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Physical chemistry @ Palacky University Olomouc @fchupol.bsky.social · 29/11/2024

We would also like to thank our collaborators from Faculty of Medicine and Dentristry Palacky University Olomouc and CATRIN UPOL

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Physical chemistry @ Palacky University Olomouc @fchupol.bsky.social · 29/11/2024

Resistance in both can be overcome> - pomegranate rind extract, which inhibits both flagellin and biofilm production, or - by covalently binding #AgNP to a composite material containing graphene sheets, which protects AgNP aggregation.

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Physical chemistry @ Palacky University Olomouc @fchupol.bsky.social · 29/11/2024

Antibacterial resistance to silver nanoparticles is the same for both types of bacteria - aggregation of AgNP to form black precipitates. However, the way in which Gram-positive and Gram-negative bacteria induce aggregation of silver nanoparticles is completely different.

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Physical chemistry @ Palacky University Olomouc @fchupol.bsky.social · 29/11/2024

Our colleagues Aleš Panáček and Lucie Hochvaldová published a Featured article in @natureportfolio.bsky.social journal @commsbio.bsky.social describing how bacteria resist AgNPs by aggregating them through the flagellin production in E. coli or biofilm formation in S. aureus and how to overcome it

Cover image in @CommsBiol about our Featured article on the development and overcoming of bacterial resistance to AgNP.

The mechanism of resistance is the same for both types of bacteria and involves the aggregation of silver nanoparticles leading to the formation of black precipitates. However, the way in which Gram-positive and Gram-negative bacteria induce aggregation of silver nanoparticles is completely different. Chemical analysis of the surface of the silver precipitates shows that aggregation is triggered by flagellin production in E. coli and by bacterial biofilm formation in S. aureus. However, resistance in both types of bacteria can be overcome by using pomegranate rind extract, which inhibits both flagellin and biofilm production, or by stabilizing the silver nanoparticles by covalently binding them to a composite material containing graphene sheets, which protects the silver nanoparticles from aggregation induced by the bacterial biofilm produced by S. aureus.

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Physical chemistry @ Palacky University Olomouc @fchupol.bsky.social · 22/11/2024

Here is a shortlist of chemical news and journals we have found so far. Please, let us know if tou know about some other. go.bsky.app/CAYUJ5B

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Physical chemistry @ Palacky University Olomouc @fchupol.bsky.social · 22/11/2024

Are there any other accounts for Chem&Biol Data? go.bsky.app/RvEm6Bh

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Physical chemistry @ Palacky University Olomouc @fchupol.bsky.social · 20/11/2024

Is there any other Chem&Biol department or institute for this starter pack? go.bsky.app/7fkRhAy

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Physical chemistry @ Palacky University Olomouc @fchupol.bsky.social · 19/11/2024

At the end of January we organize hybrid 8th Advanced in silico drug design workshop - registration is open both onsite and online www.kfc.upol.cz/8add #chemsky #compchemsky #biosky 🧪💊🧬🖥️

kfc.upol.cz

8th Advanced in silico Drug Design workshop 2025 – Katedra fyzikální chemie

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