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Fluorochem Ltd @fluorochemltd.bsky.social · 08/10/2025

We’re proud to highlight the pioneering research and manufacturing organisations we collaborate with, all working at the forefront of chemistry. On our Insights page, you’ll learn how their products integrate seamlessly into your research🧪 #ScienceSky #Collaboration #ChemSky #LifeSciences

fluorochem.co.uk

Collaborations Posts | Fluorochem

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Fluorochem Ltd @fluorochemltd.bsky.social · 02/10/2025

VHL ligands engage the VHL E3 ligase, a highly validated recruiter in PROTAC design, offering robust degradation profiles. Their structural diversity supports fine-tuning of ternary complex stability and pharmacological properties. fluorochem.co.uk/product-cate... 🧪 #TargetedProteinDegradation

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Fluorochem Ltd @fluorochemltd.bsky.social · 01/10/2025

Targeted Protein Degradation Fluorochem is here to support you as you build PROTACs or other heterobifunctional molecules with an excellent range of target-binding ligands, linkers and E3 ubiquitin ligase ligands. 🧪 #ChemicalBiology #LifeSciences #TPD fluorochem.co.uk/product-cate...

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Fluorochem Ltd @fluorochemltd.bsky.social · 25/09/2025

Cereblon (CRBN) ligands the most extensively used ligase recruiters in targeted protein degradation. The CRL4 CRBN E3 ligase complex is recruited to tag proteins for ubiquitination & degradation. 🧪 #TargetedMedicine #MedicinalChemistry #ProteinDegradation #PharmaResearch #TranslationalResearch #TPD

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Fluorochem Ltd @fluorochemltd.bsky.social · 24/09/2025

Cool cement is helping to keep surfaces cooler. It’s both strong and durable, meaning it can be incorporated into conventional concrete help cities moderate extreme summer temperatures. #ClimateChange #SustainableConstruction #MaterialsScience #Chemistry 🧪

science.org

Scalable metasurface-enhanced supercool cement

Reengineered cement enables scalable radiative cooling for energy-efficient, low-carbon construction.

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Fluorochem Ltd @fluorochemltd.bsky.social · 23/09/2025

Tertrazines are ideal for pre-targeted imaging, drug delivery, and bioorthogonal chemistry. browse our range of click chemistry reagents and much much more on our site! #Chemistry #ClickChemistry #Imaging #MolecularBiology #MedChem fluorochem.co.uk/product-cate... 🧪

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Fluorochem Ltd @fluorochemltd.bsky.social · 16/09/2025

There's till time to talk to our rep in Cambridge and find out how Fluorochem can support your ADC and PROTAC synthesis, library development or custom projects!🧪 #CamMedChem25 #ADC #PROTAC #Pharma #ChemSky #BioSky #AcademicSky

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Fluorochem Ltd @fluorochemltd.bsky.social · 15/09/2025

Another medicinal chemistry symposium this week! Drop by to hear the latest developments at Fluorochem and new ranges in chemical building blocks, biological reagents and complex medicinal agents like ADCs OR heterobifunctional protein degraders! #CamMedChem25 #ADCs #ChemSky #AcademicSky 🧪

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Fluorochem Ltd @fluorochemltd.bsky.social · 11/09/2025

Click chemistry is ideal for fast, selective and modular reactions that simplify complex molecule assembly. In biological systems, copper free reagents are ideal - find them on our site!🧪 fluorochem.co.uk/product-cate... #ChemSky #BioSky #Biochem #ClickChem #ClickReactions #MolecularBio #MedChem

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Fluorochem Ltd @fluorochemltd.bsky.social · 05/09/2025

Find everything for chemical synthesis, delivered fast, with uncompromising quality 🚚 Click chemistry simplifies complex molecule assembly with fast, selective and modular reactions. Find click reagents & more on our site!🧪 fluorochem.co.uk/product-cate... #ChemSky #Biochem #Synthesis #Clickchem

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Fluorochem Ltd @fluorochemltd.bsky.social · 02/09/2025

Come and speak to us about all things #peptides #smallmolecules and #medicinalchemistry at the EFMC-ASMC x International Symposium on advances in synthetic and medicinal chemistry. #medchem #ASMC #EFMCASMC2025 #EFMC

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Fluorochem Ltd @fluorochemltd.bsky.social · 28/08/2025

Click chemistry has become a go-to strategy for fast, selective and modular reactions that simplify complex molecule assembly. 🧩 Find everything you need to assemble your molecules with Fluorochem’s high quality click reagents!🧪 #ChemSky #ClickChem #Synthesis fluorochem.co.uk/product-cate...

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Fluorochem Ltd @fluorochemltd.bsky.social · 27/08/2025

Kinases contribute to regulation of cellular signalling and drive many diseases when dysregulated. Small molecule kinase inhibitors allow precise control over these enzymes, enabling pathway dissection, biomarker discovery and therapeutic targeting.🧪 #Kinase #MedChem fluorochem.co.uk/product-cate...

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Fluorochem Ltd @fluorochemltd.bsky.social · 21/08/2025

Ion channels control the flow of ions across membranes, governing everything from nerve impulses to cardiac rhythms. With small molecule activators and inhibitors, researchers can modulate channel activity with precision. 🧪 #ChemSky #BioSky #MedChem #IonChannel fluorochem.co.uk/product-cate...

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Fluorochem Ltd @fluorochemltd.bsky.social · 14/08/2025

Proteases are involved in processes like immunity, cancer progression, and viral replication. Small molecule protease inhibitors help control these enzymes with high specificity, useful in both research and therapeutic applications. 🧪 fluorochem.co.uk/product-cate... #SMI #protease #ChemSky #cancer

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Fluorochem Ltd @fluorochemltd.bsky.social · 12/08/2025

Lunar soil is revealing unexpected potential. A team led by Lu Wang has developed a solar-powered photothermal reactor that simultaneously extracts water from regolith and converts exhaled CO₂ into oxygen, hydrogen, and carbon monoxide, with ilmenite as a catalyst. 🧪 #Chemsky #AstroSky #Sciencenews

newscientist.com

Simple device can produce water, oxygen and fuel from lunar soil

Using samples collected by the Chinese Chang’e 5 mission, researchers have discovered a new way to release water from lunar regolith and process the carbon dioxide breathed out by astronauts

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Fluorochem Ltd @fluorochemltd.bsky.social · 07/08/2025

GPCRs are highly druggable yet complex. Fluorochem’s small molecules, including agonists & antagonists, help tune signalling processes, study ligand-receptor interactions & explore disease pathways. Perfect tools for #Biochem #DrugDiscovery #MedChem #Protein #Signalling research!

Selection of structures and product details of GPCR modulators available in the Fluorochem catalogue.

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Fluorochem Ltd @fluorochemltd.bsky.social · 05/08/2025

PFAS (“forever chemicals”) are everywhere — water, soil, even our blood. A new study finds they can build up in gut bacteria without harming them. In mice, these PFAS-loaded microbes were later excreted, opening the door to probiotic-based ways to remove PFAS. #PFAS #PublicHealth #Microbiome

nature.com

Human gut bacteria bioaccumulate per- and polyfluoroalkyl substances - Nature Microbiology

Human gut bacteria bioaccumulate per- and polyfluoroalkyl substances (PFAS), commonly known as forever chemicals, in intracellular aggregates. Colonization of gnotobiotic mice with bioaccumulating bac...

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Fluorochem Ltd @fluorochemltd.bsky.social · 31/07/2025

Phase Transfer Catalysts 🧪 Transporting reaction components between phases, our phase-transfer catalysts efficiently accelerate synthetic and industrial processes while improving solvent economy. #ChemSky #LabLife #OrgChem #OrganicChemistry #SustainableChemistry fluorochem.co.uk/product-cate...

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Fluorochem Ltd @fluorochemltd.bsky.social · 28/07/2025

Find transition-metal complexes to catalyse molecular remodelling. Fluorochem’s selection covers heavy-hitting stalwarts like Grubbs, precious metal catalysts including palladium and gold and powerful complexes using earth abundant metals.🧪 #ChemSky #Catalysts #Metal #Catalysis #AcademicSky

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Fluorochem Ltd @fluorochemltd.bsky.social · 23/07/2025

Speak to Fluorochem at the 28th International Symposium: Synthesis in Organic Chemistry. Find out how we can support your #synthesis or #medchem with our extensive range of building blocks, synthesis reagents, #NMR solvents or #photochemistry. #AcademicSky #Conference #ChemSky #orgchem

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Fluorochem Ltd @fluorochemltd.bsky.social · 17/07/2025

Organocatalysts Offering greener methods, while still producing excellent chemical results including highly selective asymmetric catalysis, Fluorochem’s organocatalysts promote countless chemical reactions. fluorochem.co.uk/product-cate... #ChemSky #Biosky #catalysts #organocatalyst 🧪

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Fluorochem Ltd @fluorochemltd.bsky.social · 15/07/2025

Controlled delivery of therapeutic molecules is an ongoing challenge of targeted medicine. This Rotaxane device can release a payload in response to force or an absence of water. This has been tested with the chemotherapy drug gemcitabine and the biliary antispasmodic drug Hymecromone. 🧪 #ChemSky

onlinelibrary.wiley.com

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Fluorochem Ltd @fluorochemltd.bsky.social · 26/06/2025

Come and speak to us today if you're at the Chemistry symposium @ucl.ac.uk and find out how Fluorochem can support your research far beyond fluorinated compounds #ChemSky #ucl #AcademicSky #chemistry #research 🧪

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Fluorochem Ltd @fluorochemltd.bsky.social · 24/06/2025

New in chemistry, imaging and cancer The new dye BhCyNK is designed to activate only in the presence of a specific enzyme found in tumours rich in natural killer cells. The dye produces a strong signal, helping researchers track these immune cells live, inside the body. 🧪 #Cancer #imaging

onlinelibrary.wiley.com

Activatable Fluorescence/Photoacoustic Macromolecular Probe for Imaging of Tumor‐Associated Natural Killer Cells

An activatable near-infrared fluorescence (NIRF)/photoacoustic (PA) macromolecular probe is developed based on the optimized fluorophore scaffold with a long absorption maximum and high PA brightness...

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Fluorochem Ltd @fluorochemltd.bsky.social · 19/06/2025

Protected amino acids - these protected forms ensure controlled stepwise synthesis, for application in solid-phase peptide synthesis (SPPS) or solution-phase methods. Premium amino acids provide the consistency and performance your science demands. #aminoacids #peptidesynthesis #ChemSky 🧪

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Fluorochem Ltd @fluorochemltd.bsky.social · 12/06/2025

Peptide synthesis and amide bond formation are essential techniques in chemical biology. Coupling reagents like COMU, HBTU, and HATU high efficiency, low racemization, and broad substrate compatibility make them go-to tools in both academic and industrial labs. 🧪 #ChemSky #Peptide #Biochem

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Fluorochem Ltd @fluorochemltd.bsky.social · 10/06/2025

A study funded by Roche trialled a novel triple therapy for breast cancer patients with PIK3CA –mutated HR+, HER2- breast cancer and demonstrated positive outcomes for the patients quality of life, with a few side effects which will need to be monitored. #ScienceNews #Cancer #MedSky #Pharma 🧪

nejm.org

Overall Survival with Inavolisib in PIK3CA-Mutated Advanced Breast Cancer | NEJM

In the phase 3, double-blind, randomized INAVO120 trial, treatment with inavolisib plus palbociclib–fulvestrant led to a significant progression-free survival benefit, as compared with placebo plus...

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Fluorochem Ltd @fluorochemltd.bsky.social · 05/06/2025

Peptides have wide applications in modern medicine and drug discovery, diagnostics and biological research. They are versatile enough to function as selective therapeutics, biomarkers and high-specificity probes in biological assays. 🧪 #ChemSky #BioSky #Peptides #Research #Benchwork

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Fluorochem Ltd @fluorochemltd.bsky.social · 29/05/2025

Photocatalytic approaches are widening the possibilities of synthetic chemistry. In the paper below aryl C-H bonds are directly alkylated with alcohol & carboxylate starting materials, using an iridium photocatalyst (F551860) to create active radical species. 🧪 Contact us for a quote! #Chemsky

nature.com

Generalizing arene C–H alkylations by radical–radical cross-coupling - Nature

Using the concept of dynamic orbital selection distinct organic radical species can be differentiated, enabling direct coupling of aromatics with alcohols or carboxylic acids.

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Reposted by Fluorochem Ltd

RSC Nucleic Acids Group @rscnucleicacids.bsky.social · 28/05/2025

Continuing with our sponsor appreciation, we would like to thank Fluorochem, Lumicks and Oxford nanopore for their support!! Remember to register now!! @fluorochemltd.bsky.social @lumicks.bsky.social @nanoporetech.com

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Fluorochem Ltd @fluorochemltd.bsky.social · 22/05/2025

Organoboron Building Blocks 🧪 Widely used as cross-coupling partners to rapidly assemble more complex molecules, boronic acids and their derivatives have been reliable features of medicinal chemistry, materials science and general synthesis for decades. #ChemSky #ScienceSky #SyntheticChem #Pharma

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Fluorochem Ltd @fluorochemltd.bsky.social · 20/05/2025

Ethanol is present in alcoholic beverages of all kinds enjoyed by humans and, it transpires, wild chimpanzees (Pan troglodytes verus)! They've been reported to eat and share fermented African Breadfruit (Treculia africana). Cheers! 🧪 www.cell.com/current-biol... #AcademicSky #BioSky #ZooSky

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Fluorochem Ltd @fluorochemltd.bsky.social · 15/05/2025

Chiral building blocks can conveniently introduce stereocentres, giving precise structure to your molecules. Fluorochem have a range of these optically active molecules for producing compounds with selective biological activity. 🧪 #ChemSky #DrugDiscovery #Pharma #ChemicalBiology

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Fluorochem Ltd @fluorochemltd.bsky.social · 12/05/2025

Delighted to be attending the 11th RSC/SCI Symposium on Kinase Inhibitor Design in the beautiful city of Edinburgh on behalf of Fluorochem Ltd Looking forward to hearing about the latest kinase related therapy development from researchers over the next 2 days.🧪 #Kinase2025 #ChemSky #MedSky

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Fluorochem Ltd @fluorochemltd.bsky.social · 08/05/2025

Reflecting the increasing interest in the therapeutic value of modulating serotonergic and dopaminergic pathways, Fluorochem stock a selection of building blocks that can be used in the creation of molecules that interact with CNS receptors like D2 and 5-HT2. 🧪 #ChemSky #ChemicalBiology #Pharma

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Fluorochem Ltd @fluorochemltd.bsky.social · 07/05/2025

🧪 The RSC Organic Division Ireland meetings yesterday featured #macrocycles, #fluorescence, improving efficiency in chemistry and moving towards #sustainable chemical synthesis, combining optimism, innovation and an acknowledgement of the significant challenges faced. #Chemsky #SciComm

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Fluorochem Ltd @fluorochemltd.bsky.social · 07/05/2025

A fantastic day of #organicchemistry 🧪 at Queen's University Belfast yesterday #Chemsky #SciComm

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Fluorochem Ltd @fluorochemltd.bsky.social · 01/05/2025

Choose the right payload from Fluorochem’s range of advanced payloads to tailor your ADC design 🧪 CAS: 474645-27-7 MMAE CAS: 171335-80-1 Exatacan CAS: 441045-17-6 Eribulin mesylate Our team of experts are here to help with custom synthesis! #MedSky #BioSky #ADC #ChemSky #Pharma

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Fluorochem Ltd @fluorochemltd.bsky.social · 30/04/2025

Bank Holiday Alert 1st of May is the national holiday In Germany, our warehouse will reopen 2nd May 🚚 5th of May is the UK bank holiday, our warehouse will reopen 6th May 🚚 We always work to ensure these closures have a minimal impact on your delivery times.🧪

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Fluorochem Ltd @fluorochemltd.bsky.social · 29/04/2025

Custom Synthesis Capabilities: Small Molecules Protein Degraders Oligonucleotides Peptides Antibodies Our deep expertise in chemical and life sciences doesn’t just shape our catalogue - it powers our ability to deliver truly customised solutions 🧪 #Medsky #antibodies #peptides #ChemSky

Cartoon of a scientist dressed in full PPE in a scene with a larger than life test tube rack behind them, and they're holding a test tube as big as the over a large drum barrel

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Fluorochem Ltd @fluorochemltd.bsky.social · 24/04/2025

Photoinitiators break apart when exposed to light, a process known as photodissociation. This reaction generates reactive species, such as radicals, cations, or anions, which initiate chemical reactions.🧪 Browse our catalogue for our photoinitators today! #ChemSky #Academicsky #Photochemistry

Scientist observing a well illuminated reaction flask containing radicals, charges and reactive chemicals.

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Fluorochem Ltd @fluorochemltd.bsky.social · 17/04/2025

With 13 FDA-approved #ADCs & more in trials, our linkers, payloads & building blocks drive targeted treatments in oncology, immunology & beyond. 🧪 Non Cleavable Linkers F079601 N-Succinimidyl 6-maleimidohexanoate F869416 Sulfo-SMCC sodium F554626 N3-PEG4-C2-NHS ester #MedSky #Chemsky

dougdiscovery.com

Doug Discovery - the intermediate chemical compound catalogue - Fluorochem Ltd

Doug Discovery offers a comprehensive online catalog specializing in intermediate chemical compounds. Explore a diverse range of precise formulations for your research needs. With Fluorochem Ltd's exp...

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Fluorochem Ltd @fluorochemltd.bsky.social · 16/04/2025

Spring Break We are closed 18th and 21st April for the Easter bank holidays 🐣 Business resumes as normal from the 22nd 🚚 Please bare this in mind when placing orders as your lead time may be slightly extended. 🧪 Hope everyone enjoys their spring break! 🌸 #ChemSky #AcademicSky #BioSky

Closeup of yellow flowers in a green field

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Fluorochem Ltd @fluorochemltd.bsky.social · 10/04/2025

Fluorochem provides essential chemical tools for developing advanced #ADCs. 13 FDA-approved ADCs and many more in trials! Cleavable Linkers F987227 F554627 F987370 F554713 Cant find what you’re looking for? Contact us, our team of experts will help you find what you need🧪 #Medsky #Chemsky

Orange compounds in an approximation of the Y shape of antibodies

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