iiinova — where your digital self keeps evolving

Reposted by Franjo Ivankovic, PhD

Cal Liao @calliao.bsky.social · 06/10/2026

Really excited to share the latest results from the Bipolar Exome (BipEx) consortium! We analyzed rare coding variation in 64,435 people with bipolar disorder and 168,101 controls across 22 countries, identifying 13 genes at exome-wide significance. 🧵 1/n www.medrxiv.org/content/10.6...

medrxiv.org

Rare coding variation implicates thirteen genes in bipolar disorder across 232,536 individuals from global populations

Bipolar disorder (BD) is highly heritable, yet the contribution of rare coding variation remains incompletely characterized. We analyzed sequencing data from 64,435 individuals with BD and 168,101 con...

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Franjo Ivankovic, PhD @franjo.us · 30/09/2026

I would count the return of hand-written letters in the plus column of post-AI world.

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Reposted by Franjo Ivankovic, PhD

Scott McGrath @smcgrath.phd · 28/09/2026

🧪 Conference hashtags and conversations were part of what made Science Twitter really interesting. @mariaa.bsky.social and @eugenevinitsky.bsky.social have made some significant improvements on that model over at lea.ac

lea.ac

Lea - A calmer Bluesky for researchers

A curated garden for researchers on the AT Protocol

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Franjo Ivankovic, PhD @franjo.us · 27/09/2026

Of course, this comes at a very convenient (sarcasm) time when the public trust in and respect of science and scientists is precipitously deteriorating. The question we must answer now is how do we survive the tidal wave that is hurling at us?!

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Franjo Ivankovic, PhD @franjo.us · 27/09/2026

After all, why train scientists for 10-15 years to do something an AI stack will be able to do in a couple of hours. And for far less money.

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Franjo Ivankovic, PhD @franjo.us · 27/09/2026

It's been only 3 years since the 1st LLM model is released, we already have something like this. I fear the scientist model as it existed this past couple of decades is effectively dead in less than 10 years.

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Franjo Ivankovic, PhD @franjo.us · 20/09/2026

Both camps commit to an essence and declare psychopathology to be more or less of it, with the symptom as its surface-level manifestation. But a single symptom is the meeting point of multiple processes, not the expression of one.

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Franjo Ivankovic, PhD @franjo.us · 20/09/2026

The pattern isn't coincidental: commit to one thing underneath, and continuity and process-primacy follow automatically. Both then check out empirically, which feels like confirmation of the entire system. The initial commitment thus seems to earn its keep, making it so hard to abandon.

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Franjo Ivankovic, PhD @franjo.us · 20/09/2026

Funnily enough, some 50 years later, Insel and the modern biomedicalists come to the same two conclusions, continuity of psychopathology and the primacy of the processes underlying a symptom, yet make a similar error of reduction, this time to neurocircuitry (RDoC).

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Franjo Ivankovic, PhD @franjo.us · 20/09/2026

Where they went wrong was reducing it all to one thing: a basic psychosocial process of adaptation to environment.

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Franjo Ivankovic, PhD @franjo.us · 20/09/2026

Menninger and other psychoanalysts of the mid-20th century had a right idea on two issues: 1. psychopathology is not discontinuous or discrete, and 2. processes underlying the symptom matter.

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Franjo Ivankovic, PhD @franjo.us · 19/09/2026

That's not how you're supposed to use the wheel, silly cat...

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Franjo Ivankovic, PhD @franjo.us · 19/09/2026

Nothing in psychopathology makes sense except in the light of consciousness.

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Franjo Ivankovic, PhD @franjo.us · 18/09/2026

If we want to prioritize learning, then we must reevaluate how we teach and evaluate knowledge and, crucially, how we conceptualize productivity. Anything else is beating a dead horse.

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Franjo Ivankovic, PhD @franjo.us · 18/09/2026

AI this, AI that... Academia needs to ask itself one simple question: should we prioritize productivity or learning?! If we want to prioritize productivity, then AI must be integrated at every level of academic work.

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Franjo Ivankovic, PhD @franjo.us · 21/06/2026

I tried getting my hands on a copy, but failed. :/

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Franjo Ivankovic, PhD @franjo.us · 15/02/2026

The DSM is Dead, Long Live the DSM open.substack.com/pub/exmente/...

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Franjo Ivankovic, PhD @franjo.us · 29/01/2026

I agree. She gave in way too easy, especially knowing what the Trump presidency would look like.

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Franjo Ivankovic, PhD @franjo.us · 29/01/2026

Dumb, and that's being nice. I'm pragmatic, not crazy.

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Franjo Ivankovic, PhD @franjo.us · 29/01/2026

I'm neither liberal nor centrist.

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Franjo Ivankovic, PhD @franjo.us · 29/01/2026

And you know what I did and did not see... How exactly?

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Franjo Ivankovic, PhD @franjo.us · 29/01/2026

Huh? What are you even talking about?

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Franjo Ivankovic, PhD @franjo.us · 29/01/2026

I can't wait to see what kind of movement will be built by warm and kind people like yourself, and how successful it will be.

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Franjo Ivankovic, PhD @franjo.us · 29/01/2026

And how did that help anything?! They'll just be replaced by MAGA syncopats who will make it all even worse. In fact, reasonable people resigning is what they're counting on, because that leaves absolutely no resistance within the system.

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Franjo Ivankovic, PhD @franjo.us · 29/01/2026

Yeah, so we don't have a choice but to live in this here system. And we can either make it gradually bearable or just let it spin into an even bigger crapshoot than it already is. And it can always get worse.

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Franjo Ivankovic, PhD @franjo.us · 29/01/2026

Okay, who's gonna make them pay and when? Because from where I stand, the only thing that's happening is regular people and minorities you claim to care about are getting brutalized...

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Franjo Ivankovic, PhD @franjo.us · 29/01/2026

I feel like you overestimate how much I care about Kamala in particular vs. how much I'm dreading all the extra work that will have to be done only to undo the damage Trump's 2nd presidency is doing. Her loss literally just added to the already too laundry list of work...

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Franjo Ivankovic, PhD @franjo.us · 29/01/2026

You cannot go more left by removing yourself as a constituent of a major party. The reason the GOP went further right is to pander to their most loyal voter bloc. The most loyal Dem voter bloc are centrists and milquetoast libs, at the moment -- so that's whom they'll pander to.

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Franjo Ivankovic, PhD @franjo.us · 29/01/2026

How would she instruct them to do that while simultaneously not being aware of it? 🤔

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Franjo Ivankovic, PhD @franjo.us · 28/01/2026

>>A spokesperson for Harris was quoted in the article saying, "Senator Harris was shocked and troubled by the use of this argument. She looked into it and directed the department’s attorneys not to make that argument again."<< www.politifact.com/article/2019...

politifact.com

Were attacks on Kamala Harris’ record on target?

Sen. Kamala Harris’ record as a prosecutor in California came under sharp criticism at last night’s Democratic president

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Franjo Ivankovic, PhD @franjo.us · 28/01/2026

Also, if you read the article, it was not her making that argument, it was one of many attorneys in her department at the time, who, and I know this will come as a shocker, do not run every single argument they would ever present in court by her.

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Franjo Ivankovic, PhD @franjo.us · 28/01/2026

I did specifically say her voting record (in the Senate), not her AG job... Besides, worry about Bernie striking down the pediatric cancer funding bill just a couple of months ago.

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Franjo Ivankovic, PhD @franjo.us · 28/01/2026

Tell that to conservatives, who party line voted from the center- to far-right party. There are only two (electable) parties in the US, you can either participate and help shift the Overton window OR not participate and help shift the Overton window. And not choosing to participate is still a choice

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Franjo Ivankovic, PhD @franjo.us · 28/01/2026

You can always look up her voting record while she was a senator, you know that, right? She has a more progressive voting record than Bernie Sanders.

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Franjo Ivankovic, PhD @franjo.us · 04/01/2026

Trade paperbacks, if possible.

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Franjo Ivankovic, PhD @franjo.us · 03/01/2026

It was a good year in the hobby realm, at least.

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Reposted by Franjo Ivankovic, PhD

Ewan Birney @ewanbirney.bsky.social · 28/10/2025

Depressingly there is more talk in many places about race and ethnicity, and how certain visible characteristics - most obviously skin colour - define people. This is squarely in the identity discussion; ie, people defining their own identity via these visible characteristics

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Franjo Ivankovic, PhD @franjo.us · 29/10/2025

As far as plots go, this one is harrowing... From: Greenspoon, L., Ramot, N., Moran, U. et al. The global biomass of mammals since 1850. Nat Commun 16, 8338 (2025). doi.org/10.1038/s414...

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Franjo Ivankovic, PhD @franjo.us · 28/10/2025

ASF and the Broad Institute are collecting data to demonstrate the effects of these cuts. If you're an early-career researcher, we want to hear from you. Please take this survey and help us advocate for restored funding and support. Click here: redcap.partners.org/redcap/surve...

redcap.partners.org

Impacts of the Recent Decisions of the New Administration

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Franjo Ivankovic, PhD @franjo.us · 28/10/2025

In addition to job insecurity and loss of support for scientific research, these cuts have the potential to affect longer-term career plans, trajectories, plans, potential breakthroughs, not to mention effects on mental health.

redcap.partners.org

Impacts of the Recent Decisions of the New Administration

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Franjo Ivankovic, PhD @franjo.us · 28/10/2025

Recent funding cuts have affected all levels of science, but as we learned from the effects of the pandemic, early career researchers are likely to be the most vulnerable.

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Franjo Ivankovic, PhD @franjo.us · 09/10/2025

Stock prices 📈📈📈📈📈📈📈📈📈

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Franjo Ivankovic, PhD @franjo.us · 14/08/2025

I mean you could argue labs could use sundry funds to cover it, but they are hanging onto those for dear life right now because they might have to use them to pay salaries in the current climate. It's not just this data repo that lost the funding.

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Franjo Ivankovic, PhD @franjo.us · 14/08/2025

Labs are not for profit organizations, they don't have some magical money waiting around, unless they specifically asked for it when they applied for the grants that fund them.

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