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Flavien Maucourt

@fmaucourt.bsky.social
66 followers 74 following 12 posts

Postdoctoral scholar at Lawrence Berkeley National Lab - Mutalik Lab. Phage-host interactions 🧬🧫🧪 He/Him LinkedIn: www.linkedin.com/in/flavien-maucour… Lab website: sites.google.com/lbl.gov/mutaliklab

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Reposted by Flavien Maucourt
Vivek Mutalik @vivekmutalik.bsky.social · 07/07/2026
A little sad to be missing #VOM2026 this year, but excited that our lab will still be well represented! 🎉 look out for @lucasmoriniere.bsky.social talk on 1000+ phage receptor predictions @fmaucourt.bsky.social poster on 70+ M smeg 😳phage screens using CRISPRi!! Cheering 🙌 them on from afar.
Poster abstract for VOM2026 by LucasPainter abstract for VOM2026 by Flavien
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Flavien Maucourt @fmaucourt.bsky.social · 21/05/2026
🎊 New Preprint from phagefoundry.org! Extremely happy to be part of this dream team! 🥰
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Reposted by Flavien Maucourt
Vivek Mutalik @vivekmutalik.bsky.social · 20/05/2026
🎊 New Preprint from phagefoundry.org ! Super excited to share our latest work on generating systematic phage-MDR P. aeruginosa interaction dataset & use of ML to predict phage susceptibility & phage cocktails from target genome sequences alone, w validations www.biorxiv.org/cgi/content/...
Systematic lytic host range characterization of 99 multidrug resistant Pseudomonas aeruginosa strains against 95 diverse double strand DNA phages, and AI/ML workflow to predict phage susceptibility and cocktail formulation based on genomic sequence alone.
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Reposted by Flavien Maucourt
Vivek Mutalik @vivekmutalik.bsky.social · 15/03/2026
New paper 🔔 Collaboration @sullivan-lab.bsky.social Marissa Gittrich led the work Klebsiella phage biology has focused almost entirely on capsulated strains, but capsule loss is the #1 resistance mechanism under phage predation. We used a naturally acapsular host to reveal the receptor landscape
Bacteriophage data on capsular Klebsiella bacteria barcoded library
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Flavien Maucourt @fmaucourt.bsky.social · 04/04/2026
🎉🥳 Preprint out 🥳🎉 Here is a work you will hear about for a while, lead by @lucasmoriniere.bsky.social in the @vivekmutalik.bsky.social's lab, we developed a workflow predicting phages receptor specifity and identifies RBP from genomes🤯 Very happy to be part of this adventure and this dream team 🥰
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Reposted by Flavien Maucourt
Vivek Mutalik @vivekmutalik.bsky.social · 03/04/2026
📣Huge preprint 🔔 Today we share something our group has been working toward for a long time, led by @lucasmoriniere.bsky.social We asked can we predict which receptor a phage targets from its genome sequence alone? For most phages, we couldn’t. So Lucas set out to do something I had only dreamed of.
Phage receptor prediction from genome sequencing alone. Bacterial receptor (blue) interacting with phage proteins (purple) is shown here
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Reposted by Flavien Maucourt
Dr. Katharine Dickson @metaomicsnerd.bsky.social · 07/01/2026
Hey #microsky #microbiome nerds! My collaborator Spencer Diamond is hiring a postdoc. You get to work with a lot of awesome microbiome data, including rumen microbiome data. Spencer's a great guy to work with and has taught me a lot. aprecruit.berkeley.edu/JPF05234
aprecruit.berkeley.edu
Postdoc - Microbiome - Innovative Genomics Institute
University of California, Berkeley is hiring. Apply now!
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Flavien Maucourt @fmaucourt.bsky.social · 02/12/2025
One more paper about phage-host interaction! www.biorxiv.org/content/10.1... #microsky #phagesky
biorxiv.org
Identifying Phage Host Receptors Using TraDIS
The growing antimicrobial resistance crisis has sparked renewed interest in using bacteriophage (phage) as a treatment for antibiotic-resistant infections. Phage are viruses that infect and often kill...
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Reposted by Flavien Maucourt
Ákos T Kovács @evolvedbiofilm.bsky.social · 27/11/2025
The host range of generalist and specialist phages in capsule-diverse Klebsiella hosts is driven by the evolvability of receptor-binding proteins @plosbiology.org from @pilardomingoc.bsky.social journals.plos.org/plosbiology/...
journals.plos.org
The host range of generalist and specialist phages in capsule-diverse Klebsiella hosts is driven by the evolvability of receptor-binding proteins
Capsule diversity limits phage host range by affecting RBP interactions in capsulated bacteria. This study shows that generalist phages evolve host range through RBP mutations and recombination, while...
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Reposted by Flavien Maucourt
Vivek Mutalik @vivekmutalik.bsky.social · 25/11/2025
#microsky 🎊🎉 High resolution lineage tracking tech from Robin & Adam D team from Berkeley! 🙌 We have used this for phage-host interaction work too in the forthcoming preprint.
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Flavien Maucourt @fmaucourt.bsky.social · 25/11/2025
Awesome work from the JBD lab! Genome-wide mutagenesis of phages is so interesting and helpful! www.biorxiv.org/content/10.1...
biorxiv.org
Bacteriophage genome-wide transposon mutagenesis
Bacteriophages have genomes that span a wide size range, are densely packed with coding sequences, and frequently encode genes of unknown function. Classical forward genetics has defined essential gen...
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Flavien Maucourt @fmaucourt.bsky.social · 24/11/2025
Hey phage lovers, What do you think of the phage-fantasy paintings I've made?
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Flavien Maucourt @fmaucourt.bsky.social · 24/11/2025
Wow! Terrific work!
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Flavien Maucourt @fmaucourt.bsky.social · 24/11/2025
📣 New preprint from phagefoundry.org team 📣 What are the phage-host interactions at a strain-level scale? Here Avery (Machine Learning) and Lucas (Experimental validation), share their new workflow to predict these interactions! I am very very grateful to work with these talented scientists!
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Flavien Maucourt @fmaucourt.bsky.social · 17/11/2025
What a nice paper!
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Flavien Maucourt @fmaucourt.bsky.social · 15/11/2025
www.science.org/doi/10.1126/... Beautiful paper describing the structure of E.coli bacteriophage Bas63!
science.org
Cryo-EM structure of bacteriophage Bas63 reveals structural conservation and diversity in the Felixounavirus genus
Cryo-EM of phage Bas63 reveals unique capsid and tail features, offering insights into Felixounavirus evolution and architecture.
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Reposted by Flavien Maucourt
Nature Biotechnology @natbiotech.nature.com · 12/08/2025
Targeted delivery of diverse biomolecules with engineered bacterial nanosyringes - @zhangf.bsky.social go.nature.com/46OFcoj
go.nature.com
Targeted delivery of diverse biomolecules with engineered bacterial nanosyringes - Nature Biotechnology
Ribonucleoproteins, nucleic acids and proteins are delivered into target cell types with nanosyringes.
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Reposted by Flavien Maucourt
Vivek Mutalik @vivekmutalik.bsky.social · 19/02/2025
This is really heartbreaking. So many, so many ppl suffering. 😢
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Reposted by Flavien Maucourt
Vivek Mutalik @vivekmutalik.bsky.social · 31/01/2025
NSF stopping salaries of postdocs and researchers is outrageous to say the least.
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Reposted by Flavien Maucourt
Vivek Mutalik @vivekmutalik.bsky.social · 28/01/2025
If you are in the USA, & want to do something worthwhile, call your elected official. This is damn 🚨 urgent. Do it today.
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Reposted by Flavien Maucourt
Rebecca Tarnopol @tarnopol.bsky.social · 20/12/2024
Excited to share the major work of my dissertation, out now in @currentbiology.bsky.social! We use Drosophila genetics to dissect the evolution of phage-derived toxins that were horizontally transferred to insects and now function as potent anti-parasitoid defenses (1/n): tinyurl.com/2k9ypyxr
sciencedirect.com
Experimental horizontal transfer of phage-derived genes to Drosophila confers innate immunity to parasitoids
Metazoan parasites have played a major role in shaping innate immunity in animals. Insect hosts and parasitoid wasps are excellent models for illumina…
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Reposted by Flavien Maucourt
Vivek Mutalik @vivekmutalik.bsky.social · 12/12/2024
Celebrating 🎉 holidays!
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