iiinova — where your digital self keeps evolving

Leibniz-Forschungsinstitut für Molekulare Pharmakologie (FMP) @fmpberlin.bsky.social · 08/10/2026

Integrated structural biology: AG Lange determined the cryo-EM structure of the mechanosensitive channel MscL from E. coli in nanodiscs. At the same time they determined its dynamics in liposomes using solid-state NMR. Read more here: www.science.org/doi/10.1126/...

031

Leibniz-Forschungsinstitut für Molekulare Pharmakologie (FMP) @fmpberlin.bsky.social · 02/10/2026

This month's scientific image: "In a slice full of neurons, I found you." A human brain slice, fixated in 4% PFA, stained with DAPI, Streptavidin and Parvalbumin -captured by Eleni Tapp from the @noalipstein.bsky.social lab

020

Leibniz-Forschungsinstitut für Molekulare Pharmakologie (FMP) @fmpberlin.bsky.social · 29/09/2026

🔬 Two PhD positions in Biophysics/Structural Biology at FMP Berlin! The Research Unit Molecular Biophysics at the Leibniz-Forschungsinstitut für Molekulare Pharmakologie (FMP), led by Adam Lange, is looking for two PhD students. Applications are open until November, 30.

033

Leibniz-Forschungsinstitut für Molekulare Pharmakologie (FMP) @fmpberlin.bsky.social · 29/09/2026

Christian Hackenberger vom Leibniz-FMP gehört zu den „100 wichtigsten Köpfen der Wissenschaft“ des Tagesspiegels. Mit seiner Forschung zur Chemischen Biologie arbeitet er an Ansätzen für die Krebstherapie und hat das Unternehmen Tubulis mitgegründet. Zum Artikel: www.tagesspiegel.de/wissen/sie-h...

050

Leibniz-Forschungsinstitut für Molekulare Pharmakologie (FMP) @fmpberlin.bsky.social · 20/08/2026

New paper from the Lange group – together with colleagues from the groups Sun, Roderer, and Schmieder: Integrated structural biology reveals binding mode of scorpion toxin to Ca²⁺-gated K⁺ channel. Out now in Nature Communications: www.nature.com/articles/s41...

042

Leibniz-Forschungsinstitut für Molekulare Pharmakologie (FMP) @fmpberlin.bsky.social · 12/08/2026

August’s Scientific Picture of the Month is a joint effort from the Schmieder, Milles and broichhagenj.bsky.social labs: May the fluorescence be with you, young scientist ⚔️ Fluoride substitution enables fluorescence, while ¹⁹F NMR provides kinetic insights.

032

Leibniz-Forschungsinstitut für Molekulare Pharmakologie (FMP) @fmpberlin.bsky.social · 03/07/2026

Our scientific image of the month: Follow your heart - said no neuron ever 🫶 Thank you for providing this beautiful picture, Pia Venneker from the lab of @noalipstein.bsky.social

030

Leibniz-Forschungsinstitut für Molekulare Pharmakologie (FMP) @fmpberlin.bsky.social · 10/04/2026

Snowflakes in a flask: Jamie Isern (Fiedler lab) shows us crystals of a protected myp-inositol derivative that bloom in a glass flask after purification. This molecule is a key building block in the synthesis of inositol polyphosphate probes, used to study cellular signaling pathways.

010

Leibniz-Forschungsinstitut für Molekulare Pharmakologie (FMP) @fmpberlin.bsky.social · 04/03/2026

Aluminium - a study in structure. Enjoy this month's scientific picture from Stephanie Wendt (Technical Services).

010

Leibniz-Forschungsinstitut für Molekulare Pharmakologie (FMP) @fmpberlin.bsky.social · 02/03/2026

Congrats to Milena Roth on receiving the Master’s Prize of the German Society for Biochemistry and Molecular Biology! 🎉 Her outstanding thesis in @agatawitkowska.bsky.social group at FMP uncovered new insights into neuronal protein–membrane interactions.

061

Leibniz-Forschungsinstitut für Molekulare Pharmakologie (FMP) @fmpberlin.bsky.social · 02/02/2026

Scientific picture of the month by Pia Venneker (Lipstein lab): An elegant mix of stardust, nervous breakdown, and fluorescent spaghetti – hippocampal neurons with astrocytes, glowing nuclei, neuron markers and dendrites. 💥

000

Leibniz-Forschungsinstitut für Molekulare Pharmakologie (FMP) @fmpberlin.bsky.social · 30/01/2026

Exciting discovery! AG Lange and the FMP Chemical Biology Section at FMP identified selective inhibitors of intramembrane rhomboid proteases and revealed their modes of action.Full paper: onlinelibrary.wiley.com/doi/10.1002/... Picture: Created in BioRender. Bohg, C. (2026) biorender.com/vi9hi4f

021

Leibniz-Forschungsinstitut für Molekulare Pharmakologie (FMP) @fmpberlin.bsky.social · 13/01/2026

Cold Snow, warm sun and bright ideas: The first scientific picture of the New Year, captured by Franziska Ringleb (FMP Directorate).

020

Leibniz-Forschungsinstitut für Molekulare Pharmakologie (FMP) @fmpberlin.bsky.social · 03/12/2025

New in PNAS: Tight junctions tune kidney Ca2+ flow. Using high‑res imaging, CLDN14 swaps in for CLDN16, breaks the CLDN16/19 pore, and lowers Ca2+ reabsorption. Read: www.pnas.org/doi/10.1073/...

020

Leibniz-Forschungsinstitut für Molekulare Pharmakologie (FMP) @fmpberlin.bsky.social · 04/11/2025

May the (icy) force be with you ⚔️: This month's scientific picture comes from Abhirup Majumdar (Fiedler lab). This ice sculpture was formed at the base of a flask during an exothermic reaction at low temperatures 🧊. Great contribution!

020

Leibniz-Forschungsinstitut für Molekulare Pharmakologie (FMP) @fmpberlin.bsky.social · 14/10/2025

Congrats to Sigrid Milles, junior group leader at @fmp-berlin.de on receiving a Boehringer Ingelheim Stiftung Exploration Grant! 🎉 Her team studies how flexible, intrinsically disordered proteins form condensates to control clathrin-mediated endocytosis — combining NMR, smFRET & live-cell work. 🧫🫧

072

Leibniz-Forschungsinstitut für Molekulare Pharmakologie (FMP) @fmpberlin.bsky.social · 10/10/2025

Our scientific picture of the month sets a spooky vibe 👻🎃 Thanks to the @broichhagenj.bsky.social lab for providing us with Chem o'lanterns

031

Leibniz-Forschungsinstitut für Molekulare Pharmakologie (FMP) @fmpberlin.bsky.social · 23/09/2025

Congrats to Volker Haucke, Director at the Leibniz-FMP on being awarded the Ernst Schering Prize 2025 for his pioneering work on the function of signaling lipids that control how cells respond to hormones, nutrients and messengers.

3174

Leibniz-Forschungsinstitut für Molekulare Pharmakologie (FMP) @fmpberlin.bsky.social · 01/09/2025

Daniel Roderer and his group revealed the first high-res structure of Fap2 from Fusobacterium nucleatum (cryo-EM/ET). Fap2 binds immune cells (TIGIT) and colorectal cancer cells (Gal-GalNAc), showing how Fusobacteria colonize tumors and escape the immune system. www.nature.com/articles/s41...

020

Leibniz-Forschungsinstitut für Molekulare Pharmakologie (FMP) @fmpberlin.bsky.social · 14/08/2025

⏰Join us for the NMR Symposium, Nov 26–27, 2025, celebrating our new 1.2 GHz NMR spectrometer. To present a poster, send your abstract to NMR2025@fmp-berlin.de. Registrations are open until September 15th!

032

Leibniz-Forschungsinstitut für Molekulare Pharmakologie (FMP) @fmpberlin.bsky.social · 13/08/2025

Great cover art by @barthvanrossum.bsky.social for @jacs.acspublications.org: Influenza lifecycle showing M2’s roles, from activation in the low-pH endosome to viral uncoating, RNA release, and budding of new particles. View the article from the Lange lab here: pubs.acs.org/doi/10.1021/...

041

Leibniz-Forschungsinstitut für Molekulare Pharmakologie (FMP) @fmpberlin.bsky.social · 12/08/2025

Thanks to Yanwei Su from @volkerhaucke-lab.bsky.social, we have a new scientific image of the month: When morphology gets romantic 🫶- this is a U2OS cell overexpressing Sec61b (ER), stained with LAMP1 (lysosome) and DAPI (nuclei), to test lysosome–ER membrane contact sites.

083

Leibniz-Forschungsinstitut für Molekulare Pharmakologie (FMP) @fmpberlin.bsky.social · 04/07/2025

Our scientific image of the month July comes from Kati Fischermanns, @broichhagenj.bsky.social lab and is titled: "96 wells celebrate diversity" 🌈 It was created by scaling up tunable photocontrol over cells.

010

Leibniz-Forschungsinstitut für Molekulare Pharmakologie (FMP) @fmpberlin.bsky.social · 03/07/2025

With his exceptional work, Prof. Dr. Volker Haucke @volkerhaucke-lab.bsky.social has made it onto the #FallingWallsFoundation shortlist for the #ScienceBreakthrough of the Year 2025 in the #LifeSciences category. Congratulations!

010

Leibniz-Forschungsinstitut für Molekulare Pharmakologie (FMP) @fmpberlin.bsky.social · 02/07/2025

The #LongNightoftheSciences at @fmp-berlin.de was a great success: Many visitors took a look behind the scenes during the lab tours and were inspired by research. Thanks to everyone who came and see you around next year!

010

Leibniz-Forschungsinstitut für Molekulare Pharmakologie (FMP) @fmpberlin.bsky.social · 23/06/2025

New in @jacs.acspublications.org: New insights into the flu virus: The Lange lab used proton-detected solid-state NMR combined with the Sun lab's expertise in QM/MM+MD simulations to reveal how pH changes drive conformational shifts in the influenza A M2 channel. pubs.acs.org/doi/10.1021/...

031

Leibniz-Forschungsinstitut für Molekulare Pharmakologie (FMP) @fmpberlin.bsky.social · 18/03/2025

Congratulations to Dr. Christopher Schmied from @fmp-berlin.de for winning the #EinsteinFoundationAward. Together with Helena Jambor, the scientists were recognized for their project "PixelQuality," improving scientific image publication practices.

030

Leibniz-Forschungsinstitut für Molekulare Pharmakologie (FMP) @fmpberlin.bsky.social · 04/03/2025

This month's scientific image runs under the motto: "Can't see the forest for the trees". It's an overloaded negative stain EM of DIBMA-nanodiscs that didn't break and caused this crystalline aggregates 💠Thanks to @hsawczyc.bsky.social (Lange lab) for providing us with this gem!

000

Leibniz-Forschungsinstitut für Molekulare Pharmakologie (FMP) @fmpberlin.bsky.social · 11/02/2025

The scientific image of the month February shows two clawed frogs (Xenopus laevis) in their colorful underwater world 🐸 Big thanks to Martina Lauersdorf!

010

Leibniz-Forschungsinstitut für Molekulare Pharmakologie (FMP) @fmpberlin.bsky.social · 07/01/2025

Mariposa Microscopy 🦋First Scientific Image of 2025 from Maria Kowald (@LipsteinNoa Lab) and @TolgaSoykan (Lehmann Lab) shows a cerebellum slice from a mutant mouse that was stained with a SNAP-tag ligand, producing a beautiful butterfly-shaped signal. #Microscopy #Neuroscience

000

Leibniz-Forschungsinstitut für Molekulare Pharmakologie (FMP) @fmpberlin.bsky.social · 17/12/2024

Exciting news! @LeibnizFMP, @kieluni & @LeibnizLIV are starting new project, supported through "Leibniz CooperativeExcellence" program. Goal: Unravel mechanisms of K2P potassium channels – with potential new therapeutic approaches. t.co/1MeuAOMDXQ #LeibnizWGL @HanSun_lab

000

Leibniz-Forschungsinstitut für Molekulare Pharmakologie (FMP) @fmpberlin.bsky.social · 28/10/2024

🎃👻 Frappy Halloween! 👻🎃 A captivating glimpse into a “haunted” sample 👀✨ Big thanks to Marie Bieck and Arbesa Saiti from the #LehmannLab for testing the FRAP laser on one of our #microscopes! 🔬🧪 #ScienceHalloween #ImageOfTheMonth

000

Leibniz-Forschungsinstitut für Molekulare Pharmakologie (FMP) @fmpberlin.bsky.social · 02/09/2024

Let the peptide sunshine brighten your day! #Microscopic image shows the crystalline form of a #peptide that is part of occludin, a transmembrane #protein localized at tight junctions. 👏Scientific Image of the Month September by Roman Shobik (Lehmann lab).

000

Leibniz-Forschungsinstitut für Molekulare Pharmakologie (FMP) @fmpberlin.bsky.social · 26/07/2024

New interaction network discovered in endocytosis! Team around @MillesSigrid used NMR spectroscopy to study the 600 unstructured amino acids of AP180, revealing a new interaction network crucial for neuronal signaling &endocytosis. Published @NatureComms t.co/CcqapzEwi7

000

Leibniz-Forschungsinstitut für Molekulare Pharmakologie (FMP) @fmpberlin.bsky.social · 10/07/2024

New insights @HanSun_lab in collaboration with the Baukrowitz lab (University of Kiel), on phosphorylation of TREK channels could offer therapeutic potential for ischemia, epilepsy & depression, published @NatureComms More: t.co/7q8IoPX9PP Illustration: @BarthvanRossum

000

Leibniz-Forschungsinstitut für Molekulare Pharmakologie (FMP) @fmpberlin.bsky.social · 03/07/2024

Happy to start working with new 1,2 GHz NMR spectrometer - perfect for precise analysis of complex biological systems like #proteinstructures ! Peter Schmieder, @HanSun_lab , Adam Lange, @MillesSigrid , Hartmut Oschkinat Read more 👇 t.co/EIx0fWmHO5

000

Leibniz-Forschungsinstitut für Molekulare Pharmakologie (FMP) @fmpberlin.bsky.social · 20/06/2024

P5 technology from Christian Hackenberger group @PhosphorusFive enables a novel ADC now being tested in Phase I/IIa clinical trials.👏 Read more: t.co/ALmtOpxipl #Innovation #CancerTherapy #ADCs #basicresearch

000

Leibniz-Forschungsinstitut für Molekulare Pharmakologie (FMP) @fmpberlin.bsky.social · 18/06/2024

Hot outside? Check out this propeller for a fresh breeze! Fusobacterium nucleatum bacterium can attach to tumors & block immune cells. Image shows sticky proteins, interacting with an immune protein. #cryoEM Congrats to picture of the month @daniel_roderer & Luca Marongiu 👏

000

Leibniz-Forschungsinstitut für Molekulare Pharmakologie (FMP) @fmpberlin.bsky.social · 15/05/2024

Discover our first “Research Highlights” issue, showcasing latest research projects and sustainability at FMP. Enjoy the journey and gain new insights! English version👇 leibniz-fmp.de/newsroom/media-libra… #FMPResearch #Sustainability #Science

000

Leibniz-Forschungsinstitut für Molekulare Pharmakologie (FMP) @fmpberlin.bsky.social · 08/05/2024

🎉Picture of the month THE BLOODY COMPOUND by Katy Franke – AG Specker. Congrats! 👏 The Multi Channel Arm (MCA) pipettes 88 compounds into a 384-wellplate with an optical illusion. The dark-red compound seems to be in front of the other ones. #compounds #opticalillusion

000

Leibniz-Forschungsinstitut für Molekulare Pharmakologie (FMP) @fmpberlin.bsky.social · 22/04/2024

FMP Retreat 2024! 🎉A big thank you to everyone who joined us. It was fantastic to see all of you presenting your science, exchanging ideas, and getting to know one another. Your enthusiasm & contributions made this event a huge success! #FMPRetreat2024 #science📸Maria Jäpel

000

Leibniz-Forschungsinstitut für Molekulare Pharmakologie (FMP) @fmpberlin.bsky.social · 08/04/2024

🎉Congratulations to Fan Liu @theliulab for her recent awards in cross-linking mass spectrometry. The scientist is dedicated to better understanding the interactions between proteins at the cellular level. 👉https://leibniz-fmp.de/newsroom/news/detail/the-protein-expert 📸Jürgen Gross

000

Leibniz-Forschungsinstitut für Molekulare Pharmakologie (FMP) @fmpberlin.bsky.social · 02/04/2024

In #NMR, high-dimensional spectra can be acquired with partial sampling und subsequent reconstruction. Here, a 7% subset of all data is collected with the data points being non-uniformly distributed. 👏Congrats! Picture of the month by Florian Lindemann.

000

Leibniz-Forschungsinstitut für Molekulare Pharmakologie (FMP) @fmpberlin.bsky.social · 04/03/2024

Ions in your eyes - Picture of the month by Haoran Liu, @HanSun_lab Congrats! CNG channels allow Na+ (green), K+ (orange), Ca2+ (pink) flow for visual signals. When you see this, ions are flowing in your eyes. #IonChannels

000

Leibniz-Forschungsinstitut für Molekulare Pharmakologie (FMP) @fmpberlin.bsky.social · 08/02/2024

Inspiring Future Talk with CEO Domink Schumacher @Tubulis_GmbH, joint spin-off #FMP and @LMU_Muenchen. We're proud of our alumnus's achievements and grateful for sharing his journey & insights with us today. @phosphorusFive #ADC

000

Leibniz-Forschungsinstitut für Molekulare Pharmakologie (FMP) @fmpberlin.bsky.social · 02/02/2024

A strong woman defies all weathers 🌧️☀️ Picture of the Month by Heike Nikolenko – AG Lange. Congrats! Marthe Louise Vogt (1903-2003), scientist in pharmacology & neuroscience. Her groundbreaking work is honored by FMP, naming a building after her. Her Bust was unveiled 2022.

000

Leibniz-Forschungsinstitut für Molekulare Pharmakologie (FMP) @fmpberlin.bsky.social · 05/01/2024

Allosteric Activation in Potassium Channels: A drug-like molecule (yellow) limits C-terminal domain movement in TREK K+ channels, keeping them active. Findings from molecular dynamics simulations & electrophysiology. Picture of the month by Berke Türkaydin @HanSun_Lab Congrats!👏

000

Leibniz-Forschungsinstitut für Molekulare Pharmakologie (FMP) @fmpberlin.bsky.social · 22/12/2023

Season's Greetings! We wish you a wonderful holiday season and a great start to the upcoming year 2024! Thank you to everyone for your dedication and commitment to the FMP. We're grateful to have such an engaged and supportive scientific community! ✨

000