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Floris van der Flier

@florisvdf.bsky.social
21 followers 95 following 21 posts

PhD Student @ WUR Bioinformatics, ML & Protein Engineering github.com/florisvdf

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Floris van der Flier @florisvdf.bsky.social · 29/06/2026
We just put out a new preprint! Preferential learning + uncertainty quantification for better protein engineering, check it out here: doi.org/10.64898/202...
doi.org
Acquiring Improved Protein Variants With Probabilistic Preferential Learning
Variant effect prediction (VEP) models can be used to select promising novel enzymes from a pool of candidates. Most supervised VEP models are framed as regression tasks, placing more emphasis on gett...
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Floris van der Flier @florisvdf.bsky.social · 14/08/2025
(1/8) Happy to share that our preprint titled “Predicting protein variant properties using electrostatics” is now online! We tested a physics-based approach to variant effect prediction (VEP). www.biorxiv.org/content/10.1...
biorxiv.org
Predicting protein variant properties with electrostatic representations
Does evolution capture the full functional potential of proteins, or is this potential restricted by selective pressures? If the former is true, providing variant effect prediction (VEP) models with e...
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Reposted by Floris van der Flier
Daniel Probst @skepteis.bsky.social · 16/12/2024
If you're looking for a (fully funded) PhD position in #ml / #ai methodology (with plenty of opportunities to apply it) at the intersection of #chemistry and #biology, don't forget to apply before the end of the year. www.wur.nl/en/vacancy/p...
wur.nl
PhD student - Machine learning in bio- and cheminformatics
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Reposted by Floris van der Flier
Daniel Probst @skepteis.bsky.social · 02/12/2024
Here's a first: I'm hiring a PhD student. If you have (or know someone who has) a strong background and interest in computational (bio)chemistry or computer science (especially 3D computer vision), let's work together 😊 www.wur.nl/nl/vacature/...
wur.nl
PhD student - Machine learning in bio- and cheminformatics
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