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You can find the link to an index of all Human Disease Model Reports flybase.org/lists/FBhh/ at the bottom of the QuickSearch Human Disease tab.

The FlyBase QuickSearch tool, open to the Human Disease tab. The tab is boxed in purple, while the link to the Human Disease Model index is circled in purple.

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There are >1600 Human Disease Model reports in FlyBase release FB2026_2, including 3 new HDMs: neurodegeneration with brain iron accumulation 5 flybase.org/reports/FBhh... Charcot-Marie-Tooth disease, axonal, type 2KK flybase.org/reports/FBhh... spinocerebellar ataxia 36 flybase.org/reports/FBhh...

A FlyBase hitlist including the three most recent Human DIsease Model Reports, neurodegeneration with brain iron accumulation 5; Charcot-Marie-Tooth disease, axonal, type 2KK; and spinocerebellar ataxia 36.

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You can find a link to this resource at the bottom of the QuickSearch 'GAL4 etc' tab

The FlyBase QuickSearch tool, opened to the GAL4 etc tab. The tab is boxed in purple, while the link to the Frequently Used GAL4 And Other Binary System Drivers resource is circled in purple.

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Also in FlyBase release FB2026_02: We have added 5 new drivers the Frequently Used GAL4 And Other Binary System Drivers resource flybase.org/GAL4/freq_us..., for a total of 387 drivers (most with images). This resource includes all GAL4's curated to 20+ papers, & lexA's curated to 15+ papers.

The FlyBase Frequently Used GAL4 and Other Binary System Drivers resource.

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FlyBase @flybase.bsky.social · 14/04/2026

& 72 signaling pathway reports flybase.org/lists/FBgg/s..., covering almost half (8,805 genes) of genome-mapped genes. You can find links to those indexes at the bottom of the relevant QuickSearch tabs.

The FlyBase QuickSearch tool, open to the Pathways tab. The tabs for Gene Groups, Complexes, and Pathways are boxed in purple The links to the indexes of Signalling Pathway reports and Metabolic Pathway reports, at the bottom of the tab, are also boxed in purple.

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FlyBase is seeking a new scientific curator at our Harvard University site. More information here: wiki.flybase.org/wiki/FlyBase...

Job Summary: The FlyBase project is an international collaboration of ~35 people distributed at several sites. This position is located at Harvard University, Cambridge, MA. All FlyBase staff work as a part of a team, in which curators and software engineers collaborate extensively. Each site has its own set of responsibilities. The Harvard FlyBase curators focus on curation/annotation of literature and high-throughput data pertaining to the Drosophila genome, transcriptome and proteome. FlyBase is constantly evolving, seeking both to improve and to expand its role within the Drosophila and wider scientific communities. The ideal applicant will be enthusiastic about participating in this process, bringing to the FlyBase group expertise and ideas concerning emerging directions in Drosophila biology and genomic/proteomic analysis. FlyBase is increasingly integrating artificial intelligence and machine learning tools into its curation workflows. The ideal candidate will be open-minded and enthusiastic about exploring AI-assisted approaches to biological data curation, including the use of large language models and AI coding assistants to accelerate and enhance curation tasks.

Job-Specific Responsibilities:
• Reading and abstracting of data from the current Drosophila literature, including its relationship to human disease, physical interactions, and gene expression
• Evaluating and validating AI generated annotations and curation suggestions, ensuring accuracy and biological relevance before integration into the database
• Using AI coding assistants (e.g. Claude Code, Codex, Gemini) to write scripts for data wrangling, format conversion, and routing curation tasks
• Providing feedback on AI model outputs and refining prompts to help improve automated curation pipelines and annotation quality over time
• Annotation and analysis of the Drosophila melanogaster genome, including gene models, mapped mutations, and regulatory features
• Together with curators and developers at other sites, interact with broad research community by answering helpmail and giving presentations and tutorials at research conferences
• Handling high-throughput datasets and associated metadata

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Susan Russo Gelbart accepted on behalf of FlyBase, and gave a rousing acceptance speech. #DROS26 #FlyForward

Susan Russo Gelbart accepted on behalf of FlyBase, and gave a rousing acceptance speech. #DROS26 #FlyForward

We appreciate that the award to the FlyBase Developer Team also recognized our support staff, including system administrators, administrative support, and program director.

The award to the FlyBase development team recognized Database developers Gil dos Santos, Ian Longden, Christopher J. Tabone, and Pinglei Zhou; Web developers Seth Campbell Victor Strelets, and Jim Thurmond; System administrators Kris Broll and Mark Zytkovicz; Administrative support Carol Sutherland and Jolen Seme; and Program director Susan Russo Gelbart.

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FlyBase @flybase.bsky.social · 12/03/2026

The 2026 Drosophila Community Service Award was presented earlier this month at #DROS26. This year's recipients were the REDFly Database Team and the FlyBase Developer Team, for their roles in the development of online repositories for the dissemination of Drosophila data.

The committee for the 2026 Drosophila Community Service Award for outstanding community service included Michelle Arbeitman (Co-chair), Cale Whitworth (Co-chair), Elizabeth Chen, Lydia Grmai, Amy Kiger, and Steven Marygold.

The Community Service Award recipients for 2026 were the REDFly Database Team and the FlyBase Developer team, for their roles in development of online repositories for the dissemination and analysis of Drosophila data.

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FlyBase release FB2026_01 is live! There is news about FlyBase funding. Go to the FlyBase homepage flybase.org for details.

FlyBase Funding Update – March 2026

The NHGRI funding for FlyBase has been restored for US-based FlyBase teams but the foreign subaward that supported the essential curation team at the University of Cambridge UK has been terminated. Therefore, the Cambridge UK team now requests annual contributions from fly labs to support curation of new data into FlyBase and the Alliance of Genome Resources. Without these annual contributions, FlyBase will become frozen in its current state and become progressively less useful.

Please visit the ‘Contribute to FlyBase’ wiki page for details of how to contribute.

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You can find a link to the Frequently Used GAL4 and Other Binary System Drivers resource at the bottom of the GAL4 etc QuickSearch tab.

The FlyBase QuickSearch tool, with the GAL4 etc tab and the link to the Frequently Used GAL4 and Other Binary System Drivers resource circled in pink.

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Updated in FB2025_05: We've added 9 new binary drivers to the Frequently Used GAL4 and Other Binary System Drivers resource flybase.org/GAL4/freq_us..., which documents all binary drivers curated to at least 15 (lexA) or 20 (GAL4) papers.

The Frequently Used GAL4 and Other System Binary Drivers resource filtered to show a newly added GAL4 driver.

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Links from FlyBase gene reports to FlyCyc pathway pages have been updated to reflect the latest associations. You can find those links in the Linkouts subsection of the External Crossrefereences and Linkouts section of Gene Reports.

A FlyBase Gene Report opened to the Linkouts subsection of the External Crossreferences and Linkouts section. The section heading and the FlyCyc Genes linkout have been boxed in bright pink.

FlyBase @flybase.bsky.social · 03/10/2025

We have recently updated FlyCyc biocyc.org/DMEL/organis..., the pathway-genome database representing Drosophila metabolism, to include enzymatic complexes as well as further improvements to enzyme annotations. #FlyCyc is now classed as a ‘Tier 1 Highly Curated Organism Database’.

Screenshot of the FlyCyc page at https://biocyc.org.

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Also #NewInFlyBase for FB2025_04: You can now access the @alliancegenome.bsky.social BLAST service directly from the FlyBase toolbar at the top of every FlyBase page. The path is Tools>Genomics Tools>Fly BLAST @ Alliance.

Screenshot of the path to find the Alliance of Genome Resources BLAST tool from a FlyBase page.

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FlyBase @flybase.bsky.social · 03/10/2025

There's an update on the state of FlyBase on the FlyBase.org front page. You can contribute to FlyBase at this link wiki.flybase.org/wiki/FlyBase... We express enormous gratitude to the people, labs, groups, and foundations who have already helped us. #FlyBase #Drosophila

FlyBase Update – October 2025
The termination of the NIH/NHGRI FlyBase grant has placed the long-term sustainability of FlyBase at risk. However, thanks to the generous support of several key individuals and institutions, we are pleased to announce that FlyBase will remain operational through the coming year. We extend our deepest gratitude to Yukiko Yamashita, Cassandra Extavour, Hugo Bellen, Thom Kaufman, the Genetics Society of America / Drosophila Board, the Bloomington Drosophila Stock Center, an anonymous donor and the Wellcome Trust. We are especially thankful for a generous gift from Seemay Chou, Jed McCaleb, and The Navigation Fund. We also greatly appreciate the continued support from the broader Drosophila community – your donations and service fees have been vital in helping us stay afloat. Special thanks also go to Jessica Manning for her tireless administrative work at Harvard, to Ruth Lehmann, Hugo Bellen, and Paul Sternberg for advice and efforts, and to the Board of the European Drosophila Society for all their efforts. Sadly, we must also share that several long-standing FlyBase team members have recently moved on. We are immensely grateful to Susan Russo-Gelbart, Lynn Crosby, Gil dos Santos, Kris Broll, Victoria Jenkins, and TyAnna Lovato for their many years of dedicated service and contributions to FlyBase. Looking ahead, ensuring FlyBase’s sustainability beyond the next year – and successfully integrating with the Alliance – will require new funding sources. We kindly ask for your continued support:
• European labs: Please consider contributing to the Cambridge, U.K. FlyBase group
• U.S. and other non-European labs: Please consider contributing to the U.S. FlyBase groups
• Both U.K. and U.S. FlyBase are working diligently to establish an invoicing system. We appreciate your continued patience.
For more information on how to support us, please visit: Contribute to FlyBase wiki page https://wiki.flybase.org/wiki/FlyBase:Contribute_to_FlyBase

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FlyBase @flybase.bsky.social · 26/09/2025

The results page, here shown for a BLASTX search shows a graphical overview at the top of the page. The hit list beneath looks like the BLAST output you know and love.

A graphical overview of the results of searching D. melanogaster protein databases with the Dll-RB transcript sequence.

The top hit resulting from searching D. melanogaster protein databases with the Dll-RB transcript sequence.

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FlyBase @flybase.bsky.social · 26/09/2025

or a search can be restricted to only Drosophila melanogaster databases. Once you enter a DNA or protein sequence in the search box, you'll be offered appropriate options for the nucleotide or protein databases you wish to search.

Screenshot of the Alliance Fly BLAST, showing the options to search D. melanogaster nucleotide and protein databases.

If you search a nucleotide database with a nucleotide sequence, you'll be offered TBLASTX and BLASTN options.

If you search a protein database with a nucleotide sequence, you'll be offered the BLASTX option.

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FlyBase @flybase.bsky.social · 26/09/2025

You can now search FlyBase and WormBase sequence data using the Alliance of Genome Resources BLAST server: www.alliancegenome.org/blastservice The Fly interface allows searching against many arthopods, #FlyBaseSkeetorial #AllianceGenomeSkeetorial #BLAST

Screenshot of the Alliance of Genome Resources BLAST page.

BLAST Service
Welcome to the BLAST Service for the Alliance of Genome Resources!

This BLAST service allows researchers to search genomic sequences using the Basic Local Alignment Search Tool (BLAST). By entering a sequence or query, users can find regions of similarity to various genomes within the Alliance. This service supports separate environments for each of the Model Organism Databases (MODs) as well as a unified environment for the Alliance. Results provide detailed alignments and annotations to aid in your research. Explore the various BLAST environments through the links below to find the one that best suits your research needs:

Fly BLAST
Worm BLAST

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FlyBase @flybase.bsky.social · 15/08/2025

Some of us at FlyBase found the contribution page a bit complicated, so we've made a video walk-through of the IU donation site. Note in particular, after you've chosen to donate 'in memory or honor' of someone, the tribute section has boxes for first and last names. Enter FlyBase in both.

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FlyBase @flybase.bsky.social · 22/05/2025

New FlyBook paper! Origin and establishment of the germline in Drosophila melanogaster academic.oup.com/genetics/art...

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FlyBase @flybase.bsky.social · 09/05/2025

You can still find interaction displays via the FlyBase Interactions Browser or the MIST tool.

FlyBase Gene Report Interactions section, with links to the FlyBase Interactions Browser and the MIST tool highlighted with a pink box.

FlyBase Allele Report Interactions section, with link to the FlyBase Interactions Browser highlighted with a pink box.

FlyBase Physical Interaction Report Interaction Network section, with link to the FlyBase Interactions Browser highlighted with a pink box.

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FlyBase @flybase.bsky.social · 28/04/2025

With the new release, FlyBase is now displaying a Bluesky social media feed on our homepage.

The Bluesky social media feed on the FlyBase hompage, found directly under the External Resources sidebar on the left side of the page.

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FlyBase @flybase.bsky.social · 28/04/2025

As with other interactive tables, users can customize the 'Members' table by reordering or filtering columns, or filtering which columns to display.

Interactive table showing the genes comprising the SWR1 complex.

The Members table for the SWR1 complex. The 'Other Gene Groups' column has been dragged left so that it is now between the 'Also Known As' and 'Source Material for Membership' columns.

The Members table for the SWR1 complex. The text string 'Arp' has been entered in the "Also Known As" text box, so that the table is now limited to showing genes for which 'Arp*' is a synonym.

The Members table for the SWR1 complex with the 'Show/Hide Columns' menu opened. It's possible to choose to display or hide columns from a menu of menu of gene-associated data and reagents including Symbol, Name, Also Known As, number of Research References, Antibody, Disease Models (potential or experimental), Alleles, Transgenic constructs, Human Orthologs, Testis-Specificity Index, GO Molecular Function, EC Enzyme Name, Pathways, Cytogenetic map location. Source Material for Membership, and Other Gene Groups.

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FlyBase @flybase.bsky.social · 06/03/2025

The Fly Lab List is public wiki.flybase.org/wiki/FlyBase..., and there's link to sign one's lab up right on the page (just above the interactive map).

Screenshot of the FlyBase Fly Lab List, with the link to add a lab highlighted with a purple box.

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FlyBase @flybase.bsky.social · 21/02/2025

Outreach funding opportunity, sponsored by the Fly Board: Non-profit programs anywhere in the world that introduce middle school, high school, or college students to Drosophila research are eligible to apply! The number of students that this funding would impact and financial need will be considered

Please provide the following to Jessica.Treisman@med.nyu.edu:
Name and contact information
A 1-page summary of the program, including an explanation of how the program would broaden participation among Drosophila scientists
Budget justification of up to $2000

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FlyBase @flybase.bsky.social · 24/01/2025

Meet the recipients of the Fall 2024 DeLill Nasser Award for Professional Development in Genetics & join us in congratulating them👏 These grad students & postdocs receive support to attend a conference or complete lab courses. Read about their research: buff.ly/3Wyb36H @genetics-gsa.bsky.social

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These tracks are listed in a new “RNA-seq long reads (Gonzalez et al., 2023)” sub-section of the “Transcript Level Features” section in JBrowse. #RNAseq #JBrowse

New long read RNA-Seq tracks displayed in JBrowse. These new tracks can be found under Transcript Level Features.
Shown here are RNA-Seq long reads encoding novel CDS for the gene Irk2.

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The Frequently Used GAL4 Drivers Table resource is now the Frequently Used GAL4 and Other Binary System Drivers Table flybase.org/GAL4/freq_us.... It now includes lexA drivers! You can access this resource from the GAL4 etc QuickSearch tab. #FrequentlyUsedGAL4DriversTable

A screenshot on the Frequently Used GAL4 and Other Binary System Drivers table showing two newly added lexA drivers.

The GAL4 etc QuickSearch tab. The link the Frequently Used GAL4 and Other Binary Systems Table is circled in purple.

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Useful links to external resources (FlyCyc, Reactome, KEGG) and publications are provided, as well as options to export the gene list to analysis, download and orthology tools. For more infor, see this Commentary: flybase.org/commentaries... #FlyBaseSkeetorial #GeneGroups #MetabolicPathways

Links to external resources, including FlyCyc (chitin biosynthesis) and KEGG (Amino sugar and nucleotide sugar metabolism).

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and a GO-Causal Activity Model (GO-CAM geneontology.org/docs/gocam-o...) that is based directly on GO annotation data.

A GO Causal Activity Model (GO-CAM) visual representation of the CHITIN SYNTHESIS metabolic pathway.

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Metabolic Pathway reports include a curated list of genes that have been experimentally shown or are predicted to act within a pathway. Two visual representations of the pathway are provided: a “text-book” representation (Pathway Thumbnail) manually drawn by FlyBase curators,

The Drosophila genes involved in CHITIN BIOSYNTHESIS: Chs2 and kkv.

A curated visual representation of the CHITIN BIOSYNTHESIS pathway.

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For example, see CHITIN BIOSYNTHESIS flybase.org/reports/FBgg.... You can access Metabolic Pathways by searching via the Pathways QuickSearch tab, or by browsing the Metabolic Pathways list flybase.org/lists/FBgg/m...

The FlyBase QuickSearch tool, open to the Pathways tab. The search term CHITIN BIOSYNTHESIS is entered in the search box. The link to the Metabolic Pathway reports browsable list is boxed in purple.

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FlyBase @flybase.bsky.social · 29/10/2024

New #GeneGroups subset: Metabolic Pathways! These manually curated reports aim to facilitate metabolic research in Drosophila by providing high-quality gene lists and visual representations of fly metabolic pathways, integrated with the other rich data in FlyBase.

FlyBase Metabolic Pathways report for CHITIN BIOSYNTHESIS.

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This is the third year of the award, with previous winners shown below. Please nominate our outstanding colleagues for this year's award.

List of Awardees

2023: For gathering and organizing the information that drives Drosophila research

Dr. James Thompson for Drosophila Information Services

Dr. Thomas Brody for Interactive Fly

FlyBase Curatorial Team: Dr. Giulia Antonazzo, Dr. Helen Attrill, Dr. Lynn Crosby, Dr. Damien Goutte-Gattat, Dr. L. Sian Gramates, Dr. Victoria Jenkins, Dr. Aoife Larkin, Dr. TyAnna Lovato, Dr. Steven Marygold, Dr. Beverley Matthews, Dr. Alex McLachlan, Dr. Gillian Millburn, Dr. Arzu Öztürk-Çolak, Dr. Clare Pilgrim; all past and present curators for their contributions and substantial efforts.

2024: For cataloging, maintaining, and distributing Drosophila stocks for the worldwide research community

Bloomington Drosophila Stock Center at Indiana University

Senior Staff Members: Dr. Kevin Cook, Dr. Annette Parks, Dr. Cale Whitworth, and Dr. Sam Zheng; all staff members and stockkeepers past and present for their contributions and substantial efforts.

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FlyBase @flybase.bsky.social · 29/10/2024

The FlyBoard is happy to announce the call for nominations for the Drosophila Community Service Award. Please submit your nomination by 01/17/2025 by email to: drosophilaserviceaward@gmail.com. Please repost. #FlyBoard

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FlyBase @flybase.bsky.social · 29/10/2024

Gene Reports for non-Drosophila melanogaster genes (foreign transgenes, non-melanogaster Drosophilids, etc.) have been improved in this release. Empty sections of the Report not relevant for these genes have been removed, & other features adjusted to be more relevant for these genes. #FB2024_05

The Navigation panel for a Drosophila melanogaster Gene Report (left) and for a non-Dmel Gene Report (right). Note that the section headings for Genomic Location, Function, Gene Model and Products, Expression Data, Gene ToolKit, Aberrations, Paralogs, Pathways, and Genomic Location and Mapping have been removed for the non-Dmel report.

FlyBase @flybase.bsky.social · 17/10/2024

The 66th Annual Drosophia Research Conference will be in San Diego March 19-23 2025 genetics-gsa.org/drosophila-2... Abstract submissions are open until Nov 14 genetics-gsa.org/drosophila-2...; workshop application will be accepted until Nov 7 genetics-gsa.org/drosophila-2... #Dros25

Picture of a courtyard at the San Diego hotel where the 66th Annual Drosophila Research Conference will be held. Small round tables draped in purple tablecloths are scattered on the courtyard lawn; each table has 4 white folding chairs, with a plastic flamingo as a centerpiece.

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Here's a single hit from the results table. For each SSC row in the left sub-table, there are two linked hemidriver rows in the right sub-table.The hemidriver side includes all the stocks and references (and other information) associated with each individual hemidriver.

The row corresponding to one hit in the Split System Combination hit-list table.

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Since the GAL4 etc hitlist is displayed as a responsive table, like all FlyBase #ResponsiveTables, you can choose which columns to view, and make a wide table easier to see by hiding some columns.

By using the 'Show/Hide Columns' button (boxed in purple), one can select which columns one wishes to view by ticking or unticking boxes in a pop-up menu (also boxed in purple).

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On the left, you'll see the SSC hits, with lnks to SSC stocks, and to references that SSC has been used in. On the right you'll see the component hemidrivers, each with its relevant information that you'd see in the single allele version of the results table.

The split system results table of a GAL4 etc search. The split system table, on the left, is boxed in purple. The hemidriver table, on the right, is unboxed.

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