iiinova — where your digital self keeps evolving

Reposted by Gemma May

McManus Lab at CMU @mcmanuslabrna.bsky.social · 07/05/2026

Happy to announce publication of a collaboration between my group, Neelam Sen's lab and Alan Hinnebusch at NAR combining FACS-uORF (MPRA) and Ribo-seq to clarify how Ded1 enhances mRNA translation. Great team effort! academic.oup.com/nar/article/...

academic.oup.com

Suppression of upstream ORF translation is not a widespread mechanism of translational stimulation by yeast helicase Ded1

Abstract. Ded1 is an essential DEAD-box helicase in yeast that broadly stimulates translation initiation and is critical for messenger RNAs (mRNAs) with st

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Reposted by Gemma May

McManus Lab at CMU @mcmanuslabrna.bsky.social · 11/05/2026

Check out our new preprint www.biorxiv.org/content/10.6...)! Most human mRNAs recruit ribosomes by cap-dependent initiation (CDI). But during viral infection & cell stress, CDI gets inhibited. So how do mRNAs keep translating? Viruses use IRESes, but do human genes? (1/5) #RNA #virology #IRES

biorxiv.org

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Reposted by Gemma May

McManus Lab at CMU @mcmanuslabrna.bsky.social · 02/04/2026

Check out our new preprint on IRES studies (www.biorxiv.org/content/10.6...). We show a recently proposed IRES “toolbox” results in mRNA annotation errors and false-positive IRES activities. We provide an alternative set of robust approaches. (1/4)

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Reposted by Gemma May

bioRxiv Genomics @biorxiv-genomic.bsky.social · 01/04/2026

Evaluating the reliability of tools for mRNA annotation and IRES studies www.biorxiv.org/content/10.64898/20…

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Reposted by Gemma May

Vaughn Smider, MD, PhD @vvsmider.bsky.social · 17/03/2025

My story: I’m a single father and cancer researcher whose wife died of a rare cancer. Science and biomedical research is personal to me. Here is my op-ed in my hometown newspaper. Pls fwd. www.vindy.com/opinion/edit...

vindy.com

DOGE ends America’s golden age of biomedical research

Biomedical research impacts all of us. I became curious about how drugs work after my mom was diagnosed with rheumatoid arthritis when I was a small boy. She received “gold shots” as treatment, which ...

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