8/8 🌎 The bigger goal: precision pain control in nociceptive x mu-opioid circuits
Via our gene therapy to mimic morphine analgesia in the cortical circuits where it works, or harness descending placebo circuits to recruit midbrain endogenous opioids:
www.cell.com/neuron/fullt...
cell.com
Top-down control of the descending pain modulatory system drives multimodal placebo analgesia
Livrizzi, Chang-Weinberg, et al. identify a cortical-brainstem circuit that mediates
top-down control of pain during placebo analgesia and find that pain relief is gated
by endogenous opioids in the v...
