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Gao Lab

@gao-lab.bsky.social

37 followers 49 following 7 posts

Exploring the genetic diversity of Earth's microbiome. Stanford Biochemistry | Run by lab members | gaolab.bio

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Gao Lab @gao-lab.bsky.social · 09/10/2026

This week, we tried to guess the number of MiSeq flow cells we’ve collected since starting the lab! Displayed: our expert lab guessers!! What would you have guessed?👀🥳

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Reposted by Gao Lab

Nature @nature.com · 05/10/2026

BREAKING: The Nobel Prize in Physiology or Medicine has been awarded to Karl Deisseroth, Peter Hegemann and Georg Nagel “for their discoveries concerning light-gated ion channels and optogenetics.” More to follow.

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Gao Lab @gao-lab.bsky.social · 23/09/2026

Hannah and Simone co-taught a crash course on cryoEM to the 1st year Stanford med students !

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Gao Lab @gao-lab.bsky.social · 15/09/2026

Congratulations to Pujuan on receiving the Katharine McCormick Advanced Postdoctoral Scholar Fellowship!! This fellowship supports exceptional postdocs pursuing faculty careers who have demonstrated a track record of uplifting women in science. We are so excited to see what’s next for you, Pujuan!

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Gao Lab @gao-lab.bsky.social · 04/08/2026

Two different structural solutions to the same sensing problem. Congrats to all who contributed (4/4)!🥳🧬

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Gao Lab @gao-lab.bsky.social · 04/08/2026

In contrast, Upx, despite sharing no sequence or structural homology with Avs2, is predicted to recognize phage terminase by binding unfolded terminase ATPase domains, via β-augmentation (3/4).

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Gao Lab @gao-lab.bsky.social · 04/08/2026

They solved a 2.3 Å cryo-EM structure of Avs2 bound to phage terminase, with an unexpected ATP molecule bridging the two proteins at their interface (2/4).

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Gao Lab @gao-lab.bsky.social · 04/08/2026

Congratulations to Simone (@simone-alma.bsky.social), Collin, and Max (@maxewilkinson.bsky.social) on their paper - out today - on terminase sensing by Avs2 and Upx (1/4)! www.nature.com/articles/s41...

nature.com

Phage terminase recognition by the bacterial immune sensors Avs2 and Upx - Nature Communications

Direct recognition of viral proteins is key to bacterial immunity. Here, Evans et al. uncover the mechanisms used by two distinct defense proteins to detect the phage DNA packaging motor mechanisms: b...

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Sofia Luengo-Woods @sluengo.bsky.social · 30/07/2026

We’re so excited to share our new paper, where we tackle the wealth of structural and functional diversity of anti-phage sensors across bacteria (1/6)

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Reposted by Gao Lab

Hyunbin @hyunbinlee0221.bsky.social · 29/07/2026

🦠🧬Immune recognition is far more universal than we thought! Our new Nature paper uncovers ≥ 90 families of bacterial immune receptors that senses conserved phage proteins—and reveals how Avs7 repurposes abundant, essential protein EF-Tu to assemble an antiviral immune complex.

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