using this definition, Long Covid would include all the long-term coronavirus-induced diseases and their component signs, symptoms, etc. 010
Crystal @gemzme.bsky.social · 12/07/2025And then there's the problem of virologists et al using outdated taxonomies, missing the new(ish)ly found genetic similarities between pathogens and being mystified by SARS2 not acting like flu, but mysteriously developing multiple IACC/ME-like signs, symptoms, syndromes and diseases… picorna-like. 110
Crystal @gemzme.bsky.social · 14/06/2025It has its good days but most of what I've seen still has echoes from the wrong end of the 1980s. 000
Crystal @gemzme.bsky.social · 14/06/2025It reads like old, mild CFS material of the Fukuda era. Nary a pwME was described in this piece, and certainly none severe. 120
Crystal @gemzme.bsky.social · 11/03/2025The spike is the key to the room, not the room occupant, their pet or the contents of their luggage. There's too much focus on the key and not enough on the other factors. 2120
Crystal @gemzme.bsky.social · 10/03/2025I suspect that if the event were held somewhere other than the home of psychobehavioural attitudes, it would be. This is "sheep in wolf skin" going into the den of the leader of the pack to challenge the carnivorous. 020
Crystal @gemzme.bsky.social · 10/03/2025True, the UNSW members of COFFI may be too "busy" to attend, but it's important that they are not the only voice on campus. A UNSW professor is advertising the event in X/Twitter. 000
Crystal @gemzme.bsky.social · 10/03/2025I've not seen much of that data. Have seen some of the prevalence reporting showing multiple Pisoniviricetes in play over the last 5 years. How many 3C(L) proteases, etc does one have to collect to be truly "healthy"? 010
