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Auclair Lab

@auclairlab.bsky.social
153 followers 126 following 135 posts

We explore many fields of chemistry and biology (many of them concerning enzymes). Located at McGill University, Montreal. Student-ran account: posts not by Dr. Auclair, DMs not monitored. RP/follow ≠ endorsement. www.auclair-group.mcgill.ca

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Auclair Lab @auclairlab.bsky.social · 29/09/2026
🚨 NEW PAPER ALERT 🚨 In BBA Proteins and Proteonomics, fresh from the Auclair lab, Yuqin investigates the fractal kinetics of moist-solid enzymatic PET depolymerization by HiC. Congratulations to Yuki! doi.org/10.1016/j.bb...
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Auclair Lab @auclairlab.bsky.social · 21/09/2026
McGill students are invited to Green Chemistry McGill's 5th annual Global Conversation on Sustainability, happening this Friday at 10:30 AM! In-person and virtual attendance are both possible. (But between the two of us, we're pretty excited about the food, too...!)
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Auclair Lab @auclairlab.bsky.social · 17/09/2026
🚨 NEW PAPER ALERT 🚨 We're going back-to-back! In ACS Sustain. Chem. Eng., Nu Thuy Tu Ton and Hannah Girard investigate mechanoenzymatic depolymerization of alginate. This method obtained lower-MW oligosaccharides with narrower polydispersity. Congrats to Tu and Hannah! doi.org/10.1021/acss...
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Auclair Lab @auclairlab.bsky.social · 15/09/2026
🚨 NEW PAPER ALERT 🚨 In Organic Letters, the Auclair lab's Dr. Blue Lan and Dr. Jake Pierscianowski report an accessible, tunable, heteroatom-containing scaffold capable of aggregation-induced emission (AIE). Uses in pH sensing and cell imaging are explored. Check it out! doi.org/10.1021/acs....
doi.org
Lights, Molecule, Action: 3-(Diarylmethylene)isobenzofuranones as Heteroatom-Containing, Tunable Aggregation-Induced Emission Luminogens
Abstract. New aggregation-induced emission luminogens (AIEgens) featuring the 3-(diarylmethylene)isobenzofuranone scaffold are reported herein. This struct
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Auclair Lab @auclairlab.bsky.social · 05/09/2026
The Auclair lab welcomes three new graduate students this fall! Jacob Couture (Université de Montréal) and Amy Gingrich (McMaster University) are joining us as PhD students. Savita Brickman-Maxwell (University of Toronto Mississauga) joins as an MSc student. 🎉
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Auclair Lab @auclairlab.bsky.social · 24/07/2026
New article: in Nature Metabolism, a study of itaconate as an inhibitor of adipose tissue thermogenesis. Featuring work from Dr. Jake Pierscianowski of the Auclair lab! doi.org/10.1038/s422...
doi.org
Macrophage-derived itaconate is a negative regulator of adipose tissue thermogenesis - Nature Metabolism
Tang et al. reveal that macrophage-derived itaconate acts as a paracrine inhibitor of adipose tissue thermogenesis by blocking succinate uptake into brown adipose tissue.
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Auclair Lab @auclairlab.bsky.social · 22/06/2026
Ryan and Luis of the Auclair Lab had a great experience at the CCVC/CGCC Summer Camp, learning about the cutting edge of green chemistry and catalysis in Quebec!
photo credits: Amir Nasreddine
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Auclair Lab @auclairlab.bsky.social · 05/06/2026
We had a fantastic time at CSC #x2026!
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Auclair Lab @auclairlab.bsky.social · 25/05/2026
Admin's taking a quick break from posting - the Auclair lab's going to CSC! Find us: Ryan, Tu: poster session Monday Luis: poster session Tuesday Karine: Wednesday 1AM, room 706 Tarasha: Thursday 4:40 PM, room 501 Gen: Thurs 5PM, room 501 Natalia: Thurs 5PM, room 706 (double booked 😢)
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Auclair Lab @auclairlab.bsky.social · 21/05/2026
We're happy to announce that two of our articles were certified as top viewed articles for 2025! Dr. Ali Zaker's work on the microstructure of PET and Dr. Blue Lan's TBD-catalyzed synthesis of 3-hydroxyisoindolin-1-ones were recognized in ChemSusChem and EurJOC respectively. Links below!
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Auclair Lab @auclairlab.bsky.social · 14/05/2026
We were delighted to host Prof. Hal Alper and Amelia Bergeson from @utaustin.bsky.social to Montreal this week! Prof. Alper is a longtime collaborator of ours and gave a fascinating talk about engineering biology.
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Auclair Lab @auclairlab.bsky.social · 08/05/2026
🚨 NEW PAPER 🚨 Fresh off the presses in @jacs.acspublications.org, the Auclair lab achieves nearly quantitative mechanoenzymatic depolymerization of highly crystalline PET plastic, revealing a unique processive mechanism exclusive to moist-solid conditions. doi.org/10.1021/jacs...
doi.org
Moist-Solid Biocatalysis Enables Processive Depolymerization of Crystalline PET
Enzymatic depolymerization of polyethylene terephthalate (PET) is typically limited to the amorphous regions of the plastic, therefore requiring energy-intensive pretreatment. Here, using the commerci...
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Auclair Lab @auclairlab.bsky.social · 07/05/2026
The Auclair lab had a great time at the 2026 Open Plastic Symposium hosted at @queensuresearch.bsky.social! Jane and Ryan (not pictured) gave oral presentations, while Alana and Natalia presented posters.
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Auclair Lab @auclairlab.bsky.social · 01/05/2026
The Auclair lab congratulates Suzana Diaconescu-Grabari for her successful Master's thesis submission! 🎉
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Auclair Lab @auclairlab.bsky.social · 17/04/2026
Important lab cleaning duty: the popcorn machine
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Auclair Lab @auclairlab.bsky.social · 07/04/2026
Spinning some lysate. For comparison, F1 engines hit a maximum of 15,000 rpm (well, maybe they're not going that high this year...) #chemsky
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Auclair Lab @auclairlab.bsky.social · 17/03/2026
NEW ARTICLE: In Science Advances, an investigation of the malarial parasite Plasmodium falciparum's PPCS enzyme, part of the CoA biosynthesis pathway. A collaboration between the Auclair, Creek, Corry, Strauss, and Saliba groups, spanning Canada and Australia. www.science.org/doi/10.1126/...
science.org
The Plasmodium falciparum PPCS is a unique heteromeric complex with prokaryote-like activity and is a target of pantothenate analogs
PPCS in the P. falciparum CoA biosynthesis pathway forms a heteromeric complex, uses CTP instead of ATP, and is a drug target.
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Auclair Lab @auclairlab.bsky.social · 04/03/2026
Some updates: The Auclair lab congratulates Aracelli Chang on a successful Master's thesis submission! And we're happy to officially welcome Dr. Jacob Pierscianowski back as a post-doc! Dr. Jake defended his thesis with us last year.
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Auclair Lab @auclairlab.bsky.social · 25/02/2026
One decade ago: the Auclair lab first examined small molecules to resensitize bacteria to macrophages. #chemsky #biosky doi.org/10.1002/cbic...
doi.org
Small Molecule Restores Itaconate Sensitivity in Salmonella enterica: A Potential New Approach to Treating Bacterial Infections
Become more sensitive: Although new antibiotics and resistance inhibitors provide temporary solutions to resistance, they are bound to become obsolete. In this work, we propose a new approach, coined...
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Auclair Lab @auclairlab.bsky.social · 06/02/2026
It's a full queue kind of day #chemsky
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Auclair Lab @auclairlab.bsky.social · 28/01/2026
Congratulations to Natalia for receiving a PROTEO graduate scholarship! proteo.ca/en/news-and-...
proteo.ca
Recipients of the graduate scholarship competition – Winter 2026 Edition - PROTEO
Congratulations to our scholarship winners ! Laureates – Winter 2026 Edition Master student : Joseph Descarreaux, Université Laval Christina Rossignol-Garon, Université Laval PhD students : Ilona Metayer, Polytechnique Montréal Arunima Sandeep, Université du Québec à Montréal Valentin Cerfeuillet, Université de Sherbrooke Mohamad Radwan, Université McGill Natalia Munoz Patino, Université McGill
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Auclair Lab @auclairlab.bsky.social · 22/01/2026
Freezer defrosting day means freezer sorting day #chemsky
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Auclair Lab @auclairlab.bsky.social · 19/01/2026
First thiol smell of the new year. And it's not even a particularly noxious one! #chemsky
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Auclair Lab @auclairlab.bsky.social · 05/01/2026
We're officially back for the new year. The built-up freezer ice looks so neat it's almost a shame to de-ice it all.
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Auclair Lab @auclairlab.bsky.social · 05/12/2025
This is our freezer for the next few hours #chemsky
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Auclair Lab @auclairlab.bsky.social · 29/11/2025
Check out some of the great work being done by our collaborators in the Schmeing lab in Biochemistry! In partnership with the Canadian Light Source's beamline, they're examining the structure and workings of itaconate-degrading enzymes. #chemsky #biochemsky www.linkedin.com/posts/canlig...
linkedin.com
#onthebeamlines #bacteria #salmonella #legionella #pseudomonas #yersinia #tuberculosis | Canadian Light Source Inc. / Centre canadien de rayonnement synchrotron
#OnTheBeamlines: Itaconate is a small molecule our immune cells make when fighting bacteria. Some #bacteria, however, fight back: they use a three-step enzyme pathway to break down itaconate so it’s n...
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Auclair Lab @auclairlab.bsky.social · 26/11/2025
Prof. Auclair presented at the McGill Interdisciplinary Initiative in Infection and Immunity (MI4) annual symposium last week!
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Auclair Lab @auclairlab.bsky.social · 17/11/2025
Come find us at @concordia.ca Loyola campus for CBGRC this Friday!
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Reposted by Auclair Lab
Auclair Lab @auclairlab.bsky.social · 30/10/2025
NEW PREPRINT: An extensive structure-activity relationship investigation of pantetheinamides and their ability to inhibit Salmonella typhimurium. We investigate the mechanisms of action of these compounds and their use with in vivo mouse models. doi.org/10.1101/2025...
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Auclair Lab @auclairlab.bsky.social · 30/10/2025
NEW PREPRINT: An extensive structure-activity relationship investigation of pantetheinamides and their ability to inhibit Salmonella typhimurium. We investigate the mechanisms of action of these compounds and their use with in vivo mouse models. doi.org/10.1101/2025...
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Auclair Lab @auclairlab.bsky.social · 23/10/2025
Here's some more balanced centrifuge arrangements #chemsky
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Auclair Lab @auclairlab.bsky.social · 10/10/2025
We're incredibly proud to announce Dr. Jacob Pierscianowski has officially defended his PhD thesis! Congratulations to Dr. Jake on the amazing work.
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Auclair Lab @auclairlab.bsky.social · 08/10/2025
Good Wordle yesterday.
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Auclair Lab @auclairlab.bsky.social · 04/10/2025
Update: purified it anyways. Fraction looks reasonably pure. Now let's see the activity tests. #chemsky
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Auclair Lab @auclairlab.bsky.social · 03/10/2025
The Auclair Lab welcomes two new members! Maya Gaylor, co-supervised by Prof. Lupien in Microbiology and Immunology, will be working on our antimicrobial projects. Dr. Alana Rangaswamy is a recent graduate from the Keillor lab @uottawa.ca and will focus on enzyme and depolymerization efforts.
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Auclair Lab @auclairlab.bsky.social · 23/09/2025
Admin got up yesterday at 7 in the morning to perform a transformation that probably didn't work. One (1) colony on the plates. This is the #chembiosky life.
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Auclair Lab @auclairlab.bsky.social · 19/09/2025
Fun fact: we scheduled our lab cleanup day a few weeks ago, and the second we finished up, we got a notification that we were having a safety inspection the very next Monday. Talk about good timing #chemsky
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Auclair Lab @auclairlab.bsky.social · 12/09/2025
Many members of the Auclair lab hosted and attended the student-led Careers After Chemistry conference! #CAC2025 #chemsky
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Auclair Lab @auclairlab.bsky.social · 10/09/2025
Literal green chemistry #chemsky
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Auclair Lab @auclairlab.bsky.social · 04/09/2025
Doing a little setup for our new baby 👀
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Auclair Lab @auclairlab.bsky.social · 03/09/2025
New instrument 🔜🔜🔜
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Auclair Lab @auclairlab.bsky.social · 29/08/2025
Sign up for McGill Chemistry's Careers After Chemistry 2025 conference! Registration ends September 5. cacmcgill.wixsite.com/cac2025/regi...
cacmcgill.wixsite.com
Register | CAC 2025
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Auclair Lab @auclairlab.bsky.social · 28/08/2025
The Auclair lab went tree trekking recently! Super fun teambuilding exercise.
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Auclair Lab @auclairlab.bsky.social · 20/08/2025
Very happy to meet 2020 Nobel Prize laureate @e-charpentier.bsky.social at @ircm.bsky.social!
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Reposted by Auclair Lab
Auclair Lab @auclairlab.bsky.social · 13/08/2025
‼️NEW PAPER ALERT In Antimicrobial Agents and Chemotherapy, we replace an enzyme-vulnerable amide bond with a thiazole to produce potent antiplasmodial and antimalarial pantothenamide mimics. A collaboration between the Auclair lab @mcgill.ca and the Saliba lab at ANU. doi.org/10.1128/aac.... 🧵
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Reposted by Auclair Lab
Bromothymol Blue @canvasblue.bsky.social · 13/08/2025
Another day, another paper 😌
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Auclair Lab @auclairlab.bsky.social · 13/08/2025
‼️NEW PAPER ALERT In Antimicrobial Agents and Chemotherapy, we replace an enzyme-vulnerable amide bond with a thiazole to produce potent antiplasmodial and antimalarial pantothenamide mimics. A collaboration between the Auclair lab @mcgill.ca and the Saliba lab at ANU. doi.org/10.1128/aac.... 🧵
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Auclair Lab @auclairlab.bsky.social · 11/08/2025
Balloons! #chemsky
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Auclair Lab @auclairlab.bsky.social · 07/08/2025
Finding the volume of our milling balls: if it was good enough for Archimedes, it's good enough for grad students #chemsky
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Auclair Lab @auclairlab.bsky.social · 30/07/2025
A wonderful moist-solid #chemsky
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