iiinova — where your digital self keeps evolving

Fabien Plisson @fabienplisson.bsky.social · 15/11/2024

Thanks to @sunnalab & @MQ_BDRC for inviting me to the symposium. I was very pleased to present our @CinvestavIra & @IngenieBio work in the #AI-driven peptide discovery & design. It stimulated some interesting questions over bias, representation learning, data scarcity and hype.

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Fabien Plisson @fabienplisson.bsky.social · 06/11/2024

Whenever possible, we employ emerging tools for protein design like #AlphaFold or #RFDiffusion. Still, many challenges are unique to peptides—short half-life, limited oral bioavailability, toxicity—and sampling bias and data scarcity to the #ML modelling process. (2/3

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Fabien Plisson @fabienplisson.bsky.social · 04/11/2024

Pleased to attend #ABACBS24 Symposium on Bioinformatics Excellence and Innovation #SBEI24 to see challenges in cloud computing, data mgt, #AI technology to #drugdiscovery research programs from @AWS, @googlecloud & bioinformatics facilities like @AusBiocommons @PeterMacCC

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Fabien Plisson @fabienplisson.bsky.social · 16/10/2024

Fantastic view over Sydney CBD to attend @ProtoAxiom #ChallengerSummit2024 and meet like-minded people pushing forward the Australian #Biotechnology industry

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Fabien Plisson @fabienplisson.bsky.social · 16/10/2024

I tried @notebooklm_pods with two of our recent peer-reviewed articles; it generated a 10-minute audio on structural bias in #ML-guided #peptide design with great accuracy. Enjoy! substack.com/home/post/p-15…

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Fabien Plisson @fabienplisson.bsky.social · 22/09/2024

I'm excited to see some computational biology & drug discovery research down at Melbourne's @bmh2024Melb #BMH2024

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Fabien Plisson @fabienplisson.bsky.social · 18/09/2024

I am very pleased to have presented @peptidicos research work about #MachineLearning #peptidedesign at Macquarie Dementia Research Centre @MQ_DRC @Macquarie_Uni. Thanks @OleTietz. Beautiful campus.

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Fabien Plisson @fabienplisson.bsky.social · 07/09/2024

Thanks to @RoySocChem + @LatinXChem for adding our seminal review, co-authored by @fersaldivar11, @DanielAldas, and @difacquim, to this themed collection.#LatinXChem #naturalproducts #drugdiscovery #machinelearning #artificial_intelligence shorturl.at/zJIaX

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Fabien Plisson @fabienplisson.bsky.social · 22/07/2024

This Thursday, I will present @UNSWBABS our research on #MachineLearning guided peptide design and how we monitor existing #bias in biological data and tackle it to develop more informed ML/DL models. #XAI #AMR #peptide2drug

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Fabien Plisson @fabienplisson.bsky.social · 14/07/2024

Traversée des rues de Montréal en découvrant avec mini-moi les statues du #Mignonisme de @Katerin55468086. Le premier Monsieur Rose est dans l'hôtel Fairmont #artwork #contemporain

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Fabien Plisson @fabienplisson.bsky.social · 19/06/2024

Most predictive/generative #machinelearning models are built on #protein sequences. With @DanielAldas we developed a fast + parallelizable strategy to map the structural landscape of training set(s), giving you insights on structural constraints #XAI #AF2 doi.org/10.1039/D3DD00…

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Fabien Plisson @fabienplisson.bsky.social · 20/03/2024

A clear and very informative talk by @DidiKieran on controllable generative modeling applied to #proteindesign #diffusion #EESAIBio

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Fabien Plisson @fabienplisson.bsky.social · 15/03/2024

Fascinating talk by Ania Di Pede @StefaniaDiPede on predicting the stability of plastic-degrading enzymes PETases using graph convolutional networks and Megascale data #proteinengineering #sustainability #circulareconomy #EESAIBio

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Fabien Plisson @fabienplisson.bsky.social · 14/03/2024

Great presentation by Ricardo Olayo @Scietwas @LMU_Muenchen showing how pre-trained molecular representations (MolE) can help us tackle chemical & biological data scarcity to accelerate antimicrobial drug discovery #AMR and beyond. #EESAIBio

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Fabien Plisson @fabienplisson.bsky.social · 13/03/2024

Catching up with the insightful talk by @mmbronstein on geometric #MachineLearning applied to protein binder design and function prediction #EESAIBio

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Fabien Plisson @fabienplisson.bsky.social · 17/01/2024

One 2024 resolution down; my personal academic website incl. @peptidicos is finally up and working#peptide2drug #drugdiscovery #machinelearning #ArtificialIntelligence #datascience #datavis #AntimicrobialResistance #CancerResearch plissonf.github.io

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Fabien Plisson @fabienplisson.bsky.social · 07/12/2023

After 3 days at #ABACBS2023 enjoying #compbio and #ArtificialIntelligence talks, I took a short stroll to visit friends at #AlmaMater @IMBatUQ

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Fabien Plisson @fabienplisson.bsky.social · 13/11/2023

The @CinvestavIra is opening faculty positions in biological sciences with research lines towards #FoodSecurity and #SustainableAgriculture. If you are an aspiring group leader like @CatedrasMx @EInvestigadores and your are passionate about these areas, check out the info.

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Fabien Plisson @fabienplisson.bsky.social · 17/10/2023

Come and see our @peptidicos works in #machinelearning and #chemoinformatics applied to peptide science (Posters 89, 335-338) @AusPeptide

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Fabien Plisson @fabienplisson.bsky.social · 04/10/2023

G'day Sydney. I am in town for the next 10 days before #AusPeptide2023.

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Fabien Plisson @fabienplisson.bsky.social · 20/08/2023

Moving back to Australia in late 2023, I am exploring new opportunities and collaborations with like-minded individuals in the research fields of #proteinengineering and #artificialintelligence, with a focus on #Health, #Energy, and #FoodSecurity. Feel free to reach out.

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Fabien Plisson @fabienplisson.bsky.social · 14/08/2023

Interesting expo by @uncountable_inc members about digitalizing & structuring lab experimental data for #ArtificialInteligence #ACSFall2023

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Fabien Plisson @fabienplisson.bsky.social · 13/08/2023

Very pleased to present our work @DanielAldas and @sakmae on "Auditing structural bias in ML-guided peptide design" #ACSFall2023 #StructureMatters #peptidelandscape #AF2 #MachineLearning

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Fabien Plisson @fabienplisson.bsky.social · 28/07/2023

Happy recipient of the bilateral mobility grant #ECOSNord between Mexico and France @ANUIES @Conahcyt_Mex @muframex in collaboration with Dr. Nicolas Gilles @CEAParisSaclay to discover natural peptides in application to neurological disorders #peptide4cure #mentalhealth

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Fabien Plisson @fabienplisson.bsky.social · 21/07/2023

Hi everyone. My lab works at the crossroads between #drugdiscovery, #peptidedesign, #proteinengineering and #machinelearning for human health at @CinvestavIra. Next October, I will participate and check out your posters at #LatinXChem23 in #chembio

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Fabien Plisson @fabienplisson.bsky.social · 12/07/2023

Intense writing period (theses, papers) for @peptidicos. I ground some ⛽ for brainstorming and keeping their spirits high #chemistwhodrinkscoffee #fairtrade

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Fabien Plisson @fabienplisson.bsky.social · 14/05/2023

What a great week networking with talented statisticians and computational biologists during a workshop in beautiful Oaxaca @CMO_oaxaca #Genomics #ProteinEngineering #RNAFolding #DataScience #MachineLearning #ArtificialIntelligence

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Fabien Plisson @fabienplisson.bsky.social · 29/03/2023

After much pre-processing, we faced a real-world dataset with its imbalances and scarcity.

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Fabien Plisson @fabienplisson.bsky.social · 29/03/2023

With the goal to develop #MachineLearning models to design cell-selective anticancer peptides, this study explores the potency and selectivity of 138 mACPs towards 77 cancer cell lines using pIC50 values. #peptide2drug

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Fabien Plisson @fabienplisson.bsky.social · 21/03/2023

Most #MachineLearning models applied to peptides learn from sequential information. Their 3D structures are often overlooked. With @DanielAldas, we benchmarked 4 PSP methods including #Alphafold to assess the structural landscape of medium-large datasets doi.org/10.26434/chemr…

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Fabien Plisson @fabienplisson.bsky.social · 23/02/2023

Adding these two new books to my collection - 1. "#Mathematics for #MachineLearning" by Mark Peter Deisenroth + A. Aldo Faisal @AnalogAldo + Cheng Soon Ong @ChengSoonOng and 2. "#Python Machine Learning" by Sebastian Raschka @rasbt + Vahid Mirjalili

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Fabien Plisson @fabienplisson.bsky.social · 18/02/2023

Very happy for one more member @peptidicos to finally conclude his MSc thesis titled "Engineering scorpion toxins using ML-guided directed evolution" #venom2drug #MachineLearning #Artificial_Intelligence

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Fabien Plisson @fabienplisson.bsky.social · 16/12/2022

Last Friday was our 2022 wrap-up after another writing retreat. What a great team of Mexican extraordinaires!

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Fabien Plisson @fabienplisson.bsky.social · 10/12/2022

Celebrating the upcoming holidays with new goodies for the lab: Grabación de KÚCHI& tasty cookies byOriginal @peptidicos logo design by my dear friend @mauguz33 altamirastudio.com.mx instagram.com/cocoa.deli/ instagram.com/estudio.kuchi/

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Fabien Plisson @fabienplisson.bsky.social · 16/11/2022

Excited to be presenting "#AI-driven peptide design - opportunities and limitations" @cimatoficial as part of the @muframex 2nd Thematic School on Deep Generative Models #machinelearning #GenerativeAI #peptide2drug #AntimicrobialResistance

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Fabien Plisson @fabienplisson.bsky.social · 11/10/2022

Very pleased to listen to Dr. Sergio Aguila Puentes @CNyN_UNAM to tell us about interactions between proteins, 🧬 aptamers and carbon nanotubes to support the early detection of Human Papilloma Virus #compchem #nanosensors

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Fabien Plisson @fabienplisson.bsky.social · 09/10/2022

And some other pics of cyclic peptides with their cystine bridges; RTD-1 and MCoTI-like

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Fabien Plisson @fabienplisson.bsky.social · 08/10/2022

2/ Veneno al Blanco with Luis and Gaby

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Fabien Plisson @fabienplisson.bsky.social · 30/09/2022

Now, @DanielAldas is introducing #MachineLearning algorithms to predict the antimicrobial activity of peptide sequences #RIIAA2022 Summer School #peptide2drug . To DIY with Google Colab, follow our Github repo github.com/plissonf/RIIAA…

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Fabien Plisson @fabienplisson.bsky.social · 28/09/2022

For all the young parents out there, I generated photorealistic portraits of Paw Patrol puppies using #stablediffusion

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