Background: BTK and BCL2 represent key therapeutic targets in B-cell lymphomas, including marginal zone lymphoma (MZL). Here, we evaluated the novel BTK degrader BGB-16673, and the second-generation B...

AbstractBackground.. Alterations in chromatin-associated proteins contribute to the rewiring of transcriptional networks, promoting lymphomagenesis, disease progression, and resistance to therapies. T...

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Marginal zone lymphomas (MZLs) are a heterogeneous group of low-grade B-cell neoplasms classified into different entities by the current lymphoma classific

The disease we now call diffuse large B-cell lymphoma (DLBCL) has gone by the names of reticulum cell sarcoma, diffuse histiocytic lymphoma, and diffuse large cell lymphoma and included both lymphomas...

Diffuse large B-cell lymphoma (DLBCL) remains a challenging disease with limited therapeutic options beyond standard immunochemotherapy. ETS transcription factors, including SPIB and SPI1, are implica...

Marginal zone lymphoma (MZL) is an indolent yet incurable B-cell malignancy in which targeted agents such as BTK and PI3K inhibitors frequently fail due to resistance or toxicity. Antimicrobial peptid...

Bryostatin analogs are found to be accumulated in the nudibranch Antiopella cristata collected in Irish waters. These are found to be potent inhibitors of activated B-cells diffuse large B-cell lymph....

The best Elliott Smith songs reflect his ability to wring beauty out of life’s traumas. His prolific output still endures.

David Bowie's career reflects a rich evolution in music and persona, showcasing his vast influence across genres from rock to jazz.

Such is the consistency and variety of their extensive catalogue, it's almost impossible to make a definitive best Sonic Youth songs list.

Slash is one of the most exciting and versatile guitarists in the world, and these top ten riffs prove exactly why that's the case.

A look at the wah-wah pedal, its history and how Jimi Hendrix perfected its use in one of his best-known and best-loved songs.

Background: CXCR4 is a chemokine receptor frequently implicated in the pathogenesis and treatment resistance of B-cell lymphomas and other tumor types. Thus, CXCR4 targeting is explored using various ...

PURPOSEImproved outcomes are needed for patients with high-risk (HR) large B-cell lymphoma (LBCL) who have <50% chance of cure with first-line (1L) R-CHOP chemotherapy. Patients with high burden or...

Maintenance with a BTK inhibitor yielded significantly longer PFS than lenalidomide in newly diagnosed PCNSL.

Comprehensive Online Course on Oncology Research and Clinical Trials FROM 19 September 2025

The advent of chimeric antigen receptor (CAR) T-cell therapy has revolutionized the treatment landscape of relapsed/refractory large B-cell lymphoma (LBCL). After achieving regulatory approval in thi...

Background Despite significant therapeutic progress, many lymphoma subtypes remain difficult to manage due to resistance, relapse, and dose-limiting toxicity. Methods To elucidate the mechanism of...

Peripheral T-cell lymphoma (PTCL) is a rare and heterogeneous group of diseases, with over 30 subtypes according to the International Consensus Classification of Mature Lymphoid Neoplasms (ICC) and W....

Mantle cell lymphoma (MCL) is a B-cell malignancy characterized by t(11;14)(q13;q32) translocation and heterogeneous clinical behavior. Advances in risk stratification enabled the distinction of conv...

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Epcoritamab monotherapy led to long-term disease-free remissions in patients with relapsed/refractory large B-cell lymphoma who achieved complete response at 2 years.

We are working our way through the catalogue of The Clash and reflecting on a career charged with authenticity and ranking their albums in order of greatness

Il gruppo Porta Gottardo vorrebbe collegare le due località attraverso una serie di cabinovie. Mauro Pini: ‘Opportunità di sviluppo per l’Alta Leventina’

Zanubrutinib retained long-term efficacy as a frontline treatment in CLL/SLL harboring 17p deletions.

The Institute of Oncology Research (IOR) The IOR, affiliated with the Università della Svizzera italiana (USI), is located in a brand-new, high-tech research building that hosts more than 20 differ