Reposted by Jess EwaldNiranj Chandrasekaran @niranjchandrasekaran.com · 07/08/2025Morph Map is now published in Nature Methods. Excited to see what the community discovers with this resource mapping ~15,000 human genes! rdcu.be/ezGrerdcu.beMorphological map of under- and overexpression of genes in human cellsNature Methods - This Resource presents the genetic subset of the 136,000 chemical and genetic perturbations tested by the Joint Undertaking for Morphological Profiling (JUMP) Cell Painting... 15419
Jess Ewald @ewaldlab.org · 07/08/2025The visa is easy to obtain, for you and for any immediate family members. It allows a spouse to work in the UK. Please reach out with any questions! 020
Jess Ewald @ewaldlab.org · 07/08/2025Project 7: Predict cellular phenotypes induced by environmental contaminants based on compound structure and cellular images using generative AI, in collaboration with Mo Lotfollahi (www.sanger.ac.uk/group/lotfol...) 110
Jess Ewald @ewaldlab.org · 07/08/2025Project 3: Decode morphological programmes of T cell activation through multimodal imaging and machine learning, in collaboration with @gosiatrynka.bsky.social (www.sanger.ac.uk/group/trynka...) 220
Jess Ewald @ewaldlab.org · 07/08/2025Two of the projects are co-hosted by my lab (ewaldlab.org)ewaldlab.orgEwald Lab@ EMBL-EBI. We identify and characterize chemical hazards to both humans and ecosystems with cell profiling data, machine learning, and integrative data analysis. 110
Jess Ewald @ewaldlab.org · 07/08/2025Check out this opportunity to join my lab as a postdoc! www.ebi.ac.uk/research/pos... Every year, faculty from EMBL-EBI and the Wellcome Sanger Institute co-develop projects that allow fellows to be part of ✨both✨ of these amazing research institutes.ebi.ac.ukEMBL-EBI-Sanger postdoctoral fellowships (ESPOD)The ESPOD fellowship builds on the collaborative relationship between EMBL-EBI and the Wellcome Sanger Institute, offering projects that combine experimental (wet-lab) and computational (dry-lab) appr... 31114
Reposted by Jess EwaldBeth Cimini 🔬💻📊 @bethcimini.bsky.social · 07/03/2025We're once again hiring a summer (+?) #bioimage #bioimageanalysis #software intern! Due to requirements of the funding program, you must be a current student, as well as work onsite in MA (+ have US work permission). Details at the link below. Spend your summer making great tools with fun people!forum.image.scSoftware engineering intern - summer/fall 2025 - Cambridge, MA USAIf you are a current student (undergraduate/masters/PhD) with permission to work in the US and ability to work in-person in Cambridge, MA, US, consider a summer internship in the Broad Institute Imagi... 02218
Jess Ewald @ewaldlab.org · 06/03/2025Two EMBL-specific quirks: - EMBL salaries are "after tax", so the stated salary is roughly equivalent to $70k USD - Employees qualify for a quick & inexpensive visa exemption that allows them and their spouse/children to work in the UK (my visa was processed in 2 days and cost me $50USD) 021
Jess Ewald @ewaldlab.org · 05/03/2025🚨 We're hiring! 🚨 The Ewald Lab at EMBL-EBI is looking for a postdoctoral researcher in multi-omics, machine learning, and predictive toxicology to analyze a groundbreaking toxicology dataset as part of the OASIS Consortium. More details & application here: lnkd.in/eHD7DMdX 211556
Reposted by Jess EwaldPatrick MacDonald🇨🇦 @bcellorg.bsky.social · 21/02/2025We link molecular and functional phenotypes of islet cells from donors with type 1 diabetes to understand impaired insulin and glucagon secretion. Immune signalling, nuclear exclusion, mTOR and lysosomes in alpha cell dysfunction. www.biorxiv.org/content/10.1101/202… 14222
Jess Ewald @ewaldlab.org · 03/02/20256/ Huge thank you to my co-authors at Axiom who were wonderful to work with, as well as to the entire OASIS Consortium. 010
Jess Ewald @ewaldlab.org · 03/02/20255/ These findings demonstrate the potential of image-based profiling as a sensitive, animal-free, early-stage screening tool for compound toxicity. 110
Jess Ewald @ewaldlab.org · 03/02/20254/ We found that the morphological profiles detect compound bioactivity at lower concentrations than standard cytotoxicity assays. In supervised analyses, they predict cytotoxicity and targeted cell-based assay readouts, but not cell-free assay readouts. 110
Jess Ewald @ewaldlab.org · 03/02/20253/ We then use supervised machine learning to predict diverse in vitro assay readouts relevant to mode-of-action and cell state using image-based profiles. We also investigate optimal strategies for extracting information from images to make mode-of-action predictions. 120
Jess Ewald @ewaldlab.org · 03/02/20252/ High-throughput, human-relevant approaches for predicting chemical toxicity are urgently needed. In our new preprint, we use Cell Painting and cytotoxicity assays to profile >1000 compounds in primary human hepatocytes, including pharmaceuticals, pesticides, and industrial chemicals. 121
Jess Ewald @ewaldlab.org · 03/02/2025First large-scale analysis of chemical toxicity in primary human hepatocytes! www.biorxiv.org/content/10.1...biorxiv.orgCell Painting for cytotoxicity and mode-of-action analysis in primary human hepatocytesHigh-throughput, human-relevant approaches for predicting chemical toxicity are urgently needed for better decision-making in human health. Here, we apply image-based profiling (the Cell Painting assa... 1114
Reposted by Jess EwaldAnne Carpenter @drannecarpenter.bsky.social · 18/12/2024We've a postdoc opening for our lab at the Broad: Cambridge MA! Must have experience in toxicology + data science Work on the wonderful OASIS dataset we are producing... Cell Painting, transcriptomics, proteomics in various liver cell and tissue models! broad.io/mlcbpostdoc 13023
Reposted by Jess EwaldBeth Cimini 🔬💻📊 @bethcimini.bsky.social · 16/12/2024New Year, new job? Delighted to announce two early-career-level (post-BA/BS or MA) positions in my lab, and an open call for computational postdocs at the Broad! First, an image analysis associate - work on high content screens for all kinds of cells and dimensionalities! See more at link (1/4)docs.google.comImage analysis associate job descriptionImage Analysis Associate Broad Institute of MIT and Harvard, Cambridge, MA Impact the discovery of new disease therapies in the Cimini laboratory at the Imaging Platform Join our vibrant, world-clas... 24435
Jess Ewald @ewaldlab.org · 13/12/2024I think about macromolecules a lot, but mainly as either targets of small molecules that cause target-mediated toxicity, or as something that we can measure at scale (omics data) to detect toxicity. 010
Jess Ewald @ewaldlab.org · 13/12/2024🎉 I'm starting my own lab at EMBL-EBI (Cambridge, UK; June 2025) 🎉 We will focus on identifying and characterizing chemical hazards to humans and ecosystems using computational biology methods. I am beginning the search for two postdocs now - stay tuned for more details! ewaldlab.orgewaldlab.orgEwald Lab@ EMBL-EBI. We identify and characterize chemical hazards to both humans and ecosystems with cell profiling data, machine learning, and integrative data analysis. 916537
Reposted by Jess EwaldJohn Arevalo @johnarevalo.bsky.social · 13/12/2024Excited to present our spotlight paper at #NeurIPS! MOTIVE is a new dataset + benchmark for predicting drug-target interactions, using Cell Painting data Location: Fri 13 Dec 4:30 p.m. PST @ East Exhibit Hall A-C #4208 Poster: neurips.cc/virtual/2024... Paper: arxiv.org/abs/2406.08649 0206
Jess Ewald @ewaldlab.org · 04/12/2024A new paper from the Carpenter-Singh Lab - such a cool project and I'm really excited about the possibilities that these data will unlock for future projects! 0100
Jess Ewald @ewaldlab.org · 16/11/2024Really loved the concept of distinguishing between 'fun challenge stress' and 'threat stress' on this Ologies podcast on burnout: open.spotify.com/episode/0ccV... Reflecting on my own work patterns as I mentally prepare to start my own lab. Any tips out there?open.spotify.comErgopathology (BURNOUT) with Kandi WiensOlogies with Alie Ward · Episode 060
Reposted by Jess EwaldSuganya @sugansivaguru.bsky.social · 15/11/2024The 2024 biennial survey by COBA, @bioimagingna.bsky.social, @royalmicrosoc.bsky.social and @globias.bsky.social is here to connect imaging users with image analysis. Check this out @biologists.bsky.social for more details - focalplane.biologists.com/2024/11/13/b...focalplane.biologists.comBridging Imaging Users to Imaging Analysis - 2024 - FocalPlaneBridging Imaging Users to Imaging Analysis - 2024 - 159