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Filip Ruzicka

@filipruzicka.bsky.social
82 followers 62 following 6 posts

Evolutionary biology, population genetics. Marie Curie fellow at the Institute of Science and Technology Austria

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Filip Ruzicka @filipruzicka.bsky.social · 16/10/2026
If you thought that X-linked genes adapt faster than autosomal genes because of recessive mutations, I'm here to convince you otherwise :). Sadly our alternative idea (large-effect mutations) doesn't seem to be the answer either. Find out more here! academic.oup.com/gbe/advance-...
academic.oup.com
Is faster-X adaptation due to large-effect mutations? An empirical test of a new theory
Abstract. A widespread observation in molecular evolution is that X-linked genes evolve faster—and often adapt faster—than autosomal genes. Three main idea
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Filip Ruzicka @filipruzicka.bsky.social · 11/10/2026
nice work! 😀
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Reposted by Filip Ruzicka
Débora Y C Brandt @deboraycb.bsky.social · 08/10/2026
Now that it's officially out, I have to say I'm quite proud of this work🙂 I got involved in it after a bit of a failure in another proj. Took way longer than it could. Started pregnant, published close to baby's 3rd bday😅 Very grateful for my patient mentors and collaborators doi.org/10.1093/molb...
academic.oup.com
Characterizing the detectable and invisible fractions of genomic loci under balancing selection
Abstract. Balancing selection refers to scenarios where selection maintains genetic polymorphisms affecting fitness and its components. Empirical studies h
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Filip Ruzicka @filipruzicka.bsky.social · 15/08/2026
A new preprint with @cmackintosh.bsky.social and Tim Connallon, where we revisit Haldane's idea that dominance might evolve during the spread of a beneficial mutation to fixation. Happy for any feedback!
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Reposted by Filip Ruzicka
Alex Mackintosh @thymelicus.bsky.social · 19/07/2026
New preprint on the effect of ancient admixture / structure on genealogical trees. I introduce a new way of summarising reconstructed genealogies that captures a clear signal of ancient gene flow into the ancestors of modern humans. Feedback welcome!
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Reposted by Filip Ruzicka
Joanna Masel @joannamasel.bsky.social · 03/06/2026
Our new paper doi.org/10.1098/rspb... on long-term genetic threats to small populations finds that "mutational meltdown" (bad mutations fixing) is less of a problem than "mutational drought" (too few good new mutations) @wmawass.bsky.social @uliseshmc.bsky.social @jeremyjberg.bsky.social 1/5
doi.org
Extinction vortices are driven more by a shortage of beneficial mutations than by deleterious mutation accumulation
Abstract. Habitat loss contributes to extinction risk in multiple ways. Genetically, small populations can face an ‘extinction vortex’—a positive feedback
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Reposted by Filip Ruzicka
Institute of Science and Technology Austria (ISTA) @istaresearch.bsky.social · 12/05/2026
In a recent @natecoevo.nature.com​ News & Views article, ISTA postdoc @filipruzicka.bsky.social​ comments on the findings of Xia and colleagues, which show opposing fitness effects of mutations in fruit flies. “Reverse genetics of sexual antagonism”. DOI: doi.org/10.1038/s41559-026-03036-y
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Reposted by Filip Ruzicka
EcoEvoRxiv @ecoevorxiv.bsky.social · 12/05/2026
"Sexually antagonistic selection: a review of the theory and its implications" doi.org/10.32942/X28M22
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Reposted by Filip Ruzicka
bioRxiv Genomics @biorxiv-genomic.bsky.social · 21/04/2026
The causes of signed linkage disequilibrium within genomic datasets www.biorxiv.org/content/10.64898/20…
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Reposted by Filip Ruzicka
School of Biological Sciences, Monash @MonashBiol @monashbiol.bsky.social · 27/01/2026
Additive genetic variance for fitness maintained by balancing selection url: academic.oup.com/evolut/artic...
academic.oup.com
Additive genetic variance for fitness maintained by balancing selection
Abstract. Levels of additive genetic variation for fitness (${{V}_A}( w )$) and its components (e.g., viability, fertility) appear to be high in nature, su
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Filip Ruzicka @filipruzicka.bsky.social · 08/02/2026
A new preprint with Beatriz Vicoso, where we highlight that a common observation in molecular evolution—X chromosomes adapting faster than autosomes—doesn't quite add up. So we tested a new theory (www.pnas.org/doi/abs/10.1...) in fruit flies, mice and humans...
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Reposted by Filip Ruzicka
Lynda Delph @lyndadelph.mastodon.social.ap.brid.gy · 23/11/2025
@EvolOdonata Aspects of the Delph and Kelly paper sat on my desks for three years until I got John on board to coauthor it with me. And then my student Jay Goldberg and I realized that there was a natural experiment we could investigate (doi.org/10.1002/evl3.157). Nice review—maybe it […]
mastodon.social
Original post on mastodon.social
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Reposted by Filip Ruzicka
Hilde Schneemann @hildeschneemann.bsky.social · 09/11/2025
New paper published together with John Welch on hybrid fitness and how it depends on ploidy and # of distinct ancestries, incl some remarkable fits of data & theory 😶. Keen to hear any thoughts/comments/questions! doi.org/10.1093/gene... Thanks to the team @ Genetics for the smooth experience :)
doi.org
Predicting Hybrid Fitness: The Effects of Ploidy and Complex Ancestry
Abstract. Hybridization between divergent populations places alleles in novel genomic contexts. This can inject adaptive variation – which is useful for br
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Filip Ruzicka @filipruzicka.bsky.social · 14/11/2025
Special thanks to @eseb.bsky.social, who funded and enabled this wonderful collaboration between empiricists and theoreticians! @martynazwoinska.bsky.social @kokkonut.bsky.social @evolodonata.ecoevo.social.ap.brid.gy and many others not on bluesky
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Filip Ruzicka @filipruzicka.bsky.social · 14/11/2025
Modestly, we decided to review a century's worth of theories of balancing selection :) onlinelibrary.wiley.com/doi/10.1111/...
onlinelibrary.wiley.com
A century of theories of balancing selection
Traits that affect organismal fitness are often highly genetically variable. This genetic variation is vital for populations to adapt to their environments, but it is also surprising given that natur...
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