iiinova — where your digital self keeps evolving

Farhan RC @farhanrc.bsky.social · 14/07/2026

Paper submissions should universally be free from formatting requirements. Some journals under Oxford University Press already dropped this requirement, which makes submission much simpler (letting you get your rejection letter asap so you can move on)

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Farhan RC @farhanrc.bsky.social · 09/10/2025

When bacteria evolve resistance to one antibiotic, they can become more vulnerable to another, a phenomenon called ‘hypersensitivity.’ We find antibiotics that leverage this, and emphasize the importance of the 'directionality' of hypersensitivities for improved therapies. #AMR #microsky

academic.oup.com

Sequential antibiotic exposure restores antibiotic susceptibility

AbstractBackground. The prevalence of antibiotic resistance continues to rise, rendering many valuable antimicrobial drugs ineffective. Pairwise cyclic ant

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Farhan RC @farhanrc.bsky.social · 17/08/2025

"It’s as if every time you took a painkiller for your headache, you increased the chance that somebody else might have to undergo an operation without anaesthetic." "It’s hard to imagine a more perfect anti-capitalist commodity than a product whose value depletes every time you use it." #AMR

theguardian.com

Why antibiotics are like fossil fuels

They helped create the modern world but are dangerously overused. How can we harness them sustainably?

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Farhan RC @farhanrc.bsky.social · 03/07/2025

Large scale experimental evolution can help identify trade-offs associated with antibiotic resistance that can have clinical relevance. We use multiple platforms to discover one such trade-off, and describe its mechanism in our report in IJAA.

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Reposted by Farhan RC

Auclair Lab @auclairlab.bsky.social · 21/06/2025

🚨NEW PREPRINT ALERT: In this paper, Jacob and Suzana from the Auclair lab investigate how Salmonella Typhimurium adapts to growing on itaconate, with detailed metabolic and genomic studies. Many thanks to our collaborators at McGill and Concordia! (Details below) #chemsky doi.org/10.1101/2025...

Metabolic and genomic adaptations of Salmonella Typhimurium grown on itaconate

Jacob Pierscianowski, Suzana Diaconescu-Grabari, Farhan R. Chowdhury, Andreanne Lupien, Brandon L. Findlay, Karine Auclair

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Farhan RC @farhanrc.bsky.social · 06/06/2025

Compensatory evolution is a menace in the clinic, enabling maintenance of costly resistance determinants. We've built 3-drug evolutionary traps where bacteria compensate for the costs of resistance by reverting back to sensitivity! #microsky

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Farhan RC @farhanrc.bsky.social · 25/01/2025

The idea of "evolution proof" antibiotics is cool, but it will probably remain an idea. We break an evolution proof antibiotic Tridecaptin in this paper. Improved lab evolution platforms will be crucial to help predict resistance. #AMR #antibiotic #resistance

sciencedirect.com

De novo evolution of antibiotic resistance to Oct-TriA1

The rise of antimicrobial resistance as a global health concern has led to a strong interest in compounds able to inhibit the growth of bacteria witho…

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