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Gustavo Della Flora Nunes

@gdfnunes.bsky.social

118 followers 128 following 12 posts

Postdoctoral researcher studying myelin and neuron-glia interactions @ethanhugheslab.bsky.social. PhD with Dr. Laura Feltri.

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Gustavo Della Flora Nunes @gdfnunes.bsky.social · 01/08/2026

Thank you very much, Laura!

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Gustavo Della Flora Nunes @gdfnunes.bsky.social · 01/08/2026

Thank you! And thank for all your support throughout my career and for this and other grants!

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Gustavo Della Flora Nunes @gdfnunes.bsky.social · 01/08/2026

Thank you very much!

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Gustavo Della Flora Nunes @gdfnunes.bsky.social · 01/08/2026

I’m deeply honored to be part of the amazing cohort of scientists awarded a 2026 @simonsfoundation.org Fellows-to-Faculty grant. I look forward to exploring how oligodendrocytes and myelin may impact developing circuits in autism, and I can’t wait to interact more with the autism community!

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Gustavo Della Flora Nunes @gdfnunes.bsky.social · 19/01/2025

Thank you very much!

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Gustavo Della Flora Nunes @gdfnunes.bsky.social · 19/01/2025

Thank you very much, Wendy!

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Gustavo Della Flora Nunes @gdfnunes.bsky.social · 18/01/2025

4. Myelin loss delayed neuronal responses to visual stimuli. Thyromimetic treatment recovered these responses when myelin levels were still below those of healthy controls. But, the level of regeneration needed is not a simple threshold, also likely depending on timing of repair

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Gustavo Della Flora Nunes @gdfnunes.bsky.social · 18/01/2025

3. A new thyromimetic developed by Autobahn Therapeutics resolved endogenous remyelination deficits by improving oligodendrocyte gain in the first 1.5 weeks of treatment. In comparison, at the tested doses, clemastine had a smaller and protracted effect

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Gustavo Della Flora Nunes @gdfnunes.bsky.social · 18/01/2025

2. The drive for remyelination is recent loss of oligodendrocytes, not a restoration of the original oligodendrocyte population. So, there may be un unknown factor released around the timing of oligodendrocyte loss to promote remyelination

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Gustavo Della Flora Nunes @gdfnunes.bsky.social · 18/01/2025

We used longitudinal in vivo 2P imaging and Neuropixels recordings in the cuprizone model to gain insights into important aspects of remyelination: 1. Endogenous remyelination is insufficient when demyelination is too severe and occurs too quickly

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Gustavo Della Flora Nunes @gdfnunes.bsky.social · 18/01/2025

Extremely happy to share our manuscript jointly authored by me and the amazing Lyndsay Osso! An awesome collaboration between the @ethanhugheslab.bsky.social , Dan Denman and Autobahn Therapeutics. www.nature.com/articles/s41... 🧵

nature.com

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Gustavo Della Flora Nunes @gdfnunes.bsky.social · 12/12/2024

Nice! Can you add me to the list?

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